RGD Reference Report - ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON.

General

ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON.
Authors:	Santos, Kemper Nunes dos Almeida, Marcella Kelly Costa de Fecury, Amanda Alves Costa, Carlos Araújo da Martins, Luísa Caricio
Citation:	Santos KN, etal., Arq Gastroenterol. 2015 Jul-Sep;52(3):222-7. doi: 10.1590/S0004-28032015000300013.
RGD ID:	14696654
Pubmed:	PMID:26486291 (View Abstract at PubMed)
DOI:	DOI:10.1590/S0004-28032015000300013 (Journal Full-text)
BACKGROUND: The hepatitis C virus has been recognized as the leading cause of chronic liver disease in the world. Host genetic factors have been implicated in the persistence of hepatitis C virus infection. Single nucleotide polymorphisms at positions -607 C/A (rs1946518) and -137 G/C (rs187238) in the IL-18 gene promoter have been suggested to be associated with delayed hepatitis C virus clearance and persistence of the disease. OBJECTIVE: Identify these polymorphisms in a population infected with hepatitis C virus from the Brazilian Amazon region. METHODS: In a cross-sectional analytical study conducted in Belém, Pará, Brazil, 304 patients infected with hepatitis C virus were divided into two groups: group A, patients with persistent infection; group B, patients with spontaneous clearance. The control group consisted of 376 volunteers not infected with hepatitis C virus. Samples were analyzed by RT-PCR for the detection of viral RNA and by RFLP-PCR to evaluate the presence of the -137 G/C and -607 C/A IL-18 gene promoter polymorphisms. RESULTS: Comparison of polymorphism allele frequencies between the patient and control groups showed a higher frequency of allele C at position -607 among patients (P=0.02). When the association between the polymorphisms and viral infection was analyzed, patients carrying genotype C/A at position -607 were found to be at higher risk of persistent hepatitis C virus infection (P=0.03). CONCLUSION: The present results suggest a possible role of the -607 IL-18 gene promoter polymorphism in the pathogenesis of hepatitis C virus infection.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
hepatitis C	susceptibility	IAGP		14696654	DNA:SNP:promoter:-607C>A (rs1946518)(human)	RGD
hepatitis C	susceptibility	ISO	IL18 (Homo sapiens)	14696654; 14696654	DNA:SNP:promoter:-607C>A (rs1946518)(human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Il18 (interleukin 18)

Genes (Mus musculus)

Il18 (interleukin 18)

Genes (Homo sapiens)

IL18 (interleukin 18)

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ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON.