IL18 (interleukin 18) - Rat Genome Database

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Gene: IL18 (interleukin 18) Homo sapiens
Symbol: IL18
Name: interleukin 18
RGD ID: 730894
Description: Enables cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Biomarker of several diseases, including autoimmune disease (multiple); cholestasis (multiple); liver disease (multiple); lung disease (multiple); and myositis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: iboctadekin; IFN-gamma-inducing factor; IGIF; IL-1 gamma; IL-18; IL-1g; IL1F4; interferon gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma; interleukin-18; MGC12320
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11112,143,253 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3811112,143,251 - 112,164,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
alcoholic hepatitis  (IEP)
allergic contact dermatitis  (EXP,ISO)
allergic disease  (EXP)
allergic rhinitis  (IAGP)
alopecia areata  (IAGP)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (IAGP,IEP,IMP,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (IAGP,IEP,ISO,ISS)
autoimmune hepatitis  (EXP)
autoimmune thrombocytopenic purpura  (IEP)
bacterial pneumonia  (ISO)
Behcet's disease  (IAGP,IEP,ISO)
biliary atresia  (IAGP,IEP)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (EXP,ISO)
breast cancer  (IAGP,IEP)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
calcinosis  (EXP)
Carcinoma, Lewis Lung  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (EXP)
Carotid Artery Injuries  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
Chronic Hepatitis B  (IAGP)
Chronic Hepatitis C  (IAGP,IEP)
chronic obstructive pulmonary disease  (IEP)
contact dermatitis  (EXP)
Coronary Disease  (IAGP)
cutaneous T cell lymphoma  (IEP)
cystic fibrosis  (IEP)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (IEP)
diabetic retinopathy  (IEP,ISO)
disease of cellular proliferation  (EXP)
Drug Eruptions  (EXP)
Eczema  (IAGP)
Edema  (ISO)
Embryo Loss  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (EXP)
Experimental Melanoma  (ISO)
eye disease  (IAGP)
familial Mediterranean fever  (IEP)
fatty liver disease  (ISO)
glomerulonephritis  (EXP)
Graves Ophthalmopathy  (IEP)
Graves' disease  (IAGP,IEP)
heart disease  (ISO)
heart valve disease  (EXP)
hemophagocytic lymphohistiocytosis  (IEP)
Hemorrhagic Shock  (ISO)
hepatitis B  (IAGP)
hepatitis C  (IAGP,IEP)
hepatocellular carcinoma  (IAGP,IEP)
herpes simplex  (ISO)
high grade glioma  (ISO)
HIV-Associated Lipodystrophy Syndrome  (IAGP,IEP)
human immunodeficiency virus infectious disease  (IEP)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (ISO)
IgA glomerulonephritis  (IEP)
Immediate Hypersensitivity  (EXP)
Insulin Resistance  (IEP,ISO)
intellectual disability  (IAGP)
interstitial lung disease  (IEP,ISO)
intrahepatic cholestasis of pregnancy  (IEP)
invasive ductal carcinoma  (IEP)
ischemia  (ISO)
Kawasaki disease  (IAGP,IEP)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
leishmaniasis  (EXP,ISO)
liver cirrhosis  (IEP)
Liver Failure  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IAGP,IEP,ISO)
lung non-small cell carcinoma  (IEP)
lupus nephritis  (ISO)
Lymphatic Metastasis  (IEP)
Macrophage Activation Syndrome  (IEP)
Metabolic Syndrome  (EXP,ISO)
Mouth Neoplasms  (EXP)
Myocardial Reperfusion Injury  (ISO)
myositis  (IEP)
Neoplasm Metastasis  (EXP,IAGP,IEP)
neuroblastoma  (ISO)
non-alcoholic fatty liver disease  (IEP,ISO)
Nontuberculous Mycobacterium Infections  (IEP)
obesity  (ISO)
Oral Lichen Planus  (IAGP)
Pain  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (IEP)
Perennial Allergic Rhinitis  (IAGP)
perinatal necrotizing enterocolitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (EXP,IEP,ISO)
polymyositis  (IEP)
Polyomavirus Infections  (EXP)
Prostatic Neoplasms  (EXP)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (IEP)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (IEP)
pulmonary tuberculosis  (IEP)
Radiation Injuries, Experimental  (EXP)
Reperfusion Injury  (ISO)
respiratory failure  (IEP)
respiratory syncytial virus infectious disease  (IAGP,ISO)
Retinal Neovascularization  (IEP,ISO)
rheumatoid arthritis  (EXP)
rhinitis  (IEP,ISO)
sarcoidosis  (EXP,IEP)
Schistosomiasis Japonica  (ISO)
Seasonal Allergic Rhinitis  (IAGP)
severe acute respiratory syndrome  (IEP)
Sjogren's syndrome  (IEP)
sleep apnea  (IDA)
Spinal Cord Injuries  (ISO)
Staphylococcal Skin Infections  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
strongyloidiasis  (ISO)
temporal arteritis  (IAGP)
Tibial Fractures  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IEP)
urinary tract infection  (ISO)
urticaria  (EXP,IAGP,IEP)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
visceral leishmaniasis  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(E)-cinnamyl alcohol  (EXP)
(R)-mevalonic acid  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (EXP)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (EXP)
4-nitrobenzyl bromide  (EXP)
4-phenylbutyric acid  (ISO)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
8-chloro-2'-deoxyguanosine  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldosterone  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
aluminium sulfate (anhydrous)  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthranilic acid  (EXP)
antirheumatic drug  (EXP)
apocynin  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asperentin  (ISO)
atrazine  (EXP)
benzalkonium chloride  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (ISO)
benzylpenicillin  (EXP)
Bergenin  (ISO)
beryllium sulfate  (EXP)
bexarotene  (ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (EXP)
biliverdin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BQ 123  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
cefaloridine  (ISO)
celastrol  (ISO)
cerium trichloride  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cimetidine  (EXP,ISO)
cinnamyl alcohol  (EXP)
cisplatin  (EXP,ISO)
citral  (EXP)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dichlorine  (ISO)
dicrotophos  (EXP)
dieckol  (ISO)
dieldrin  (ISO)
diethyl malate  (ISO)
diethyl maleate  (EXP)
diethylamine  (ISO)
dihydroartemisinin  (EXP)
Dimaprit  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
eplerenone  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
famotidine  (EXP)
fasudil hydrochloride  (ISO)
felodipine  (ISO)
ferulic acid  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geranial  (EXP)
geraniol  (ISO)
glyburide  (ISO)
glyoxal  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
hemin  (EXP)
hexachlorobenzene  (ISO)
histamine  (EXP,ISO)
Honokiol  (EXP)
hydrocortisone succinate  (EXP)
hydrogen peroxide  (EXP)
IC-87114  (ISO)
ICI 118551  (ISO)
imiquimod  (ISO)
immunological adjuvant  (EXP)
indometacin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoeugenol  (EXP)
isoprenaline  (ISO)
lead diacetate  (ISO)
lipid As  (EXP)
lipopolysaccharide  (EXP,ISO)
lonafarnib  (ISO)
lovastatin  (ISO)
lucanthone  (EXP)
LY294002  (EXP)
m-xylene  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
Manumycin A  (ISO)
melittin  (EXP)
metam  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotinamide  (ISO)
nifuroxazide  (ISO)
nilotinib  (ISO)
NMN zwitterion  (ISO)
ochratoxin A  (ISO)
olmesartan  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
Palbinone  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (EXP)
pentane-2,3-dione  (ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenytoin  (ISO)
phosgene  (ISO)
phthalic anhydride  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
prednisolone  (ISO)
procyanidin B2  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (EXP)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (EXP)
ranitidine  (EXP)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
reserpine  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
sarpogrelate  (EXP)
SB 203580  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (ISO)
spironolactone  (ISO)
sterigmatocystin  (ISO)
streptozocin  (ISO)
sulfamic acid  (EXP)
sulfur dioxide  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
theophylline  (EXP)
thiram  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trans-isoeugenol  (EXP)
trichostatin A  (EXP)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
uranium atom  (ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zinc protoporphyrin  (EXP)
zirconium atom  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IDA)
angiogenesis  (IDA)
cell population proliferation  (IEA,ISO)
cell-cell signaling  (TAS)
cellular response to cAMP  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cholesterol homeostasis  (ISS)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
digestive tract morphogenesis  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
inflammatory response  (IDA,ISO)
interleukin-18-mediated signaling pathway  (IDA,ISO)
lipopolysaccharide-mediated signaling pathway  (IDA)
liver regeneration  (ISO)
lung development  (ISO)
MAPK cascade  (IMP)
natural killer cell activation  (IEA,ISO)
natural killer cell mediated cytotoxicity  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
neutrophil activation  (IEA,ISO)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel remodeling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO,TAS)
positive regulation of cold-induced thermogenesis  (ISS)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IDA)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of inflammatory response  (IC)
positive regulation of interferon-gamma production  (IDA,ISO,TAS)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-13 production  (TAS)
positive regulation of interleukin-17 production  (IDA)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISS)
positive regulation of male germ cell proliferation  (ISO)
positive regulation of natural killer cell proliferation  (IDA)
positive regulation of neuroinflammatory response  (TAS)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IDA)
positive regulation of NIK/NF-kappaB signaling  (IEA,ISO)
positive regulation of NK T cell proliferation  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IDA)
positive regulation of protein kinase B signaling  (IDA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (IDA,ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 1 cell cytokine production  (IDA)
positive regulation of T-helper 2 cell differentiation  (ISS)
positive regulation of tissue remodeling  (IC)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
positive regulation of vascular permeability  (ISO)
regulation of cell adhesion  (IDA)
response to cold  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
sleep  (ISS)
T-helper 1 type immune response  (IDA)
triglyceride homeostasis  (ISS)
type 2 immune response  (TAS)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype

References - curated
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PMID:18949051   PMID:18983635   PMID:19016763   PMID:19019335   PMID:19031096   PMID:19036565   PMID:19064572   PMID:19073159   PMID:19074166   PMID:19074885   PMID:19077897   PMID:19088061  
PMID:19091595   PMID:19092166   PMID:19097518   PMID:19102398   PMID:19104048   PMID:19110334   PMID:19126646   PMID:19131059   PMID:19138654   PMID:19176284   PMID:19178691   PMID:19200605  
PMID:19229765   PMID:19230467   PMID:19236760   PMID:19247692   PMID:19258923   PMID:19263242   PMID:19265133   PMID:19285156   PMID:19309308   PMID:19339355   PMID:19342689   PMID:19347053  
PMID:19387647   PMID:19390575   PMID:19394601   PMID:19403407   PMID:19420105   PMID:19443970   PMID:19453784   PMID:19469892   PMID:19470251   PMID:19473509   PMID:19508433   PMID:19509137  
PMID:19527514   PMID:19538326   PMID:19550095   PMID:19553661   PMID:19573080   PMID:19581111   PMID:19584085   PMID:19593889   PMID:19605669   PMID:19622039   PMID:19633236   PMID:19637196  
PMID:19638090   PMID:19638429   PMID:19639049   PMID:19642044   PMID:19657406   PMID:19669125   PMID:19669363   PMID:19684151   PMID:19687159   PMID:19692203   PMID:19699611   PMID:19712260  
PMID:19757044   PMID:19758166   PMID:19773279   PMID:19789190   PMID:19796548   PMID:19811440   PMID:19816189   PMID:19817957   PMID:19865096   PMID:19879772   PMID:19900154   PMID:19907017  
PMID:19913121   PMID:19954659   PMID:19961286   PMID:19961892   PMID:20003764   PMID:20017708   PMID:20027291   PMID:20056178   PMID:20060272   PMID:20061784   PMID:20083555   PMID:20096599  
PMID:20097272   PMID:20137369   PMID:20140262   PMID:20140691   PMID:20150558   PMID:20169140   PMID:20186552   PMID:20216908   PMID:20227257   PMID:20227263   PMID:20233133   PMID:20237496  
PMID:20304021   PMID:20306652   PMID:20306665   PMID:20339966   PMID:20340055   PMID:20349123   PMID:20350254   PMID:20374388   PMID:20380696   PMID:20399512   PMID:20412718   PMID:20414054  
PMID:20416077   PMID:20418295   PMID:20423837   PMID:20424918   PMID:20441695   PMID:20452482   PMID:20478055   PMID:20482998   PMID:20485444   PMID:20490717   PMID:20490891   PMID:20525402  
