(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid multiple interactions ISO RGD:730895 6480464 zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL18 mRNA] CTD PMID:21334316 (E)-cinnamyl alcohol increases expression ISO RGD:730894 6480464 cinnamyl alcohol results in increased expression of IL18 protein CTD PMID:23063874 (R)-mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]] CTD PMID:18660453 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE increases expression EXP 6480464 Topotecan results in increased expression of IL18 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of IL18 mRNA CTD PMID:25729387 1,2-dichloroethane decreases expression ISO RGD:730895 6480464 ethylene dichloride results in decreased expression of IL18 mRNA CTD PMID:28189721 1,3-benzothiazole-2-thiol increases expression ISO RGD:730894 6480464 captax results in increased expression of IL18 protein CTD PMID:23063874 1,4-phenylenediamine increases expression ISO RGD:730894 6480464 4-phenylenediamine results in increased expression of IL18 protein CTD PMID:23063874 , PMID:27585668 1,4-phenylenediamine multiple interactions ISO RGD:730894 6480464 PRDM1 protein promotes the reaction [4-phenylenediamine results in increased expression of IL18 protein] CTD PMID:27585668 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:730894 6480464 CASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL18 protein] CTD PMID:17429439 1-chloro-2,4,6-trinitrobenzene increases secretion ISO RGD:730895 6480464 Picryl Chloride results in increased secretion of IL18 protein CTD PMID:20381601 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:730895 6480464 Picryl Chloride results in increased expression of IL18 mRNA, Picryl Chloride results in increased expression of IL18 protein CTD PMID:15734285 more ... 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:730895 6480464 Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] more ... CTD PMID:16442096 , PMID:20381601 1-chloro-2,4,6-trinitrobenzene increases cleavage ISO RGD:730894 6480464 Picryl Chloride results in increased cleavage of IL18 protein CTD PMID:17429439 1-chloro-2,4-dinitrobenzene increases activity ISO RGD:730895 6480464 Dinitrochlorobenzene results in increased activity of IL18 protein CTD PMID:15840424 1-chloro-2,4-dinitrobenzene multiple interactions ISO RGD:730894 6480464 PRDM1 protein promotes the reaction [Dinitrochlorobenzene results in increased expression of IL18 protein] CTD PMID:27585668 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:730894 6480464 Dinitrochlorobenzene results in increased expression of IL18 protein CTD PMID:23063874 more ... 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:730895 6480464 Dinitrochlorobenzene results in increased expression of IL18 mRNA CTD PMID:11708898 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of IL18 mRNA CTD PMID:12075121 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of IL18 mRNA CTD PMID:15576828 , PMID:17351261 17beta-estradiol affects expression ISO RGD:730894 6480464 Estradiol affects the expression of IL18 mRNA CTD PMID:22574217 17beta-estradiol increases expression ISO RGD:730894 6480464 Estradiol results in increased expression of IL18 mRNA CTD PMID:23373633 , PMID:25878060 17beta-estradiol decreases expression ISO RGD:730894 6480464 Estradiol results in decreased expression of IL18 mRNA CTD PMID:25878060 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:730894 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL18 mRNA CTD PMID:16039398 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:730895 6480464 KL protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 mRNA]] more ... CTD PMID:29885354 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of IL18 mRNA CTD PMID:20959002 , PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:730895 6480464 Tetrachlorodibenzodioxin affects the expression of IL18 mRNA CTD PMID:12167310 , PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of IL18 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:730894 6480464 Tetrachlorodibenzodioxin affects the expression of IL18 mRNA CTD PMID:22298810 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:730895 6480464 Trinitrobenzenesulfonic Acid results in increased expression of IL18 mRNA CTD PMID:15973123 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP 6480464 bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL18 protein] CTD PMID:30365937 2,4,6-trinitrobenzenesulfonic acid increases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in increased expression of IL18 protein CTD PMID:30365937 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione increases expression ISO RGD:730895 6480464 Thalidomide results in increased expression of IL18 CTD PMID:17089043 2-amino-2-deoxy-D-galactopyranose increases expression ISO RGD:730895 6480464 Galactosamine results in increased expression of IL18 mRNA, Galactosamine results in increased expression of IL18 protein CTD PMID:20102673 2-amino-2-deoxy-D-galactopyranose increases expression EXP 6480464 Galactosamine results in increased expression of IL18 mRNA CTD PMID:22310181 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP 6480464 mangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA] CTD PMID:22310181 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:730895 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 mRNA more ... CTD PMID:19913045 , PMID:20102673 2-bromo-2-(bromomethyl)pentanedinitrile increases expression ISO RGD:730894 6480464 1 more ... CTD PMID:23063874 2-hydroxypropanoic acid decreases expression ISO RGD:730894 6480464 Lactic Acid results in decreased expression of IL18 mRNA CTD PMID:30851411 3,3',4,4',5-pentachlorobiphenyl affects expression ISO RGD:730894 6480464 3 more ... CTD PMID:21703328 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of IL18 mRNA CTD PMID:28300664 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of IL18 mRNA CTD PMID:28522335 3-methyladenine multiple interactions ISO RGD:730894 6480464 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein] CTD PMID:30205151 3-methylcholanthrene increases expression ISO RGD:730894 6480464 Methylcholanthrene results in increased expression of IL18 mRNA CTD PMID:14993811 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of IL18 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane decreases expression ISO RGD:730895 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of IL18 mRNA CTD PMID:18648102 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:730894 6480464 Oxazolone results