Hibch (3-hydroxyisobutyryl-CoA hydrolase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hibch (3-hydroxyisobutyryl-CoA hydrolase) Rattus norvegicus
Analyze
Symbol: Hibch
Name: 3-hydroxyisobutyryl-CoA hydrolase
RGD ID: 1308392
Description: Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-Coenzyme A hydrolase; HIB-CoA hydrolase; HIBYL-CoA-H; LOC301384
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,082,082 - 56,161,796 (-)NCBIGRCr8
mRatBN7.2948,590,097 - 48,669,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,590,099 - 48,669,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,131,763 - 57,211,849 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,254,592 - 62,334,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,550,578 - 60,630,667 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,446,185 - 53,526,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,446,194 - 53,526,728 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,112,579 - 53,193,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,564,702 - 45,645,252 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1945,566,124 - 45,624,624 (-)NCBI
Celera946,259,906 - 46,339,124 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acryloyl-CoA  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glyphosate  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
kojic acid  (ISO)
leflunomide  (EXP)
methacrylyl-CoA  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
Muraglitazar  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
membrane  (IEA)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8188708   PMID:8824301   PMID:18614015   PMID:23376485  


Genomics

Comparative Map Data
Hibch
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,082,082 - 56,161,796 (-)NCBIGRCr8
mRatBN7.2948,590,097 - 48,669,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,590,099 - 48,669,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,131,763 - 57,211,849 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,254,592 - 62,334,677 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,550,578 - 60,630,667 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,446,185 - 53,526,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,446,194 - 53,526,728 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,112,579 - 53,193,190 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,564,702 - 45,645,252 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1945,566,124 - 45,624,624 (-)NCBI
Celera946,259,906 - 46,339,124 (-)NCBICelera
Cytogenetic Map9q22NCBI
HIBCH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,189,735 - 190,319,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,189,735 - 190,344,193 (-)EnsemblGRCh38hg38GRCh38
GRCh372191,068,646 - 191,184,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,777,605 - 190,892,804 (-)NCBINCBI36Build 36hg18NCBI36
Build 342190,894,866 - 191,010,065NCBI
Celera2184,664,402 - 184,779,775 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,929,253 - 183,044,631 (-)NCBIHuRef
CHM1_12191,075,217 - 191,190,581 (-)NCBICHM1_1
T2T-CHM13v2.02190,693,510 - 190,809,397 (-)NCBIT2T-CHM13v2.0
Hibch
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,884,197 - 52,960,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,884,088 - 52,960,145 (+)EnsemblGRCm39 Ensembl
GRCm38152,845,038 - 52,920,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,844,929 - 52,920,986 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,901,890 - 52,977,704 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,789,591 - 52,865,405 (+)NCBIMGSCv36mm8
Celera153,386,006 - 53,461,488 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Hibch
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,752,309 - 8,792,927 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,752,339 - 8,796,693 (+)NCBIChiLan1.0ChiLan1.0
HIBCH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,896,951 - 93,041,587 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,911,935 - 93,053,182 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B77,510,938 - 77,652,911 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B195,429,787 - 195,544,564 (-)NCBIpanpan1.1PanPan1.1panPan2
HIBCH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137841,385 - 943,972 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37841,414 - 943,941 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha371,797,343 - 1,893,653 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.037735,664 - 832,314 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37735,666 - 832,320 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137746,020 - 842,670 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037713,636 - 809,463 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037742,338 - 838,606 (-)NCBIUU_Cfam_GSD_1.0
Hibch
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,955,211 - 149,026,449 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,811,600 - 7,882,642 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,811,624 - 7,882,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIBCH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,792,985 - 94,941,266 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11594,795,744 - 94,941,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,964,875 - 105,973,529 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HIBCH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,711,829 - 75,852,055 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,715,996 - 75,828,310 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040123,643,515 - 123,757,713 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hibch
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,705,044 - 5,769,628 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,705,067 - 5,770,145 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hibch
