RGD Reference Report - Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection. - Rat Genome Database

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Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection.

Authors: Wei, XQ  Niedbala, W  Xu, D  Luo, ZX  Pollock, KG  Brewer, JM 
Citation: Wei XQ, etal., Immunol Lett. 2004 Jun 15;94(1-2):35-7.
RGD ID: 8655927
Pubmed: (View Article at PubMed) PMID:15234532
DOI: Full-text: DOI:10.1016/j.imlet.2004.04.001

Interleukin-18 (IL-18) plays an important role in innate and acquired immunity. IL-18 gene deficient (IL-18-/-) mice of the 129 x CD1 strain were reported to be more susceptible to Leishmania major infection than the wild-type mice. In contrast IL-18-/- mice of the C57BL/6 background were found to be as resistant as the wild-type (WT) mice. To resolve this discrepancy, IL-18 gene deficiency was introduced by backcrossing on to the highly susceptible BALB/c, or the moderately resistant DBA/1 backgrounds. Here we have demonstrated that BALB/c IL-18-/- mice were more resistant to L. major infection than WT BALB/c mice, whereas DBA/1 IL-18-/- mice were markedly more susceptible than their WT littermates. BALB/c IL-18-/- mice produced less IFNgamma and IL-4, whereas DBA/1 IL-18ko mice produced more IFNgamma and IL-4 than their respective WT controls. These result clearly demonstrate that the role of IL-18 in resistance or susceptibility to L. major is determined by host genetic background.

Annotation

Disease Annotations    
Behcet's disease  (IMP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information