Il18r1 (interleukin 18 receptor 1) - Rat Genome Database

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Gene: Il18r1 (interleukin 18 receptor 1) Rattus norvegicus
Analyze
Symbol: Il18r1
Name: interleukin 18 receptor 1
RGD ID: 1308589
Description: Predicted to enable interleukin-18 binding activity and interleukin-18 receptor activity. Predicted to be involved in several processes, including interleukin-18-mediated signaling pathway; negative regulation of cold-induced thermogenesis; and regulation of gene expression. Predicted to act upstream of or within T-helper 1 cell differentiation and natural killer cell activation. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL18R1 (interleukin 18 receptor 1); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL18Ralpha2; interleukin-18 receptor 1; LOC301365
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,223,274 - 50,257,370 (+)NCBIGRCr8
mRatBN7.2942,727,416 - 42,760,971 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,727,869 - 42,760,715 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,230,237 - 51,262,481 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,352,925 - 56,385,173 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,628,554 - 54,660,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,184,404 - 47,217,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,185,443 - 47,219,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,869,486 - 46,902,498 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,627,915 - 39,659,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,637,036 - 39,660,796 (+)NCBI
Celera940,471,472 - 40,503,622 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-methylcholanthrene  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dioxygen  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
indometacin  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
progesterone  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sulforaphane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Hoshino T, etal., Am J Respir Cell Mol Biol. 2009 Dec;41(6):661-70. Epub 2009 Mar 5.
4. Expression of Th1 markers by lung accumulated T cells in pulmonary sarcoidosis. Katchar K, etal., J Intern Med. 2003 Dec;254(6):564-71.
5. Blockade of IL-18 receptor signaling delays the onset of autoimmune disease in MRL-Faslpr mice. Kinoshita K, etal., J Immunol. 2004 Oct 15;173(8):5312-8.
6. Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis. Kitasato Y, etal., Am J Respir Cell Mol Biol. 2004 Dec;31(6):619-25. Epub 2004 Aug 12.
7. Effects of post-inhalation treatment with interleukin-12 on airway hyper-reactivity, eosinophilia and interleukin-18 receptor expression in a mouse model of asthma. Kuribayashi K, etal., Clin Exp Allergy. 2002 Apr;32(4):641-9.
8. Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes. Markowitz GJ, etal., Cancer Res. 2016 Apr 15;76(8):2394-405. doi: 10.1158/0008-5472.CAN-15-1548. Epub 2016 Feb 18.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. A large-scale, consortium-based genomewide association study of asthma. Moffatt MF, etal., N Engl J Med. 2010 Sep 23;363(13):1211-21.
11. Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice. Pazos P, etal., Sci Rep. 2015 Dec 10;5:17977. doi: 10.1038/srep17977.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. Reijmerink NE, etal., J Allergy Clin Immunol. 2008 Sep;122(3):651-4.e8.
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. Thessen Hedreul M, etal., J Neuroimmunol. 2009 May 29;210(1-2):30-9. Epub 2009 Mar 9.
18. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. Wu H, etal., J Allergy Clin Immunol. 2010 Feb;125(2):321-327.e13. Epub 2009 Nov 11.
19. Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. Zhu G, etal., Eur J Hum Genet. 2008 Sep;16(9):1083-90. Epub 2008 Apr 2.
Additional References at PubMed
PMID:10227969   PMID:10653850   PMID:14528293   PMID:18547159   PMID:25250214   PMID:25261253   PMID:25500532   PMID:33137409  