PMID:20530519   PMID:20538124   PMID:20545903   PMID:20558561   PMID:20565717   PMID:20568250   PMID:20586818   PMID:20617584   PMID:20627039   PMID:20628086   PMID:20673868   PMID:20689079  
PMID:20725807   PMID:20735470   PMID:20797704   PMID:20818961   PMID:20824296   PMID:20885390   PMID:20960175   PMID:20964873   PMID:20971720   PMID:21035858   PMID:21061265   PMID:21118329  
PMID:21120501   PMID:21126942   PMID:21145535   PMID:21147091   PMID:21149337   PMID:21149398   PMID:21224476   PMID:21225442   PMID:21239711   PMID:21241672   PMID:21249128   PMID:21264805  
PMID:21273776   PMID:21288140   PMID:21321938   PMID:21323571   PMID:21323573   PMID:21334074   PMID:21336086   PMID:21356600   PMID:21382268   PMID:21393015   PMID:21394384   PMID:21395662  
PMID:21398142   PMID:21418456   PMID:21418867   PMID:21421008   PMID:21437204   PMID:21440322   PMID:21448661   PMID:21464751   PMID:21470492   PMID:21481392   PMID:21484426   PMID:21487696  
PMID:21510800   PMID:21526496   PMID:21538928   PMID:21571262   PMID:21611751   PMID:21636628   PMID:21656327   PMID:21661419   PMID:21672342   PMID:21681500   PMID:21710494   PMID:21723753  
PMID:21733366   PMID:21742406   PMID:21742843   PMID:21802664   PMID:21832842   PMID:21836143   PMID:21836147   PMID:21840518   PMID:21842238   PMID:21864160   PMID:21867627   PMID:21876975  
PMID:21922295   PMID:21943853   PMID:21965503   PMID:21969001   PMID:21988832   PMID:22008665   PMID:22015107   PMID:22058412   PMID:22125454   PMID:22135309   PMID:22136483   PMID:22141572  
PMID:22149501   PMID:22226490   PMID:22228436   PMID:22289535   PMID:22307326   PMID:22325058   PMID:22347372   PMID:22364914   PMID:22373801   PMID:22386125   PMID:22462419   PMID:22468101  
PMID:22484385   PMID:22489883   PMID:22493490   PMID:22515481   PMID:22531046   PMID:22537138   PMID:22537218   PMID:22587568   PMID:22595646   PMID:22596175   PMID:22613414   PMID:22639237  
PMID:22658674   PMID:22661400   PMID:22664470   PMID:22678894   PMID:22686311   PMID:22723447   PMID:22749533   PMID:22811364   PMID:22825306   PMID:22837141   PMID:22863216   PMID:22883217  
PMID:22898364   PMID:22900713   PMID:22913567   PMID:22945280   PMID:22980562   PMID:22996386   PMID:23018032   PMID:23023653   PMID:23027874   PMID:23028054   PMID:23056251   PMID:23073298  
PMID:23075512   PMID:23085113   PMID:23121308   PMID:23132931   PMID:23137633   PMID:23153245   PMID:23171362   PMID:23178856   PMID:23207179   PMID:23214284   PMID:23232703   PMID:23238919  
PMID:23242610   PMID:23263551   PMID:23269628   PMID:23276493   PMID:23298491   PMID:23302036   PMID:23327592   PMID:23376485   PMID:23403235   PMID:23419721   PMID:23433789   PMID:23459183  
PMID:23499732   PMID:23522322   PMID:23526823   PMID:23546966   PMID:23557801   PMID:23587914   PMID:23603311   PMID:23632060   PMID:23656272   PMID:23675517   PMID:23702484   PMID:23702978  
PMID:23707237   PMID:23723976   PMID:23739747   PMID:23741523   PMID:23746337   PMID:23769880   PMID:23778029   PMID:23793845   PMID:23794112   PMID:23856797   PMID:23873689   PMID:23883285  
PMID:23885403   PMID:23888552   PMID:23901078   PMID:23904224   PMID:23914907   PMID:23938462   PMID:23957657   PMID:23958877   PMID:23978570   PMID:24026885   PMID:24033965   PMID:24036181  
PMID:24040261   PMID:24054338   PMID:24066061   PMID:24084330   PMID:24111610   PMID:24129807   PMID:24130810   PMID:24167151   PMID:24168677   PMID:24182552   PMID:24259949   PMID:24265116  
PMID:24275551   PMID:24285455   PMID:24307760   PMID:24331389   PMID:24349532   PMID:24375576   PMID:24376549   PMID:24379519   PMID:24402877   PMID:24460336   PMID:24465163   PMID:24475975  
PMID:24531812   PMID:24599060   PMID:24615654   PMID:24621393   PMID:24664725   PMID:24671718   PMID:24701032   PMID:24711060   PMID:24717026   PMID:24742099   PMID:24767355   PMID:24778454  
PMID:24780928   PMID:24786926   PMID:24804827   PMID:24815843   PMID:24861285   PMID:24872585   PMID:24876666   PMID:24897237   PMID:24898701   PMID:24906108   PMID:24909718   PMID:24917023  
PMID:24935632   PMID:24963217   PMID:24965773   PMID:24995282   PMID:25012128   PMID:25052265   PMID:25060131   PMID:25123522   PMID:25131111   PMID:25138786   PMID:25192895   PMID:25204040  
