RGD Reference Report - Betaine supplementation protects against high-fructose-induced renal injury in rats. - Rat Genome Database

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Betaine supplementation protects against high-fructose-induced renal injury in rats.

Authors: Fan, CY  Wang, MX  Ge, CX  Wang, X  Li, JM  Kong, LD 
Citation: Fan CY, etal., J Nutr Biochem. 2014 Mar;25(3):353-62. doi: 10.1016/j.jnutbio.2013.11.010. Epub 2013 Dec 4.
RGD ID: 8655985
Pubmed: PMID:24456735   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jnutbio.2013.11.010   (Journal Full-text)

High fructose intake causes metabolic syndrome, being an increased risk of chronic kidney disease development in humans and animals. In this study, we examined the influence of betaine on high-fructose-induced renal damage involving renal inflammation, insulin resistance and lipid accumulation in rats and explored its possible mechanisms. Betaine was found to improve high-fructose-induced metabolic syndrome including hyperuricemia, dyslipidemia and insulin resistance in rats with systemic inflammation. Betaine also showed a protection against renal dysfunction and tubular injury with its restoration of the increased glucose transporter 9 and renal-specific transporter in renal brush bolder membrane and the decreased organic anion transporter 1 and adenosine-triphosphate-binding cassette transporter 2 in the renal cortex in this model. These protective effects were relevant to the anti-inflammatory action by inhibiting the production of inflammatory cytokines including interleukin (IL)-1beta, IL-18, IL-6 and tumor necrosis factor-alpha in renal tissue of high-fructose-fed rat, being more likely to suppress renal NOD-like receptor superfamily, pyrin domain containing 3 inflammasome activation than nuclear factor kappaB activation. Subsequently, betaine with anti-inflammation ameliorated insulin signaling impairment by reducing the up-regulation of suppressor of cytokine signaling 3 and lipid accumulation partly by regulating peroxisome proliferator-activated receptor alpha/palmityltransferase 1/carnitine/organic cation transporter 2 pathway in kidney of high-fructose-fed rats. These results indicate that the inflammatory inhibition plays a pivotal role in betaine's improvement of high-fructose-induced renal injury with insulin resistance and lipid accumulation in rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL18HumanMetabolic Syndrome treatmentISOIl18 (Rattus norvegicus) RGD 
Il18RatMetabolic Syndrome treatmentIEP  RGD 
Il18MouseMetabolic Syndrome treatmentISOIl18 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information