in increased expression of IL18 protein CTD PMID:23063874 4-hydroxynon-2-enal decreases expression ISO RGD:730895 6480464 4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA CTD PMID:19191707 4-hydroxynon-2-enal decreases expression ISO RGD:730894 6480464 4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA CTD PMID:12419474 4-hydroxyphenyl retinamide decreases expression ISO RGD:730895 6480464 Fenretinide results in decreased expression of IL18 mRNA CTD PMID:28973697 4-methylhistamine multiple interactions ISO RGD:730894 6480464 4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] more ... CTD PMID:11752121 , PMID:12364868 4-nitrobenzyl bromide increases expression ISO RGD:730894 6480464 4-nitrobenzyl bromide results in increased expression of IL18 protein CTD PMID:23063874 4-phenylbutyric acid multiple interactions ISO RGD:730895 6480464 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL18 mRNA] CTD PMID:30796460 5-(1,4-diazepane-1-sulfonyl)isoquinoline multiple interactions EXP 6480464 fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 5-fluorouracil multiple interactions ISO RGD:730894 6480464 [Fluorouracil co-treated with irinotecan] results in decreased expression of IL18 mRNA more ... CTD PMID:15162350 , PMID:16391804 5-fluorouracil affects expression ISO RGD:730895 6480464 Fluorouracil affects the expression of IL18 mRNA CTD PMID:20421339 8-bromo-3',5'-cyclic AMP increases expression ISO RGD:730894 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL18 mRNA CTD PMID:22079614 8-chloro-2'-deoxyguanosine increases expression ISO RGD:730895 6480464 8-chloro-2'-deoxyguanosine results in increased expression of IL18 mRNA CTD PMID:31066272 acetylsalicylic acid multiple interactions ISO RGD:730895 6480464 Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA] CTD PMID:19164858 acetylsalicylic acid affects response to substance ISO RGD:730894 6480464 IL18 polymorphism affects the susceptibility to Aspirin CTD PMID:21692767 acrolein multiple interactions ISO RGD:730894 6480464 1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3 more ... CTD PMID:30205151 acrylamide multiple interactions ISO RGD:730895 6480464 MCC-950 inhibits the reaction [Acrylamide results in increased expression of IL18 protein] CTD PMID:31073625 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of IL18 mRNA, Acrylamide results in increased expression of IL18 protein CTD PMID:31073625 acrylamide increases expression ISO RGD:730895 6480464 Acrylamide results in increased expression of IL18 mRNA, Acrylamide results in increased expression of IL18 protein CTD PMID:31073625 aflatoxin B1 affects expression ISO RGD:730894 6480464 Aflatoxin B1 affects the expression of IL18 protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:730894 6480464 Aflatoxin B1 results in decreased methylation of IL18 gene CTD PMID:27153756 aldosterone increases expression EXP 6480464 Aldosterone results in increased expression of IL18 mRNA, Aldosterone results in increased expression of IL18 protein CTD PMID:18660453 aldosterone multiple interactions EXP 6480464 [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] more ... CTD PMID:18660453 alendronic acid multiple interactions ISO RGD:730895 6480464 [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein more ... CTD PMID:21430599 all-trans-retinoic acid affects expression ISO RGD:730895 6480464 Tretinoin affects the expression of IL18 mRNA CTD PMID:20421339 allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein], Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:22426011 , PMID:23647015 aluminium sulfate (anhydrous) increases expression ISO RGD:730894 6480464 aluminum sulfate results in increased expression of IL18 protein CTD PMID:16100009 amiodarone multiple interactions ISO RGD:730895 6480464 Amiodarone promotes the reaction [Dexamethasone results in decreased expression of IL18 mRNA] CTD PMID:25900201 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of IL18 mRNA CTD PMID:16483693 amphibole asbestos increases expression ISO RGD:730894 6480464 Asbestos, Amphibole results in increased expression of IL18 protein CTD PMID:20855422 amphibole asbestos increases expression EXP 6480464 Asbestos, Amphibole results in increased expression of IL18 mRNA CTD PMID:27083413 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:730894 6480464 pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein] CTD PMID:26431797 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:730895 6480464 pyrazolanthrone inhibits the reaction [irinotecan results in increased expression of and results in increased secretion of IL18 protein] more ... CTD PMID:20381601 , PMID:26431797 anthranilic acid multiple interactions ISO RGD:730894 6480464 anthranilic acid analog inhibits the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 antirheumatic drug decreases expression ISO RGD:730894 6480464 Antirheumatic Agents results in decreased expression of IL18 mRNA CTD PMID:24449571 apocynin multiple interactions ISO RGD:730895 6480464 acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA] CTD PMID:28539244 Aroclor 1254 decreases expression ISO RGD:730894 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of IL18 mRNA CTD PMID:17851650 arsenite(3-) decreases expression ISO RGD:730894 6480464 arsenite results in decreased expression of IL18 mRNA CTD PMID:16085347 arsenite(3-) multiple interactions ISO RGD:730894 6480464 caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL18 mRNA] CTD PMID:16085347 asperentin increases expression ISO RGD:730895 6480464 cladosporin results in increased expression of IL18 mRNA CTD PMID:19818335 ATP multiple interactions ISO RGD:730894 6480464 [Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein more ... CTD PMID:17404311 more ... ATP increases secretion ISO RGD:730895 6480464 Adenosine Triphosphate results in increased secretion of IL18 protein CTD PMID:27311643 ATP multiple interactions ISO RGD:730895 6480464 3-(5-(2 more ... CTD PMID:26431797 , PMID:27311643 atrazine decreases expression ISO RGD:730894 6480464 Atrazine results in decreased expression of IL18 mRNA CTD PMID:22378314 benzalkonium chloride increases expression ISO RGD:730895 6480464 Benzalkonium Compounds results in increased expression of IL18 protein CTD PMID:30517752 benzalkonium chloride increases expression ISO RGD:730894 6480464 Benzalkonium Compounds results in increased expression of IL18 mRNA CTD PMID:30806763 benzo[a]pyrene increases expression ISO RGD:730894 6480464 Benzo(a)pyrene results in increased expression of IL18 mRNA, Benzo(a)pyrene