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Gene: Il18 (interleukin 18) Mus musculus
Symbol: Il18
Name: interleukin 18
Description: Exhibits cytokine activity. Involved in several processes, including cytokine production; lipid homeostasis; and positive regulation of cell differentiation. Localizes to extracellular space. Is expressed in several structures, including back skin; colon; dorsal aorta; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; biliary atresia; hepatitis B; and vasculitis (multiple). Orthologous to human IL18 (interleukin 18); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; 1,2-dichloroethane; 1-chloro-2,4,6-trinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IFN-gamma-inducing factor; Igif; IL-1 gamma; Il-18; interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin-1 gamma; interleukin-18
Homo sapiens (human) : IL18 (interleukin 18)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il18 (interleukin 18)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il18 (interleukin 18)
Pan paniscus (bonobo/pygmy chimpanzee) : IL18 (interleukin 18)
Canis lupus familiaris (dog) : IL18 (interleukin 18)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il18 (interleukin 18)
Sus scrofa (pig) : IL18 (interleukin 18)
Chlorocebus sabaeus (African green monkey) : IL18 (interleukin 18)
Heterocephalus glaber (naked mole-rat) : Il18 (interleukin 18)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBImm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il18
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730895
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.