IL18 (interleukin 18) - Rat Genome Database

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Gene: IL18 (interleukin 18) Homo sapiens
Symbol: IL18
Name: interleukin 18
RGD ID: 730894
HGNC Page HGNC:5986
Description: Enables cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Biomarker of several diseases, including autoimmune disease (multiple); cholestasis (multiple); liver disease (multiple); lung disease (multiple); and myositis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: iboctadekin; IFN-gamma-inducing factor; IGIF; IL-1 gamma; IL-18; IL-1g; IL1F4; interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma; interleukin-18; MGC12320
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811112,143,260 - 112,164,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11112,143,253 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
alcoholic hepatitis  (IEP)
allergic contact dermatitis  (EXP,ISO)
allergic disease  (EXP)
allergic rhinitis  (IAGP,IEA)
alopecia areata  (IAGP,IEA)
anti-basement membrane glomerulonephritis  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (IAGP,IEA,IEP,ISO,ISS)
autoimmune hepatitis  (EXP)
autoimmune thrombocytopenic purpura  (IEP)
bacterial pneumonia  (ISO)
Behcet's disease  (IAGP,IEA,IEP,ISO)
biliary atresia  (IAGP,IEA,IEP)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (EXP,ISO)
breast cancer  (IAGP,IEA,IEP)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
calcinosis  (EXP)
Carcinoma, Lewis Lung  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (EXP)
Carotid Artery Injuries  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
Chromosome 11, Partial Trisomy 11q  (IAGP)
Chronic Hepatitis B  (IAGP)
Chronic Hepatitis C  (IAGP,IEP)
chronic obstructive pulmonary disease  (IEP)
contact dermatitis  (EXP)
Coronary Disease  (IAGP)
cystic fibrosis  (IEP)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (IEP)
diabetic retinopathy  (IEP,ISO)
disease of cellular proliferation  (EXP)
Drug Eruptions  (EXP)
Eczema  (IAGP)
Edema  (ISO)
Embryo Loss  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (EXP)
Experimental Melanoma  (ISO)
eye disease  (IAGP,IEA)
familial Mediterranean fever  (IEP)
fatty liver disease  (ISO)
glomerulonephritis  (EXP)
Graves ophthalmopathy  (IEP)
Graves' disease  (IAGP,IEP)
heart disease  (ISO)
heart valve disease  (EXP)
hemophagocytic lymphohistiocytosis  (IEP)
Hemorrhagic Shock  (ISO)
hepatitis B  (IAGP,IEA)
hepatitis C  (IAGP,IEA,IEP)
hepatocellular carcinoma  (IAGP,IEA,IEP)
herpes simplex  (ISO)
high grade glioma  (ISO)
HIV-Associated Lipodystrophy Syndrome  (IAGP,IEP)
human immunodeficiency virus infectious disease  (IEP)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (ISO)
IgA glomerulonephritis  (IEP)
Immediate Hypersensitivity  (EXP)
Insulin Resistance  (IEP,ISO)
intellectual disability  (IAGP)
interstitial lung disease  (IEP,ISO)
intrahepatic cholestasis of pregnancy  (IEP)
invasive ductal carcinoma  (IEP)
ischemia  (ISO)
Kawasaki disease  (IAGP,IEA,IEP)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
leishmaniasis  (EXP,ISO)
liver cirrhosis  (IEP)
Liver Failure  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IAGP,IEA,IEP,ISO)
lung non-small cell carcinoma  (IEP)
lupus nephritis  (ISO)
Lymphatic Metastasis  (IEP)
Macrophage Activation Syndrome  (IEP)
Metabolic Syndrome  (EXP,ISO)
Mouth Neoplasms  (EXP)
Myocardial Reperfusion Injury  (ISO)
myositis  (IEP)
Neoplasm Metastasis  (EXP,IAGP,IEP)
neuroblastoma  (ISO)
non-alcoholic fatty liver disease  (IEP,ISO)
Nontuberculous Mycobacterium Infections  (IEP)
obesity  (ISO)
Oral Lichen Planus  (IAGP)
Pain  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (IEP)
Perennial Allergic Rhinitis  (IAGP)
perinatal necrotizing enterocolitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (EXP,IEP,ISO)
polymyositis  (IEP)
Polyomavirus Infections  (EXP)
primary cutaneous T-cell non-Hodgkin lymphoma  (IEP)
Prostatic Neoplasms  (EXP)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (IEP)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (IEP)
pulmonary tuberculosis  (IEP)
Radiation Injuries, Experimental  (EXP)
Reperfusion Injury  (ISO)
respiratory failure  (IEP)
respiratory syncytial virus infectious disease  (IAGP,IEA,ISO)
Retinal Neovascularization  (IEP,ISO)
rheumatoid arthritis  (EXP)
