Il18 (interleukin 18) - Rat Genome Database

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Gene: Il18 (interleukin 18) Chinchilla lanigera
Analyze
Symbol: Il18
Name: interleukin 18
RGD ID: 8816121
Description: ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-18 receptor binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); angiogenesis (ortholog); cell population proliferation (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); alcoholic hepatitis (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: interleukin 18 (interferon-gamma-inducing factor); interleukin-18
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
alcoholic hepatitis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Carcinoma, Lewis Lung  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
cutaneous T cell lymphoma  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Eczema  (ISO)
Edema  (ISO)
Embryo Loss  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
glomerulonephritis  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hemophagocytic lymphohistiocytosis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
high grade glioma  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (ISO)
IgA glomerulonephritis  (ISO)
Immediate Hypersensitivity  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
interstitial lung disease  (ISO)
intrahepatic cholestasis of pregnancy  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
leishmaniasis  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrophage Activation Syndrome  (ISO)
Metabolic Syndrome  (ISO)
Mouth Neoplasms  (ISO)
Myocardial Reperfusion Injury  (ISO)
myositis  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
obesity  (ISO)
Oral Lichen Planus  (ISO)
Pain  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Injuries, Experimental  (ISO)
Reperfusion Injury  (ISO)
respiratory failure  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retinal Neovascularization  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
Schistosomiasis Japonica  (ISO)
Seasonal Allergic Rhinitis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (ISO)
Staphylococcal Skin Infections  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
strongyloidiasis  (ISO)
temporal arteritis  (ISO)
Tibial Fractures  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
visceral leishmaniasis  (ISO)
Wallerian Degeneration  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
angiogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to cAMP  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cholesterol homeostasis  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
digestive tract morphogenesis  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
inflammatory response  (ISO)
interleukin-18-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
liver regeneration  (ISO)
lung development  (ISO)
MAPK cascade  (ISO)
natural killer cell activation  (ISO)
natural killer cell mediated cytotoxicity  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
neutrophil activation  (ISO)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel remodeling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of male germ cell proliferation  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of NK T cell proliferation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 1 cell cytokine production  (ISO)
positive regulation of T-helper 2 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular permeability  (ISO)
regulation of cell adhesion  (ISO)
response to cold  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
sleep  (ISO)
T-helper 1 type immune response  (ISO)
triglyceride homeostasis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Il18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
IL18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11112,143,253 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3811112,143,251 - 112,164,104 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
Il18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBImm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Il18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2850,904,630 - 50,932,887 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)Ensembl
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
IL18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111110,867,586 - 110,888,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,867,586 - 110,888,371 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011107,024,376 - 107,045,194 (-)NCBIMhudiblu_PPA_v0panPan3
IL18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1520,972,742 - 20,995,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,972,871 - 20,995,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,907,590 - 20,917,853 (+)NCBI
ROS_Cfam_1.0520,994,967 - 21,017,974 (+)NCBI
UMICH_Zoey_3.1521,069,981 - 21,080,260 (+)NCBI
UNSW_CanFamBas_1.0520,970,245 - 20,980,530 (+)NCBI
UU_Cfam_GSD_1.0521,018,633 - 21,028,888 (+)NCBI
Il18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,380,523 - 94,398,669 (-)NCBI
SpeTri2.0NW_0049366122,306,963 - 2,325,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,834,966 - 39,873,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,839,959 - 39,861,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,692,120 - 44,713,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,485,868 - 103,511,632 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,482,083 - 103,510,150 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604322,475,303 - 22,498,316 (+)NCBIVero_WHO_p1.0
Il18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017753   ⟹   ENSCLAP00000017581
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000017754   ⟹   ENSCLAP00000017582
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)Ensembl
RefSeq Acc Id: XM_005378111   ⟹   XP_005378168
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005378112   ⟹   XP_005378169
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005378168 (Get FASTA)   NCBI Sequence Viewer  
  XP_005378169 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005378169   ⟸   XM_005378112
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005378168   ⟸   XM_005378111
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000017582   ⟸   ENSCLAT00000017754
RefSeq Acc Id: ENSCLAP00000017581   ⟸   ENSCLAT00000017753


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012063 Ensembl
NCBI Gene Il18 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Il18  interleukin 18    interleukin 18 (interferon-gamma-inducing factor)  Symbol and/or name change 5135510 APPROVED