IL18 (interleukin 18) - Rat Genome Database

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Gene: IL18 (interleukin 18) Homo sapiens
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Symbol: IL18
Name: interleukin 18
RGD ID: 730894
HGNC Page HGNC:5986
Description: Enables cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including interleukin-18-mediated signaling pathway; positive regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Is active in extracellular space. Implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Biomarker of several diseases, including autoimmune disease (multiple); cholestasis (multiple); liver disease (multiple); lung disease (multiple); and myositis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: iboctadekin; IFN-gamma-inducing factor; IGIF; IL-1 gamma; IL-18; IL-1g; IL1F4; interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma; interleukin-18; MGC12320
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,143,260 - 112,164,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,143,251 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
alcoholic hepatitis  (IEP)
allergic contact dermatitis  (EXP,ISO)
allergic disease  (EXP)
allergic rhinitis  (IAGP)
alopecia areata  (IAGP)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (IAGP,IEP,IMP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (IAGP,IEP,ISO,ISS)
autoimmune hepatitis  (EXP)
autoimmune thrombocytopenic purpura  (IEP)
bacterial pneumonia  (ISO)
Behcet's disease  (IAGP,IEP,ISO)
BH4-deficient hyperphenylalaninemia A  (IAGP)
biliary atresia  (IAGP,IEP)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (EXP,ISO)
breast cancer  (IAGP,IEP)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
calcinosis  (EXP)
Carcinoma, Lewis Lung  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (EXP)
Carotid Artery Injuries  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
chromosome 11 partial duplication syndrome  (IAGP)
Chronic Hepatitis B  (IAGP)
Chronic Hepatitis C  (IAGP,IEP)
chronic obstructive pulmonary disease  (IEP)
contact dermatitis  (EXP)
Coronary Disease  (IAGP)
COVID-19  (HEP,IEP)
cystic fibrosis  (IEP)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (IEP)
diabetic retinopathy  (IEP,ISO)
disease of cellular proliferation  (EXP)
Drug Eruptions  (EXP)
Eczema  (IAGP)
Edema  (ISO)
Embryo Loss  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (EXP)
Experimental Melanoma  (ISO)
Experimental Radiation Injuries  (EXP)
eye disease  (IAGP)
familial Mediterranean fever  (IEP)
glomerulonephritis  (EXP)
Graves ophthalmopathy  (IEP)
Graves' disease  (IAGP,IEP)
heart disease  (ISO)
heart valve disease  (EXP)
hemophagocytic lymphohistiocytosis  (IEP)
Hemorrhagic Shock  (ISO)
hepatitis B  (IAGP)
hepatitis C  (IAGP,IEP)
hepatocellular carcinoma  (IAGP,IEP)
herpes simplex  (ISO)
high grade glioma  (ISO)
HIV-Associated Lipodystrophy Syndrome  (IAGP,IEP)
human immunodeficiency virus infectious disease  (IEP)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (ISO)
IgA glomerulonephritis  (IEP)
Immediate Hypersensitivity  (EXP)
Insulin Resistance  (IEP,ISO)
intellectual disability  (IAGP)
interstitial lung disease  (IEP,ISO)
intrahepatic cholestasis of pregnancy  (IEP)
invasive ductal carcinoma  (IEP)
ischemia  (ISO)
Kawasaki disease  (IAGP,IEP)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
leishmaniasis  (EXP,ISO)
liver cirrhosis  (IEP)
Liver Failure  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IAGP,IEP,ISO)
lung non-small cell carcinoma  (IEP)
lupus nephritis  (ISO)
Lymphatic Metastasis  (IEP)
Macrophage Activation Syndrome  (IEP)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (EXP,ISO)
Mouth Neoplasms  (EXP)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myositis  (IEP)
Neoplasm Metastasis  (EXP,IAGP,IEP)
neuroblastoma  (ISO)
Nontuberculous Mycobacterium Infections  (IEP)
obesity  (ISO)
Oral Lichen Planus  (IAGP)
Pain  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (IEP)
Perennial Allergic Rhinitis  (IAGP)
perinatal necrotizing enterocolitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (EXP,IEP,ISO)
polymyositis  (IEP)
Polyomavirus Infections  (EXP)
primary cutaneous T-cell non-Hodgkin lymphoma  (IEP)
Prostatic Neoplasms  (EXP)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (IEP)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (IEP)
pulmonary tuberculosis  (IEP)
Pyruvate Dehydrogenase E2 Deficiency  (IAGP)
Reperfusion Injury  (ISO)
respiratory failure  (IEP)
respiratory syncytial virus infectious disease  (IAGP,ISO)
Retinal Neovascularization  (IEP,ISO)
rheumatoid arthritis  (EXP)
rhinitis  (IEP,ISO)
sarcoidosis  (EXP,IEP)
Schistosomiasis Japonica  (ISO)
Seasonal Allergic Rhinitis  (IAGP)
severe acute respiratory syndrome  (IEP)
Sjogren's syndrome  (IEP)
sleep apnea  (IDA)
Spinal Cord Injuries  (ISO)
Staphylococcal Skin Infections  (ISO)
status epilepticus  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
strongyloidiasis  (ISO)
temporal arteritis  (IAGP)
Tibial Fractures  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IEP)
urinary tract infection  (ISO)
urticaria  (EXP,IAGP,IEP)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
visceral leishmaniasis  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(E)-cinnamyl alcohol  (EXP)
(R)-carnitine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-phenylenediamine  (EXP)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (EXP)
2-hydroxypropanoic acid  (EXP)
2-palmitoylglycerol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (EXP)
4-nitrobenzyl bromide  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (EXP)
8-chloro-2'-deoxyguanosine  (ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-Zearalanol  (ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP,ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthranilic acid  (EXP)
antirheumatic drug  (EXP)
apocynin  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
asperentin  (ISO)
atorvastatin calcium  (ISO)
ATP  (EXP,ISO)
atrazine  (EXP,ISO)
aucubin  (ISO)
aurantio-obtusin  (ISO)
Azoxymethane  (ISO)
bellidifolin  (EXP)
Belnacasan  (EXP,ISO)
benzalkonium chloride  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzocaine  (ISO)
benzylpenicillin  (EXP)
Bergenin  (ISO)
beryllium sulfate  (EXP)
beta-cyclodextrin  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (EXP)
biliverdin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
boron atom  (ISO)
BQ 123  (ISO)
Brevianamide A  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
cefaloridine  (ISO)
celastrol  (ISO)
cerium trichloride  (ISO)
chloroethene  (ISO)
chloropicrin  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
cimetidine  (EXP,ISO)
cinnamyl alcohol  (EXP)