rhinitis  (IEP,ISO)
sarcoidosis  (EXP,IEP)
Schistosomiasis Japonica  (ISO)
Seasonal Allergic Rhinitis  (IAGP)
severe acute respiratory syndrome  (IEP)
Sjogren's syndrome  (IEP)
sleep apnea  (IDA,IEA)
Spinal Cord Injuries  (ISO)
Staphylococcal Skin Infections  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
strongyloidiasis  (ISO)
temporal arteritis  (IAGP,IEA)
Tibial Fractures  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IEP)
urinary tract infection  (ISO)
urticaria  (EXP,IAGP,IEP)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
visceral leishmaniasis  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(E)-cinnamyl alcohol  (EXP)
(R)-mevalonic acid  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (EXP)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (EXP)
4-nitrobenzyl bromide  (EXP)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
8-chloro-2'-deoxyguanosine  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
aluminium sulfate (anhydrous)  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthranilic acid  (EXP)
antirheumatic drug  (EXP)
apocynin  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asperentin  (ISO)
atrazine  (EXP)
aurantio-obtusin  (ISO)
Belnacasan  (EXP,ISO)
benzalkonium chloride  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (ISO)
benzylpenicillin  (EXP)
Bergenin  (ISO)
beryllium sulfate  (EXP)
bexarotene  (ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (EXP)
biliverdin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BQ 123  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
cefaloridine  (ISO)
celastrol  (ISO)
cerium trichloride  (ISO)
chloroethene  (ISO)
chloropicrin  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cimetidine  (EXP,ISO)
cinnamyl alcohol  (EXP)
cisplatin  (EXP,ISO)
citral  (EXP)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dichlorine  (ISO)
dicrotophos  (EXP)
dieckol  (ISO)
dieldrin  (ISO)
diethyl malate  (ISO)
diethyl maleate  (EXP)
diethylamine  (ISO)
dihydroartemisinin  (EXP)
Dimaprit  (EXP)
diosmetin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
doxorubicin  (ISO)
eplerenone  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
famotidine  (EXP)
fasudil  (ISO)
felodipine  (ISO)
ferulic acid  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
Fraxinellone  (EXP,ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geranial  (EXP)
geraniol  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
glyoxal  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
hemin  (EXP)
hexachlorobenzene  (ISO)
histamine  (EXP,ISO)
Honokiol  (EXP)
hydrocortisone succinate  (EXP)
hydrogen peroxide  (EXP)
IC-87114  (ISO)
ICI 118551  (ISO)
imiquimod  (ISO)
immunological adjuvant  (EXP)
indometacin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoeugenol  (EXP)
isoflurane  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
lead diacetate  (ISO)
lipid As  (EXP)
lipopolysaccharide  (EXP,ISO)
lonafarnib  (ISO)
lovastatin  (ISO)
lucanthone  (EXP)
LY294002  (EXP)
lysophosphatidylcholine  (EXP)
m-xylene  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
manumycin A  (ISO)
melittin  (EXP)
metam  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotinamide  (ISO)
nicotine  (EXP)
nifuroxazide  (ISO)
nilotinib  (ISO)
nitrofen  (ISO)
NMN zwitterion  (ISO)
ochratoxin A  (ISO)
olmesartan  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
Palbinone  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (EXP)
PD 0325901  (EXP)
pentane-2,3-dione  (ISO)
perfluoroundecanoic acid  (EXP)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenytoin  (ISO)
phosgene  (ISO)
phthalic anhydride  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
prednisolone  (ISO)
procyanidin B2  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (EXP)
pterostilbene  (EXP)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
ranitidine  (EXP)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
reserpine  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rolipram  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
Salidroside  (ISO)
sarpogrelate  (EXP)
SB 203580  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
spironolactone  (ISO)
sterigmatocystin  (ISO)
streptozocin  (ISO)
sulfamic acid  (EXP)
sulfur dioxide  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