PMID:25207880   PMID:25231602   PMID:25261253   PMID:25267095   PMID:25308526   PMID:25342490   PMID:25362180   PMID:25398690   PMID:25405235   PMID:25427791   PMID:25446437   PMID:25451609  
PMID:25487141   PMID:25500532   PMID:25548255   PMID:25576800   PMID:25591548   PMID:25599738   PMID:25645216   PMID:25690033   PMID:25710036   PMID:25712187   PMID:25727011   PMID:25730877  
PMID:25732728   PMID:25736367   PMID:25743241   PMID:25776473   PMID:25802197   PMID:25807634   PMID:25822970   PMID:25832634   PMID:25873755   PMID:25880879   PMID:25892571   PMID:25921117  
PMID:25922275   PMID:25952099   PMID:26026656   PMID:26041375   PMID:26046663   PMID:26057800   PMID:26079218   PMID:26096341   PMID:26116895   PMID:26168332   PMID:26205090   PMID:26214646  
PMID:26216891   PMID:26229413   PMID:26292095   PMID:26302971   PMID:26320490   PMID:26346467   PMID:26376814   PMID:26381575   PMID:26396182   PMID:26438531   PMID:26474654   PMID:26496610  
PMID:26600055   PMID:26656097   PMID:26669254   PMID:26681034   PMID:26683353   PMID:26690141   PMID:26728085   PMID:26743536   PMID:26753638   PMID:26800664   PMID:26804591   PMID:26830320  
PMID:26856767   PMID:26885772   PMID:26897018   PMID:26898120   PMID:26909913   PMID:26974498   PMID:26983036   PMID:26990875   PMID:27001087   PMID:27021370   PMID:27027876   PMID:27028244  
PMID:27045344   PMID:27058587   PMID:27082857   PMID:27098064   PMID:27109946   PMID:27114524   PMID:27121382   PMID:27174093   PMID:27177146   PMID:27219123   PMID:27286581   PMID:27313119  
PMID:27352267   PMID:27356067   PMID:27362289   PMID:27430614   PMID:27455146   PMID:27496752   PMID:27543331   PMID:27636349   PMID:27636371   PMID:27663212   PMID:27669650   PMID:27693669  
PMID:27706625   PMID:27741477   PMID:27794266   PMID:27810076   PMID:27813570   PMID:27881017   PMID:27888626   PMID:27914933   PMID:27928589   PMID:27965258   PMID:27997912   PMID:28000712  
PMID:28002583   PMID:28057714   PMID:28059484   PMID:28139755   PMID:28167281   PMID:28195558   PMID:28231690   PMID:28246425   PMID:28300059   PMID:28342224   PMID:28395725   PMID:28415798  
PMID:28430754   PMID:28508444   PMID:28514442   PMID:28526653   PMID:28580570   PMID:28634744   PMID:28652186   PMID:28692122   PMID:28766916   PMID:28830544   PMID:28842466   PMID:28858634  
PMID:28922563   PMID:28973736   PMID:29017770   PMID:29042061   PMID:29061223   PMID:29097263   PMID:29105174   PMID:29105530   PMID:29129846   PMID:29185028   PMID:29218606   PMID:29247988  
PMID:29282220   PMID:29326099   PMID:29342149   PMID:29349811   PMID:29353540   PMID:29394248   PMID:29453279   PMID:29467282   PMID:29472914   PMID:29499224   PMID:29505668   PMID:29528575  
PMID:29551594   PMID:29601578   PMID:29627485   PMID:29648472   PMID:29672590   PMID:29724886   PMID:29855451   PMID:29926984   PMID:29930551   PMID:29979096   PMID:30045250   PMID:30092066  
PMID:30211233   PMID:30269670   PMID:30311406   PMID:30316805   PMID:30326484   PMID:30341522   PMID:30392846   PMID:30431529   PMID:30483730   PMID:30526181   PMID:30672022   PMID:30706178  
PMID:30782515   PMID:30857465   PMID:30903865   PMID:30925760   PMID:30940725   PMID:30992532   PMID:31003186   PMID:31017261   PMID:31065235   PMID:31084469   PMID:31129625   PMID:31169028  
PMID:31244277   PMID:31277710   PMID:31296089   PMID:31301271   PMID:31372853   PMID:31379247   PMID:31400853   PMID:31401307   PMID:31519608   PMID:31522432   PMID:31554361   PMID:31554368  
PMID:31586073   PMID:31634439   PMID:31661113   PMID:31669192   PMID:31670094   PMID:31680001   PMID:31681257   PMID:31698031   PMID:31744330   PMID:31751351   PMID:31799681   PMID:31801640  
PMID:31914650   PMID:31931428   PMID:31935500   PMID:31963531   PMID:31983439   PMID:31991315   PMID:32039628   PMID:32045661   PMID:32060657   PMID:32135277   PMID:32151994   PMID:32152765  
PMID:32193584   PMID:32209332   PMID:32245311   PMID:32251712   PMID:32264954   PMID:32270468   PMID:32289486   PMID:32296183   PMID:32304293   PMID:32315287   PMID:32338205   PMID:32347623  
PMID:32560261   PMID:32597834   PMID:32630059   PMID:32644977   PMID:32687059   PMID:32794180   PMID:32795736   PMID:32826615   PMID:32851082   PMID:32944849   PMID:33002740   PMID:33073324  