results in increased expression of IL18 protein CTD PMID:21632981 , PMID:30726812 benzo[a]pyrene multiple interactions ISO RGD:730894 6480464 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in increased expression of IL18 protein, IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL18 protein] CTD PMID:30726812 benzo[a]pyrene multiple interactions ISO RGD:730895 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of IL18 mRNA] CTD PMID:22228805 benzocaine increases activity ISO RGD:730895 6480464 Benzocaine results in increased activity of IL18 protein CTD PMID:15840424 benzylpenicillin increases expression ISO RGD:730894 6480464 Penicillin G results in increased expression of IL18 protein CTD PMID:23063874 Bergenin multiple interactions EXP 6480464 bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL18 protein] CTD PMID:30365937 beryllium sulfate increases expression ISO RGD:730894 6480464 beryllium sulfate results in increased expression of IL18 mRNA, beryllium sulfate results in increased expression of IL18 protein CTD PMID:16100009 bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of IL18 mRNA CTD PMID:16648578 bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 bilirubin IXalpha multiple interactions ISO RGD:730894 6480464 Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein], Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 bilirubin IXalpha decreases response to substance ISO RGD:730894 6480464 Bilirubin results in decreased susceptibility to IL18 protein CTD PMID:18215737 biliverdin multiple interactions ISO RGD:730894 6480464 Biliverdine inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein], Biliverdine inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 biliverdin decreases response to substance ISO RGD:730894 6480464 Biliverdine results in decreased susceptibility to IL18 protein CTD PMID:18215737 bis(2-chloroethyl) sulfide decreases expression ISO RGD:730895 6480464 Mustard Gas results in decreased expression of IL18 mRNA CTD PMID:18955075 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IL18 mRNA CTD PMID:12075121 bisphenol A multiple interactions EXP 6480464 Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL18 mRNA] CTD PMID:28285737 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of IL18 mRNA CTD PMID:28285737 bisphenol A decreases expression ISO RGD:730895 6480464 bisphenol A results in decreased expression of IL18 mRNA CTD PMID:26063408 bisphenol A increases secretion ISO RGD:730894 6480464 bisphenol A results in increased secretion of IL18 protein CTD PMID:25878060 bisphenol A increases expression ISO RGD:730894 6480464 bisphenol A results in increased expression of IL18 mRNA CTD PMID:25878060 BQ 123 multiple interactions EXP 6480464 [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 butyric acid increases expression ISO RGD:730894 6480464 Butyric Acid results in increased expression of IL18 mRNA CTD PMID:17928716 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of IL18 protein CTD PMID:28759707 cadmium dichloride multiple interactions ISO RGD:730895 6480464 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL18 mRNA] CTD PMID:30796460 cadmium dichloride multiple interactions ISO RGD:730894 6480464 NLRP3 protein affects the reaction [Cadmium Chloride results in increased expression of IL18 mRNA], STF 083010 inhibits the reaction [Cadmium Chloride results in increased expression of IL18 mRNA] CTD PMID:30796460 cadmium dichloride increases secretion ISO RGD:730894 6480464 Cadmium Chloride results in increased secretion of IL18 protein CTD PMID:30796460 cadmium dichloride increases expression ISO RGD:730894 6480464 Cadmium Chloride results in increased expression of IL18 mRNA CTD PMID:30796460 carbon monoxide decreases response to substance ISO RGD:730894 6480464 Carbon Monoxide results in decreased susceptibility to IL18 protein CTD PMID:18215737 carbon monoxide multiple interactions ISO RGD:730894 6480464 Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein], Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 carbon nanotube decreases expression ISO RGD:730895 6480464 Nanotubes, Carbon analog results in decreased expression of IL18 mRNA, Nanotubes, Carbon results in decreased expression of IL18 mRNA CTD PMID:25554681 , PMID:25620056 carbon nanotube increases secretion ISO RGD:730895 6480464 Nanotubes, Carbon results in increased secretion of IL18 protein CTD PMID:19371758 carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases expression ISO RGD:730894 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of IL18 mRNA CTD PMID:16039398 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of IL18 mRNA CTD PMID:18500788 cerium trichloride increases expression ISO RGD:730895 6480464 cerous chloride results in increased expression of IL18 CTD PMID:23712967 chloropicrin increases expression ISO RGD:730894 6480464 chloropicrin results in increased expression of IL18 mRNA CTD PMID:26352163 cimetidine multiple interactions ISO RGD:730894 6480464 CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein] more ... CTD PMID:16723495 cimetidine multiple interactions ISO RGD:730895 6480464 HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein] CTD PMID:16723495 cimetidine increases expression ISO RGD:730895 6480464 Cimetidine results in increased expression of IL18 protein CTD PMID:16723495 cimetidine increases expression ISO RGD:730894 6480464 Cimetidine results in increased expression of IL18 protein CTD PMID:16723495 cinnamyl alcohol increases expression ISO RGD:730894 6480464 cinnamyl alcohol results in increased expression of IL18 protein CTD PMID:23063874 cisplatin decreases expression ISO RGD:730894 6480464 Cisplatin results in decreased expression of IL18 CTD PMID:17021654 cisplatin increases expression ISO RGD:730894 6480464 Cisplatin results in increased expression of IL18 mRNA CTD PMID:27594783 cisplatin multiple interactions ISO RGD:730894 6480464 [Cisplatin co-treated with Paclitaxel] results in increased expression of IL18 mRNA CTD PMID:20705681 cisplatin increases expression ISO RGD:730895 6480464 Cisplatin results in increased expression of IL18 mRNA, Cisplatin results in increased expression of IL18 protein CTD PMID:21151649 , PMID:25308879 citral increases expression ISO RGD:730894 6480464 citral results in increased expression of IL18 protein CTD PMID:23063874 clenbuterol increases expression ISO RGD:730895 6480464 Clenbuterol results in increased expression of IL18 mRNA, Clenbuterol results in increased expression of IL18 protein CTD PMID:15178407 clofibrate