Als2 (alsin Rho guanine nucleotide exchange factor ALS2) - Rat Genome Database

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Gene: Als2 (alsin Rho guanine nucleotide exchange factor ALS2) Rattus norvegicus
Analyze
Symbol: Als2
Name: alsin Rho guanine nucleotide exchange factor ALS2
RGD ID: 1310372
Description: Predicted to enable several functions, including GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; in utero embryonic development; and regulation of endosome size. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH (+)-schisandrin B; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ALS2, alsin Rho guanine nucleotide exchange factor; alsin; alsin Rho guanine nucleotide exchange factor; amyotrophic lateral sclerosis 2 (juvenile); amyotrophic lateral sclerosis 2 (juvenile) homolog (human); amyotrophic lateral sclerosis 2 protein homolog; amyotrophic lateral sclerosis protein 2 homolog; LOC363235
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8968,107,310 - 68,180,192 (-)NCBIGRCr8
mRatBN7.2960,613,182 - 60,686,394 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,613,167 - 60,670,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx969,109,629 - 69,180,766 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0974,225,596 - 74,296,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,543,871 - 72,615,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,961,361 - 66,034,396 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,961,346 - 66,033,871 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,768,594 - 65,841,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,741,679 - 57,812,652 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,887,443 - 57,959,517 (-)NCBI
Celera958,052,438 - 58,123,222 (-)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
lipopolysaccharide  (ISO)
lutein  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metam  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
Pyridostigmine bromide  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
centrosome  (IBA,IEA,ISO)
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (IEA,ISO,ISS)
dendrite  (IBA,IDA,IEA,ISO,ISS)
dendritic spine  (IEA,ISO)
early endosome  (IEA,ISO,ISS)
glutamatergic synapse  (IEA,ISO)
growth cone  (IDA)
lamellipodium  (IEA,ISO)
membrane  (IDA)
neuronal cell body  (IDA)
nucleus  (IEA,ISO)
postsynaptic density  (IEA,ISO)
protein-containing complex  (IEA,ISO,ISS)
ruffle  (IEA,ISO)
vesicle  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Alsin/Rac1 signaling controls survival and growth of spinal motoneurons. Jacquier A, etal., Ann Neurol. 2006 Jul;60(1):105-17.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor. Topp JD, etal., J Biol Chem. 2004 Jun 4;279(23):24612-23. Epub 2004 Mar 19.
12. ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth. Tudor EL, etal., J Biol Chem. 2005 Oct 14;280(41):34735-40. Epub 2005 Jul 26.
13. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Yang Y, etal., Nat Genet. 2001 Oct;29(2):160-5.
Additional References at PubMed
PMID:12837691   PMID:15247254   PMID:15371724   PMID:15579468   PMID:15686953   PMID:16085057   PMID:16107644   PMID:16321985   PMID:16769894   PMID:17093100   PMID:17239822   PMID:18482800  


Genomics

Comparative Map Data
Als2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8968,107,310 - 68,180,192 (-)NCBIGRCr8
mRatBN7.2960,613,182 - 60,686,394 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,613,167 - 60,670,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx969,109,629 - 69,180,766 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0974,225,596 - 74,296,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,543,871 - 72,615,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,961,361 - 66,034,396 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,961,346 - 66,033,871 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,768,594 - 65,841,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,741,679 - 57,812,652 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,887,443 - 57,959,517 (-)NCBI
Celera958,052,438 - 58,123,222 (-)NCBICelera
Cytogenetic Map9q31NCBI
ALS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,700,267 - 201,780,933 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2201,700,267 - 201,782,112 (-)EnsemblGRCh38hg38GRCh38
