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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730894
Species: Homo sapiens
RGD Object: Gene
Symbol: IL18
Name: interleukin 18
Acc ID: CHEBI:50847
Term: immunological adjuvant
Definition: A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
Chemical ID: MESH:D000276
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL18multiple interactionsEXP 6480464CTD[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein; CASP1 protein affects the reaction [[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein]PMID:17404311
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