Il18 (interleukin 18) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Il18 (interleukin 18) Heterocephalus glaber
Analyze
Symbol: Il18
Name: interleukin 18
RGD ID: 18920996
Description: ENCODES a protein that exhibits cytokine activity (inferred); interleukin-18 receptor binding (inferred); receptor ligand activity (inferred); INVOLVED IN cell population proliferation (ortholog); cellular response to cAMP (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); alcoholic hepatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin 18 (interferon-gamma-inducing factor); interleukin-18; interleukin-18 isoform 2 proprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,294,183 - 7,304,687 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
alcoholic hepatitis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
BH4-deficient hyperphenylalaninemia A  (ISO)
biliary atresia  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Carcinoma, Lewis Lung  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
cataract  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chromosome 11 partial duplication syndrome  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
dermatitis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Eczema  (ISO)
Edema  (ISO)
Embryo Loss  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (ISO)
Experimental Radiation Injuries  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
glomerulonephritis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hemophagocytic lymphohistiocytosis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
high grade glioma  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (ISO)
IgA glomerulonephritis  (ISO)
Immediate Hypersensitivity  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
interstitial lung disease  (ISO)
intrahepatic cholestasis of pregnancy  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
leishmaniasis  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrophage Activation Syndrome  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Mouth Neoplasms  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myositis  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
obesity  (ISO)
Oral Lichen Planus  (ISO)
Pain  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Pyruvate Dehydrogenase E2 Deficiency  (ISO)
Reperfusion Injury  (ISO)
respiratory failure  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retinal Neovascularization  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
Schistosomiasis Japonica  (ISO)
Seasonal Allergic Rhinitis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (ISO)
Staphylococcal Skin Infections  (ISO)
status epilepticus  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
strongyloidiasis  (ISO)
temporal arteritis  (ISO)
Tibial Fractures  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
urticaria  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
visceral leishmaniasis  (ISO)
Wallerian Degeneration  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
cell population proliferation  (IEA,ISO)
cellular response to cAMP  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cholesterol homeostasis  (IEA)
cytokine-mediated signaling pathway  (IEA)
defense response to Gram-positive bacterium  (IEA)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
digestive tract morphogenesis  (ISO)
establishment of skin barrier  (IEA)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
interleukin-18-mediated signaling pathway  (IEA,ISO)
liver regeneration  (ISO)
lung development  (ISO)
natural killer cell activation  (IEA,ISO)
natural killer cell mediated cytotoxicity  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of neutrophil apoptotic process  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
neutrophil activation  (IEA,ISO)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel remodeling  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-17 production  (IEA)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of male germ cell proliferation  (ISO)
positive regulation of natural killer cell proliferation  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NK T cell proliferation  (IEA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 1 cell cytokine production  (IEA)
positive regulation of T-helper 2 cell differentiation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular permeability  (ISO)
regulation of cell adhesion  (IEA)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
sleep  (ISO)
T-helper 1 type immune response  (IEA)
triglyceride homeostasis  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Il18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,294,183 - 7,304,687 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IL18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,143,260 - 112,164,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,143,251 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBIT2T-CHM13v2.0
Il18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)EnsemblGRCm39 Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBIMGSCv36mm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Il18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,802,072 - 59,829,275 (+)NCBIGRCr8
mRatBN7.2850,904,630 - 50,932,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,411,470 - 56,438,574 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,690,368 - 54,717,472 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,554,644 - 52,581,752 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
Il18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
IL18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,888,641 - 112,913,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,981,627 - 114,007,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011107,024,376 - 107,045,194 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,867,586 - 110,888,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,867,586 - 110,888,371 (-)Ensemblpanpan1.1panPan2
IL18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1520,972,742 - 20,995,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,972,871 - 20,995,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,907,590 - 20,917,853 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0520,994,967 - 21,017,974 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl520,995,094 - 21,019,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,069,981 - 21,080,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0520,970,245 - 20,980,530 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,018,633 - 21,028,888 (+)NCBIUU_Cfam_GSD_1.0
Il18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,380,523 - 94,398,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,306,875 - 2,325,189 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,306,963 - 2,325,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,834,973 - 39,861,219 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,839,959 - 39,861,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,692,120 - 44,713,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,485,868 - 103,511,632 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,482,083 - 103,510,150 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,475,303 - 22,498,316 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000014889   ⟹   ENSHGLP00000014744
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247847,294,183 - 7,304,687 (-)Ensembl
RefSeq Acc Id: XM_004856580   ⟹   XP_004856637
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBI
RefSeq Acc Id: XM_004856581   ⟹   XP_004856638
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247847,294,286 - 7,312,949 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004856637 (Get FASTA)   NCBI Sequence Viewer  
  XP_004856638 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014744
  ENSHGLP00000035288
  ENSHGLP00100053008
GenBank Protein JAO02728 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004856637   ⟸   XM_004856580
- UniProtKB: A0A0P6JG86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004856638   ⟸   XM_004856581
- UniProtKB: A0A0P6JG86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000014744   ⟸   ENSHGLT00000014889


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010536 Ensembl, ENTREZGENE
  ENSHGLG00000042137 UniProtKB/TrEMBL
  ENSHGLG00100040411 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000014889 ENTREZGENE
  ENSHGLT00000042924 UniProtKB/TrEMBL
  ENSHGLT00100056849 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro IL-18 UniProtKB/TrEMBL
  IL-1_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
NCBI Gene Il18 ENTREZGENE
PANTHER INTERLEUKIN-1 FAMILY MEMBER UniProtKB/TrEMBL
  INTERLEUKIN-18 UniProtKB/TrEMBL
Pfam IL1 UniProtKB/TrEMBL
PIRSF Interleukin_18 UniProtKB/TrEMBL
PRINTS INTRLEUKIN18 UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A0P6JG86 ENTREZGENE, UniProtKB/TrEMBL