Cxcl9 (C-X-C motif chemokine ligand 9) - Rat Genome Database

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Gene: Cxcl9 (C-X-C motif chemokine ligand 9) Rattus norvegicus
Analyze
Symbol: Cxcl9
Name: C-X-C motif chemokine ligand 9
RGD ID: 628798
Description: Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space. Orthologous to human CXCL9 (C-X-C motif chemokine ligand 9); PARTICIPATES IN interleukin-23 signaling pathway; chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-X-C motif chemokine 9; chemokine (C-X-C motif) ligand 9; MGC105312; Mig; monokine induced by gamma interferon; Scyb9; small inducible cytokine B9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,722,868 - 15,727,779 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,722,908 - 15,728,435 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1415,731,069 - 15,735,970 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,049,915 - 17,054,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,745,354 - 15,750,255 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,228,832 - 17,233,743 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,228,856 - 17,234,712 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,144,966 - 17,150,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,284,085 - 17,288,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11417,284,135 - 17,289,652 (+)NCBI
Celera1415,117,313 - 15,122,212 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
ceric oxide  (EXP)
chloroquine  (ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
digoxin  (ISO)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
diquat  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dopamine  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fragrance  (ISO)
gadodiamide hydrate  (ISO)
Genipin  (ISO)
glafenine  (EXP)
Imipenem-cilastatin  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
metam  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
monosodium L-glutamate  (ISO)
mycotoxin  (ISO)
N-nitrosodimethylamine  (EXP,ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nimesulide  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
roxarsone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sterigmatocystin  (ISO)
sulindac  (ISO)
tamibarotene  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vincristine  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis. Agostini C, etal., Respir Res. 2005 Feb 22;6:20.
2. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
3. Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. Belperio JA, etal., J Immunol 2003 Nov 1;171(9):4844-52.
4. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
5. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
6. Diminished inflammatory responses to natural pneumovirus infection among older mice. Bonville CA, etal., Virology. 2007 Nov 10;368(1):182-90. Epub 2007 Jul 25.
7. Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. Brozyna S, etal., COPD. 2009 Feb;6(1):4-16.
8. Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model. Chavez-Bueno S, etal., Virol J. 2005 May 25;2:46.
9. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
10. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Chien JY, etal., Respirology. 2006 Nov;11(6):715-22.
11. CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Costa C, etal., Chest. 2008 Jan;133(1):26-33. Epub 2007 Oct 9.
12. Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. Crawford MA, etal., PLoS Pathog. 2010 Nov 18;6(11):e1001199.
13. Angiogenic and angiostatic chemokines in idiopathic pulmonary fibrosis and granulomatous lung disease. Cui A, etal., Respiration. 2010;80(5):372-8. Epub 2009 Oct 6.
14. Local production of inflammatory mediators during childhood parainfluenza virus infection. El Feghaly RE, etal., Pediatr Infect Dis J. 2010 Apr;29(4):e26-31.
15. Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG/CXCL9 via MyD88-dependent signaling in a murine model of airway infection. Eliasson M, etal., Microbes Infect. 2010 Jul;12(7):565-73. Epub 2010 Apr 8.
16. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
17. Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
18. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
21. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
22. Relationship between circulating levels of IFN-gamma, IL-10, CXCL9 and CCL2 in pulmonary and extrapulmonary tuberculosis is dependent on disease severity. Hasan Z, etal., Scand J Immunol. 2009 Mar;69(3):259-67.
23. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
24. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
25. An interferon-gamma-related cytokine storm in SARS patients. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
26. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
27. Accumulation of CXCR3-expressing eosinophils and increased concentration of its ligands (IP10 and Mig) in bronchoalveolar lavage fluid of patients with chronic eosinophilic pneumonia. Katoh S, etal., Int Arch Allergy Immunol. 2005 Jul;137(3):229-35. Epub 2005 Jun 13.
28. Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
29. Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice. Kishi J, etal., Eur Respir J. 2011 Aug;38(2):415-24. Epub 2011 Jan 27.
30. Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome. Landi A, etal., Cytokine. 2016 Feb;78:27-36. doi: 10.1016/j.cyto.2015.11.018. Epub 2015 Nov 28.
31. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Chemokine production during hypersensitivity pneumonitis. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
34. Chemokine response in children with SARS. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
35. CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. Nishioka Y, etal., Clin Exp Immunol. 2007 Aug;149(2):317-26. Epub 2007 Jun 5.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Comprehensive gene review and curation RGD comprehensive gene curation
42. Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Richards TJ, etal., Arthritis Rheum. 2009 Jul;60(7):2183-92.
43. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
44. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
45. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
46. Regulation of cockroach antigen-induced allergic airway hyperreactivity by the CXCR3 ligand CXCL9. Thomas MS, etal., J Immunol. 2004 Jul 1;173(1):615-23.
47. Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Valbuena G, etal., Am J Pathol. 2003 Oct;163(4):1357-69.
48. NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. Wallace KL, etal., Blood. 2009 Jul 16;114(3):667-76. Epub 2009 May 11.
49. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
50. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
51. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
Additional References at PubMed
PMID:12477932   PMID:12782716   PMID:12949249   PMID:15096188   PMID:16055446   PMID:17277142   PMID:19008373   PMID:23012479   PMID:23819906   PMID:23844157   PMID:31550444   PMID:32061390  
PMID:35548957  


Genomics

Comparative Map Data
Cxcl9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,722,868 - 15,727,779 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,722,908 - 15,728,435 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1415,731,069 - 15,735,970 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,049,915 - 17,054,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,745,354 - 15,750,255 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,228,832 - 17,233,743 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,228,856 - 17,234,712 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,144,966 - 17,150,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,284,085 - 17,288,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11417,284,135 - 17,289,652 (+)NCBI
Celera1415,117,313 - 15,122,212 (+)NCBICelera
Cytogenetic Map14p22NCBI
CXCL9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38476,001,275 - 76,007,509 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl476,001,275 - 76,007,509 (-)EnsemblGRCh38hg38GRCh38
GRCh37476,922,428 - 76,928,662 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,141,647 - 77,147,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 34477,279,801 - 77,285,820NCBI
Celera474,223,036 - 74,229,163 (-)NCBICelera
Cytogenetic Map4q21.1NCBI
HuRef472,674,915 - 72,680,933 (-)NCBIHuRef
CHM1_1476,899,188 - 76,905,206 (-)NCBICHM1_1
T2T-CHM13v2.0479,341,778 - 79,348,012 (-)NCBIT2T-CHM13v2.0
Cxcl9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,469,190 - 92,475,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl592,469,206 - 92,475,938 (-)EnsemblGRCm39 Ensembl
GRCm38592,321,331 - 92,328,079 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,321,347 - 92,328,079 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,750,357 - 92,757,105 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36593,398,190 - 93,403,317 (-)NCBIMGSCv36mm8
Celera590,465,046 - 90,472,120 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.51NCBI
Cxcl9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433724,515 - 732,192 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433724,566 - 731,945 (-)NCBIChiLan1.0ChiLan1.0
CXCL9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1454,255,545 - 54,261,580 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0448,198,478 - 48,204,658 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1454,036,343 - 54,042,502 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,036,342 - 54,042,502 (+)Ensemblpanpan1.1panPan2
Cxcl9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,466,180 - 11,472,856 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493667632,128 - 40,329 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493667633,580 - 40,323 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,663,501 - 71,670,271 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,665,541 - 71,670,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,801,515 - 75,806,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,507,121 - 24,513,830 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl724,507,130 - 24,513,121 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660372,849,313 - 2,855,487 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcl9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475714,995,716 - 15,011,893 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475714,995,649 - 15,009,771 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cxcl9
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:52
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000003082
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat

Markers in Region
AI044222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,726,436 - 15,727,691 (+)MAPPERmRatBN7.2
Rnor_6.01417,232,401 - 17,233,655NCBIRnor6.0
Rnor_5.01417,148,878 - 17,150,132UniSTSRnor5.0
RGSC_v3.41417,287,654 - 17,288,908UniSTSRGSC3.4
Celera1415,120,870 - 15,122,124UniSTS
RH 3.4 Map14182.3UniSTS
Cytogenetic Map14p22UniSTS
RH141482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,728,127 - 15,728,338 (+)MAPPERmRatBN7.2
Rnor_6.01417,234,092 - 17,234,302NCBIRnor6.0
Rnor_5.01417,150,569 - 17,150,779UniSTSRnor5.0
RGSC_v3.41417,289,345 - 17,289,555UniSTSRGSC3.4
Celera1415,122,561 - 15,122,771UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 15 7 18 7 7 10 14 4 7
Low 1 23 24 16 1 16 1 1 7 35 19 7 1
Below cutoff 6 12 12 12 47 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003082   ⟹   ENSRNOP00000003627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1415,722,908 - 15,728,435 (+)Ensembl
Rnor_6.0 Ensembl1417,228,856 - 17,234,712 (+)Ensembl
RefSeq Acc Id: NM_145672   ⟹   NP_663705
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21415,722,868 - 15,727,779 (+)NCBI
Rnor_6.01417,228,832 - 17,233,743 (+)NCBI
Rnor_5.01417,144,966 - 17,150,220 (+)NCBI
RGSC_v3.41417,284,085 - 17,288,996 (+)RGD
Celera1415,117,313 - 15,122,212 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_663705 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87594 (Get FASTA)   NCBI Sequence Viewer  
  AAM73881 (Get FASTA)   NCBI Sequence Viewer  
  AAQ10775 (Get FASTA)   NCBI Sequence Viewer  
  EDL88617 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_663705   ⟸   NM_145672
- Peptide Label: precursor
- UniProtKB: Q8K4B1 (UniProtKB/TrEMBL),   A6KK93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003627   ⟸   ENSRNOT00000003082
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4B1-F1-model_v2 AlphaFold Q8K4B1 1-125 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628798 AgrOrtholog
BioCyc Gene G2FUF-16259 BioCyc
Ensembl Genes ENSRNOG00000022242 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003627 ENTREZGENE
  ENSRNOP00000003627.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003082 ENTREZGENE
  ENSRNOT00000003082.8 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7310193 IMAGE-MGC_LOAD
InterPro Chemokine_IL8 UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/TrEMBL
  CXC_chmkine_smll UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
  Small_chemokine_CXC_CS UniProtKB/TrEMBL
KEGG Report rno:246759 UniProtKB/TrEMBL
MGC_CLONE MGC:105312 IMAGE-MGC_LOAD
NCBI Gene 246759 ENTREZGENE
PANTHER C-X-C MOTIF CHEMOKINE 9 UniProtKB/TrEMBL
  PTHR10179 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PhenoGen Cxcl9 PhenoGen
PRINTS SMALLCYTKCXC UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP Chemokine_IL8 UniProtKB/TrEMBL
UniProt A6KK93 ENTREZGENE
  F7F001_RAT UniProtKB/TrEMBL
  Q8K4B1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6KK93 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Cxcl9  C-X-C motif chemokine ligand 9  Cxcl9  chemokine (C-X-C motif) ligand 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cxcl9  chemokine (C-X-C motif) ligand 9  Mig  monokine induced by gamma interferon  Symbol and Name updated 1299863 APPROVED
2003-02-27 Mig  monokine induced by gamma interferon      Symbol and Name status set to provisional 70820 PROVISIONAL