RGD Reference Report - IL-18 enhances protective effect in mice immunized with a Schistosoma japonicum FABP DNA vaccine. - Rat Genome Database

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IL-18 enhances protective effect in mice immunized with a Schistosoma japonicum FABP DNA vaccine.

Authors: Wei, Feng  Liu, Quan  Zhai, Yujia  Fu, Zhiqiang  Liu, Wensen  Shang, Limin  Men, Jingtao  Gao, Shengyan  Lian, Hai  Jin, Hongtao  Chen, Chen  Lin, Jiaojiao  Shi, Yaojun  Xia, Zhiping  Zhu, Xing-Quan 
Citation: Wei F, etal., Acta Trop. 2009 Sep;111(3):284-8. doi: 10.1016/j.actatropica.2009.03.010. Epub 2009 May 23.
RGD ID: 14696662
Pubmed: PMID:19467215   (View Abstract at PubMed)
DOI: DOI:10.1016/j.actatropica.2009.03.010   (Journal Full-text)

Two recombinant plasmids, pVAX/SjFABP and pVAX/mIL-18 containing Schistosoma japonicum 14 kDa fatty acid binding protein (SjFABP) and murine IL-18, were constructed and evaluated for their ability to induce immune responses and to protect against S. japonicum challenge in mice. Mice were intramuscularly immunized twice at three-weekly intervals, and challenged with S. japonicum cercariae at 4 weeks after the last vaccination. All animals vaccinated with pVAX/SjFABP alone or plus pVAX/mIL-18 developed specific anti-SWAP ELISA antibody and T lymphocyte proliferation. Co-injection of pVAX/mIL-18 significantly increased the production of IFN-gamma and IL-2 compared with pVAX/SjFABP alone, indicating that IL-18 enhances the Th1-dominant immune response. The challenge experiment showed that co-injection of plasmid encoding IL-18 significantly enhances protective effect against S. japonicum infection, as demonstrated by worm reduction rates and the hepatic egg reduction rates 45 days post-challenge. These results indicated that IL-18 may become a novel vaccine adjuvant for development of vaccines against schistosomiasis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Schistosomiasis Japonica treatmentISOIl18 (Mus musculus)14696662; 14696662 RGD 
Schistosomiasis Japonica treatmentIDA 14696662 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information