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Gene: Il18 (interleukin 18) Rattus norvegicus
Symbol: Il18
Name: interleukin 18
RGD ID: 2889
Description: Predicted to have cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Localizes to apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; and vasculitis. Biomarker of several diseases, including cardiac arrest; ischemia (multiple); lung disease (multiple); obesity; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; biliary atresia; hepatitis B; and vasculitis (multiple). Orthologous to human IL18 (interleukin 18); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH (R)-mevalonic acid; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: IFN-gamma-inducing factor; IL-1 gamma; IL-18; interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin-1 gamma; interleukin-18
Homo sapiens (human) : IL18 (interleukin 18)  HGNC  Alliance
Mus musculus (house mouse) : Il18 (interleukin 18)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il18 (interleukin 18)
Pan paniscus (bonobo/pygmy chimpanzee) : IL18 (interleukin 18)
Canis lupus familiaris (dog) : IL18 (interleukin 18)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il18 (interleukin 18)
Sus scrofa (pig) : IL18 (interleukin 18)
Chlorocebus sabaeus (African green monkey) : IL18 (interleukin 18)
Heterocephalus glaber (naked mole-rat) : Il18 (interleukin 18)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Il18
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2889
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.