Il18 (interleukin 18) - Rat Genome Database

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Gene: Il18 (interleukin 18) Mus musculus
Analyze
Symbol: Il18
Name: interleukin 18
RGD ID: 730895
MGI Page MGI
Description: Enables cytokine activity. Involved in several processes, including cholesterol homeostasis; establishment of skin barrier; and positive regulation of cell differentiation. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; negative regulation of myoblast differentiation; and positive regulation of type II interferon production. Is active in extracellular space. Is expressed in extraembryonic component; gut; lymphatic system; reproductive system; and trunk. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IFN-gamma-inducing factor; Ig; Igif; Il-; IL-1 gamma; Il-18; interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin-1 gamma; interleukin-18
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)EnsemblGRCm39 Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBIMGSCv36mm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IMP)
Acute Lung Injury  (ISO)
alcoholic hepatitis  (ISO)
allergic contact dermatitis  (IEP,IMP,ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (ISO)
anti-basement membrane glomerulonephritis  (IMP)
asthma  (IMP,ISO)
atherosclerosis  (IMP,ISO)
atopic dermatitis  (IAGP,IEP,ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (IMP)
Behcet's disease  (IMP,ISO)
BH4-deficient hyperphenylalaninemia A  (ISO)
biliary atresia  (ISO)
brain edema  (ISO)
Brain Injuries  (IAGP,ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (IMP)
Burns  (IEP)
calcinosis  (ISO)
Carcinoma, Lewis Lung  (IMP)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
dermatitis  (IMP)
dermatomyositis  (ISO)
diabetic retinopathy  (IDA,ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Eczema  (ISO)
Edema  (ISO)
Embryo Loss  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (IMP)
Experimental Radiation Injuries  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
glomerulonephritis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hemophagocytic lymphohistiocytosis  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (IDA)
high grade glioma  (IMP)
HIV-Associated Lipodystrophy Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IMP)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (IMP)
IgA glomerulonephritis  (ISO)
Immediate Hypersensitivity  (ISO)
Insulin Resistance  (IMP,ISO)
intellectual disability  (ISO)
interstitial lung disease  (IDA,ISO)
intrahepatic cholestasis of pregnancy  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (IDA)
leishmaniasis  (IDA,ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Injury  (IMP,ISO)
Liver Reperfusion Injury  (IMP,ISO)
lung disease  (IDA,IMP,ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (IEP)
Lymphatic Metastasis  (ISO)
Macrophage Activation Syndrome  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Mouth Neoplasms  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IMP,ISO)
myositis  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (IMP)
Nontuberculous Mycobacterium Infections  (ISO)
obesity  (IMP,ISO)
Oral Lichen Planus  (ISO)
Pain  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (IMP,ISO)
Peripheral Nerve Injuries  (ISO)
Pneumococcal Pneumonia  (IMP)
pneumonia  (IMP,ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (IMP)
psoriasis  (ISO)
pulmonary edema  (IMP)
pulmonary emphysema  (IMP,ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IMP)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Pyruvate Dehydrogenase E2 Deficiency  (ISO)
Reperfusion Injury  (IEP,IMP)
respiratory failure  (ISO)
respiratory syncytial virus infectious disease  (IDA,ISO)
Retinal Neovascularization  (IMP,ISO)
rheumatoid arthritis  (ISO)
rhinitis  (IEP,ISO)
sarcoidosis  (ISO)
Schistosomiasis Japonica  (IDA)
Seasonal Allergic Rhinitis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (ISO)
Staphylococcal Skin Infections  (IDA)
status epilepticus  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
strongyloidiasis  (IDA)
temporal arteritis  (ISO)
Tibial Fractures  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
visceral leishmaniasis  (IMP)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(E)-cinnamyl alcohol  (ISO)
(R)-carnitine  (ISO)
(S)-nicotine  (ISO)
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-methylhistamine  (ISO)
4-nitrobenzyl bromide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
8-chloro-2'-deoxyguanosine  (EXP)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP)
allopurinol  (ISO)
alpha-Zearalanol  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
ampicillin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthranilic acid  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asperentin  (EXP)
atorvastatin calcium  (EXP)
ATP  (EXP,ISO)
atrazine  (ISO)
aucubin  (EXP)
aurantio-obtusin  (EXP)
bellidifolin  (ISO)
Belnacasan  (EXP,ISO)
benzalkonium chloride  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzocaine  (EXP)
benzylpenicillin  (ISO)
Bergenin  (ISO)
beryllium sulfate  (ISO)
beta-cyclodextrin  (EXP)
bexarotene  (ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
boric acid  (ISO)
boron atom  (ISO)
BQ 123  (ISO)
Brevianamide A  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (ISO)
celastrol  (ISO)
cerium trichloride  (EXP)
chloroethene  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
cimetidine  (EXP,ISO)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
citral  (ISO)
clenbuterol  (EXP)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP,ISO)
corn oil  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieckol  (EXP)
dieldrin  (ISO)
diethyl malate  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diethylamine  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
Dimaprit  (ISO)
diosmetin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
elemental boron  (ISO)
emodin  (EXP)
eplerenone  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
eugenol  (ISO)
famotidine  (ISO)
fasudil  (ISO)
felodipine  (ISO)
ferulic acid  (EXP)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (EXP)
Fraxinellone  (EXP,ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (ISO)
geranial  (ISO)
geraniol  (EXP,ISO)
ginsenoside Rb1  (EXP,ISO)
glucose  (EXP,ISO)
glyburide  (EXP,ISO)
glyoxal  (ISO)
gossypin  (ISO)
graphene oxide  (EXP)
graphite  (ISO)
hemin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
histamine  (EXP,ISO)
Honokiol  (ISO)
hydrocortisone succinate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxysafflor yellow A  (EXP)
ibuprofen  (EXP)
IC-87114  (EXP)
ICI 118551  (EXP)
imiquimod  (EXP)
immunological adjuvant  (ISO)
indometacin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
JTE-013  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lipid As  (ISO)
lipopolysaccharide  (EXP,ISO)
lixisenatide  (ISO)
loganin  (EXP,ISO)
lonafarnib  (EXP)
lonidamine  (EXP)
lovastatin  (EXP)
lucanthone  (ISO)
LY294002  (ISO)
lycopene  (EXP)
lysophosphatidylcholine  (ISO)
m-xylene  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
manumycin A  (EXP)
melatonin  (EXP,ISO)
melittin  (ISO)
mesalamine  (EXP)
metam  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
metronidazole  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
mitomycin C  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (EXP)
muramyl dipeptide  (EXP)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
neomycin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nifuroxazide  (ISO)
nigericin  (ISO)
nilotinib  (EXP)
nitrofen  (ISO)
NMN zwitterion  (EXP,ISO)
Nonylphenol  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP,ISO)
oleic acid  (ISO)
olmesartan  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Palbinone  (ISO)
pamidronate  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
pentane-2,3-dione  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenytoin  (EXP)
phosgene  (ISO)
phthalic anhydride  (EXP)
Phytolaccoside E  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
prednisolone  (EXP)
PRIM-O-GLUCOSYLCIMIFUGIN  (EXP)
procyanidin B2  (ISO)
progesterone  (EXP)
propofol  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
reserpine  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhein  (EXP)
rifampicin  (EXP)
rimonabant  (ISO)
rolipram  (EXP)
rotenone  (ISO)
Ruscogenin  (ISO)
rutin  (ISO)
Salidroside  (EXP)
sarpogrelate  (ISO)
SB 203580  (ISO)
scutellarin  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sulfamic acid  (ISO)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
tetrachloromethane  (EXP)
thalidomide  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
tipifarnib  (EXP)
titanium dioxide  (EXP)
TMC-120A  (EXP)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trans-isoeugenol  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
undecan-2-one  (EXP)
uranium atom  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vanillin  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)
zearalenone  (EXP)
zinc protoporphyrin  (ISO)
zirconium atom  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO,ISS)
cell population proliferation  (IDA,IGI)
cellular response to cAMP  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cholesterol homeostasis  (IMP)
defense response to Gram-positive bacterium  (IDA)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
digestive tract morphogenesis  (ISO)
establishment of skin barrier  (IMP)
extrinsic apoptotic signaling pathway via death domain receptors  (TAS)
immune response  (TAS)
inflammatory response  (IGI)
interleukin-18-mediated signaling pathway  (IDA,ISO)
liver regeneration  (ISO)
lung development  (ISO)
natural killer cell activation  (IDA)
natural killer cell mediated cytotoxicity  (IDA)
negative regulation of myoblast differentiation  (IMP)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
neutrophil activation  (IDA)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (ISO,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel remodeling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of inflammatory response  (IMP)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-13 production  (TAS)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage derived foam cell differentiation  (IMP)
positive regulation of male germ cell proliferation  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NK T cell proliferation  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 1 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (IDA,IGI,IMP,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular permeability  (ISO)
regulation of cell adhesion  (ISO,ISS)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
signal transduction  (IDA)
sleep  (ISO,ISS)
T-helper 1 type immune response  (ISO,ISS)
triglyceride homeostasis  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cytokine level  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased circulating interleukin-18 level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased energy expenditure  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased IgE level  (IAGP)
decreased IgG1 level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased oxygen consumption  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
gastrointestinal hemorrhage  (IAGP)
hyperchlorhydria  (IAGP)
impaired natural killer cell mediated cytotoxicity  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased dendritic cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased NK cell number  (IAGP)
increased percent body fat/body weight  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased total fat pad weight  (IAGP)
increased white adipose tissue amount  (IAGP)
myocarditis  (IAGP)
polyphagia  (IAGP)
premature death  (IAGP)
retina hemorrhage  (IAGP)
sepsis  (IAGP)
stomach inflammation  (IAGP)
References

References - curated
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107. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Netea MG, etal., Nat Med. 2006 Jun;12(6):650-6. doi: 10.1038/nm1415. Epub 2006 May 28.
108. Serum levels of interleukin-18 are elevated in the subacute phase of kawasaki syndrome. Nomura Y, etal., Int Arch Allergy Immunol. 2004 Oct;135(2):161-5. Epub 2004 Sep 2.
109. Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema. Novak N, etal., J Allergy Clin Immunol. 2005 Apr;115(4):828-33.
110. Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection. Ohkusu K, etal., Infect Immun. 2000 May;68(5):2449-56.
111. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
112. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Oku H, etal., Eur J Pharmacol. 2008 Aug 20;590(1-3):400-8. Epub 2008 Jun 16.
113. Suppressive effects of interleukin-18 on liver function in rat liver allografts. Ono S, etal., J Surg Res. 2012 Jul;176(1):293-300. doi: 10.1016/j.jss.2011.07.053. Epub 2011 Aug 27.
114. Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis. Palomino-Morales RJ, etal., Arthritis Res Ther. 2010;12(2):R51. doi: 10.1186/ar2962. Epub 2010 Mar 23.
115. Role of interleukin-18 in experimental infections with Streptococcus pneumoniae. Paterson GK, etal., J Med Microbiol. 2005 Apr;54(Pt 4):323-6.
116. Interleukin-18 promoter polymorphism in patients with atopic asthma. Pawlik A, etal., Tissue Antigens. 2007 Oct;70(4):314-8.
117. Plasma interleukin-18 and dendritic cells in males with psoriasis vulgaris. Pietrzak A, etal., Mediators Inflamm. 2007;2007:61254.
118. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
119. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
120. IL-18 binding protein protects against contact hypersensitivity. Plitz T, etal., J Immunol. 2003 Aug 1;171(3):1164-71.
121. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. Puthothu B, etal., Pediatr Infect Dis J. 2007 Dec;26(12):1094-8.
122. Interleukin-18 regulates pathological intraocular neovascularization. Qiao H, etal., J Leukoc Biol. 2007 Apr;81(4):1012-21. Epub 2007 Jan 18.
123. Interleukin-18 expression and the response to treatment in patients with psoriasis. Rasmy H, etal., Arch Med Sci. 2011 Aug;7(4):713-9. doi: 10.5114/aoms.2011.24144. Epub 2011 Sep 2.
124. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. Reeves EP, etal., J Immunol. 2010 Feb 1;184(3):1642-52. Epub 2009 Dec 21.
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