cisplatin  (EXP,ISO)
citral  (EXP)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP,ISO)
corn oil  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
dieckol  (ISO)
dieldrin  (ISO)
diethyl malate  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diethylamine  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
Dimaprit  (EXP)
dimethyl fumarate  (EXP)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
doxorubicin  (ISO)
elemental boron  (ISO)
emodin  (ISO)
eplerenone  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
Evodiamine  (ISO)
famotidine  (EXP)
fasudil  (ISO)
felodipine  (ISO)
ferulic acid  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
Fraxinellone  (EXP,ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
furfural  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
geranial  (EXP)
geraniol  (ISO)
ginsenoside Rb1  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
glyoxal  (EXP)
gossypin  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
GSK2193874  (ISO)
hemin  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
histamine  (EXP,ISO)
Honokiol  (EXP)
hydrocortisone succinate  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
hydroxysafflor yellow A  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
ICI 118551  (ISO)
imiquimod  (ISO)
immunological adjuvant  (EXP)
indometacin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoeugenol  (EXP)
isoflurane  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
JTE-013  (ISO)
Jujuboside A  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipid As  (EXP)
lipopolysaccharide  (EXP,ISO)
lixisenatide  (EXP)
loganin  (EXP,ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (ISO)
lucanthone  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
lysophosphatidylcholine  (EXP)
m-xylene  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
manumycin A  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP)
mesalamine  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
metronidazole  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
neomycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nifuroxazide  (ISO)
nigericin  (EXP)
nilotinib  (ISO)
nitrofen  (ISO)
NMN zwitterion  (ISO)
Nonylphenol  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleic acid  (EXP)
olmesartan  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paeoniflorin  (EXP,ISO)
Palbinone  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (EXP)
PD 0325901  (EXP)
pentachlorophenol  (EXP)
pentane-2,3-dione  (ISO)
perfluorodecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenytoin  (ISO)
phosgene  (ISO)
phthalic anhydride  (ISO)
Phytolaccoside E  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
prednisolone  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
procyanidin B2  (ISO)
progesterone  (ISO)
propofol  (EXP)
protein kinase inhibitor  (EXP)
pterostilbene  (EXP)
puerarin  (EXP)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
ranitidine  (EXP)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
reserpine  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rolipram  (ISO)
rotenone  (EXP,ISO)
Ruscogenin  (EXP)
rutin  (ISO)
Salidroside  (ISO)
sarpogrelate  (EXP)
SB 203580  (EXP)
scutellarin  (ISO)
serpentine asbestos  (EXP)
sevoflurane  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (ISO)
sterigmatocystin  (ISO)
streptozocin  (ISO)
sulfamic acid  (EXP)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
theophylline  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trans-isoeugenol  (EXP)
tributylstannane  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (EXP)
undecan-2-one  (ISO)
uranium atom  (ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vanillin  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
wedelolactone  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc protoporphyrin  (EXP)
zirconium atom  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IDA)
cell population proliferation  (IEA,ISO)
cell-cell signaling  (TAS)
cellular response to cAMP  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (IBA,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cholesterol homeostasis  (IEA,ISS)
cytokine-mediated signaling pathway  (IBA)
defense response to Gram-positive bacterium  (IEA,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
digestive tract morphogenesis  (ISO)
establishment of skin barrier  (IEA,ISS)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
immune response  (IBA,IEA)
inflammatory response  (IBA,IEA,ISO)
interleukin-18-mediated signaling pathway  (IDA,IEA,ISO)
liver regeneration  (ISO)
lung development  (ISO)
natural killer cell activation  (IEA,ISO)
natural killer cell mediated cytotoxicity  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
neutrophil activation  (IEA,ISO)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel remodeling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO,TAS)
positive regulation of cold-induced thermogenesis  (IEA,ISS)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IDA)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of inflammatory response  (IC,IEA,ISS)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-13 production  (TAS)
positive regulation of interleukin-17 production  (IDA)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISS)
positive regulation of male germ cell proliferation  (ISO)
positive regulation of natural killer cell proliferation  (IDA)
positive regulation of neuroinflammatory response  (TAS)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IDA)
positive regulation of NK T cell proliferation  (IDA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (IDA,ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 1 cell cytokine production  (IDA)
positive regulation of T-helper 2 cell differentiation  (IEA,ISS)
positive regulation of tissue remodeling  (IC)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (IDA,IEA,ISO,TAS)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
positive regulation of vascular permeability  (ISO)
regulation of cell adhesion  (IDA)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
signal transduction  (IEA)
sleep  (ISS)
T-helper 1 type immune response  (IDA)
triglyceride homeostasis  (IEA,ISS)
type 2 immune response  (TAS)

Cellular Component
apical plasma membrane  (ISO)
cytoplasm  (IEA)
cytosol  (IEA,TAS)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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93. Induction of the proinflammatory cytokine interleukin-18 by axonal injury. Menge T, etal., J Neurosci Res. 2001 Aug 15;65(4):332-9.
94. Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice. Menke J, etal., Kidney Int. 2011 Feb;79(4):452-63. Epub 2010 Oct 27.
95. Interleukin-18 induces insulin resistance in the hyperthyroid state. Miyauchi S, etal., Endocr J. 2013;60(4):449-55. Epub 2012 Dec 19.
96. Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. Miyoshi K, etal., J Neurosci. 2008 Nov 26;28(48):12775-87. doi: 10.1523/JNEUROSCI.3512-08.2008.
97. Expression of interleukin-18 in a rat model of deep vein thrombosis. Mo J, etal., J Cardiovasc Surg (Torino). 2012 Oct;53(5):625-30. Epub 2012 Feb 8.
98. Lack of association of interleukin-18 gene polymorphisms with susceptibility of Japanese populations to Graves' disease or Graves' ophthalmopathy. Mukai T, etal., Thyroid. 2006 Mar;16(3):243-8.
99. Endogenous interleukin-18 is involved in immunity to Leishmania donovani but its absence does not adversely influence the therapeutic activity of sodium stibogluconate. Mullen AB, etal., Immunology. 2006 Nov;119(3):348-54. Epub 2006 Jul 26.
100. Interleukin 18 and transforming growth factor beta1 in the serum of patients with Graves' ophthalmopathy treated with corticosteroids. Mysliwiec J, etal., Int Immunopharmacol. 2003 Apr;3(4):549-52.
101. Gene transfer of secreted-type modified interleukin-18 gene to B16F10 melanoma cells suppresses in vivo tumor growth through inhibition of tumor vessel formation. Nagai H, etal., J Invest Dermatol. 2002 Sep;119(3):541-8.
102. Involvement of interleukin 18 in lens opacification of Otsuka Long-Evans Tokushima Fatty rats, a model of human type 2 diabetes. Nagai N, etal., Curr Eye Res. 2011 Jun;36(6):497-506. doi: 10.3109/02713683.2010.549602.
103. Involvement of interleukin 18 in cataract development in hereditary cataract UPL rats. Nagai N, etal., J Biochem. 2007 Nov;142(5):597-603.
104. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Netea MG, etal., Nat Med. 2006 Jun;12(6):650-6. doi: 10.1038/nm1415. Epub 2006 May 28.
105. Serum levels of interleukin-18 are elevated in the subacute phase of kawasaki syndrome. Nomura Y, etal., Int Arch Allergy Immunol. 2004 Oct;135(2):161-5. Epub 2004 Sep 2.
106. Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema. Novak N, etal., J Allergy Clin Immunol. 2005 Apr;115(4):828-33.
107. Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection. Ohkusu K, etal., Infect Immun. 2000 May;68(5):2449-56.
108. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Oku H, etal., Eur J Pharmacol. 2008 Aug 20;590(1-3):400-8. Epub 2008 Jun 16.
109. Suppressive effects of interleukin-18 on liver function in rat liver allografts. Ono S, etal., J Surg Res. 2012 Jul;176(1):293-300. doi: 10.1016/j.jss.2011.07.053. Epub 2011 Aug 27.
110. Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis. Palomino-Morales RJ, etal., Arthritis Res Ther. 2010;12(2):R51. doi: 10.1186/ar2962. Epub 2010 Mar 23.
111. Role of interleukin-18 in experimental infections with Streptococcus pneumoniae. Paterson GK, etal., J Med Microbiol. 2005 Apr;54(Pt 4):323-6.
112. Interleukin-18 promoter polymorphism in patients with atopic asthma. Pawlik A, etal., Tissue Antigens. 2007 Oct;70(4):314-8.
113. Plasma interleukin-18 and dendritic cells in males with psoriasis vulgaris. Pietrzak A, etal., Mediators Inflamm. 2007;2007:61254.
114. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
115. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
116. IL-18 binding protein protects against contact hypersensitivity. Plitz T, etal., J Immunol. 2003 Aug 1;171(3):1164-71.
117. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. Puthothu B, etal., Pediatr Infect Dis J. 2007 Dec;26(12):1094-8.
118. Interleukin-18 regulates pathological intraocular neovascularization. Qiao H, etal., J Leukoc Biol. 2007 Apr;81(4):1012-21. Epub 2007 Jan 18.
119. Interleukin-18 expression and the response to treatment in patients with psoriasis. Rasmy H, etal., Arch Med Sci. 2011 Aug;7(4):713-9. doi: 10.5114/aoms.2011.24144. Epub 2011 Sep 2.
120. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. Reeves EP, etal., J Immunol. 2010 Feb 1;184(3):1642-52. Epub 2009 Dec 21.
121. Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation. Reyes L, etal., BMC Infect Dis. 2009 Jan 26;9:9.
122. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
123. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:22484385   PMID:22489883   PMID:22493490   PMID:22515481   PMID:22531046   PMID:22537138   PMID:22537218   PMID:22587568   PMID:22595646   PMID:22596175   PMID:22613414   PMID:22639237  
PMID:22658674   PMID:22661400   PMID:22664470   PMID:22678894   PMID:22686311   PMID:22723447   PMID:22749533   PMID:22811364   PMID:22825306   PMID:22837141   PMID:22863216   PMID:22883217  
PMID:22898364   PMID:22900713   PMID:22913567   PMID:22945280   PMID:22980562   PMID:22996386   PMID:23018032   PMID:23023653   PMID:23027874   PMID:23028054   PMID:23056251   PMID:23073298  
PMID:23075512   PMID:23085113   PMID:23121308   PMID:23132931   PMID:23137633   PMID:23153245   PMID:23171362   PMID:23178856   PMID:23207179   PMID:23214284   PMID:23232703   PMID:23238919  
PMID:23242610   PMID:23263551   PMID:23269628   PMID:23276493   PMID:23298491   PMID:23302036   PMID:23327592   PMID:23376485   PMID:23403235   PMID:23419721   PMID:23433789   PMID:23459183  
PMID:23499732   PMID:23522322   PMID:23526823   PMID:23546966   PMID:23557801   PMID:23587914   PMID:23603311   PMID:23632060   PMID:23656272   PMID:23675517   PMID:23702484   PMID:23702978  
PMID:23707237   PMID:23723976   PMID:23739747   PMID:23741523   PMID:23746337   PMID:23769880   PMID:23778029   PMID:23793845   PMID:23794112   PMID:23856797   PMID:23873689   PMID:23883285  
PMID:23885403   PMID:23888552   PMID:23901078   PMID:23904224   PMID:23914907   PMID:23938462   PMID:23957657   PMID:23958877   PMID:23978570   PMID:24026885   PMID:24033965   PMID:24036181  
PMID:24040261   PMID:24054338   PMID:24066061   PMID:24084330   PMID:24111610   PMID:24129807   PMID:24130810   PMID:24167151   PMID:24168677   PMID:24182552   PMID:24259949   PMID:24265116  
PMID:24275551   PMID:24285455   PMID:24307760   PMID:24331389   PMID:24349532   PMID:24375576   PMID:24376549   PMID:24379519   PMID:24402877   PMID:24460336   PMID:24465163   PMID:24531812  
PMID:24599060   PMID:24615654   PMID:24621393   PMID:24664725   PMID:24671718   PMID:24701032   PMID:24711060   PMID:24717026   PMID:24742099   PMID:24767355   PMID:24778454   PMID:24780928  
PMID:24786926   PMID:24804827   PMID:24815843   PMID:24861285   PMID:24872585   PMID:24876666   PMID:24897237   PMID:24898701   PMID:24906108   PMID:24909718   PMID:24917023   PMID:24935632  
PMID:24963217   PMID:24965773   PMID:24995282   PMID:25012128   PMID:25052265   PMID:25060131   PMID:25123522   PMID:25131111   PMID:25138786   PMID:25192895   PMID:25204040   PMID:25207880  
PMID:25231602   PMID:25261253   PMID:25267095   PMID:25308526   PMID:25342490   PMID:25362180   PMID:25398690   PMID:25405235   PMID:25427791   PMID:25446437   PMID:25451609   PMID:25487141  
PMID:25500532   PMID:25548255   PMID:25576800   PMID:25591548   PMID:25599738   PMID:25645216   PMID:25690033   PMID:25710036   PMID:25712187   PMID:25727011   PMID:25730877   PMID:25732728  
PMID:25736367   PMID:25743241   PMID:25776473   PMID:25802197   PMID:25807634   PMID:25822970   PMID:25832634   PMID:25873755   PMID:25880879   PMID:25892571   PMID:25921117   PMID:25922275  
PMID:25952099   PMID:26026656   PMID:26041375   PMID:26046663   PMID:26057800   PMID:26079218   PMID:26096341   PMID:26116895   PMID:26168332   PMID:26205090   PMID:26214646   PMID:26216891  
PMID:26229413   PMID:26292095   PMID:26302971   PMID:26320490   PMID:26346467   PMID:26376814   PMID:26381575   PMID:26396182   PMID:26438531   PMID:26474654   PMID:26496610   PMID:26600055  
PMID:26656097   PMID:26669254   PMID:26681034   PMID:26683353   PMID:26690141   PMID:26728085   PMID:26743536   PMID:26753638   PMID:26800664   PMID:26804591   PMID:26830320   PMID:26856767  
PMID:26885772   PMID:26897018   PMID:26898120   PMID:26909913   PMID:26974498   PMID:26983036   PMID:26990875   PMID:27001087   PMID:27021370   PMID:27027876   PMID:27028244   PMID:27045344  
PMID:27058587   PMID:27082857   PMID:27098064   PMID:27109946   PMID:27114524   PMID:27121382   PMID:27174093   PMID:27177146   PMID:27219123   PMID:27286581   PMID:27313119   PMID:27352267  
PMID:27356067   PMID:27362289   PMID:27430614   PMID:27455146   PMID:27496752   PMID:27543331   PMID:27636349   PMID:27636371   PMID:27663212   PMID:27669650   PMID:27693669   PMID:27706625  
PMID:27741477   PMID:27794266   PMID:27810076   PMID:27813570   PMID:27881017   PMID:27888626   PMID:27914933   PMID:27928589   PMID:27965258   PMID:27997912   PMID:28000712   PMID:28002583  
PMID:28057714   PMID:28059484   PMID:28139755   PMID:28167281   PMID:28195558   PMID:28231690   PMID:28246425   PMID:28300059   PMID:28342224   PMID:28395725   PMID:28415798   PMID:28430754  
PMID:28508444   PMID:28514442   PMID:28526653   PMID:28580570   PMID:28634744   PMID:28652186   PMID:28692122   PMID:28766916   PMID:28830544   PMID:28842466   PMID:28858634   PMID:28922563  
PMID:28973736   PMID:29017770   PMID:29042061   PMID:29061223   PMID:29097263   PMID:29105174   PMID:29105530   PMID:29129846   PMID:29185028   PMID:29218606   PMID:29247988   PMID:29282220  
PMID:29326099   PMID:29342149   PMID:29349811   PMID:29353540   PMID:29394248   PMID:29453279   PMID:29467282   PMID:29472914   PMID:29499224   PMID:29505668   PMID:29528575   PMID:29551594  
PMID:29601578   PMID:29627485   PMID:29648472   PMID:29672590   PMID:29724886   PMID:29855451   PMID:29926984   PMID:29930551   PMID:29979096   PMID:30045250   PMID:30092066   PMID:30211233  