decreases expression ISO RGD:730895 6480464 Clofibrate results in decreased expression of IL18 mRNA CTD PMID:17585979 cobalt atom multiple interactions ISO RGD:730895 6480464 [Cobalt co-treated with Organometallic Compounds] results in increased expression of IL18 mRNA CTD PMID:22147119 cobalt atom increases expression ISO RGD:730895 6480464 Cobalt results in increased expression of IL18 mRNA CTD PMID:22147119 cobalt atom multiple interactions EXP 6480464 [Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA CTD PMID:22198552 cobalt dichloride increases expression ISO RGD:730894 6480464 cobaltous chloride results in increased expression of IL18 mRNA CTD PMID:19376846 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of IL18 mRNA CTD PMID:24386269 cobalt(2+) multiple interactions ISO RGD:730895 6480464 [Cobalt co-treated with Organometallic Compounds] results in increased expression of IL18 mRNA CTD PMID:22147119 cobalt(2+) multiple interactions EXP 6480464 [Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA CTD PMID:22198552 cobalt(2+) increases expression ISO RGD:730895 6480464 Cobalt results in increased expression of IL18 mRNA CTD PMID:22147119 copper(II) sulfate increases expression ISO RGD:730894 6480464 Copper Sulfate results in increased expression of IL18 mRNA CTD PMID:19549813 crocidolite asbestos increases secretion ISO RGD:730894 6480464 Asbestos, Crocidolite results in increased secretion of IL18 protein CTD PMID:23937860 crocidolite asbestos decreases expression ISO RGD:730894 6480464 Asbestos, Crocidolite results in decreased expression of IL18 mRNA CTD PMID:24160326 , PMID:29523930 curcumin multiple interactions ISO RGD:730894 6480464 Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA] more ... CTD PMID:16368150 , PMID:17399992 curcumin decreases expression ISO RGD:730895 6480464 Curcumin results in decreased expression of IL18 mRNA CTD PMID:16751071 curcumin decreases expression ISO RGD:730894 6480464 Curcumin results in decreased expression of IL18 mRNA, Curcumin results in decreased expression of IL18 protein CTD PMID:17399992 cycloheximide multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of IL18 protein CTD PMID:18848347 cyclosporin A increases expression ISO RGD:730894 6480464 Cyclosporine results in increased expression of IL18 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:730894 6480464 Cyclosporine results in decreased expression of IL18 mRNA CTD PMID:27989131 cyclosporin A multiple interactions ISO RGD:730895 6480464 Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 deoxynivalenol decreases expression ISO RGD:730895 6480464 deoxynivalenol results in decreased expression of IL18 mRNA CTD PMID:22968694 dexamethasone multiple interactions ISO RGD:730894 6480464 Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein] more ... CTD PMID:18951874 dexamethasone decreases expression ISO RGD:730895 6480464 Dexamethasone results in decreased expression of IL18 mRNA CTD PMID:25900201 dexamethasone multiple interactions ISO RGD:730895 6480464 Amiodarone promotes the reaction [Dexamethasone results in decreased expression of IL18 mRNA], Dexamethasone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein] CTD PMID:25448682 , PMID:25900201 dexamethasone increases expression ISO RGD:730895 6480464 Dexamethasone results in increased expression of IL18 mRNA CTD PMID:21041162 dextran sulfate affects response to substance ISO RGD:730895 6480464 IL18 protein affects the susceptibility to Dextran Sulfate CTD PMID:12940437 dextran sulfate increases secretion ISO RGD:730895 6480464 Dextran Sulfate results in increased secretion of IL18 protein CTD PMID:30270565 dextran sulfate multiple interactions ISO RGD:730895 6480464 [Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL18 mRNA more ... CTD PMID:25448682 more ... dextran sulfate increases expression ISO RGD:730895 6480464 Dextran Sulfate results in increased expression of IL18 mRNA, Dextran Sulfate results in increased expression of IL18 protein CTD PMID:25448682 , PMID:30270565 dibenziodolium multiple interactions ISO RGD:730894 6480464 diphenyleneiodonium inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species], diphenyleneiodonium inhibits the reaction [IL18 protein results in increased expression of BSG mRNA] CTD PMID:19561311 dibenziodolium multiple interactions ISO RGD:730895 6480464 diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein], diphenyleneiodonium inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein] CTD PMID:27311643 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of IL18 mRNA CTD PMID:18636392 dicrotophos decreases expression ISO RGD:730894 6480464 dicrotophos results in decreased expression of IL18 mRNA CTD PMID:28302478 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of IL18 mRNA CTD PMID:22546817 diethyl malate affects expression ISO RGD:730895 6480464 diethyl malate affects the expression of IL18 mRNA CTD PMID:24814887 diethyl maleate increases expression ISO RGD:730894 6480464 diethyl maleate results in increased expression of IL18 protein CTD PMID:23063874 diethylamine increases activity ISO RGD:730895 6480464 diethylamine results in increased activity of IL18 protein CTD PMID:15840424 Dimaprit multiple interactions ISO RGD:730894 6480464 Dimaprit inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] more ... CTD PMID:11752121 , PMID:12364868 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 mRNA more ... CTD PMID:26464617 disodium selenite multiple interactions EXP 6480464 Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL18 mRNA] CTD PMID:28285737 eplerenone multiple interactions EXP 6480464 eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 ethanol affects response to substance ISO RGD:730894 6480464 IL18 gene SNP affects the susceptibility to Ethanol CTD PMID:24349532 ethanol affects expression ISO RGD:730895 6480464 Ethanol affects the expression of IL18 mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:730894 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of IL18 mRNA more ... CTD PMID:23378141 , PMID:28964808 ethanol increases expression ISO RGD:730894 6480464 Ethanol results in increased expression of IL18 mRNA, Ethanol results in increased expression of IL18 protein CTD PMID:28964808 ethanol multiple interactions ISO RGD:730895 6480464 acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA] CTD PMID:28964808 ethanol increases expression ISO RGD:730895 6480464 Ethanol results in increased expression of IL18 mRNA CTD PMID:28964808 eugenol increases expression ISO RGD:730894 6480464 