RGD Reference Report - Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease. - Rat Genome Database

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Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease.

Authors: Ludwiczek, Othmar  Kaser, Arthur  Novick, Daniela  Dinarello, Charles A  Rubinstein, Menachem  Vogel, Wolfgang  Tilg, Herbert 
Citation: Ludwiczek O, etal., J Clin Immunol. 2002 Nov;22(6):331-7.
RGD ID: 14695542
Pubmed: PMID:12462332   (View Abstract at PubMed)

Interleukin 18 (IL-18) is a recently described proinflammatory cytokine. In mouse models it has been shown to play a key role in the development of liver injury. IL-18 binding protein (IL-18BP) is a naturally occurring antagonist of IL-18. In this study we investigated whether IL-18/IL-18BP levels are altered in patients with chronic liver disease (CLD). We measured IL-18 and IL-18BP plasma levels in 153 patients with CLD and 41 healthy controls by a specific ELISA. Plasma levels of IL-18 were significantly higher in CLD patients than in healthy controls. Cirrhotics had higher levels than noncirrhotics. IL-18 levels increased with disease progression. IL-18BP plasma levels paralled the increase of IL-18 with disease progression, except in stage Child C cirrhosis. IL-18 and IL-18BP levels were elevated independent of the etiology of CLD. IL-18 and IL-18BP correlated with laboratory parameters of inflammation and liver injury. Plasma levels of IL-18 and its antagonist, IL-18BP, are elevated in CLD and correlate with severity of disease. IL-18BP may not be sufficient to counteract the overwhelming proinflammatory response in end stage liver disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
liver cirrhosis  IEP 14695542protein:increased expression:plasma:RGD 
liver cirrhosis disease_progressionIEP 14695542protein:increased expression:plasma:RGD 
liver cirrhosis  ISOIL18 (Homo sapiens)14695542; 14695542protein:increased expression:plasma:RGD 
liver cirrhosis disease_progressionISOIL18BP (Homo sapiens)14695542; 14695542protein:increased expression:plasma:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)
Il18bp  (interleukin 18 binding protein)

Genes (Mus musculus)
Il18  (interleukin 18)
Il18bp  (interleukin 18 binding protein)

Genes (Homo sapiens)
IL18  (interleukin 18)
IL18BP  (interleukin 18 binding protein)


Additional Information