PMID:30269670   PMID:30311406   PMID:30316805   PMID:30326484   PMID:30341522   PMID:30392846   PMID:30431529   PMID:30483730   PMID:30526181   PMID:30672022   PMID:30706178   PMID:30782515  
PMID:30857465   PMID:30903865   PMID:30925760   PMID:30940725   PMID:30992532   PMID:31003186   PMID:31017261   PMID:31065235   PMID:31084469   PMID:31129625   PMID:31169028   PMID:31244277  
PMID:31277710   PMID:31296089   PMID:31301271   PMID:31372853   PMID:31379247   PMID:31400853   PMID:31401307   PMID:31448710   PMID:31519608   PMID:31522432   PMID:31554361   PMID:31554368  
PMID:31586073   PMID:31634439   PMID:31661113   PMID:31669192   PMID:31670094   PMID:31680001   PMID:31681257   PMID:31698031   PMID:31744330   PMID:31751351   PMID:31799681   PMID:31801640  
PMID:31914650   PMID:31931428   PMID:31935500   PMID:31963531   PMID:31983439   PMID:31991315   PMID:32039628   PMID:32045661   PMID:32060657   PMID:32135277   PMID:32151994   PMID:32152765  
PMID:32193584   PMID:32209332   PMID:32245311   PMID:32251712   PMID:32264954   PMID:32270468   PMID:32289486   PMID:32296048   PMID:32296183   PMID:32304293   PMID:32315287   PMID:32338205  
PMID:32347623   PMID:32375555   PMID:32560261   PMID:32573302   PMID:32597834   PMID:32616329   PMID:32630059   PMID:32633568   PMID:32644977   PMID:32687059   PMID:32794180   PMID:32795736  
PMID:32826615   PMID:32851082   PMID:32902142   PMID:32944849   PMID:33002740   PMID:33038386   PMID:33073324   PMID:33073951   PMID:33103874   PMID:33117339   PMID:33143466   PMID:33163049  
PMID:33181835   PMID:33188073   PMID:33200207   PMID:33202974   PMID:33203036   PMID:33294056   PMID:33332577   PMID:33412574   PMID:33453262   PMID:33464225   PMID:33507690   PMID:33522333  
PMID:33576397   PMID:33633218   PMID:33651323   PMID:33660570   PMID:33678651   PMID:33711216   PMID:33760111   PMID:33773554   PMID:33823154   PMID:33883744   PMID:33961781   PMID:34003678  
PMID:34082505   PMID:34092668   PMID:34165682   PMID:34183442   PMID:34196131   PMID:34204067   PMID:34263421   PMID:34282497   PMID:34321563   PMID:34330167   PMID:34354705   PMID:34367188  
PMID:34431037   PMID:34460061   PMID:34487815   PMID:34526450   PMID:34550451   PMID:34583255   PMID:34596583   PMID:34627076   PMID:34663245   PMID:34691064   PMID:34708129   PMID:34734091  
PMID:34758379   PMID:34763449   PMID:34773548   PMID:34920659   PMID:34923222   PMID:34933714   PMID:34948026   PMID:35016441   PMID:35017327   PMID:35017329   PMID:35038547   PMID:35090723  
PMID:35263047   PMID:35301151   PMID:35302191   PMID:35398099   PMID:35675813   PMID:35705877   PMID:35760570   PMID:35767893   PMID:35790262   PMID:35811828   PMID:35831314   PMID:35843146  
PMID:35862204   PMID:35931995   PMID:36032110   PMID:36111789   PMID:36182709   PMID:36211331   PMID:36222965   PMID:36288881   PMID:36299462   PMID:36469254   PMID:36551320   PMID:36656063  
PMID:36707882   PMID:36708448   PMID:36739764   PMID:36742296   PMID:36853287   PMID:36861887   PMID:36902104   PMID:36905404   PMID:36947659   PMID:37068092   PMID:37075015   PMID:37268060  
PMID:37268663   PMID:37298187   PMID:37304287   PMID:37306504   PMID:37453156   PMID:37480196   PMID:37741261   PMID:37794779   PMID:37847180   PMID:37848720   PMID:37877723   PMID:37933422  
PMID:37934469   PMID:37958774   PMID:37964584   PMID:37993712   PMID:37993714   PMID:38031150   PMID:38103201   PMID:38128426   PMID:38216380   PMID:38295914   PMID:38325197   PMID:38328001  
PMID:38338685   PMID:38339924   PMID:38402570   PMID:38407846   PMID:38408992   PMID:38774744   PMID:38787309   PMID:38792907   PMID:38918874   PMID:38922725   PMID:38928186   PMID:39116343  
PMID:39191434   PMID:39240632   PMID:39292786   PMID:39445015  


Genomics

Comparative Map Data
IL18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,143,260 - 112,164,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,143,251 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBIT2T-CHM13v2.0
Il18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)EnsemblGRCm39 Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBIMGSCv36mm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Il18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,802,072 - 59,829,275 (+)NCBIGRCr8
mRatBN7.2850,904,630 - 50,932,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,411,470 - 56,438,574 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,690,368 - 54,717,472 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,554,644 - 52,581,752 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
Il18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
IL18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,888,641 - 112,913,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,981,627 - 114,007,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011107,024,376 - 107,045,194 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,867,586 - 110,888,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,867,586 - 110,888,371 (-)Ensemblpanpan1.1panPan2
IL18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1520,972,742 - 20,995,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,972,871 - 20,995,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,907,590 - 20,917,853 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0520,994,967 - 21,017,974 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl520,995,094 - 21,019,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,069,981 - 21,080,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0520,970,245 - 20,980,530 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,018,633 - 21,028,888 (+)NCBIUU_Cfam_GSD_1.0