Genomics

Comparative Map Data
Il18r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,223,274 - 50,257,370 (+)NCBIGRCr8
mRatBN7.2942,727,416 - 42,760,971 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,727,869 - 42,760,715 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,230,237 - 51,262,481 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,352,925 - 56,385,173 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,628,554 - 54,660,655 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,184,404 - 47,217,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,185,443 - 47,219,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,869,486 - 46,902,498 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,627,915 - 39,659,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,637,036 - 39,660,796 (+)NCBI
Celera940,471,472 - 40,503,622 (+)NCBICelera
Cytogenetic Map9q22NCBI
IL18R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,355,796 - 102,398,776 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,311,529 - 102,398,777 (+)EnsemblGRCh38hg38GRCh38
GRCh372102,972,256 - 103,015,236 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,345,529 - 102,381,650 (+)NCBINCBI36Build 36hg18NCBI36
Build 342102,437,614 - 102,473,736NCBI
Celera297,180,238 - 97,216,360 (+)NCBICelera
Cytogenetic Map2q12.1NCBI
HuRef296,743,456 - 96,779,581 (+)NCBIHuRef
CHM1_12102,983,402 - 103,019,517 (+)NCBICHM1_1
T2T-CHM13v2.02102,814,660 - 102,857,641 (+)NCBIT2T-CHM13v2.0
Il18r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,504,712 - 40,540,014 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,504,712 - 40,540,014 (+)EnsemblGRCm39 Ensembl
GRCm38140,465,552 - 40,500,854 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,465,552 - 40,500,854 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,522,397 - 40,557,699 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,410,552 - 40,445,379 (+)NCBIMGSCv36mm8
Celera140,277,562 - 40,312,984 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map119.27NCBI
Il18r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554707,854,988 - 7,887,883 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554707,854,995 - 7,887,810 (+)NCBIChiLan1.0ChiLan1.0
IL18R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,306,682 - 25,349,161 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A25,309,447 - 25,351,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A99,419,686 - 99,462,650 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A103,459,397 - 103,488,025 (+)NCBIpanpan1.1PanPan1.1panPan2
IL18R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,614,336 - 40,653,300 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,615,312 - 40,653,454 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,540,478 - 40,579,255 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,480,814 - 41,519,805 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,481,796 - 41,559,352 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11041,195,303 - 41,234,260 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,475,963 - 41,515,541 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,668,634 - 41,707,879 (-)NCBIUU_Cfam_GSD_1.0
Il18r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629290,056,410 - 90,094,061 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367131,038,877 - 1,075,811 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367131,038,985 - 1,075,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL18R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,803,175 - 51,844,684 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1351,803,383 - 51,844,758 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,285,206 - 54,288,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL18R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,026,683 - 6,067,808 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,026,443 - 6,066,884 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041173,708,426 - 173,751,738 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il18r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,875,750 - 6,909,734 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247496,875,934 - 6,909,702 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il18r1
216 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:77
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000020194
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 39 81 87 86 55 25 55 6 203 86 61 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000020194   ⟹   ENSRNOP00000020194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,727,869 - 42,760,715 (+)Ensembl
Rnor_6.0 Ensembl947,185,443 - 47,219,175 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095201   ⟹   ENSRNOP00000085021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,727,869 - 42,759,976 (+)Ensembl
RefSeq Acc Id: NM_001106905   ⟹   NP_001100375
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,223,491 - 50,255,596 (+)NCBI
mRatBN7.2942,727,869 - 42,759,976 (+)NCBI
Rnor_6.0947,185,303 - 47,217,403 (+)NCBI
Rnor_5.0946,869,486 - 46,902,498 (+)NCBI
RGSC_v3.4939,627,915 - 39,659,828 (+)RGD
Celera940,471,472 - 40,503,622 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266931   ⟹   XP_063123001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,223,274 - 50,257,370 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100375 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123001 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AIR76262 (Get FASTA)   NCBI Sequence Viewer  
  AIR76263 (Get FASTA)   NCBI Sequence Viewer  
  EDL99171 (Get FASTA)   NCBI Sequence Viewer  
  EDL99172 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020194.6
  ENSRNOP00000085021.1
RefSeq Acc Id: NP_001100375   ⟸   NM_001106905
- Peptide Label: precursor
- UniProtKB: A0A8I6A1C2 (UniProtKB/TrEMBL),   A6INN8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020194   ⟸   ENSRNOT00000020194
Ensembl Acc Id: ENSRNOP00000085021   ⟸   ENSRNOT00000095201
RefSeq Acc Id: XP_063123001   ⟸   XM_063266931
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1C2 (UniProtKB/TrEMBL),   A6INN8 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRM2-F1-model_v2 AlphaFold D3ZRM2 1-537 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308589 AgrOrtholog
BioCyc Gene G2FUF-27722 BioCyc
Ensembl Genes ENSRNOG00000015027 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020194.8 UniProtKB/TrEMBL
  ENSRNOT00000095201.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  IL1-receptor UniProtKB/TrEMBL
  Toll-Interleukin_rcpt UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report rno:301365 UniProtKB/TrEMBL
NCBI Gene 301365 ENTREZGENE
PANTHER IL1-receptor UniProtKB/TrEMBL
  INTERLEUKIN-18 RECEPTOR 1 UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PhenoGen Il18r1 PhenoGen
PRINTS INTRLKN1R1F UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015027 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
UniProt A0A089VQK7_RAT UniProtKB/TrEMBL
  A0A089X9D3_RAT UniProtKB/TrEMBL
  A0A8I6A1C2 ENTREZGENE, UniProtKB/TrEMBL
  A6INN8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRM2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Il18r1  interleukin 18 receptor 1   Il18r1_predicted  interleukin 18 receptor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Il18r1_predicted  interleukin 18 receptor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED