RGD Reference Report - Expression of interleukin-18 in a rat model of deep vein thrombosis. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Expression of interleukin-18 in a rat model of deep vein thrombosis.

Authors: Mo, J  Bai, B  Li, Y  Deng, J  Zhang, S  Chen, Y  Zeng, Y 
Citation: Mo J, etal., J Cardiovasc Surg (Torino). 2012 Oct;53(5):625-30. Epub 2012 Feb 8.
RGD ID: 8655957
Pubmed: PMID:22318348   (View Abstract at PubMed)

AIM: Interleukin-18 (IL-18) is an important proinflammatory cytokine. However, little is known about the roles of IL-18 in the process of venous thrombosis. This study aimed to investigate the roles of IL-18 during deep vein thrombosis (DVT). METHODS: Fifty rats were randomly divided into 0 (control group), 12, 24, 36 and 48 h groups (10 rats in each group) by observation time. The inferior vena cava (IVC) was ligated to establish the DVT model. Serum samples were extracted to determine the levels of IL-18, tumor necrosis factor-alpha (TNF-alpha), thromboxane B2 (TXB2) and 6-keto-prostaglandin Fl alpha (6-keto-PG Flalpha) by enzyme-linked immunosorbent assay (ELISA). The weight and length of IVC was also measured. RESULTS: The DVT model was successfully established by ligating IVC. The injury of vein endothelium was observed in the model groups. IL-18, TNF-alpha, TXB2, TXB2/6-keto-PG Flalpha levels and thrombus weight were significantly increased in the model groups as compared with the control group, and peaked at 24 h after IVC ligation. 6-keto-PG F1alpha slightly decreased in the model groups comparing with the control group. IL-18 was positively correlated with TNF-alpha, TXB2, TXB2/6-keto-PG Flalpha ratio and thrombus weight. However, IL-18 was negatively correlated with 6-keto-PG Flalpha. There was a positive correlation between TXB2/6-keto-PG Flalpha ratio and thrombus weight. CONCLUSION: Serum IL-18 level increased in the process of DVT, which might impair venous endothelial cells and result in venous thrombosis. IL-18 might be a new potential therapeutic target of DVT prevention.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Venous Thrombosis  ISOIl18 (Rattus norvegicus)8655957; 8655957protein:increased expression:serumRGD 
Venous Thrombosis  IEP 8655957protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information