Eugenol results in increased expression of IL18 protein CTD PMID:23063874 famotidine multiple interactions ISO RGD:730894 6480464 Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein] more ... CTD PMID:11752121 more ... fasudil hydrochloride multiple interactions EXP 6480464 fasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 felodipine multiple interactions EXP 6480464 Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA], Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein] CTD PMID:18504504 ferulic acid multiple interactions ISO RGD:730895 6480464 ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA] CTD PMID:31054998 folic acid multiple interactions ISO RGD:730894 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of IL18 mRNA CTD PMID:23378141 formaldehyde increases expression ISO RGD:730895 6480464 Formaldehyde results in increased expression of IL18 mRNA CTD PMID:12161283 fructose increases expression EXP 6480464 Fructose results in increased expression of IL18 mRNA, Fructose results in increased expression of IL18 protein CTD PMID:18504504 , PMID:22426011 fructose multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein] more ... CTD PMID:18504504 , PMID:22426011 fulvestrant multiple interactions ISO RGD:730895 6480464 [fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]] CTD PMID:17850464 furan decreases expression ISO RGD:730895 6480464 furan results in decreased expression of IL18 mRNA CTD PMID:20194422 genistein decreases expression EXP 6480464 Genistein results in decreased expression of IL18 mRNA CTD PMID:12075121 gentamycin decreases expression ISO RGD:730894 6480464 Gentamicins results in decreased expression of IL18 mRNA CTD PMID:29992668 geranial increases expression ISO RGD:730894 6480464 citral results in increased expression of IL18 protein CTD PMID:23063874 geraniol multiple interactions ISO RGD:730895 6480464 geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] more ... CTD PMID:21430599 glyburide multiple interactions EXP 6480464 Glyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein] CTD PMID:25338942 glyburide multiple interactions ISO RGD:730895 6480464 Glyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein] CTD PMID:25338942 glyoxal increases expression ISO RGD:730894 6480464 Glyoxal results in increased expression of IL18 protein CTD PMID:23063874 graphite increases expression EXP 6480464 Graphite results in increased expression of IL18 protein CTD PMID:29933104 hemin multiple interactions ISO RGD:730894 6480464 Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein] more ... CTD PMID:18215737 hemin decreases response to substance ISO RGD:730894 6480464 Hemin results in decreased susceptibility to IL18 protein CTD PMID:18215737 hexachlorobenzene increases expression EXP 6480464 Hexachlorobenzene results in increased expression of IL18 mRNA CTD PMID:15159207 histamine multiple interactions ISO RGD:730894 6480464 [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] more ... CTD PMID:11752121 more ... histamine increases expression ISO RGD:730895 6480464 Histamine results in increased expression of IL18 protein CTD PMID:16723495 histamine multiple interactions ISO RGD:730895 6480464 HRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein] CTD PMID:16723495 histamine increases expression ISO RGD:730894 6480464 Histamine results in increased expression of IL18 protein CTD PMID:16723495 Honokiol multiple interactions ISO RGD:730894 6480464 honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein] CTD PMID:21147091 hydrocortisone succinate decreases secretion ISO RGD:730894 6480464 hydrocortisone hemisuccinate results in decreased secretion of IL18 protein CTD PMID:20421217 hydrogen peroxide multiple interactions ISO RGD:730894 6480464 Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]], Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]] CTD PMID:18951874 hydrogen peroxide decreases expression ISO RGD:730894 6480464 Hydrogen Peroxide results in decreased expression of IL18 mRNA CTD PMID:12419474 , PMID:26339600 hydrogen peroxide affects expression ISO RGD:730894 6480464 Hydrogen Peroxide affects the expression of IL18 mRNA CTD PMID:21179406 ICI 118551 multiple interactions ISO RGD:730895 6480464 ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA], ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 protein] CTD PMID:15178407 imiquimod increases expression ISO RGD:730895 6480464 Imiquimod results in increased expression of IL18 mRNA CTD PMID:31054998 imiquimod multiple interactions ISO RGD:730895 6480464 ferulic acid inhibits the reaction [Imiquimod results in increased expression of IL18 mRNA] CTD PMID:31054998 immunological adjuvant multiple interactions ISO RGD:730894 6480464 [Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein, CASP1 protein affects the reaction [[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein] CTD PMID:17404311 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of IL18 mRNA, Indomethacin results in increased expression of IL18 protein CTD PMID:18996434 irinotecan increases expression ISO RGD:730895 6480464 Irinotecan results in increased expression of IL18 mRNA, Irinotecan results in increased expression of IL18 protein CTD PMID:26431797 irinotecan multiple interactions ISO RGD:730894 6480464 [Fluorouracil co-treated with Irinotecan] results in decreased expression of IL18 mRNA more ... CTD PMID:16391804 , PMID:26431797 irinotecan multiple interactions ISO RGD:730895 6480464 [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein more ... CTD PMID:26431797 iron atom multiple interactions ISO RGD:730894 6480464 Iron affects the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 iron(0) multiple interactions ISO RGD:730894 6480464 Iron affects the reaction [IL18 protein results in increased secretion of IFNG protein] CTD PMID:15799959 isoeugenol increases expression ISO RGD:730894 6480464 isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 isoprenaline multiple interactions ISO RGD:730895 6480464 ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA] more ... CTD PMID:15178407 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of IL18 protein CTD PMID:24286936 isoprenaline decreases expression ISO RGD:730895 6480464 Isoproterenol results in decreased expression of IL18 mRNA CTD PMID:21335049 lead diacetate affects expression ISO RGD:730895 6480464 lead acetate affects the expression of IL18 protein CTD PMID:21322097 lipid As increases expression ISO RGD:730894 6480464 Lipid A results in increased expression of IL18 mRNA