GRCh372202,564,990 - 202,645,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,273,522 - 202,353,983 (-)NCBINCBI36Build 36hg18NCBI36
Build 342202,390,782 - 202,471,244NCBI
Celera2196,316,786 - 196,398,012 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2194,413,010 - 194,494,230 (-)NCBIHuRef
CHM1_12202,571,473 - 202,652,371 (-)NCBICHM1_1
T2T-CHM13v2.02202,180,871 - 202,263,022 (-)NCBIT2T-CHM13v2.0
Als2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,201,915 - 59,276,390 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,202,085 - 59,276,390 (-)EnsemblGRCm39 Ensembl
GRCm38159,162,756 - 59,237,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,162,926 - 59,237,231 (-)EnsemblGRCm38mm10GRCm38
MGSCv37159,219,600 - 59,294,075 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36159,107,478 - 59,181,765 (-)NCBIMGSCv36mm8
Celera159,678,988 - 59,753,541 (-)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.33NCBI
Als2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,449 - 104,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,449 - 104,577 (+)NCBIChiLan1.0ChiLan1.0
ALS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213104,323,577 - 104,405,299 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B104,338,577 - 104,420,295 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B88,954,167 - 89,034,764 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B207,108,952 - 207,189,681 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,108,952 - 207,189,623 (-)Ensemblpanpan1.1panPan2
ALS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,755,595 - 10,825,073 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,756,515 - 10,812,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3711,639,022 - 11,709,699 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03710,660,479 - 10,730,278 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,660,802 - 10,761,621 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,641,412 - 10,711,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,620,145 - 10,691,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,613,682 - 10,683,474 (-)NCBIUU_Cfam_GSD_1.0
Als2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,970,697 - 159,045,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726939,341 - 1,015,799 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936726940,696 - 1,015,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,328,719 - 105,401,093 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,328,717 - 105,401,152 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11087,389,130 - 87,473,134 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040111,943,033 - 112,023,399 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Als2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462489974,080 - 170,565 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Als2
367 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:123
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000035209
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
AA848990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,613,332 - 60,613,455 (+)MAPPERmRatBN7.2
Rnor_6.0965,961,512 - 65,961,634NCBIRnor6.0
Rnor_5.0965,768,745 - 65,768,867UniSTSRnor5.0
RGSC_v3.4957,740,611 - 57,740,733UniSTSRGSC3.4
Celera958,051,370 - 58,051,492UniSTS
RH 3.4 Map9522.6UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000035209   ⟹   ENSRNOP00000036116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,616,652 - 60,668,251 (-)Ensembl
Rnor_6.0 Ensembl965,962,580 - 66,033,871 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088729   ⟹   ENSRNOP00000072428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,613,167 - 60,670,737 (-)Ensembl
Rnor_6.0 Ensembl965,961,346 - 66,019,065 (-)Ensembl
RefSeq Acc Id: NM_001013413   ⟹   NP_001013431
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,108,529 - 68,179,660 (-)NCBI
mRatBN7.2960,614,401 - 60,685,533 (-)NCBI
Rnor_6.0965,962,580 - 66,033,871 (-)NCBI
Rnor_5.0965,768,594 - 65,841,938 (-)NCBI
RGSC_v3.4957,741,679 - 57,812,652 (-)RGD
Celera958,052,438 - 58,123,222 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245001   ⟹   XP_006245063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,107,310 - 68,180,182 (-)NCBI
mRatBN7.2960,613,182 - 60,686,393 (-)NCBI
Rnor_6.0965,961,361 - 66,034,391 (-)NCBI
Rnor_5.0965,768,594 - 65,841,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596517   ⟹   XP_017452006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,107,310 - 68,180,184 (-)NCBI
mRatBN7.2960,613,182 - 60,686,394 (-)NCBI
Rnor_6.0965,961,361 - 66,034,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063267376   ⟹   XP_063123446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,107,310 - 68,180,182 (-)NCBI
RefSeq Acc Id: XR_010054614
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,146,820 - 68,180,192 (-)NCBI
RefSeq Acc Id: NP_001013431   ⟸   NM_001013413
- UniProtKB: P0C5Y8 (UniProtKB/Swiss-Prot),   A0A8L2R6D9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245063   ⟸   XM_006245001
- Peptide Label: isoform X1
- UniProtKB: P0C5Y8 (UniProtKB/Swiss-Prot),   A0A8L2R6D9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452006   ⟸   XM_017596517
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R6D9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036116   ⟸   ENSRNOT00000035209
Ensembl Acc Id: ENSRNOP00000072428   ⟸   ENSRNOT00000088729
RefSeq Acc Id: XP_063123446   ⟸   XM_063267376
- Peptide Label: isoform X1
- UniProtKB: P0C5Y8 (UniProtKB/Swiss-Prot),   A0A8L2R6D9 (UniProtKB/TrEMBL)
Protein Domains
5-aminolevulinate synthase presequence   DH   PH   VPS9

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C5Y8-F1-model_v2 AlphaFold P0C5Y8 1-1651 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696700
Promoter ID:EPDNEW_R7225
Type:multiple initiation site
Name:Als2_1
Description:ALS2, alsin Rho guanine nucleotide exchange factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0966,033,866 - 66,033,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310372 AgrOrtholog
BioCyc Gene G2FUF-27416 BioCyc
Ensembl Genes ENSRNOG00000023280 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000088729 ENTREZGENE
Gene3D-CATH 1.20.1050.80 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot
  2.130.10.30 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain UniProtKB/Swiss-Prot
InterPro Alsin_GEFs/MotNeuronReg UniProtKB/Swiss-Prot
  DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  MORN UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  RCC1/BLIP-II UniProtKB/Swiss-Prot
  Reg_chr_condens UniProtKB/Swiss-Prot
  VPS9 UniProtKB/Swiss-Prot
  VPS9_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:363235 UniProtKB/Swiss-Prot
NCBI Gene 363235 ENTREZGENE
PANTHER ALSIN UniProtKB/Swiss-Prot
  ALSIN HOMOLOG UniProtKB/Swiss-Prot
Pfam MORN UniProtKB/Swiss-Prot
  RCC1 UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  VPS9 UniProtKB/Swiss-Prot
PhenoGen Als2 PhenoGen
PRINTS RCCNDNSATION UniProtKB/Swiss-Prot
PROSITE DH_2 UniProtKB/Swiss-Prot
  RCC1_2 UniProtKB/Swiss-Prot
  RCC1_3 UniProtKB/Swiss-Prot
  VPS9 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023280 RatGTEx
SMART MORN UniProtKB/Swiss-Prot
Superfamily-SCOP Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain UniProtKB/Swiss-Prot
  PH domain-like UniProtKB/Swiss-Prot
  SSF109993 UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF50985 UniProtKB/Swiss-Prot
UniProt A0A8L2R6D9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UL81_RAT UniProtKB/TrEMBL
  A6IPA3_RAT UniProtKB/TrEMBL
  ALS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9ESE3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-26 Als2  alsin Rho guanine nucleotide exchange factor ALS2  Als2  ALS2, alsin Rho guanine nucleotide exchange factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-11-14 Als2  ALS2, alsin Rho guanine nucleotide exchange factor  Als2  alsin Rho guanine nucleotide exchange factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Als2  alsin Rho guanine nucleotide exchange factor  Als2  amyotrophic lateral sclerosis 2 (juvenile)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-03 Als2  amyotrophic lateral sclerosis 2 (juvenile)  Als2  amyotrophic lateral sclerosis 2 (juvenile) homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Als2  amyotrophic lateral sclerosis 2 (juvenile) homolog (human)    amyotrophic lateral sclerosis 2 (juvenile)  Name updated 1299863 APPROVED
2005-12-06 Als2  amyotrophic lateral sclerosis 2 (juvenile)  Als2_predicted  amyotrophic lateral sclerosis 2 (juvenile) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Als2_predicted  amyotrophic lateral sclerosis 2 (juvenile) (predicted)      Symbol and Name status set to approved 70820 APPROVED