Il18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,380,523 - 94,398,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,306,875 - 2,325,189 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,306,963 - 2,325,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,834,973 - 39,861,219 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,839,959 - 39,861,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,692,120 - 44,713,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,485,868 - 103,511,632 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,482,083 - 103,510,150 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,475,303 - 22,498,316 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,294,183 - 7,304,687 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL18
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25		 pathogenic
NM_001562.3(IL18):c.532G>A (p.Asp178Asn) single nucleotide variant Malignant melanoma [RCV000069160] Chr11:112143646 [GRCh38]
Chr11:112014369 [GRCh37]
Chr11:111519579 [NCBI36]
Chr11:11q23.1		 not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh38/hg38 11q23.1(chr11:111659380-112255732)x3 copy number gain See cases [RCV000134885] Chr11:111659380..112255732 [GRCh38]
Chr11:111530104..112126455 [GRCh37]
Chr11:111035314..111631665 [NCBI36]
Chr11:11q23.1		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_001562.4(IL18):c.361-1974C>T single nucleotide variant Three Vessel Coronary Disease [RCV001003438] Chr11:112145791 [GRCh38]
Chr11:112016514 [GRCh37]
Chr11:11q23.1		 benign
NM_001562.4(IL18):c.-8-919T>C single nucleotide variant Three Vessel Coronary Disease [RCV001003439] Chr11:112155980 [GRCh38]
Chr11:112026703 [GRCh37]
Chr11:11q23.1		 benign
NM_001562.4(IL18):c.216T>G (p.Ser72=) single nucleotide variant not provided [RCV000926909] Chr11:112150082 [GRCh38]
Chr11:112020805 [GRCh37]
Chr11:11q23.1		 likely benign
NM_001562.4(IL18):c.80-5C>A single nucleotide variant not provided [RCV000968237] Chr11:112153608 [GRCh38]
Chr11:112024331 [GRCh37]
Chr11:11q23.1		 benign
GRCh37/hg19 11q22.3-23.3(chr11:104101411-116680918)x1 copy number loss not provided [RCV000848741] Chr11:104101411..116680918 [GRCh37]
Chr11:11q22.3-23.3		 pathogenic
GRCh37/hg19 11q22.3-23.3(chr11:105699599-114524876)x1 copy number loss not provided [RCV001006445] Chr11:105699599..114524876 [GRCh37]
Chr11:11q22.3-23.3		 pathogenic
GRCh37/hg19 11q23.1-23.3(chr11:110969076-114578509)x1 copy number loss not provided [RCV000848936] Chr11:110969076..114578509 [GRCh37]
Chr11:11q23.1-23.3		 uncertain significance
GRCh37/hg19 11q22.3-23.2(chr11:103320065-114349787)x1 copy number loss not provided [RCV001006439] Chr11:103320065..114349787 [GRCh37]
Chr11:11q22.3-23.2		 pathogenic
NM_001562.4(IL18):c.105A>C (p.Ser35=) single nucleotide variant Three Vessel Coronary Disease [RCV001003437]|not provided [RCV004709018] Chr11:112150193 [GRCh38]
Chr11:112020916 [GRCh37]
Chr11:11q23.1		 benign
GRCh37/hg19 11q23.1(chr11:111974627-112188807)x1 copy number loss not provided [RCV001258500] Chr11:111974627..112188807 [GRCh37]
Chr11:11q23.1		 uncertain significance
NC_000011.9:g.104288964_134937416dup duplication Distal trisomy 11q [RCV001250234] Chr11:104288964..134937416 [GRCh37]
Chr11:11q22.3-25		 pathogenic
GRCh37/hg19 11q14.1-23.3(chr11:85422071-118022671)x1 copy number loss not provided [RCV001832892] Chr11:85422071..118022671 [GRCh37]
Chr11:11q14.1-23.3		 uncertain significance
NC_000011.9:g.(?_111171709)_(112104278_?)dup duplication 6-Pyruvoyl-tetrahydrobiopterin synthase deficiency [RCV003111003]|Pyruvate dehydrogenase E2 deficiency [RCV003111004] Chr11:111171709..112104278 [GRCh37]
Chr11:11q23.1		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_001562.4(IL18):c.500G>A (p.Arg167Lys) single nucleotide variant not specified [RCV004309110] Chr11:112143678 [GRCh38]
Chr11:112014401 [GRCh37]
Chr11:11q23.1		 uncertain significance
GRCh37/hg19 11q22.3-23.3(chr11:109328787-116414966)x1 copy number loss not provided [RCV002474547] Chr11:109328787..116414966 [GRCh37]
Chr11:11q22.3-23.3		 pathogenic
GRCh37/hg19 11q23.1(chr11:111855954-112293098)x3 copy number gain not provided [RCV003484851] Chr11:111855954..112293098 [GRCh37]
Chr11:11q23.1		 uncertain significance
Single allele duplication not provided [RCV003448710] Chr11:102134973..134945611 [GRCh37]
Chr11:11q22.2-25		 pathogenic
NM_001562.4(IL18):c.398G>A (p.Ser133Asn) single nucleotide variant not specified [RCV004405065] Chr11:112143780 [GRCh38]
Chr11:112014503 [GRCh37]
Chr11:11q23.1		 likely benign
NM_001562.4(IL18):c.74T>G (p.Phe25Cys) single nucleotide variant not specified [RCV004405066] Chr11:112154980 [GRCh38]
Chr11:112025703 [GRCh37]
Chr11:11q23.1		 uncertain significance
NM_001562.4(IL18):c.197T>G (p.Phe66Cys) single nucleotide variant not specified [RCV004627977] Chr11:112150101 [GRCh38]
Chr11:112020824 [GRCh37]
Chr11:11q23.1		 uncertain significance
GRCh37/hg19 11q23.1(chr11:111957826-112026707)x1 copy number loss not provided [RCV004819373] Chr11:111957826..112026707 [GRCh37]
Chr11:11q23.1		 pathogenic
NM_001562.4(IL18):c.446T>C (p.Met149Thr) single nucleotide variant not specified [RCV004934091] Chr11:112143732 [GRCh38]
Chr11:112014455 [GRCh37]
Chr11:11q23.1		 uncertain significance
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR346hsa-miR-346Mirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Non-Functional MTI19342689

Predicted Target Of
Summary Value
Count of predictions:896
Count of miRNA genes:407
Interacting mature miRNAs:443
Transcripts:ENST00000280357, ENST00000524595, ENST00000525547, ENST00000528832, ENST00000533858, ENST00000534225
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597371020GWAS1467094_Hinterleukin 18 measurement QTL GWAS1467094 (human)1e-08interleukin 18 measurement11112153104112153105Human
597216623GWAS1312697_Hinterleukin 18 measurement QTL GWAS1312697 (human)1e-119interleukin 18 measurement11112154583112154584Human
597310561GWAS1406635_Hvaginal microbiome measurement QTL GWAS1406635 (human)0.000001vaginal microbiome measurement11112160680112160681Human
1559115SCL20_HSerum cholesterol level QTL 20 (human)3.220.001213Lipid levelLDL cholesterol11100442501126442501Human
597138121GWAS1234195_Hinterleukin 18 measurement QTL GWAS1234195 (human)2e-51interleukin 18 measurement11112154583112154584Human
597225159GWAS1321233_Hsmoking initiation QTL GWAS1321233 (human)4e-10smoking initiation11112153880112153881Human

Markers in Region
RH38662  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711112,014,337 - 112,014,535UniSTSGRCh37
Build 3611111,519,547 - 111,519,745RGDNCBI36
Celera11109,167,575 - 109,167,773RGD
Cytogenetic Map11q22.2-q22.3UniSTS
HuRef11107,938,458 - 107,938,656UniSTS
IL18_1978  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711112,013,822 - 112,014,522UniSTSGRCh37
Build 3611111,519,032 - 111,519,732RGDNCBI36
Celera11109,167,060 - 109,167,760RGD
HuRef11107,937,943 - 107,938,643UniSTS
RH80030  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic MapXq26.1UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map9p13UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map12q15-q21UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map2p22.2UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map11q22.2-q22.3UniSTS
Cytogenetic Map1p36-p35UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map10q26.13-q26.3UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map2q32.2UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2432 2788 2244 4926 1724 2315 5 623 1854 465 2246 7195 6369 45 3702 1 847 1741 1580 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_028143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001386420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB095532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF077611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF380360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ295724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY044641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY266351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU633686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF444989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000280357   ⟹   ENSP00000280357
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11112,143,260 - 112,164,094 (-)Ensembl
Ensembl Acc Id: ENST00000524595   ⟹   ENSP00000434561
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11112,143,251 - 112,164,074 (-)Ensembl
Ensembl Acc Id: ENST00000525547
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11112,143,257 - 112,151,073 (-)Ensembl
Ensembl Acc Id: ENST00000528832   ⟹   ENSP00000434161
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11112,143,596 - 112,164,089 (-)Ensembl
Ensembl Acc Id: ENST00000533858
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11112,143,683 - 112,164,096 (-)Ensembl
Ensembl Acc Id: ENST00000534225
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11112,152,999 - 112,164,093 (-)Ensembl
RefSeq Acc Id: NM_001243211   ⟹   NP_001230140
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811112,143,260 - 112,164,094 (-)NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBI
CHM1_111111,897,441 - 111,918,303 (-)NCBI
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001386420   ⟹   NP_001373349
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811112,143,260 - 112,164,094 (-)NCBI
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001562   ⟹   NP_001553
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811112,143,260 - 112,164,094 (-)NCBI
GRCh3711112,013,974 - 112,034,840 (-)NCBI
Build 3611111,519,186 - 111,540,050 (-)NCBI Archive
HuRef11107,938,095 - 107,959,011 (-)NCBI
CHM1_111111,897,441 - 111,918,303 (-)NCBI
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011542805   ⟹   XP_011541107
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811112,143,260 - 112,164,094 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054368670   ⟹   XP_054224645
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001230140 (Get FASTA)   NCBI Sequence Viewer  
  NP_001373349 (Get FASTA)   NCBI Sequence Viewer  
  NP_001553 (Get FASTA)   NCBI Sequence Viewer  
  XP_011541107 (Get FASTA)   NCBI Sequence Viewer  
  XP_054224645 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB50010 (Get FASTA)   NCBI Sequence Viewer  
  AAC27787 (Get FASTA)   NCBI Sequence Viewer  
  AAH07007 (Get FASTA)   NCBI Sequence Viewer  
  AAH07461 (Get FASTA)   NCBI Sequence Viewer  
  AAK57024 (Get FASTA)   NCBI Sequence Viewer  
  AAK95950 (Get FASTA)   NCBI Sequence Viewer  
  AAP92112 (Get FASTA)   NCBI Sequence Viewer  
  ACA06006 (Get FASTA)   NCBI Sequence Viewer  
  BAA08706 (Get FASTA)   NCBI Sequence Viewer  
  CAC01436 (Get FASTA)   NCBI Sequence Viewer  
  CAG46771 (Get FASTA)   NCBI Sequence Viewer  
  CAG46798 (Get FASTA)   NCBI Sequence Viewer  
  EAW67184 (Get FASTA)   NCBI Sequence Viewer  
  EAW67185 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000280357
  ENSP00000280357.7
  ENSP00000434161
  ENSP00000434161.1
  ENSP00000434561
  ENSP00000434561.1
GenBank Protein Q14116 (Get FASTA)   NCBI Sequence Viewer  
  QUP51703 (Get FASTA)   NCBI Sequence Viewer  
  QUP51704 (Get FASTA)   NCBI Sequence Viewer  
  QUP51705 (Get FASTA)   NCBI Sequence Viewer  
  QUP51706 (Get FASTA)   NCBI Sequence Viewer  
  QUP51707 (Get FASTA)   NCBI Sequence Viewer  
  QUP51708 (Get FASTA)   NCBI Sequence Viewer  
  QUP51709 (Get FASTA)   NCBI Sequence Viewer  
  QUP51710 (Get FASTA)   NCBI Sequence Viewer  
  QUP51711 (Get FASTA)   NCBI Sequence Viewer  
  QUP51712 (Get FASTA)   NCBI Sequence Viewer  
  QUP51713 (Get FASTA)   NCBI Sequence Viewer  
  QUP51714 (Get FASTA)   NCBI Sequence Viewer  
  QUP51715 (Get FASTA)   NCBI Sequence Viewer  
  QUP51716 (Get FASTA)   NCBI Sequence Viewer  
  QUP51717 (Get FASTA)   NCBI Sequence Viewer  
  QUP51718 (Get FASTA)   NCBI Sequence Viewer  
  QUP51719 (Get FASTA)   NCBI Sequence Viewer  
  QUP51720 (Get FASTA)   NCBI Sequence Viewer  
  QUP51721 (Get FASTA)   NCBI Sequence Viewer  
  QUP51722 (Get FASTA)   NCBI Sequence Viewer  
  QUP51723 (Get FASTA)   NCBI Sequence Viewer  
  QUP51724 (Get FASTA)   NCBI Sequence Viewer  
  QUP51725 (Get FASTA)   NCBI Sequence Viewer  
  QUP51726 (Get FASTA)   NCBI Sequence Viewer  
  QUP51727 (Get FASTA)   NCBI Sequence Viewer  
  QUP51728 (Get FASTA)   NCBI Sequence Viewer  
  QUP51729 (Get FASTA)   NCBI Sequence Viewer  
  QUP51730 (Get FASTA)   NCBI Sequence Viewer  
  QUP51731 (Get FASTA)   NCBI Sequence Viewer  
  QUP51732 (Get FASTA)   NCBI Sequence Viewer  
  QUP51733 (Get FASTA)   NCBI Sequence Viewer  
  QUP51734 (Get FASTA)   NCBI Sequence Viewer  
  QUP51735 (Get FASTA)   NCBI Sequence Viewer  
  QUP51736 (Get FASTA)   NCBI Sequence Viewer  
  QUP51737 (Get FASTA)   NCBI Sequence Viewer  
  QUP51738 (Get FASTA)   NCBI Sequence Viewer  
  QUP51739 (Get FASTA)   NCBI Sequence Viewer  
  QUP51740 (Get FASTA)   NCBI Sequence Viewer  
  QUP51741 (Get FASTA)   NCBI Sequence Viewer  
  QUP51742 (Get FASTA)   NCBI Sequence Viewer  
  QUP51743 (Get FASTA)   NCBI Sequence Viewer  
  QUP51744 (Get FASTA)   NCBI Sequence Viewer  
  QUP51745 (Get FASTA)   NCBI Sequence Viewer  
  QUP51746 (Get FASTA)   NCBI Sequence Viewer  
  QUP51747 (Get FASTA)   NCBI Sequence Viewer  
  QUP51748 (Get FASTA)   NCBI Sequence Viewer  
  QUP51749 (Get FASTA)   NCBI Sequence Viewer  
  QUP51750 (Get FASTA)   NCBI Sequence Viewer  
  QUP51751 (Get FASTA)   NCBI Sequence Viewer  
  QUP51752 (Get FASTA)   NCBI Sequence Viewer  
  QUP51753 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001553   ⟸   NM_001562
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6FGY3 (UniProtKB/Swiss-Prot),   O75599 (UniProtKB/Swiss-Prot),   Q6WWJ7 (UniProtKB/Swiss-Prot),   Q14116 (UniProtKB/Swiss-Prot),   Q96KJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230140   ⟸   NM_001243211
- Peptide Label: isoform 2
- UniProtKB: B0YJ28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541107   ⟸   XM_011542805
- Peptide Label: isoform X1
- UniProtKB: B0YJ28 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000280357   ⟸   ENST00000280357
Ensembl Acc Id: ENSP00000434561   ⟸   ENST00000524595
Ensembl Acc Id: ENSP00000434161   ⟸   ENST00000528832
RefSeq Acc Id: NP_001373349   ⟸   NM_001386420
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6FGY3 (UniProtKB/Swiss-Prot),   Q14116 (UniProtKB/Swiss-Prot),   O75599 (UniProtKB/Swiss-Prot),   Q6WWJ7 (UniProtKB/Swiss-Prot),   Q96KJ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054224645   ⟸   XM_054368670
- Peptide Label: isoform X1
- UniProtKB: B0YJ28 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14116-F1-model_v2 AlphaFold Q14116 1-193 view protein structure

Promoters
RGD ID:6789007
Promoter ID:HG_KWN:14182
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000280357,   NM_001562,   UC009YYM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3611111,539,754 - 111,540,254 (-)MPROMDB
RGD ID:7222141
Promoter ID:EPDNEW_H16816
Type:initiation region
Name:IL18_1
Description:interleukin 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811112,164,093 - 112,164,153EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5986 AgrOrtholog
COSMIC IL18 COSMIC
Ensembl Genes ENSG00000150782 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000280357 ENTREZGENE
  ENST00000280357.12 UniProtKB/Swiss-Prot
  ENST00000524595 ENTREZGENE
  ENST00000524595.6 UniProtKB/Swiss-Prot
  ENST00000528832 ENTREZGENE
  ENST00000528832.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000150782 GTEx
HGNC ID HGNC:5986 ENTREZGENE
Human Proteome Map IL18 Human Proteome Map
InterPro IL-18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3606 UniProtKB/Swiss-Prot
NCBI Gene 3606 ENTREZGENE
OMIM 600953 OMIM
PANTHER INTERLEUKIN-1 FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29802 PharmGKB
PIRSF Interleukin_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTRLEUKIN18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B0YJ28 ENTREZGENE, UniProtKB/TrEMBL
  IL18_HUMAN UniProtKB/Swiss-Prot
  O75599 ENTREZGENE
  Q14116 ENTREZGENE
  Q6FGY3 ENTREZGENE
  Q6WWJ7 ENTREZGENE
  Q96KJ8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O75599 UniProtKB/Swiss-Prot
  Q6FGY3 UniProtKB/Swiss-Prot
  Q6WWJ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-15 IL18  interleukin 18    interleukin 18 (interferon-gamma-inducing factor)  Symbol and/or name change 5135510 APPROVED