CTD PMID:16299289 lipopolysaccharide multiple interactions ISO RGD:730894 6480464 1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3 more ... CTD PMID:17399992 more ... lipopolysaccharide increases secretion ISO RGD:730894 6480464 Lipopolysaccharides results in increased secretion of IL18 protein CTD PMID:15289356 more ... lipopolysaccharide increases expression ISO RGD:730894 6480464 Lipopolysaccharides results in increased expression of IL18 mRNA, Lipopolysaccharides results in increased expression of IL18 protein CTD PMID:16100009 more ... lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of IL18 mRNA, Lipopolysaccharides results in increased expression of IL18 protein CTD PMID:21882482 , PMID:28693884 lipopolysaccharide increases expression ISO RGD:730895 6480464 Lipopolysaccharides results in increased expression of IL18 mRNA, Lipopolysaccharides results in increased expression of IL18 protein CTD PMID:17321000 more ... lipopolysaccharide affects expression ISO RGD:730895 6480464 Lipopolysaccharides affects the expression of IL18 protein CTD PMID:21055422 lipopolysaccharide multiple interactions ISO RGD:730895 6480464 (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA] more ... CTD PMID:15933225 more ... lonafarnib multiple interactions ISO RGD:730895 6480464 geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]], lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 lovastatin multiple interactions ISO RGD:730895 6480464 [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein more ... CTD PMID:21430599 lucanthone decreases expression ISO RGD:730894 6480464 Lucanthone results in decreased expression of IL18 mRNA CTD PMID:21148553 LY294002 increases expression ISO RGD:730894 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of IL18 protein CTD PMID:30726812 LY294002 multiple interactions ISO RGD:730894 6480464 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in increased expression of IL18 protein CTD PMID:30726812 m-xylene decreases expression EXP 6480464 3-xylene results in decreased expression of IL18 mRNA CTD PMID:12815608 manganese(II) chloride multiple interactions ISO RGD:730895 6480464 acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA] CTD PMID:28539244 manganese(II) chloride increases expression ISO RGD:730895 6480464 manganese chloride results in increased expression of IL18 mRNA CTD PMID:28539244 mangiferin multiple interactions EXP 6480464 mangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA] CTD PMID:22310181 Manumycin A multiple interactions ISO RGD:730895 6480464 geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]], manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 melittin increases expression ISO RGD:730894 6480464 Melitten results in increased expression of IL18 protein CTD PMID:22973906 melittin multiple interactions ISO RGD:730894 6480464 AIM2 protein promotes the reaction [Melitten results in increased expression of IL18 protein] CTD PMID:22973906 methotrexate increases expression ISO RGD:730894 6480464 Methotrexate results in increased expression of IL18 mRNA CTD PMID:17400583 methotrexate multiple interactions ISO RGD:730894 6480464 [Methotrexate co-treated with Glucocorticoids] results in decreased expression of IL18 mRNA CTD PMID:22133036 methoxyacetic acid affects expression ISO RGD:730895 6480464 methoxyacetic acid affects the expression of IL18 mRNA CTD PMID:20421339 mifepristone multiple interactions ISO RGD:730895 6480464 [fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]] CTD PMID:17850464 mitomycin C decreases expression ISO RGD:730894 6480464 Mitomycin results in decreased expression of IL18, Mitomycin results in decreased expression of IL18 protein CTD PMID:16019139 , PMID:17021654 Monobutylphthalate affects expression ISO RGD:730895 6480464 monobutyl phthalate affects the expression of IL18 mRNA CTD PMID:20421339 monocrotaline multiple interactions ISO RGD:730895 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 muramyl dipeptide multiple interactions ISO RGD:730895 6480464 [Pamidronate results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine] which results in increased secretion of IL18 protein CTD PMID:21282739 mycophenolic acid decreases expression ISO RGD:730895 6480464 Mycophenolic Acid results in decreased expression of IL18 mRNA CTD PMID:19818335 mycotoxin increases expression ISO RGD:730895 6480464 Mycotoxins results in increased expression of IL18 mRNA CTD PMID:19818335 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:730894 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein] CTD PMID:16723495 N-acetyl-L-cysteine multiple interactions ISO RGD:730895 6480464 Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein], Acetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein] CTD PMID:27311643 N-acetyl-L-cysteine multiple interactions ISO RGD:730894 6480464 Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein] CTD PMID:30205151 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:730895 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein] CTD PMID:15178407 N-nitrosodimethylamine multiple interactions ISO RGD:730895 6480464 CSF3 protein affects the reaction [Dimethylnitrosamine affects the expression of IL18 mRNA] CTD PMID:17869372 N-nitrosodimethylamine affects expression ISO RGD:730895 6480464 Dimethylnitrosamine affects the expression of IL18 mRNA CTD PMID:17869372 N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions ISO RGD:730894 6480464 Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein] more ... CTD PMID:11752121 , PMID:16723495 nickel atom multiple interactions EXP 6480464 [Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA CTD PMID:22198552 nickel atom decreases expression ISO RGD:730894 6480464 Nickel results in decreased expression of IL18 mRNA CTD PMID:24768652 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of IL18 mRNA CTD PMID:22546817 nickel dichloride affects expression ISO RGD:730895 6480464 nickel chloride affects the expression of IL18 mRNA CTD PMID:24670797 nickel sulfate decreases expression ISO RGD:730894 6480464 nickel sulfate results in decreased expression of IL18 mRNA CTD PMID:18651567 nickel sulfate increases expression ISO RGD:730894 6480464 nickel sulfate results in increased expression of IL18 protein CTD PMID:23063874 nifuroxazide multiple interactions EXP 6480464 nifuroxazide inhibits the reaction [Streptozocin results in increased expression of IL18 mRNA] CTD PMID:29291386 NMN zwitterion multiple interactions ISO RGD:730895 6480464 Nicotinamide Mononucleotide inhibits