theophylline  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trans-isoeugenol  (EXP)
trichostatin A  (EXP)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
undecan-2-one  (ISO)
uranium atom  (ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
vanillin  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zinc protoporphyrin  (EXP)
zirconium atom  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IDA)
angiogenesis  (IDA)
cell population proliferation  (IEA,ISO)
cell-cell signaling  (TAS)
cellular response to cAMP  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cholesterol homeostasis  (IEA,ISS)
defense response to Gram-positive bacterium  (IEA,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
digestive tract morphogenesis  (ISO)
establishment of skin barrier  (IEA,ISS)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
immune response  (IEA)
inflammatory response  (IDA,IEA,ISO)
interleukin-18-mediated signaling pathway  (IDA,IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IDA)
liver regeneration  (ISO)
lung development  (ISO)
MAPK cascade  (IMP)
natural killer cell activation  (IEA,ISO)
natural killer cell mediated cytotoxicity  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
neutrophil activation  (IEA,ISO)
NIK/NF-kappaB signaling  (IEA,ISO)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel remodeling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO,TAS)
positive regulation of cold-induced thermogenesis  (IEA,ISS)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IDA)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of inflammatory response  (IC,IEA,ISS)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-13 production  (TAS)
positive regulation of interleukin-17 production  (IDA)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macromolecule metabolic process  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISS)
positive regulation of male germ cell proliferation  (ISO)
positive regulation of natural killer cell proliferation  (IDA)
positive regulation of neuroinflammatory response  (TAS)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IDA)
positive regulation of NIK/NF-kappaB signaling  (IEA,ISO)
positive regulation of NK T cell proliferation  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IDA)
positive regulation of protein kinase B signaling  (IDA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (IDA,ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 1 cell cytokine production  (IDA)
positive regulation of T-helper 2 cell differentiation  (IEA,ISS)
positive regulation of tissue remodeling  (IC)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (IDA,IEA,ISO,TAS)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
positive regulation of vascular permeability  (ISO)
regulation of cell adhesion  (IDA)
regulation of gene expression  (IEA)
response to cold  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
signal transduction  (IEA)
sleep  (ISS)
T-helper 1 type immune response  (IDA)
triglyceride homeostasis  (IEA,ISS)
type 2 immune response  (TAS)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype

References - curated
# Reference Title Reference Citation
1. Serum IL-18 levels in tuberculosis: comparison with pneumonia, lung cancer and healthy controls. Akgun M, etal., Respirology. 2005 Jun;10(3):295-9.
2. Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. Akhtar S, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G340-7. Epub 2009 Jun 4.
3. Serum IL-18 levels in patients with type 1 diabetes: relations to metabolic control and microvascular complications. Altinova AE, etal., Cytokine. 2008 May;42(2):217-21. doi: 10.1016/j.cyto.2008.02.006. Epub 2008 Mar 24.
4. Differential production of interleukin-1 family cytokines (IL-1β, IL-18, IL-33 and IL-37) in patients with paracoccidioidomycosis: correlation with clinical form and antifungal therapy. Alves ABRM, etal., Med Mycol. 2018 Apr 1;56(3):332-343. doi: 10.1093/mmy/myx050.
5. Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance. An P, etal., J Infect Dis. 2008 Oct 15;198(8):1159-65. doi: 10.1086/592047.
6. Serum interleukins 12 and 18 and immunoglobulin E concentrations and allergic symptoms in Japanese schoolchildren. Ando M and Shima M, J Investig Allergol Clin Immunol. 2007;17(1):14-9.