653 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:214
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000029677, ENSRNOT00000040650
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
6903937Bp356Blood pressure QTL 3560.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94790220852283252Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 18 41 8 10 74 35 37 11 8
Low 1 1 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000029677   ⟹   ENSRNOP00000032041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,590,101 - 48,669,798 (-)Ensembl
Rnor_6.0 Ensembl953,446,593 - 53,526,728 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000040650   ⟹   ENSRNOP00000046370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,590,099 - 48,669,824 (-)Ensembl
Rnor_6.0 Ensembl953,446,194 - 53,526,641 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111639   ⟹   ENSRNOP00000078527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,590,101 - 48,663,172 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116077   ⟹   ENSRNOP00000084082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,590,101 - 48,656,597 (-)Ensembl
RefSeq Acc Id: NM_001013112   ⟹   NP_001013130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,161,796 (-)NCBI
mRatBN7.2948,590,097 - 48,669,815 (-)NCBI
Rnor_6.0953,446,185 - 53,526,641 (-)NCBI
Rnor_5.0953,112,579 - 53,193,190 (-)NCBI
RGSC_v3.4945,564,702 - 45,645,252 (-)RGD
Celera946,259,906 - 46,339,124 (-)RGD
Sequence:
RefSeq Acc Id: NM_001398668   ⟹   NP_001385597
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,161,796 (-)NCBI
mRatBN7.2948,590,097 - 48,669,815 (-)NCBI
RefSeq Acc Id: XM_039083288   ⟹   XP_038939216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,148,344 (-)NCBI
mRatBN7.2948,590,121 - 48,656,290 (-)NCBI
RefSeq Acc Id: XM_039083289   ⟹   XP_038939217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,151,645 (-)NCBI
mRatBN7.2948,590,121 - 48,662,740 (-)NCBI
RefSeq Acc Id: XM_063266936   ⟹   XP_063123006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,148,344 (-)NCBI
RefSeq Acc Id: XM_063266937   ⟹   XP_063123007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,088,967 - 56,148,344 (-)NCBI
RefSeq Acc Id: XM_063266938   ⟹   XP_063123008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,667 - 56,148,344 (-)NCBI
RefSeq Acc Id: XM_063266939   ⟹   XP_063123009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,092,615 - 56,161,792 (-)NCBI
RefSeq Acc Id: NP_001013130   ⟸   NM_001013112
- Peptide Label: isoform 2
- UniProtKB: Q5XIE6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032041   ⟸   ENSRNOT00000029677
RefSeq Acc Id: ENSRNOP00000046370   ⟸   ENSRNOT00000040650
RefSeq Acc Id: XP_038939217   ⟸   XM_039083289
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A0J8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939216   ⟸   XM_039083288
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000084082   ⟸   ENSRNOT00000116077
RefSeq Acc Id: ENSRNOP00000078527   ⟸   ENSRNOT00000111639
RefSeq Acc Id: NP_001385597   ⟸   NM_001398668
- Peptide Label: isoform 1
- UniProtKB: Q5XIE6 (UniProtKB/Swiss-Prot),   A6INV5 (UniProtKB/TrEMBL),   A0A8I6A0J8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123006   ⟸   XM_063266936
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063123008   ⟸   XM_063266938
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063123007   ⟸   XM_063266937
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063123009   ⟸   XM_063266939
- Peptide Label: isoform X5
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIE6-F1-model_v2 AlphaFold Q5XIE6 1-385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696652
Promoter ID:EPDNEW_R7176
Type:initiation region
Name:Hibch_1
Description:3-hydroxyisobutyryl-CoA hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0953,526,668 - 53,526,728EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308392 AgrOrtholog
BioCyc Gene G2FUF-27618 BioCyc
BioCyc Pathway VALDEG-PWY [L-valine degradation I] BioCyc
BioCyc Pathway Image VALDEG-PWY BioCyc
Ensembl Genes ENSRNOG00000028557 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004858 UniProtKB/Swiss-Prot
  ENSRNOG00060017354 UniProtKB/Swiss-Prot
  ENSRNOG00065029782 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029677 ENTREZGENE
  ENSRNOT00000029677.7 UniProtKB/Swiss-Prot
  ENSRNOT00000040650 ENTREZGENE
  ENSRNOT00000040650.4 UniProtKB/Swiss-Prot
  ENSRNOT00000111639.1 UniProtKB/TrEMBL
  ENSRNOT00000116077.1 UniProtKB/TrEMBL
  ENSRNOT00055007750 UniProtKB/Swiss-Prot
  ENSRNOT00060029771 UniProtKB/Swiss-Prot
  ENSRNOT00065051540 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191666 IMAGE-MGC_LOAD
InterPro ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ECH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIBYL-CoA-H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301384 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94647 IMAGE-MGC_LOAD
NCBI Gene 301384 ENTREZGENE
PANTHER 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ECH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hibch PhenoGen
RatGTEx ENSRNOG00000028557 RatGTEx
  ENSRNOG00055004858 RatGTEx
  ENSRNOG00060017354 RatGTEx
  ENSRNOG00065029782 RatGTEx
Superfamily-SCOP SSF52096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZL23_RAT UniProtKB/TrEMBL
  A0A8I6A0J8 ENTREZGENE, UniProtKB/TrEMBL
  A6INV5 ENTREZGENE, UniProtKB/TrEMBL
  HIBCH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Hibch  3-hydroxyisobutyryl-CoA hydrolase  Hibch  3-hydroxyisobutyryl-Coenzyme A hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Hibch  3-hydroxyisobutyryl-Coenzyme A hydrolase  Hibch_predicted  3-hydroxyisobutyryl-Coenzyme A hydrolase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hibch_predicted  3-hydroxyisobutyryl-Coenzyme A hydrolase (predicted)      Symbol and Name status set to approved 70820 APPROVED