the reaction [Aluminum Chloride results in increased expression of IL18 protein] CTD PMID:30292833 NMN zwitterion multiple interactions EXP 6480464 Nicotinamide Mononucleotide inhibits the reaction [Aluminum Chloride results in increased expression of IL18 protein] CTD PMID:30292833 olmesartan multiple interactions EXP 6480464 olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of IL18 mRNA CTD PMID:25729387 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of IL18 mRNA CTD PMID:25729387 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of IL18 mRNA CTD PMID:18636392 paclitaxel multiple interactions ISO RGD:730894 6480464 [Cisplatin co-treated with Paclitaxel] results in increased expression of IL18 mRNA CTD PMID:20705681 pamidronate multiple interactions ISO RGD:730895 6480464 [Pamidronate results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine] which results in increased secretion of IL18 protein CTD PMID:21282739 paracetamol affects expression ISO RGD:730895 6480464 Acetaminophen affects the expression of IL18 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:730894 6480464 Acetaminophen results in increased expression of IL18 mRNA CTD PMID:29067470 paracetamol increases expression ISO RGD:730895 6480464 Acetaminophen results in increased expression of IL18 mRNA, Acetaminophen results in increased expression of IL18 protein CTD PMID:17585979 more ... paracetamol multiple interactions ISO RGD:730895 6480464 Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA] more ... CTD PMID:19164858 , PMID:20102673 paraquat increases expression ISO RGD:730894 6480464 Paraquat results in increased expression of IL18 mRNA CTD PMID:20883675 paraquat multiple interactions EXP 6480464 Glyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein] CTD PMID:25338942 paraquat increases expression EXP 6480464 Paraquat results in increased expression of IL18 protein CTD PMID:25338942 paraquat multiple interactions ISO RGD:730895 6480464 Glyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein], Silymarin inhibits the reaction [Paraquat results in increased secretion of IL18 protein] CTD PMID:25338942 , PMID:29054699 paraquat increases secretion ISO RGD:730895 6480464 Paraquat results in increased secretion of IL18 protein CTD PMID:25338942 , PMID:29054699 PD 0325901 multiple interactions ISO RGD:730894 6480464 PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein] CTD PMID:27563819 pentane-2,3-dione increases expression EXP 6480464 2, 3-pentanedione results in increased expression of IL18 mRNA CTD PMID:25710175 phenethyl caffeate multiple interactions ISO RGD:730894 6480464 caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL18 mRNA] CTD PMID:16085347 phenytoin multiple interactions ISO RGD:730895 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 phthalic anhydride increases activity ISO RGD:730895 6480464 phthalic anhydride results in increased activity of IL18 protein CTD PMID:15840424 pioglitazone multiple interactions EXP 6480464 pioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 pirinixic acid multiple interactions ISO RGD:730895 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of IL18 mRNA, PPARA protein affects the reaction [pirinixic acid results in decreased expression of IL18 mRNA] CTD PMID:17321000 , PMID:20813756 pirinixic acid decreases expression ISO RGD:730895 6480464 pirinixic acid results in decreased expression of IL18 mRNA CTD PMID:17321000 more ... prednisolone multiple interactions ISO RGD:730895 6480464 Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 progesterone multiple interactions ISO RGD:730895 6480464 [fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]] more ... CTD PMID:17850464 protein kinase inhibitor multiple interactions ISO RGD:730894 6480464 Protein Kinase Inhibitors inhibits the reaction [IL18 protein results in increased expression of IFNG protein] CTD PMID:28003376 pyrrolidine dithiocarbamate multiple interactions ISO RGD:730895 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL18 protein], pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA] CTD PMID:15178407 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Fructose results in increased expression of IL18 protein], Quercetin inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:22426011 , PMID:23647015 rac-lactic acid decreases expression ISO RGD:730894 6480464 Lactic Acid results in decreased expression of IL18 mRNA CTD PMID:30851411 ranitidine multiple interactions ISO RGD:730894 6480464 Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein] more ... CTD PMID:11752121 , PMID:16723495 reactive oxygen species increases abundance ISO RGD:730894 6480464 IL18 protein results in increased abundance of Reactive Oxygen Species CTD PMID:19561311 reactive oxygen species multiple interactions ISO RGD:730894 6480464 diphenyleneiodonium inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species], resveratrol inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:19561311 Rebamipide increases expression EXP 6480464 rebamipide results in increased expression of IL18 mRNA CTD PMID:18299717 reserpine increases expression EXP 6480464 Reserpine results in increased expression of IL18 mRNA CTD PMID:8999896 resorcinol increases expression ISO RGD:730894 6480464 resorcinol results in increased expression of IL18 mRNA, resorcinol results in increased expression of IL18 protein CTD PMID:23063874 , PMID:30806763 resveratrol multiple interactions ISO RGD:730894 6480464 resveratrol inhibits the reaction [BSG protein results in increased expression of and results in increased secretion of IL18 protein] more ... CTD PMID:19561311 , PMID:24149798 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 mRNA], resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 protein] CTD PMID:26464617 rifampicin multiple interactions ISO RGD:730895 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 rolipram multiple interactions ISO RGD:730895 6480464 Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 rotenone multiple interactions ISO RGD:730894 6480464 Rotenone promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of IL18 protein], Rotenone promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein] CTD PMID:30205151 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein] CTD PMID:22426011 rutin decreases expression EXP 6480464 Rutin results in decreased expression of IL18 mRNA CTD PMID:28693884 sarpogrelate decreases expression ISO RGD:730894 6480464 sarpogrelate results in decreased expression of IL18 protein CTD PMID:15080020 SB 203580 