Il18 (interleukin 18) - Rat Genome Database

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Gene: Il18 (interleukin 18) Mus musculus
Analyze
Symbol: Il18
Name: interleukin 18
RGD ID: 730895
MGI Page MGI
Description: Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IFN-gamma-inducing factor; Ig; Igif; Il-; IL-1 gamma; Il-18; interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin-1 gamma; interleukin-18
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBImm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IMP)
Acute Lung Injury  (ISO)
alcoholic hepatitis  (ISO)
allergic contact dermatitis  (IEP,IMP,ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (ISO)
anti-basement membrane glomerulonephritis  (IMP)
asthma  (IMP,ISO)
atherosclerosis  (IMP,ISO)
atopic dermatitis  (IEA,IEP,ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (IMP)
Behcet's disease  (IMP,ISO)
biliary atresia  (ISO)
brain edema  (ISO)
Brain Injuries  (IAGP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (IMP)
Burns  (IEP)
calcinosis  (ISO)
Carcinoma, Lewis Lung  (IMP)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
cutaneous T cell lymphoma  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
dermatitis  (IMP)
dermatomyositis  (ISO)
diabetic retinopathy  (IDA,ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Eczema  (ISO)
Edema  (ISO)
Embryo Loss  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (IMP)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
glomerulonephritis  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hemophagocytic lymphohistiocytosis  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (IDA)
high grade glioma  (IMP)
HIV-Associated Lipodystrophy Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IMP)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (IMP)
IgA glomerulonephritis  (ISO)
Immediate Hypersensitivity  (ISO)
Insulin Resistance  (IMP,ISO)
intellectual disability  (ISO)
interstitial lung disease  (IDA,ISO)
intrahepatic cholestasis of pregnancy  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (IDA)
leishmaniasis  (IDA,ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Injury  (IMP,ISO)
Liver Reperfusion Injury  (IMP,ISO)
lung disease  (IDA,IMP,ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (IEP)
Lymphatic Metastasis  (ISO)
Macrophage Activation Syndrome  (ISO)
Metabolic Syndrome  (ISO)
Mouth Neoplasms  (ISO)
Myocardial Reperfusion Injury  (IMP,ISO)
myositis  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (IMP)
non-alcoholic fatty liver disease  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
obesity  (IMP,ISO)
Oral Lichen Planus  (ISO)
Pain  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (IMP,ISO)
Peripheral Nerve Injuries  (ISO)
Pneumococcal Pneumonia  (IMP)
pneumonia  (IMP,ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (IMP)
psoriasis  (ISO)
pulmonary edema  (IMP)
pulmonary emphysema  (IMP,ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IMP)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries, Experimental  (ISO)
Reperfusion Injury  (IEP,IMP)
respiratory failure  (ISO)
respiratory syncytial virus infectious disease  (IDA,ISO)
Retinal Neovascularization  (IMP,ISO)
rheumatoid arthritis  (ISO)
rhinitis  (IEP,ISO)
sarcoidosis  (ISO)
Schistosomiasis Japonica  (IDA)
Seasonal Allergic Rhinitis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (ISO)
Staphylococcal Skin Infections  (IDA)
status epilepticus  (ISO)
Stroke  (ISO)
strongyloidiasis  (IDA)
temporal arteritis  (ISO)
Tibial Fractures  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
visceral leishmaniasis  (IMP)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(E)-cinnamyl alcohol  (ISO)
(R)-mevalonic acid  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-methylhistamine  (ISO)
4-nitrobenzyl bromide  (ISO)
4-phenylbutyric acid  (EXP)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
8-chloro-2'-deoxyguanosine  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldosterone  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP)
allopurinol  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthranilic acid  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asperentin  (EXP)
ATP  (EXP,ISO)
atrazine  (ISO)
benzalkonium chloride  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (EXP)
benzylpenicillin  (ISO)
Bergenin  (ISO)
beryllium sulfate  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
BQ 123  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (ISO)
celastrol  (ISO)
cerium trichloride  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cimetidine  (EXP,ISO)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
citral  (ISO)
clenbuterol  (EXP)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (EXP,ISO)
dichlorine  (ISO)
dicrotophos  (ISO)
dieckol  (EXP)
dieldrin  (ISO)
diethyl malate  (EXP)
diethyl maleate  (ISO)
diethylamine  (EXP)
dihydroartemisinin  (ISO)
Dimaprit  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
eplerenone  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
famotidine  (ISO)
fasudil hydrochloride  (ISO)
felodipine  (ISO)
ferulic acid  (EXP)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (ISO)