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PMID:26216891   PMID:26229413   PMID:26292095   PMID:26302971   PMID:26320490   PMID:26346467   PMID:26376814   PMID:26381575   PMID:26396182   PMID:26438531   PMID:26474654   PMID:26496610  
PMID:26600055   PMID:26656097   PMID:26669254   PMID:26681034   PMID:26683353   PMID:26690141   PMID:26728085   PMID:26743536   PMID:26753638   PMID:26800664   PMID:26804591   PMID:26830320  
PMID:26856767   PMID:26885772   PMID:26897018   PMID:26898120   PMID:26909913   PMID:26974498   PMID:26983036   PMID:26990875   PMID:27001087   PMID:27021370   PMID:27027876   PMID:27028244  
PMID:27045344   PMID:27058587   PMID:27082857   PMID:27098064   PMID:27109946   PMID:27114524   PMID:27121382   PMID:27174093   PMID:27177146   PMID:27219123   PMID:27286581   PMID:27313119  
PMID:27352267   PMID:27356067   PMID:27362289   PMID:27430614   PMID:27455146   PMID:27496752   PMID:27543331   PMID:27636349   PMID:27636371   PMID:27663212   PMID:27669650   PMID:27693669  
PMID:27706625   PMID:27741477   PMID:27794266   PMID:27810076   PMID:27813570   PMID:27881017   PMID:27888626   PMID:27914933   PMID:27928589   PMID:27965258   PMID:27997912   PMID:28000712  
PMID:28002583   PMID:28057714   PMID:28059484   PMID:28139755   PMID:28167281   PMID:28195558   PMID:28231690   PMID:28246425   PMID:28300059   PMID:28342224   PMID:28395725   PMID:28415798  
PMID:28430754   PMID:28508444   PMID:28514442   PMID:28526653   PMID:28580570   PMID:28634744   PMID:28652186   PMID:28692122   PMID:28766916   PMID:28830544   PMID:28842466   PMID:28858634  
PMID:28922563   PMID:28973736   PMID:29017770   PMID:29042061   PMID:29061223   PMID:29097263   PMID:29105174   PMID:29105530   PMID:29129846   PMID:29185028   PMID:29218606   PMID:29247988  
PMID:29282220   PMID:29326099   PMID:29342149   PMID:29349811   PMID:29353540   PMID:29394248   PMID:29453279   PMID:29467282   PMID:29472914   PMID:29499224   PMID:29505668   PMID:29528575  
PMID:29551594   PMID:29601578   PMID:29627485   PMID:29648472   PMID:29672590   PMID:29724886   PMID:29855451   PMID:29926984   PMID:29930551   PMID:29979096   PMID:30045250   PMID:30092066  
PMID:30211233   PMID:30269670   PMID:30311406   PMID:30316805   PMID:30326484   PMID:30341522   PMID:30392846   PMID:30431529   PMID:30483730   PMID:30526181   PMID:30672022   PMID:30706178  
PMID:30782515   PMID:30857465   PMID:30903865   PMID:30925760   PMID:30940725   PMID:30992532   PMID:31003186   PMID:31017261   PMID:31065235   PMID:31084469   PMID:31129625   PMID:31169028  
PMID:31244277   PMID:31277710   PMID:31296089   PMID:31301271   PMID:31372853   PMID:31379247   PMID:31400853   PMID:31401307   PMID:31448710   PMID:31519608   PMID:31522432   PMID:31554361  
PMID:31554368   PMID:31586073   PMID:31634439   PMID:31661113   PMID:31669192   PMID:31670094   PMID:31680001   PMID:31681257   PMID:31698031   PMID:31744330   PMID:31751351   PMID:31799681  
PMID:31801640   PMID:31914650   PMID:31931428   PMID:31935500   PMID:31963531   PMID:31983439   PMID:31991315   PMID:32039628   PMID:32045661   PMID:32060657   PMID:32135277   PMID:32151994  
PMID:32152765   PMID:32193584   PMID:32209332   PMID:32245311   PMID:32251712   PMID:32264954   PMID:32270468   PMID:32289486   PMID:32296048   PMID:32296183   PMID:32304293   PMID:32315287  
PMID:32338205   PMID:32347623   PMID:32375555   PMID:32560261   PMID:32573302   PMID:32597834   PMID:32616329   PMID:32630059   PMID:32644977   PMID:32687059   PMID:32794180   PMID:32795736  
PMID:32826615   PMID:32851082   PMID:32902142   PMID:32944849   PMID:33002740   PMID:33038386   PMID:33073324   PMID:33073951   PMID:33117339   PMID:33143466   PMID:33163049   PMID:33181835  
PMID:33188073   PMID:33200207   PMID:33202974   PMID:33203036   PMID:33294056   PMID:33332577   PMID:33412574   PMID:33453262   PMID:33507690   PMID:33522333   PMID:33576397   PMID:33633218  
PMID:33651323   PMID:33660570   PMID:33678651   PMID:33711216   PMID:33760111   PMID:33773554   PMID:33823154   PMID:33961781   PMID:34003678   PMID:34082505   PMID:34092668   PMID:34165682  
PMID:34183442   PMID:34196131   PMID:34204067   PMID:34233421   PMID:34263421   PMID:34282497   PMID:34321563   PMID:34330167   PMID:34354705   PMID:34367188   PMID:34431037   PMID:34460061  
