Il1r2 (interleukin 1 receptor type 2) - Rat Genome Database

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Gene: Il1r2 (interleukin 1 receptor type 2) Rattus norvegicus
Analyze
Symbol: Il1r2
Name: interleukin 1 receptor type 2
RGD ID: 621147
Description: Predicted to enable interleukin-1 binding activity and interleukin-1 receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in aggressive periodontitis; esophageal cancer; lung cancer; and organ system cancer. Orthologous to human IL1R2 (interleukin 1 receptor type 2); PARTICIPATES IN interleukin-1 signaling pathway; cytokine mediated signaling pathway; Entamoebiasis pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD121 antigen-like family member B; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL-1RT-2; IL-1RT2; interleukin 1 receptor, type II; interleukin-1 receptor beta; interleukin-1 receptor type 2; interleukin-1 receptor type II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,879,928 - 49,920,374 (+)NCBIGRCr8
mRatBN7.2942,384,280 - 42,424,726 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,384,433 - 42,424,725 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx950,886,244 - 50,926,603 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,008,981 - 56,049,339 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,285,126 - 54,325,423 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0946,840,646 - 46,881,241 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,840,992 - 46,881,264 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,526,290 - 46,566,513 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,279,397 - 39,319,672 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,280,810 - 39,321,085 (+)NCBI
Celera940,130,004 - 40,170,463 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzyl bromide  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
capecitabine  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
elemental selenium  (ISO)
erlotinib hydrochloride  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
farnesol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
geraniol  (ISO)
glutaraldehyde  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
malathion  (EXP)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quartz  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evidence of associations between cytokine gene polymorphisms and quality of life in patients with cancer and their family caregivers. Alexander K, etal., Oncol Nurs Forum. 2014 Sep;41(5):E267-81. doi: 10.1188/14.ONF.E267-E281.
2. Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA. Bristulf J, etal., Eur Cytokine Netw 1994 May-Jun;5(3):319-30.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Guo X, etal., Nat Med. 2018 Jul;24(7):978-985. doi: 10.1038/s41591-018-0045-3. Epub 2018 Jun 25.
5. Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4(+) T cells. Iwai H and Inaba M, J Neuroimmunol. 2012 Sep 15;250(1-2):1-8. doi: 10.1016/j.jneuroim.2012.05.007. Epub 2012 May 29.
6. Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese. Kamei H, etal., Arch Oral Biol. 2014 Jul;59(7):756-63. doi: 10.1016/j.archoralbio.2014.04.006. Epub 2014 Apr 20.
7. IL1R2 Polymorphisms are Associated with Increased Risk of Esophageal Cancer. Liu J, etal., Curr Mol Med. 2020;20(5):379-387. doi: 10.2174/1566524019666191025091204.
8. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, etal., PeerJ. 2019 Oct 31;7:e7968. doi: 10.7717/peerj.7968. eCollection 2019.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. The IL-1 family: regulators of immunity. Sims JE and Smith DE, Nat Rev Immunol. 2010 Feb;10(2):89-102. Epub 2010 Jan 18.
17. Soluble interleukin-1 receptor type II levels in gingival crevicular fluid in aggressive and chronic periodontitis. Suzuki M, etal., J Periodontol. 2008 Mar;79(3):495-500. doi: 10.1902/jop.2008.070111 .
18. Association between IL-1R2 polymorphisms and lung cancer risk in the Chinese Han population: A case-control study. Wang C, etal., Mol Genet Genomic Med. 2019 May;7(5):e644. doi: 10.1002/mgg3.644. Epub 2019 Mar 20.
19. An Immune-Related Signature Predicts Survival in Patients With Lung Adenocarcinoma. Zhang M, etal., Front Oncol. 2019 Dec 10;9:1314. doi: 10.3389/fonc.2019.01314. eCollection 2019.
Additional References at PubMed
PMID:12477932   PMID:23395675   PMID:27440742   PMID:34575945   PMID:35087030  


Genomics

Comparative Map Data
Il1r2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,879,928 - 49,920,374 (+)NCBIGRCr8
mRatBN7.2942,384,280 - 42,424,726 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,384,433 - 42,424,725 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx950,886,244 - 50,926,603 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,008,981 - 56,049,339 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,285,126 - 54,325,423 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0946,840,646 - 46,881,241 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,840,992 - 46,881,264 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,526,290 - 46,566,513 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,279,397 - 39,319,672 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,280,810 - 39,321,085 (+)NCBI
Celera940,130,004 - 40,170,463 (+)NCBICelera
Cytogenetic Map9q22NCBI
IL1R2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382101,991,960 - 102,028,544 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2101,991,960 - 102,028,544 (+)EnsemblGRCh38hg38GRCh38
GRCh372102,608,422 - 102,645,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362101,974,738 - 102,011,317 (+)NCBINCBI36Build 36hg18NCBI36
Build 342102,073,976 - 102,103,400NCBI
Celera296,809,517 - 96,846,098 (+)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef296,372,116 - 96,408,738 (+)NCBIHuRef
CHM1_12102,612,636 - 102,649,275 (+)NCBICHM1_1
T2T-CHM13v2.02102,450,049 - 102,486,842 (+)NCBIT2T-CHM13v2.0
Il1r2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,123,872 - 40,164,390 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,113,239 - 40,164,391 (+)EnsemblGRCm39 Ensembl
GRCm38140,084,692 - 40,125,230 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,074,079 - 40,125,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,141,613 - 40,182,070 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,029,314 - 40,069,771 (+)NCBIMGSCv36mm8
Celera139,891,137 - 39,931,702 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map118.65NCBI
Il1r2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554707,518,663 - 7,559,470 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554707,518,565 - 7,562,219 (+)NCBIChiLan1.0ChiLan1.0
IL1R2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,203,743 - 26,240,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A26,206,507 - 26,242,837 (-)NCBINHGRI_mPanPan1
PanPan1.12A103,015,318 - 103,078,308 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,042,328 - 103,078,190 (+)Ensemblpanpan1.1panPan2
IL1R2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,967,532 - 41,003,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,896,669 - 41,034,113 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,892,186 - 40,928,279 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,832,945 - 41,869,144 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,820,543 - 41,869,408 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11041,546,904 - 41,582,999 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,828,893 - 41,865,064 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01042,020,863 - 42,057,056 (-)NCBIUU_Cfam_GSD_1.0
Il1r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629290,416,062 - 90,484,706 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936713701,155 - 716,650 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936713679,680 - 716,801 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1R2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl352,367,437 - 52,406,334 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1352,367,434 - 52,406,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,901,383 - 54,919,899 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL1R2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,672,434 - 5,708,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,673,163 - 5,708,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041173,354,598 - 173,390,365 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1r2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,511,584 - 6,586,511 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247496,549,112 - 6,586,409 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il1r2
246 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:152
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000019415
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 109 90 89 58 25 58 6 212 97 89 40 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000019415   ⟹   ENSRNOP00000019415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,384,433 - 42,424,725 (+)Ensembl
Rnor_6.0 Ensembl946,840,992 - 46,881,264 (+)Ensembl
RefSeq Acc Id: NM_053953   ⟹   NP_446405
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,880,075 - 49,920,374 (+)NCBI
mRatBN7.2942,384,429 - 42,424,726 (+)NCBI
Rnor_6.0946,841,024 - 46,881,236 (+)NCBI
Rnor_5.0946,526,290 - 46,566,513 (+)NCBI
RGSC_v3.4939,279,397 - 39,319,672 (+)RGD
Celera940,130,004 - 40,170,463 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082947   ⟹   XP_038938875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,879,928 - 49,917,401 (+)NCBI
mRatBN7.2942,384,280 - 42,421,753 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446405 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938875 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91564 (Get FASTA)   NCBI Sequence Viewer  
  CAA80465 (Get FASTA)   NCBI Sequence Viewer  
  EDL99182 (Get FASTA)   NCBI Sequence Viewer  
  EDL99183 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019415.4
GenBank Protein P43303 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446405   ⟸   NM_053953
- Peptide Label: precursor
- UniProtKB: Q5BJ99 (UniProtKB/Swiss-Prot),   P43303 (UniProtKB/Swiss-Prot),   A0A0H2UHL7 (UniProtKB/TrEMBL),   A6INM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019415   ⟸   ENSRNOT00000019415
RefSeq Acc Id: XP_038938875   ⟸   XM_039082947
- Peptide Label: isoform X1
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43303-F1-model_v2 AlphaFold P43303 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696628
Promoter ID:EPDNEW_R7153
Type:single initiation site
Name:Il1r2_1
Description:interleukin 1 receptor type 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0946,841,028 - 46,841,088EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621147 AgrOrtholog
BioCyc Gene G2FUF-27730 BioCyc
Ensembl Genes ENSRNOG00000014378 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019415.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7445971 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I/II-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_II-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117022 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114281 IMAGE-MGC_LOAD
NCBI Gene 117022 ENTREZGENE
PANTHER INTERLEUKIN-1 RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il1r2 PhenoGen
PRINTS INTRLEUKN1R2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLKN1R12F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014378 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHL7 ENTREZGENE, UniProtKB/TrEMBL
  A6INM7 ENTREZGENE, UniProtKB/TrEMBL
  A6INM8_RAT UniProtKB/TrEMBL
  IL1R2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BJ99 ENTREZGENE
UniProt Secondary Q5BJ99 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Il1r2  interleukin 1 receptor type 2  Il1r2  interleukin 1 receptor, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Il1r2  interleukin 1 receptor, type II      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il1r2  interleukin 1 receptor, type II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is induced by Interleukin 1 728991