RGD Reference Report - Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis. - Rat Genome Database

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Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis.

Authors: Kitasato, Y  Hoshino, T  Okamoto, M  Kato, S  Koda, Y  Nagata, N  Kinoshita, M  Koga, H  Yoon, DY  Asao, H  Ohmoto, H  Koga, T  Rikimaru, T  Aizawa, H 
Citation: Kitasato Y, etal., Am J Respir Cell Mol Biol. 2004 Dec;31(6):619-25. Epub 2004 Aug 12.
RGD ID: 4889841
Pubmed: PMID:15308504   (View Abstract at PubMed)
DOI: DOI:10.1165/rcmb.2003-0306OC   (Journal Full-text)

Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP) is a major interstitial lung disease (ILD). Recently, we established a new mouse model for ILD in which daily administration of interleukin (IL)-18 with IL-2 induces lethal lung injury, suggesting that IL-18 is involved in the pathogenesis of ILD. Here, utilizing immunohistochemistry, we have analyzed IL-18 and IL-18 receptor (IL-18R) alpha expression in the lungs of 18 patients with IPF/UIP and 13 control subjects by using monoclonal anti-IL-18 antibodies and a new monoclonal antibody for IL-18Ralpha (H44). IL-18 was expressed in bronchoalveolar epithelium, alveolar macrophages, and the endothelium of small vessels in control subjects, and was abundantly expressed in the majority of pulmonary cells in patients with IPF. IL-18Ralpha was expressed in bronchoalveolar epithelium and alveolar macrophages in control subjects, and was strongly expressed in interstitial cells in patients with IPF, especially in the fibroblastic foci (FF). Interestingly, IL-18Ralpha expression was only weakly observed in areas showing established fibrosis. Semiquantitative analysis revealed that the histologic FF score was significantly correlated with the IL-18Ralpha expression level in FF lesions. Moreover, IL-18 levels in the serum and bronchoalveolar lavage fluid of patients with IPF were significantly higher than those in control subjects. Our findings suggest IL-18 and IL-18R are involved in the pathogenesis of IPF/UIP.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL18Humanpulmonary fibrosis  IEP idiopathic pulmonary fibrosis more ...RGD 
IL18R1Humanpulmonary fibrosis  IEP protein:increased expression:lungRGD 
Il18Ratpulmonary fibrosis  ISOIL18 (Homo sapiens)idiopathic pulmonary fibrosis more ...RGD 
Il18Mousepulmonary fibrosis  ISOIL18 (Homo sapiens)idiopathic pulmonary fibrosis more ...RGD 
Il18r1Ratpulmonary fibrosis  ISOIL18R1 (Homo sapiens)protein:increased expression:lungRGD 
Il18r1Mousepulmonary fibrosis  ISOIL18R1 (Homo sapiens)protein:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)
Il18r1  (interleukin 18 receptor 1)

Genes (Mus musculus)
Il18  (interleukin 18)
Il18r1  (interleukin 18 receptor 1)

Genes (Homo sapiens)
IL18  (interleukin 18)
IL18R1  (interleukin 18 receptor 1)


Additional Information