geranial  (ISO)
geraniol  (EXP)
glyburide  (EXP,ISO)
glyoxal  (ISO)
graphene oxide  (EXP)
graphite  (ISO)
hemin  (ISO)
hexachlorobenzene  (ISO)
histamine  (EXP,ISO)
Honokiol  (ISO)
hydrocortisone succinate  (ISO)
hydrogen peroxide  (ISO)
IC-87114  (EXP)
ICI 118551  (EXP)
imiquimod  (EXP)
immunological adjuvant  (ISO)
indometacin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoprenaline  (EXP,ISO)
lead diacetate  (EXP)
lipid As  (ISO)
lipopolysaccharide  (EXP,ISO)
lonafarnib  (EXP)
lovastatin  (EXP)
lucanthone  (ISO)
LY294002  (ISO)
m-xylene  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
Manumycin A  (EXP)
melittin  (ISO)
metam  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
mifepristone  (EXP)
mitomycin C  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (EXP)
muramyl dipeptide  (EXP)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nifuroxazide  (ISO)
nilotinib  (EXP)
NMN zwitterion  (EXP,ISO)
ochratoxin A  (EXP)
olmesartan  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
Palbinone  (ISO)
pamidronate  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
pentane-2,3-dione  (ISO)
permethrin  (EXP)
phenethyl caffeate  (ISO)
phenytoin  (EXP)
phosgene  (ISO)
phthalic anhydride  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
prednisolone  (EXP)
procyanidin B2  (ISO)
progesterone  (EXP)
protein kinase inhibitor  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
reserpine  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
rolipram  (EXP)
rotenone  (ISO)
rutin  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
spironolactone  (ISO)
sterigmatocystin  (EXP)
streptozocin  (ISO)
sulfamic acid  (ISO)
sulfur dioxide  (ISO)
tetrachloromethane  (EXP)
thalidomide  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thiram  (ISO)
tipifarnib  (EXP)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trans-isoeugenol  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
trovafloxacin  (EXP)
tungsten  (ISO)
uranium atom  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)
zearalenone  (EXP)
zinc protoporphyrin  (ISO)
zirconium atom  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
angiogenesis  (ISO,ISS)
cell population proliferation  (IDA,IGI)
cellular response to cAMP  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cholesterol homeostasis  (IMP)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
digestive tract morphogenesis  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (TAS)
immune response  (TAS)
inflammatory response  (IGI,ISO)
interleukin-18-mediated signaling pathway  (IDA,ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
liver regeneration  (ISO)
lung development  (ISO)
MAPK cascade  (ISO)
natural killer cell activation  (IDA)
natural killer cell mediated cytotoxicity  (IDA)
negative regulation of myoblast differentiation  (IMP)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
neutrophil activation  (IDA)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (ISO,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel remodeling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of interferon-gamma production  (IDA,IGI,IMP,ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-13 production  (TAS)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage derived foam cell differentiation  (IMP)
positive regulation of male germ cell proliferation  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (IDA)
positive regulation of NK T cell proliferation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 1 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular permeability  (ISO)
regulation of cell adhesion  (ISO,ISS)
response to cold  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
sleep  (ISO,ISS)
T-helper 1 type immune response  (ISO,ISS)
triglyceride homeostasis  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cytokine level  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal retinal vasculature morphology  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
decreased cerebral infarction size  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased circulating interleukin-18 level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased energy expenditure  (IAGP)
decreased IgE level  (IAGP)
decreased IgG1 level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased oxygen consumption  (IAGP)
decreased spleen weight  (IEA)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased ventricle muscle contractility  (IAGP)
gastrointestinal hemorrhage  (IAGP)
hyperchlorhydria  (IAGP)
impaired natural killer cell mediated cytotoxicity  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased dendritic cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased NK cell number  (IAGP)
increased percent body fat/body weight  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased total fat pad weight  (IAGP)
increased white adipose tissue amount  (IAGP)
myocarditis  (IAGP)
polyphagia  (IAGP)
premature death  (IAGP)
retinal hemorrhage  (IAGP)
sepsis  (IAGP)
stomach inflammation  (IAGP)
References

References - curated
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11. Blease K, etal., Inflamm Res. 2001 Nov;50(11):552-60.
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PMID:17979156   PMID:17984289   PMID:18003981   PMID:18022572   PMID:18086672   PMID:18165223   PMID:18178624   PMID:18247160   PMID:18250323   PMID:18250441   PMID:18299270   PMID:18299271  
PMID:18374640   PMID:18386818   PMID:18387310   PMID:18490713   PMID:18511039   PMID:18514661   PMID:18515422   PMID:18523249   PMID:18545704   PMID:18566365   PMID:18573894   PMID:18575774  
PMID:18599478   PMID:18641298   PMID:18664530   PMID:18692153   PMID:18705842   PMID:18753296   PMID:18786924   PMID:18802047   PMID:18805969   PMID:18815244   PMID:18818761   PMID:18930950  
PMID:18940934   PMID:18981133   PMID:19006696   PMID:19039317   PMID:19046143   PMID:19052080   PMID:19054060   PMID:19075023   PMID:19129255   PMID:19141531   PMID:19164858   PMID:19201478  
PMID:19223481   PMID:19406942   PMID:19406986   PMID:19451398   PMID:19535628   PMID:19536084   PMID:19571816   PMID:19638429   PMID:19657092   PMID:19666510   PMID:19710462   PMID:19727119  
PMID:19758166   PMID:19802695   PMID:19844803   PMID:19853308   PMID:19950174   PMID:19950176   PMID:20056085   PMID:20089076   PMID:20111957   PMID:20130211   PMID:20200276   PMID:20213736  
PMID:20351186   PMID:20536664   PMID:20538003   PMID:20565717   PMID:20574004   PMID:20580925   PMID:20592282   PMID:20624890   PMID:20644165   PMID:20693392   PMID:20802146   PMID:20805006  
PMID:20855874   PMID:20962258   PMID:20974942   PMID:20974986   PMID:21042583   PMID:21057511   PMID:21059855   PMID:21106820   PMID:21148802   PMID:21182088   PMID:21248035   PMID:21263463  
PMID:21267068   PMID:21414755   PMID:21471445   PMID:21511702   PMID:21555485   PMID:21557898   PMID:21565393   PMID:21611811   PMID:21677750   PMID:21681738   PMID:21708993   PMID:21712396  
PMID:21715688   PMID:21724589   PMID:21905011   PMID:21954451   PMID:21987662   PMID:22058412   PMID:22089189   PMID:22135456   PMID:22206036   PMID:22231517   PMID:22241982   PMID:22297845  
PMID:22307326   PMID:22347372   PMID:22383501   PMID:22384183   PMID:22403439   PMID:22412194   PMID:22427351   PMID:22461621   PMID:22484808   PMID:22665806   PMID:22682244   PMID:22705105  
PMID:22723524   PMID:22740067   PMID:22837383   PMID:22840842   PMID:22908325   PMID:22908875   PMID:22911706   PMID:22980983   PMID:23071286   PMID:23075849   PMID:23077611   PMID:23102661  
PMID:23115038   PMID:23132931   PMID:23144495   PMID:23219391   PMID:23221343   PMID:23260234   PMID:23348507   PMID:23382928   PMID:23460746   PMID:23492189   PMID:23525089   PMID:23689355  
PMID:23696660   PMID:23844157   PMID:23904166   PMID:23904224   PMID:23938462   PMID:24012762   PMID:24055061   PMID:24084736   PMID:24168450   PMID:24194600   PMID:24286318   PMID:24316258  
PMID:24412617   PMID:24456467   PMID:24503119   PMID:24515951   PMID:24531812   PMID:24565845   PMID:24581500   PMID:24585936   PMID:24603356   PMID:24610009   PMID:24634489   PMID:24646956  
PMID:24695684   PMID:24700550   PMID:24756108   PMID:24824897   PMID:24827856   PMID:24846540   PMID:24952429   PMID:25012128   PMID:25155632   PMID:25166912   PMID:25182570   PMID:25198773  
PMID:25200363   PMID:25251560   PMID:25254654   PMID:25405768   PMID:25473914   PMID:25589075   PMID:25600646   PMID:25680273   PMID:25704009   PMID:25736457   PMID:25780034   PMID:25801352  
PMID:25808972   PMID:25825440   PMID:25888640   PMID:25918710   PMID:25922275   PMID:25934945   PMID:25955000   PMID:25955511   PMID:26008898   PMID:26009021   PMID:26011644   PMID:26037070  
PMID:26099046   PMID:26214524   PMID:26320999   PMID:26332085   PMID:26367131   PMID:26384545   PMID:26440469   PMID:26465326   PMID:26516283   PMID:26572063   PMID:26603191   PMID:26638072  
PMID:26638073   PMID:26639507   PMID:26655906   PMID:26656097   PMID:26747780   PMID:26998763   PMID:27007676   PMID:27063959   PMID:27114524   PMID:27125672   PMID:27149934   PMID:27288439  
PMID:27300652   PMID:27322540   PMID:27339979   PMID:27341123   PMID:27371534   PMID:27413021   PMID:27465336   PMID:27524110   PMID:27590137   PMID:27626380   PMID:27653694   PMID:27668799  
PMID:27692610   PMID:27731803   PMID:27794001   PMID:27846608   PMID:27863204   PMID:27912077   PMID:27982687   PMID:28002730   PMID:28264883   PMID:28299442   PMID:28336525   PMID:28373090  
PMID:28404595   PMID:28410991   PMID:28468974   PMID:28526544   PMID:28549109   PMID:28895072   PMID:28900426   PMID:28922563   PMID:28951422   PMID:29120744   PMID:29130929   PMID:29146733  
PMID:29195684   PMID:29241547   PMID:29282220   PMID:29295842   PMID:29326099   PMID:29472923   PMID:29499224   PMID:29551594   PMID:29559970   PMID:29576451   PMID:29603367   PMID:29681594  
PMID:29688375   PMID:29847790   PMID:30087443   PMID:30127003   PMID:30201992   PMID:30316805   PMID:30404813   PMID:30453990   PMID:30590393   PMID:30624775   PMID:30675064   PMID:30696773  
PMID:30748031   PMID:30779114   PMID:30870716   PMID:30940725   PMID:30981863   PMID:31010959   PMID:31017261   PMID:31405732   PMID:31420376   PMID:31445353   PMID:31507610   PMID:31554824  
