RGD Reference Report - Prognostic value of serum IL-18 and nitric oxide activity in breast cancer patients at operable stage. - Rat Genome Database

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Prognostic value of serum IL-18 and nitric oxide activity in breast cancer patients at operable stage.

Authors: Gunel, N  Coskun, U  Sancak, B  Hasdemir, O  Sare, M  Bayram, O  Celenkoglu, G  Ozkan, S 
Citation: Gunel N, etal., Am J Clin Oncol. 2003 Aug;26(4):416-21.
RGD ID: 8655867
Pubmed: PMID:12902898   (View Abstract at PubMed)
DOI: DOI:10.1097/01.COC.0000027416.15170.53   (Journal Full-text)

Interleukin-18 (IL-18) is a multifunctional cytokine that was previously termed interferon-gamma-inducing factor. It has been suggested that serum IL-18 level may be used as a prognostic factor in some cancer types. Nitric oxide is a potent biologic molecule involved in the pathogenesis of cancer. In this study, we measured serum IL-18 and nitrate + nitrite levels in 56 patients with nonmetastatic breast cancer and 14 control subjects. Serum IL-18* and nitrate + nitrite** levels were significantly higher in patients with breast cancer when compared to the control subjects (*p < 0.05, **p < 0.001). Serum IL-18 levels were significantly higher in patients whose tumor size was greater than or equal to 5 cm when compared to patients whose tumor size was less than or equal to 2 cm (p < 0.05). Patients who were axillary lymph node negative (ALN) had lower serum IL-18 levels when compared to patients with positive ALN (p < 0.001). Serum IL-18 levels were significantly higher in patients with stage IIB or IIIA when compared to patients with stage I or IIA (p < 0.05). There was no significant difference in serum nitrate + nitrite levels in terms of age, tumor stage, estrogen receptor, and menopausal and ALN status (p > 0.05). In conclusion, serum IL-18 level may be a useful marker to predict prognosis of patients with breast cancer in complete remission after surgery. Long-term follow-up is required to clarify this hypothesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL18HumanLymphatic Metastasis  IEP associated with Breast Neoplasms and protein:increased expression:serumRGD 
Il18RatLymphatic Metastasis  ISOIL18 (Homo sapiens)associated with Breast Neoplasms and protein:increased expression:serumRGD 
Il18MouseLymphatic Metastasis  ISOIL18 (Homo sapiens)associated with Breast Neoplasms and protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information