multiple interactions ISO RGD:730894 6480464 SB 203580 inhibits the reaction [IL18 protein results in increased expression of PTEN mRNA] more ... CTD PMID:18215737 serpentine asbestos decreases expression ISO RGD:730894 6480464 Asbestos, Serpentine results in decreased expression of IL18 mRNA CTD PMID:24160326 silicon dioxide increases expression ISO RGD:730894 6480464 Silicon Dioxide analog results in increased expression of IL18 mRNA CTD PMID:23806026 silicon dioxide multiple interactions ISO RGD:730895 6480464 3-(5-(2 more ... CTD PMID:27311643 silicon dioxide increases secretion ISO RGD:730895 6480464 Silicon Dioxide analog results in increased secretion of IL18 protein CTD PMID:27311643 silver atom decreases expression ISO RGD:730895 6480464 Silver results in decreased expression of IL18 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:730895 6480464 Silver results in decreased expression of IL18 mRNA CTD PMID:27131904 silver(1+) decreases expression ISO RGD:730895 6480464 Silver results in decreased expression of IL18 mRNA CTD PMID:27131904 simvastatin multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]], Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 simvastatin multiple interactions ISO RGD:730894 6480464 Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein] CTD PMID:27377765 sirolimus multiple interactions ISO RGD:730894 6480464 Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein] CTD PMID:30205151 sodium arsenite decreases expression ISO RGD:730895 6480464 sodium arsenite results in decreased expression of IL18 mRNA CTD PMID:21911445 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of IL18 mRNA CTD PMID:22561333 Soman increases expression EXP 6480464 Soman results in increased expression of IL18 mRNA CTD PMID:19281266 spironolactone multiple interactions EXP 6480464 Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 sterigmatocystin increases expression ISO RGD:730895 6480464 Sterigmatocystin results in increased expression of IL18 mRNA CTD PMID:19818335 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of IL18 mRNA, Streptozocin results in increased expression of IL18 protein CTD PMID:23647015 , PMID:29291386 streptozocin multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein] more ... CTD PMID:23647015 , PMID:29291386 sulfamic acid increases expression ISO RGD:730894 6480464 sulfamic acid results in increased expression of IL18 protein CTD PMID:23063874 sulfur dioxide increases expression EXP 6480464 Sulfur Dioxide results in increased expression of IL18 protein CTD PMID:27565714 tetrachloromethane decreases expression ISO RGD:730895 6480464 Carbon Tetrachloride results in decreased expression of IL18 mRNA CTD PMID:27339419 thalidomide increases expression ISO RGD:730895 6480464 Thalidomide results in increased expression of IL18 CTD PMID:17089043 thapsigargin increases expression ISO RGD:730894 6480464 Thapsigargin results in increased expression of IL18 mRNA CTD PMID:30796460 theophylline multiple interactions ISO RGD:730894 6480464 Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]], Theophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]] CTD PMID:18951874 thiram increases expression ISO RGD:730894 6480464 Thiram results in increased expression of IL18 protein CTD PMID:23063874 tipifarnib multiple interactions ISO RGD:730895 6480464 geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]], tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 titanium dioxide multiple interactions ISO RGD:730895 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL18 mRNA CTD PMID:29950665 toluene 2,4-diisocyanate increases expression ISO RGD:730895 6480464 Toluene 2, 4-Diisocyanate results in increased expression of IL18 protein CTD PMID:31070765 toluene 2,4-diisocyanate multiple interactions ISO RGD:730895 6480464 1-(2-((1-(4-amino-3-chlorophenyl)methanoyl)amino)-3 more ... CTD PMID:30517707 , PMID:31070765 toluene 2,4-diisocyanate increases secretion ISO RGD:730895 6480464 Toluene 2, 4-Diisocyanate results in increased secretion of IL18 protein CTD PMID:30517707 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of IL18 mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of IL18 mRNA CTD PMID:25729387 trans-isoeugenol increases expression ISO RGD:730894 6480464 isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 trichostatin A increases expression ISO RGD:730894 6480464 trichostatin A results in increased expression of IL18 mRNA CTD PMID:24935251 trovafloxacin multiple interactions ISO RGD:730895 6480464 IL18 protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] more ... CTD PMID:18930950 , PMID:19638433 tungsten multiple interactions EXP 6480464 [Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA CTD PMID:22198552 tungsten(4+) multiple interactions EXP 6480464 [Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA CTD PMID:22198552 uranium atom decreases secretion ISO RGD:730895 6480464 Uranium results in decreased secretion of IL18 protein CTD PMID:23659960 usnic acid multiple interactions ISO RGD:730894 6480464 [usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA CTD PMID:22777745 valproic acid affects expression ISO RGD:730895 6480464 Valproic Acid affects the expression of IL18 mRNA CTD PMID:20421339 valproic acid increases expression ISO RGD:730894 6480464 Valproic Acid results in increased expression of IL18 mRNA CTD PMID:23179753 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of IL18 mRNA CTD PMID:18629315 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of IL18 mRNA CTD PMID:19015723 vorinostat decreases expression ISO RGD:730894 6480464 vorinostat results in decreased expression of IL18 protein CTD PMID:17593366 wortmannin multiple interactions ISO RGD:730895 6480464 wortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein] CTD PMID:15178407 zearalenone increases secretion ISO RGD:730895 6480464 Zearalenone results in increased secretion of IL18 protein CTD PMID:30270565 zearalenone multiple interactions ISO RGD:730895 6480464 [Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL18 mRNA more ... CTD PMID:30270565 zearalenone increases expression ISO RGD:730895 6480464 Zearalenone results in increased expression of IL18 mRNA CTD PMID:30270565 zinc protoporphyrin multiple interactions ISO RGD:730894 6480464 zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein] CTD PMID:18215737 zirconium atom increases expression ISO RGD:730894 6480464 Zirconium results in increased expression of IL18 protein CTD PMID:16100009
Gene-Chemical Interaction Annotations
