RGD Reference Report - An interferon-gamma-related cytokine storm in SARS patients. - Rat Genome Database

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An interferon-gamma-related cytokine storm in SARS patients.

Authors: Huang, Kao-Jean  Su, Ih-Jen  Theron, Michel  Wu, Yi-Chun  Lai, Shu-Kuan  Liu, Ching-Chuan  Lei, Huan-Yao 
Citation: Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
RGD ID: 32716399
Pubmed: PMID:15602737   (View Abstract at PubMed)
PMCID: PMC7166886   (View Article at PubMed Central)
DOI: DOI:10.1002/jmv.20255   (Journal Full-text)

Fourteen cytokines or chemokines were analyzed on 88 RT-PCR-confirmed severe acute respiratory syndrome (SARS) patients. IFN-gamma, IL-18, TGF-beta, IL-6, IP-10, MCP-1, MIG, and IL-8, but not of TNF-alpha, IL-2, IL-4, IL-10, IL-13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN-gamma was significantly higher in the Ab(+) group than in the Ab(-) group. IFN-gamma, IL-18, MCP-1, MIG, and IP-10 were already elevated at early days post fever onset. Furthermore, levels of IL-18, IP-10, MIG, and MCP-1 were significantly higher in the death group than in the survival group. For the survival group, IFN-gamma and MCP-1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon-gamma-related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL2Humansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
CXCL10Humansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
CXCL9Humansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
Ccl2Ratsevere acute respiratory syndrome  ISOCCL2 (Homo sapiens)protein:increased expression:serum (human)RGD 
Ccl2Mousesevere acute respiratory syndrome  ISOCCL2 (Homo sapiens)protein:increased expression:serum (human)RGD 
Cxcl10Ratsevere acute respiratory syndrome  ISOCXCL10 (Homo sapiens)protein:increased expression:serum (human)RGD 
Cxcl10Mousesevere acute respiratory syndrome  ISOCXCL10 (Homo sapiens)protein:increased expression:serum (human)RGD 
Cxcl9Ratsevere acute respiratory syndrome  ISOCXCL9 (Homo sapiens)protein:increased expression:serum (human)RGD 
Cxcl9Mousesevere acute respiratory syndrome  ISOCXCL9 (Homo sapiens)protein:increased expression:serum (human)RGD 
IFNGHumansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
IL18Humansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
IfngRatsevere acute respiratory syndrome  ISOIFNG (Homo sapiens)protein:increased expression:serum (human)RGD 
IfngMousesevere acute respiratory syndrome  ISOIFNG (Homo sapiens)protein:increased expression:serum (human)RGD 
Il18Ratsevere acute respiratory syndrome  ISOIL18 (Homo sapiens)protein:increased expression:serum (human)RGD 
Il18Mousesevere acute respiratory syndrome  ISOIL18 (Homo sapiens)protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)
Cxcl10  (C-X-C motif chemokine ligand 10)
Cxcl9  (C-X-C motif chemokine ligand 9)
Ifng  (interferon gamma)
Il18  (interleukin 18)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)
Cxcl10  (C-X-C motif chemokine ligand 10)
Cxcl9  (C-X-C motif chemokine ligand 9)
Ifng  (interferon gamma)
Il18  (interleukin 18)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)
CXCL10  (C-X-C motif chemokine ligand 10)
CXCL9  (C-X-C motif chemokine ligand 9)
IFNG  (interferon gamma)
IL18  (interleukin 18)


Additional Information