RGD Reference Report - Increased expression of interleukin-18 in the trigeminal spinal subnucleus caudalis after inferior alveolar nerve injury in the rat. - Rat Genome Database

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Increased expression of interleukin-18 in the trigeminal spinal subnucleus caudalis after inferior alveolar nerve injury in the rat.

Authors: Daigo, E  Sakuma, Y  Miyoshi, K  Noguchi, K  Kotani, J 
Citation: Daigo E, etal., Neurosci Lett. 2012 Oct 31;529(1):39-44. doi: 10.1016/j.neulet.2012.09.007. Epub 2012 Sep 18.
RGD ID: 8655963
Pubmed: PMID:23000553   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2012.09.007   (Journal Full-text)

Interleukin-18 (IL-18) is an important regulator of innate and immune responses, and is known to be expressed in various types of cells and upregulated in pathological conditions including tissue injury and inflammation, suggesting it has both proinflammatory and compensatory roles. Here we show that IL-18 was increased in microglia in the trigeminal spinal subnucleus caudalis (Vc) after peripheral nerve injury. We used a trigeminal neuropathic pain model in which the withdrawal threshold of maxillary whisker pad skin was significantly decreased after inferior alveolar nerve transection, and observed a striking increase in IL-18 expression in the Vc around the obex area from 3d and continued until 14d after nerve injury. The IL-18 labeled cells were largely colocalized with Iba1, suggesting this upregulation occurred in hyperactive microglia. We also found that the IL-18 induction coexisted with phosphorylated p38 MAPK, indicating a possible role of p38 in the regulation of IL-18. Our findings are the first report that injury of trigeminal nerve induced IL-18 upregulation in activated microglia in the Vc, suggesting a possible role of IL-18 in orofacial neuropathic pain.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL18HumanPeripheral Nerve Injuries  ISOIl18 (Rattus norvegicus) RGD 
Il18RatPeripheral Nerve Injuries  IEP  RGD 
Il18MousePeripheral Nerve Injuries  ISOIl18 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information