PMID:34487815   PMID:34526450   PMID:34550451   PMID:34583255   PMID:34596583   PMID:34627076   PMID:34663245   PMID:34691064   PMID:34708129   PMID:34734091   PMID:34758379   PMID:34763449  
PMID:34773548   PMID:34920659   PMID:34923222   PMID:34933714   PMID:34948026   PMID:35016441   PMID:35017327   PMID:35017329   PMID:35038547   PMID:35090723   PMID:35263047   PMID:35301151  
PMID:35302191   PMID:35398099   PMID:35535228   PMID:35675813   PMID:35760570   PMID:35767893   PMID:35790262  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811112,143,260 - 112,164,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11112,143,253 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBImm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2850,904,630 - 50,932,887 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)Ensembl
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.111110,867,586 - 110,888,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,867,586 - 110,888,371 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011107,024,376 - 107,045,194 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1520,972,742 - 20,995,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,972,871 - 20,995,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,907,590 - 20,917,853 (+)NCBI
ROS_Cfam_1.0520,994,967 - 21,017,974 (+)NCBI
ROS_Cfam_1.0 Ensembl520,995,094 - 21,019,245 (+)Ensembl
UMICH_Zoey_3.1521,069,981 - 21,080,260 (+)NCBI
UNSW_CanFamBas_1.0520,970,245 - 20,980,530 (+)NCBI
UU_Cfam_GSD_1.0521,018,633 - 21,028,888 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494794,380,523 - 94,398,669 (-)NCBI
SpeTri2.0NW_0049366122,306,963 - 2,325,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl939,834,973 - 39,861,219 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,839,959 - 39,861,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,692,120 - 44,713,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11103,485,868 - 103,511,632 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,482,083 - 103,510,150 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604322,475,303 - 22,498,316 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247847,294,183 - 7,304,687 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711112,014,337 - 112,014,535UniSTSGRCh37
Build 3611111,519,547 - 111,519,745RGDNCBI36
Celera11109,167,575 - 109,167,773RGD
Cytogenetic Map11q22.2-q22.3UniSTS
HuRef11107,938,458 - 107,938,656UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711112,013,822 - 112,014,522UniSTSGRCh37
Build 3611111,519,032 - 111,519,732RGDNCBI36
Celera11109,167,060 - 109,167,760RGD
HuRef11107,937,943 - 107,938,643UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic MapXq26.1UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map9p13UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map12q15-q21UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map2p22.2UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map11q22.2-q22.3UniSTS
Cytogenetic Map1p36-p35UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map10q26.13-q26.3UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map2q32.2UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR346hsa-miR-346Mirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Non-Functional MTI19342689

Predicted Target Of
Summary Value
Count of predictions:896
Count of miRNA genes:407
Interacting mature miRNAs:443
Transcripts:ENST00000280357, ENST00000524595, ENST00000525547, ENST00000528832, ENST00000533858, ENST00000534225
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
Medium 1014 655 317 157 877 76 2360 327 966 323 517 905 94 714 1454
Low 1410 2198 1393 459 803 382 1907 1712 2455 91 907 629 80 1 489 1323 4 1
Below cutoff 8 128 14 7 174 7 66 144 281 2 33 42 1 1 11 1


Nucleotide Sequences
RefSeq Transcripts NG_028143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001386420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB095532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF077611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF380360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ295724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY044641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY266351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU633686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF444989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles