RGD Reference Report - An interferon-gamma-related cytokine storm in SARS patients. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

An interferon-gamma-related cytokine storm in SARS patients.

Authors: Huang, Kao-Jean  Su, Ih-Jen  Theron, Michel  Wu, Yi-Chun  Lai, Shu-Kuan  Liu, Ching-Chuan  Lei, Huan-Yao 
Citation: Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
RGD ID: 32716399
Pubmed: PMID:15602737   (View Abstract at PubMed)
PMCID: PMC7166886   (View Article at PubMed Central)
DOI: DOI:10.1002/jmv.20255   (Journal Full-text)

Fourteen cytokines or chemokines were analyzed on 88 RT-PCR-confirmed severe acute respiratory syndrome (SARS) patients. IFN-gamma, IL-18, TGF-beta, IL-6, IP-10, MCP-1, MIG, and IL-8, but not of TNF-alpha, IL-2, IL-4, IL-10, IL-13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN-gamma was significantly higher in the Ab(+) group than in the Ab(-) group. IFN-gamma, IL-18, MCP-1, MIG, and IP-10 were already elevated at early days post fever onset. Furthermore, levels of IL-18, IP-10, MIG, and MCP-1 were significantly higher in the death group than in the survival group. For the survival group, IFN-gamma and MCP-1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon-gamma-related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients.



1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
CCL2Humansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
CXCL10Humansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
CXCL9Humansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
Ccl2Ratsevere acute respiratory syndrome  ISORGD:731046protein:increased expression:serum (human)RGD 
Ccl2Mousesevere acute respiratory syndrome  ISORGD:731046protein:increased expression:serum (human)RGD 
Cxcl10Ratsevere acute respiratory syndrome  ISORGD:1352024protein:increased expression:serum (human)RGD 
Cxcl10Mousesevere acute respiratory syndrome  ISORGD:1352024protein:increased expression:serum (human)RGD 
Cxcl9Ratsevere acute respiratory syndrome  ISORGD:1348195protein:increased expression:serum (human)RGD 
Cxcl9Mousesevere acute respiratory syndrome  ISORGD:1348195protein:increased expression:serum (human)RGD 
IFNGHumansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
IL18Humansevere acute respiratory syndrome  IEP protein:increased expression:serum (human)RGD 
IfngRatsevere acute respiratory syndrome  ISORGD:737487protein:increased expression:serum (human)RGD 
IfngMousesevere acute respiratory syndrome  ISORGD:737487protein:increased expression:serum (human)RGD 
Il18Ratsevere acute respiratory syndrome  ISORGD:730894protein:increased expression:serum (human)RGD 
Il18Mousesevere acute respiratory syndrome  ISORGD:730894protein:increased expression:serum (human)RGD 
1 to 15 of 15 rows


Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2) Cxcl10  (C-X-C motif chemokine ligand 10) Cxcl9  (C-X-C motif chemokine ligand 9)
Ifng  (interferon gamma) Il18  (interleukin 18)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2) Cxcl10  (C-X-C motif chemokine ligand 10) Cxcl9  (C-X-C motif chemokine ligand 9)
Ifng  (interferon gamma) Il18  (interleukin 18)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2) CXCL10  (C-X-C motif chemokine ligand 10) CXCL9  (C-X-C motif chemokine ligand 9)
IFNG  (interferon gamma) IL18  (interleukin 18)