PMID:31681274   PMID:31821481   PMID:31923399   PMID:32272223   PMID:32546483   PMID:32589707   PMID:33178225   PMID:33202693   PMID:33268895   PMID:33372132  


Genomics

Comparative Map Data
Il18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBImm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
IL18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11112,143,253 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3811112,143,251 - 112,164,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
Il18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2850,904,630 - 50,932,887 (+)NCBI
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
Il18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
IL18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111110,867,586 - 110,888,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,867,586 - 110,888,371 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011107,024,376 - 107,045,194 (-)NCBIMhudiblu_PPA_v0panPan3
IL18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1520,972,742 - 20,995,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,972,871 - 20,995,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,907,590 - 20,917,853 (+)NCBI
ROS_Cfam_1.0520,994,967 - 21,017,974 (+)NCBI
UMICH_Zoey_3.1521,069,981 - 21,080,260 (+)NCBI
UNSW_CanFamBas_1.0520,970,245 - 20,980,530 (+)NCBI
UU_Cfam_GSD_1.0521,018,633 - 21,028,888 (+)NCBI
Il18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,380,523 - 94,398,669 (-)NCBI
SpeTri2.0NW_0049366122,306,963 - 2,325,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,834,966 - 39,873,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,839,959 - 39,861,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,692,120 - 44,713,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,485,868 - 103,511,632 (-)NCBI
ChlSab1.1 Ensembl1103,482,083 - 103,510,150 (-)Ensembl
Vero_WHO_p1.0NW_02366604322,475,303 - 22,498,316 (+)NCBI
Il18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBI

Position Markers
D49949  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38950,581,707 - 50,581,787UniSTSGRCm38
MGSCv37950,389,812 - 50,389,892UniSTSGRCm37
Celera947,876,952 - 47,877,032UniSTS
Cytogenetic Map9A5.3UniSTS
Whitehead/MRC_RH9524.51UniSTS
Il18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37950,389,592 - 50,389,732UniSTSGRCm37
Celera947,876,732 - 47,876,872UniSTS
Cytogenetic Map9A5.3UniSTS
cM Map929.0UniSTS
Il18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A5.3UniSTS
Il18  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38950,581,487 - 50,581,627UniSTSGRCm38
MGSCv37950,389,592 - 50,389,732UniSTSGRCm37
Celera947,876,732 - 47,876,872UniSTS
Cytogenetic Map9A5.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13504834Hdlq109_mHDL QTL 109 (mouse)91679834550798345Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91706754451067647Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined92003211054032229Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92024206654242196Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92039490154395074Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92039490154395074Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92039490154395074Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92039490154395074Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92094144454941444Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94050829851897370Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94089776474897921Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94357343177573577Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94357343177573577Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4668637365923895Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94763172657897921Mouse
13515057Adip20b_madiposity 20b (mouse)94878960853884418Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94892377482923895Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94892377482923895Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94950899863332570Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94950899867244166Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
14746993Manh66_mmandible shape 66 (mouse)94990676683906766Mouse
11080993Tglq7_mtriglyceride level QTL 7 (mouse)95020000051600000Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95024403884244166Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:96
Interacting mature miRNAs:101
Transcripts:ENSMUST00000059081, ENSMUST00000180021
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC025500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV328761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY157834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY157835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY362457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY916131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX123286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ316604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY491641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L37150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000059081   ⟹   ENSMUSP00000054591