PMID:33117339   PMID:33163049   PMID:33188073   PMID:33200207   PMID:33202974   PMID:33203036   PMID:33332577   PMID:33678651   PMID:33760111   PMID:33823154  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl11112,143,253 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3811112,143,251 - 112,164,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBImm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2850,904,630 - 50,932,887 (+)NCBI
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.111110,867,586 - 110,888,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,867,586 - 110,888,371 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011107,024,376 - 107,045,194 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1520,972,742 - 20,995,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,972,871 - 20,995,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,907,590 - 20,917,853 (+)NCBI
ROS_Cfam_1.0520,994,967 - 21,017,974 (+)NCBI
UMICH_Zoey_3.1521,069,981 - 21,080,260 (+)NCBI
UNSW_CanFamBas_1.0520,970,245 - 20,980,530 (+)NCBI
UU_Cfam_GSD_1.0521,018,633 - 21,028,888 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494794,380,523 - 94,398,669 (-)NCBI
SpeTri2.0NW_0049366122,306,963 - 2,325,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl939,834,966 - 39,873,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,839,959 - 39,861,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,692,120 - 44,713,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11103,485,868 - 103,511,632 (-)NCBI
ChlSab1.1 Ensembl1103,482,083 - 103,510,150 (-)Ensembl
Vero_WHO_p1.0NW_02366604322,475,303 - 22,498,316 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711112,014,337 - 112,014,535UniSTSGRCh37
Build 3611111,519,547 - 111,519,745RGDNCBI36
Celera11109,167,575 - 109,167,773RGD
Cytogenetic Map11q22.2-q22.3UniSTS
HuRef11107,938,458 - 107,938,656UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711112,013,822 - 112,014,522UniSTSGRCh37
Build 3611111,519,032 - 111,519,732RGDNCBI36
Celera11109,167,060 - 109,167,760RGD
HuRef11107,937,943 - 107,938,643UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic MapXq26.1UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map9p13UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map12q15-q21UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map2p22.2UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map11q22.2-q22.3UniSTS
Cytogenetic Map1p36-p35UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map10q26.13-q26.3UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map2q32.2UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR346hsa-miR-346Mirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Non-Functional MTI19342689

Predicted Target Of
Summary Value
Count of predictions:896
Count of miRNA genes:407
Interacting mature miRNAs:443
Transcripts:ENST00000280357, ENST00000524595, ENST00000525547, ENST00000528832, ENST00000533858, ENST00000534225
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
Medium 1014 655 317 157 877 76 2360 327 966 323 517 905 94 714 1454
Low 1410 2198 1393 459 803 382 1907 1712 2455 91 907 629 80 1 489 1323 4 1
Below cutoff 8 128 14 7 174 7 66 144 281 2 33 42 1 1 11 1


Nucleotide Sequences
RefSeq Transcripts NG_028143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001386420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB095532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF077611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF380360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ295724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY044641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY266351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU633686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF444989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW526171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000280357   ⟹   ENSP00000280357
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11112,143,260 - 112,164,094 (-)Ensembl
RefSeq Acc Id: ENST00000524595   ⟹   ENSP00000434561
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11112,143,253 - 112,164,074 (-)Ensembl
RefSeq Acc Id: ENST00000525547
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11112,143,257 - 112,151,073 (-)Ensembl
RefSeq Acc Id: ENST00000528832   ⟹   ENSP00000434161
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11112,143,596 - 112,164,089 (-)Ensembl
RefSeq Acc Id: ENST00000533858
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11112,143,683 - 112,164,096 (-)Ensembl
RefSeq Acc Id: ENST00000534225
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11112,152,999 - 112,164,093 (-)Ensembl
RefSeq Acc Id: NM_001243211   ⟹   NP_001230140
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh3811112,143,260 - 112,164,094 (-)NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBI
CHM1_111111,897,441 - 111,918,303 (-)NCBI
RefSeq Acc Id: NM_001386420   ⟹   NP_001373349
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh3811112,143,260 - 112,164,094 (-)NCBI
RefSeq Acc Id: NM_001562   ⟹   NP_001553
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh3811112,143,260 - 112,164,094 (-)NCBI
GRCh3711112,013,974 - 112,034,840 (-)NCBI
Build 3611111,519,186 - 111,540,050 (-)NCBI Archive
HuRef11107,938,095 - 107,959,011 (-)NCBI
CHM1_111111,897,441 - 111,918,303 (-)NCBI
RefSeq Acc Id: XM_011542805   ⟹   XP_011541107
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh3811112,143,251 - 112,164,104 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001230140 (Get FASTA)   NCBI Sequence Viewer  
  NP_001373349 (Get FASTA)   NCBI Sequence Viewer  
  NP_001553 (Get FASTA)   NCBI Sequence Viewer  
  XP_011541107 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB50010 (Get FASTA)   NCBI Sequence Viewer  
  AAC27787 (Get FASTA)   NCBI Sequence Viewer  
  AAH07007 (Get FASTA)   NCBI Sequence Viewer  
  AAH07461 (Get FASTA)   NCBI Sequence Viewer  
  AAK57024 (Get FASTA)   NCBI Sequence Viewer  
  AAK95950 (Get FASTA)   NCBI Sequence Viewer  
  AAP92112 (Get FASTA)   NCBI Sequence Viewer  
  ACA06006 (Get FASTA)   NCBI Sequence Viewer  
  BAA08706 (Get FASTA)   NCBI Sequence Viewer  
  CAC01436 (Get FASTA)   NCBI Sequence Viewer  
  CAG46771 (Get FASTA)   NCBI Sequence Viewer  
  CAG46798 (Get FASTA)   NCBI Sequence Viewer  
  EAW67184 (Get FASTA)   NCBI Sequence Viewer  
  EAW67185 (Get FASTA)   NCBI Sequence Viewer  
  Q14116 (Get FASTA)   NCBI Sequence Viewer  
  QUP51703 (Get FASTA)   NCBI Sequence Viewer  
  QUP51704 (Get FASTA)   NCBI Sequence Viewer  
  QUP51705 (Get FASTA)   NCBI Sequence Viewer  
  QUP51706 (Get FASTA)   NCBI Sequence Viewer  
  QUP51707 (Get FASTA)   NCBI Sequence Viewer  
  QUP51708 (Get FASTA)   NCBI Sequence Viewer  
  QUP51709 (Get FASTA)   NCBI Sequence Viewer  
  QUP51710 (Get FASTA)   NCBI Sequence Viewer  
  QUP51711 (Get FASTA)   NCBI Sequence Viewer  
  QUP51712 (Get FASTA)   NCBI Sequence Viewer  
  QUP51713 (Get FASTA)   NCBI Sequence Viewer  
  QUP51714 (Get FASTA)   NCBI Sequence Viewer  
  QUP51715 (Get FASTA)   NCBI Sequence Viewer  
  QUP51716 (Get FASTA)   NCBI Sequence Viewer  
  QUP51717 (Get FASTA)   NCBI Sequence Viewer  
  QUP51718 (Get FASTA)   NCBI Sequence Viewer  
  QUP51719 (Get FASTA)   NCBI Sequence Viewer  
  QUP51720 (Get FASTA)   NCBI Sequence Viewer  
  QUP51721 (Get FASTA)   NCBI Sequence Viewer  
  QUP51722 (Get FASTA)   NCBI Sequence Viewer  
  QUP51723 (Get FASTA)   NCBI Sequence Viewer  
  QUP51724 (Get FASTA)   NCBI Sequence Viewer  
  QUP51725 (Get FASTA)   NCBI Sequence Viewer  
  QUP51726 (Get FASTA)   NCBI Sequence Viewer  
  QUP51727 (Get FASTA)   NCBI Sequence Viewer  
  QUP51728 (Get FASTA)   NCBI Sequence Viewer  
  QUP51729 (Get FASTA)   NCBI Sequence Viewer  
  QUP51730 (Get FASTA)   NCBI Sequence Viewer  
  QUP51731 (Get FASTA)   NCBI Sequence Viewer  
  QUP51732 (Get FASTA)   NCBI Sequence Viewer  
  QUP51733 (Get FASTA)   NCBI Sequence Viewer  
  QUP51734 (Get FASTA)   NCBI Sequence Viewer  
  QUP51735 (Get FASTA)   NCBI Sequence Viewer  
  QUP51736 (Get FASTA)   NCBI Sequence Viewer  
  QUP51737 (Get FASTA)   NCBI Sequence Viewer  
  QUP51738 (Get FASTA)   NCBI Sequence Viewer  
  QUP51739 (Get FASTA)   NCBI Sequence Viewer  
  QUP51740 (Get FASTA)   NCBI Sequence Viewer  
  QUP51741 (Get FASTA)   NCBI Sequence Viewer  
  QUP51742 (Get FASTA)   NCBI Sequence Viewer  
  QUP51743 (Get FASTA)   NCBI Sequence Viewer  
  QUP51744 (Get FASTA)   NCBI Sequence Viewer  
  QUP51745 (Get FASTA)   NCBI Sequence Viewer  
  QUP51746 (Get FASTA)   NCBI Sequence Viewer  
  QUP51747 (Get FASTA)   NCBI Sequence Viewer  
  QUP51748 (Get FASTA)   NCBI Sequence Viewer  
  QUP51749 (Get FASTA)   NCBI Sequence Viewer  
  QUP51750 (Get FASTA)   NCBI Sequence Viewer  
  QUP51751 (Get FASTA)   NCBI Sequence Viewer  
  QUP51752 (Get FASTA)   NCBI Sequence Viewer  
  QUP51753 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001553   ⟸   NM_001562
- Peptide Label: isoform 1 precursor
- UniProtKB: Q14116 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001230140   ⟸   NM_001243211
- Peptide Label: isoform 2
- UniProtKB: Q14116 (UniProtKB/Swiss-Prot),   A0A024R3E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541107   ⟸   XM_011542805
- Peptide Label: isoform X1
- UniProtKB: Q14116 (UniProtKB/Swiss-Prot),   A0A024R3E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000280357   ⟸   ENST00000280357
RefSeq Acc Id: ENSP00000434561   ⟸   ENST00000524595
RefSeq Acc Id: ENSP00000434161   ⟸   ENST00000528832
RefSeq Acc Id: NP_001373349   ⟸   NM_001386420
- Peptide Label: isoform 1

RGD ID:6789007
Promoter ID:HG_KWN:14182
SO ACC ID:SO:0000170
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000280357,   NM_001562,   UC009YYM.1
Human AssemblyChrPosition (strand)Source
Build 3611111,539,754 - 111,540,254 (-)MPROMDB
RGD ID:7222141
Promoter ID:EPDNEW_H16816
Type:initiation region
Description:interleukin 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh3811112,164,093 - 112,164,153EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
NM_001562.3(IL18):c.532G>A (p.Asp178Asn) single nucleotide variant Malignant melanoma [RCV000069160] Chr11:112143646 [GRCh38]
Chr11:112014369 [GRCh37]
Chr11:111519579 [NCBI36]
not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
GRCh38/hg38 11q23.1(chr11:111659380-112255732)x3 copy number gain See cases [RCV000134885] Chr11:111659380..112255732 [GRCh38]
Chr11:111530104..112126455 [GRCh37]
Chr11:111035314..111631665 [NCBI36]
uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
NM_001562.4(IL18):c.361-1974C>T single nucleotide variant Three Vessel Coronary Disease [RCV001003438] Chr11:112145791 [GRCh38]
Chr11:112016514 [GRCh37]
NM_001562.4(IL18):c.-8-919T>C single nucleotide variant Three Vessel Coronary Disease [RCV001003439] Chr11:112155980 [GRCh38]
Chr11:112026703 [GRCh37]
NM_001562.4(IL18):c.216T>G (p.Ser72=) single nucleotide variant not provided [RCV000926909] Chr11:112150082 [GRCh38]
Chr11:112020805 [GRCh37]
likely benign
NM_001562.4(IL18):c.80-5C>A single nucleotide variant not provided [RCV000968237] Chr11:112153608 [GRCh38]
Chr11:112024331 [GRCh37]
GRCh37/hg19 11q22.3-23.3(chr11:104101411-116680918)x1 copy number loss not provided [RCV000848741] Chr11:104101411..116680918 [GRCh37]
GRCh37/hg19 11q22.3-23.3(chr11:105699599-114524876)x1 copy number loss not provided [RCV001006445] Chr11:105699599..114524876 [GRCh37]
GRCh37/hg19 11q23.1-23.3(chr11:110969076-114578509)x1 copy number loss not provided [RCV000848936] Chr11:110969076..114578509 [GRCh37]
uncertain significance
GRCh37/hg19 11q22.3-23.2(chr11:103320065-114349787)x1 copy number loss not provided [RCV001006439] Chr11:103320065..114349787 [GRCh37]
NM_001562.4(IL18):c.105A>C (p.Ser35=) single nucleotide variant Three Vessel Coronary Disease [RCV001003437] Chr11:112150193 [GRCh38]
Chr11:112020916 [GRCh37]
GRCh37/hg19 11q23.1(chr11:111974627-112188807)x1 copy number loss not provided [RCV001258500] Chr11:111974627..112188807 [GRCh37]
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5986 AgrOrtholog
Ensembl Genes ENSG00000150782 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000280357 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000434161 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000434561 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000280357 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000524595 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000528832 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000150782 GTEx
Human Proteome Map IL18 Human Proteome Map
InterPro IL-18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3606 UniProtKB/Swiss-Prot
OMIM 600953 OMIM
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29802 PharmGKB
PIRSF Interleukin_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary O75599 UniProtKB/Swiss-Prot
  Q6FGY3 UniProtKB/Swiss-Prot
  Q6WWJ7 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-15 IL18  interleukin 18    interleukin 18 (interferon-gamma-inducing factor)  Symbol and/or name change 5135510 APPROVED