RGD Reference Report - Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease. - Rat Genome Database

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Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease.

Authors: Gono, T  Kawaguchi, Y  Sugiura, T  Ichida, H  Takagi, K  Katsumata, Y  Hanaoka, M  Okamoto, Y  Ota, Y  Yamanaka, H 
Citation: Gono T, etal., Rheumatology (Oxford). 2010 Oct;49(10):1878-81. Epub 2010 Jul 3.
RGD ID: 4889547
Pubmed: PMID:20601655   (View Abstract at PubMed)
DOI: DOI:10.1093/rheumatology/keq196   (Journal Full-text)

OBJECTIVE: To determine whether IL-18 is involved in the inflammation of DM and PM. METHODS: Thirty-three patients with DM were enrolled in this study, including 25 with interstitial lung disease (ILD). In addition, 16 patients with PM were enrolled, including 6 with ILD. All patients were admitted to our hospital as a result of their condition requiring treatment, and clinical laboratory data including serum IL-18 were recorded on admission. RESULTS: Serum IL-18 was significantly (P < 0.0001) higher in both DM and PM patients than in healthy controls (n = 30). Serum ferritin and IL-18 were significantly (P = 0.003 and 0.0044, respectively) higher in DM than in PM patients. Additionally, ferritin and IL-18 were significantly (P = 0.023 and 0.034, respectively) higher in DM patients with ILD than in DM patients without ILD. Significant positive correlations were found between creatine kinase (CK) and ferritin (r(s) = 0.39, P = 0.024); CK and IL-18 (r(s) = 0.48, P = 0.005); and IL-18 and ferritin (r(s) = 0.54, P = 0.0012) in the DM group as a whole. These findings were different for the DM plus ILD subgroup: significant positive correlations were found between CK and ferritin (r(s) = 0.40, P = 0.047); CK and IL-18 (r(s) = 0.63, P = 0.0008); and IL-18 and ferritin (r(s) = 0.41, P = 0.042). CONCLUSION: Serum IL-18 was strikingly elevated in patients with DM and was associated particularly with disease activity and ILD complication in DM.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dermatomyositis  IEP 4889547protein:increased expression:serumRGD 
dermatomyositis  ISOIL18 (Homo sapiens)4889547; 4889547protein:increased expression:serumRGD 
interstitial lung disease  IEP 4889547associated with dermatomyositis and protein:increased expression:serumRGD 
interstitial lung disease  ISOIL18 (Homo sapiens)4889547; 4889547associated with dermatomyositis and protein:increased expression:serumRGD 
polymyositis  IEP 4889547protein:increased expression:serumRGD 
polymyositis  ISOIL18 (Homo sapiens)4889547; 4889547protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information