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl950,575,273 - 50,581,837 (+)Ensembl
RefSeq Acc Id: ENSMUST00000180021   ⟹   ENSMUSP00000137193
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl950,575,273 - 50,581,837 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213916   ⟹   ENSMUSP00000150305
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)Ensembl
RefSeq Acc Id: ENSMUST00000214117   ⟹   ENSMUSP00000151002
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl950,565,374 - 50,581,837 (+)Ensembl
RefSeq Acc Id: NM_001357221   ⟹   NP_001344150
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,000 - 50,493,141 (+)NCBI
GRCm38950,554,700 - 50,581,841 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357222   ⟹   NP_001344151
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,000 - 50,493,141 (+)NCBI
GRCm38950,554,700 - 50,581,841 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008360   ⟹   NP_032386
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,000 - 50,493,141 (+)NCBI
GRCm38950,554,700 - 50,581,841 (+)NCBI
MGSCv37950,373,473 - 50,389,942 (+)RGD
Celera947,860,314 - 47,877,082 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510024   ⟹   XP_006510087
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,005 - 50,493,141 (+)NCBI
GRCm38950,554,705 - 50,581,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017313137   ⟹   XP_017168626
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,091 - 50,493,141 (+)NCBI
GRCm38950,554,758 - 50,581,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244066   ⟹   XP_030099926
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,085 - 50,493,141 (+)NCBI
GRCm38950,554,755 - 50,581,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154615   ⟹   XP_036010508
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,091 - 50,493,141 (+)NCBI
RefSeq Acc Id: XM_036154616   ⟹   XP_036010509
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,085 - 50,493,141 (+)NCBI
RefSeq Acc Id: XM_036154617   ⟹   XP_036010510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,091 - 50,493,141 (+)NCBI
RefSeq Acc Id: XM_036154618   ⟹   XP_036010511
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,005 - 50,493,141 (+)NCBI
RefSeq Acc Id: XM_036154619   ⟹   XP_036010512
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39950,466,077 - 50,493,141 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_032386   ⟸   NM_008360
- Peptide Label: isoform a
- UniProtKB: P70380 (UniProtKB/Swiss-Prot),   Q2PMY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510087   ⟸   XM_006510024
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017168626   ⟸   XM_017313137
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001344150   ⟸   NM_001357221
- Peptide Label: isoform a
RefSeq Acc Id: NP_001344151   ⟸   NM_001357222
- Peptide Label: isoform b
RefSeq Acc Id: XP_030099926   ⟸   XM_030244066
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000150305   ⟸   ENSMUST00000213916
RefSeq Acc Id: ENSMUSP00000054591   ⟸   ENSMUST00000059081
RefSeq Acc Id: ENSMUSP00000137193   ⟸   ENSMUST00000180021
RefSeq Acc Id: ENSMUSP00000151002   ⟸   ENSMUST00000214117
RefSeq Acc Id: XP_036010511   ⟸   XM_036154618
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036010512   ⟸   XM_036154619
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036010509   ⟸   XM_036154616
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036010508   ⟸   XM_036154615
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036010510   ⟸   XM_036154617
- Peptide Label: isoform X3

Promoters
RGD ID:6844686
Promoter ID:MM_KWN:57292
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:NM_008360
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36950,373,281 - 50,373,781 (+)MPROMDB
RGD ID:8669542
Promoter ID:EPDNEW_M12802
Type:initiation region
Name:Il18_1
Description:Mus musculus interleukin 18 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38950,565,346 - 50,565,406EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107936 AgrOrtholog
Ensembl Genes ENSMUSG00000039217 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000054591 UniProtKB/TrEMBL
  ENSMUSP00000137193 UniProtKB/Swiss-Prot
  ENSMUSP00000150305 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000151002 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059081 UniProtKB/TrEMBL
  ENSMUST00000180021 UniProtKB/Swiss-Prot
  ENSMUST00000213916 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000214117 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro IL-18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107936 ENTREZGENE
NCBI Gene 16173 ENTREZGENE
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il18 PhenoGen
PIRSF Interleukin_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTRLEUKIN18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1STF5_MOUSE UniProtKB/TrEMBL
  A0PJ18_MOUSE UniProtKB/TrEMBL
  IL18_MOUSE UniProtKB/Swiss-Prot
  K3W4N2_MOUSE UniProtKB/TrEMBL
  P70380 ENTREZGENE
  Q2PMY2 ENTREZGENE, UniProtKB/TrEMBL
  Q6USQ6_MOUSE UniProtKB/TrEMBL
  Q80SS8_MOUSE UniProtKB/TrEMBL