Cxcl10 (C-X-C motif chemokine ligand 10) - Rat Genome Database

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Gene: Cxcl10 (C-X-C motif chemokine ligand 10) Rattus norvegicus
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Symbol: Cxcl10
Name: C-X-C motif chemokine ligand 10
RGD ID: 620209
Description: Exhibits chemokine activity. Involved in several processes, including response to auditory stimulus; response to gamma radiation; and response to vitamin D. Localizes to extracellular space. Used to study adult respiratory distress syndrome; myocarditis; proteinuria; renovascular hypertension; and type 1 diabetes mellitus. Biomarker of brain ischemia; encephalitis; and uveitis. Human ortholog(s) of this gene implicated in hepatitis B and middle cerebral artery infarction. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; influenza A pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; chemokine (C-X-C motif) ligand 10; gamma-IP10; interferon-inducible cytokine IP-10; interferon-inducible protein 10; IP-10; protein Mob-1; Scyb10; small inducible cytokine B subfamily (Cys-X-Cys) member 10; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small-inducible cytokine B10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,704,772 - 15,706,969 (+)NCBI
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
RH 3.4 Map14182.09RGD
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (IMP)
alopecia areata  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (IEP,ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
Carrington Syndrome  (ISO)
celiac disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
common cold  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
cryoglobulinemia  (ISO)
Cytomegalovirus Infections  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
encephalitis  (IEP)
Experimental Autoimmune Myasthenia Gravis  (IEP,IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
fatty liver disease  (ISO)
Foot Ulcer  (ISO)
Graft vs Host Disease  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hypothermia  (IEP)
inhalation anthrax  (ISO)
interstitial cystitis  (ISO)
interstitial lung disease  (ISO)
ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
myocarditis  (IMP)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (IMP)
pulmonary emphysema  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renovascular hypertension  (IDA)
Reperfusion Injury  (IEP,ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (IEP)
Spontaneous Abortions  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
Thyroid Neoplasms  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IMP,ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (IEP)
Viral Bronchiolitis  (IEP,ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acteoside  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alloxanthine  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
amorolfine  (ISO)
amoxicillin  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
atorvastatin calcium  (EXP)
Aurin  (ISO)
bafilomycin A1  (ISO)
bazedoxifene  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (ISO)
butenafine  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium phosphate  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
ceric oxide  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chloroquine  (ISO)
chondroitin sulfate  (ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
dimethoate  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
doramapimod  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
eriodictyol  (ISO)
ethanol  (EXP,ISO)
ethionamide  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gadodiamide hydrate  (EXP,ISO)
gemfibrozil  (EXP)
Genipin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
halothane  (EXP)
heparan sulfate  (ISO)
heparin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hydrazine  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indometacin  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isotretinoin  (EXP,ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
leptomycin B  (ISO)
levonorgestrel  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lucanthone  (ISO)
Luliconazole  (ISO)
luteolin  (ISO)
LY294002  (ISO)
magnesium dihydroxide  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
mycotoxin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
Nonylphenol  (EXP)
NS-398  (ISO)
oleic acid  (ISO)
ospemifene  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 168393  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
procymidone  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
Pyridostigmine bromide  (EXP)
quartz  (EXP)
quercetin  (ISO)
quinapril hydrochloride  (EXP)
raloxifene  (ISO)
remdesivir  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
roflumilast  (ISO)
rolipram  (ISO)
rotenone  (EXP)
rutin  (ISO)
S-nitrosoglutathione  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sterigmatocystin  (ISO)
succimer  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trans-piceid  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO,ISS)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA,ISO)
antiviral innate immune response  (IEA,ISO)
cellular response to heat  (IEP)
cellular response to lipopolysaccharide  (IBA)
cellular response to virus  (IEA,ISO)
chemokine-mediated signaling pathway  (IBA,ISO)
chemotaxis  (ISO,ISS)
defense response to virus  (ISO)
endothelial cell activation  (ISO)
G protein-coupled receptor signaling pathway  (ISO,ISS)
immune response  (IDA)
inflammatory response  (IBA)
killing of cells of other organism  (ISO)
negative regulation of angiogenesis  (IDA,ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of myoblast fusion  (ISO)
neutrophil chemotaxis  (IBA)
positive chemotaxis  (IEA)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of leukocyte chemotaxis  (IDA)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO,ISS)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO,ISS)
regulation of endothelial tube morphogenesis  (ISO)
regulation of T cell chemotaxis  (ISO)
response to auditory stimulus  (IEP)
response to bacterium  (ISO)
response to cold  (IEP)
response to gamma radiation  (IEP)
response to lipopolysaccharide  (IEP)
response to virus  (IEP)
response to vitamin D  (IEP)
T cell chemotaxis  (ISO)

Cellular Component

Molecular Function

References

References - curated
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69. Matsumoto Y, etal., J Immunol. 2004 Sep 1;173(5):3535-41.
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73. MGD data from the GO Consortium
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Additional References at PubMed
PMID:7540647   PMID:8608232   PMID:11157474   PMID:11894098   PMID:12581489   PMID:12782716   PMID:12949249   PMID:15465598   PMID:16382019   PMID:16484616   PMID:16830364   PMID:17277142  
PMID:18645041   PMID:19008373   PMID:19470579   PMID:20041150   PMID:20452033   PMID:20720435   PMID:21917786   PMID:22292067   PMID:22634718   PMID:22652417   PMID:23012479   PMID:23270423  
PMID:23620790   PMID:23776175   PMID:23844157   PMID:24337539   PMID:24732949   PMID:24770897   PMID:25561167   PMID:26572542   PMID:26891076   PMID:27271043   PMID:28046003   PMID:29637744  
PMID:29880386   PMID:30448292   PMID:31881846   PMID:32265928  


Genomics

Comparative Map Data
Cxcl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,704,772 - 15,706,969 (+)NCBI
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
RH 3.4 Map14182.09RGD
Cytogenetic Map14p22NCBI
CXCL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,942,271 - 76,944,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
Cxcl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,494,497 - 92,496,748 (-)NCBIGRCm39mm39
GRCm39 Ensembl592,494,497 - 92,496,748 (-)Ensembl
GRCm38592,346,638 - 92,348,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,346,638 - 92,348,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,775,667 - 92,777,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36593,421,841 - 93,424,054 (-)NCBImm8
Celera590,490,436 - 90,492,644 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.57NCBI
Cxcl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433748,284 - 750,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433748,392 - 750,890 (-)NCBIChiLan1.0ChiLan1.0
CXCL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1454,020,204 - 54,022,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,020,204 - 54,022,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0448,182,355 - 48,184,733 (+)NCBIMhudiblu_PPA_v0panPan3
CXCL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132598,406 - 599,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32597,987 - 599,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,282,571 - 41,284,090 (+)NCBI
ROS_Cfam_1.032623,230 - 624,745 (-)NCBI
UMICH_Zoey_3.132622,982 - 624,501 (-)NCBI
UNSW_CanFamBas_1.032577,290 - 578,808 (-)NCBI
UU_Cfam_GSD_1.03239,590,894 - 39,592,413 (+)NCBI
Cxcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,442,665 - 11,446,615 (+)NCBI
SpeTri2.0NW_00493667660,869 - 63,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,829,909 - 75,831,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2875,881,457 - 75,882,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,526,657 - 24,529,193 (-)NCBI
ChlSab1.1 Ensembl724,526,680 - 24,529,130 (-)Ensembl
Vero_WHO_p1.0NW_0236660372,868,983 - 2,871,422 (-)NCBI
Cxcl10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475714,989,241 - 14,991,650 (+)NCBI

Position Markers
RH130528  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01417,212,616 - 17,212,833NCBIRnor6.0
Rnor_5.01417,128,748 - 17,128,965UniSTSRnor5.0
RGSC_v3.41417,267,869 - 17,268,086UniSTSRGSC3.4
Celera1415,101,100 - 15,101,317UniSTS
RH 3.4 Map14178.3UniSTS
Cytogenetic Map14p22UniSTS
RH142310  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01417,212,387 - 17,212,567NCBIRnor6.0
Rnor_5.01417,128,519 - 17,128,699UniSTSRnor5.0
RGSC_v3.41417,267,640 - 17,267,820UniSTSRGSC3.4
Celera1415,100,871 - 15,101,051UniSTS
RH 3.4 Map14182.09UniSTS
Cytogenetic Map14p22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14134403399Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14222782519230541Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14483323319909932Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14483323319909932Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14483323323004027Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14483323326466248Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14483323333040042Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14975643572854397Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin141053997755539977Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)141053997755539977Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)141072926861873323Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141268042430155192Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141268061332593926Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141633698833163485Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:86
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000003075
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 14 2 18 2 12 6 1
Low 2 39 43 39 1 39 8 9 37 23 32 10 8
Below cutoff 4 2 37 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_139089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U22520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000003075   ⟹   ENSRNOP00000003649
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)Ensembl
RefSeq Acc Id: NM_139089   ⟹   NP_620789
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21415,704,772 - 15,706,969 (+)NCBI
Rnor_6.01417,210,733 - 17,212,930 (+)NCBI
Rnor_5.01417,126,865 - 17,129,062 (+)NCBI
RGSC_v3.41417,265,986 - 17,268,183 (+)RGD
Celera1415,099,217 - 15,101,414 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620789 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB60485 (Get FASTA)   NCBI Sequence Viewer  
  AAC52811 (Get FASTA)   NCBI Sequence Viewer  
  AAH58444 (Get FASTA)   NCBI Sequence Viewer  
  EDL88637 (Get FASTA)   NCBI Sequence Viewer  
  P48973 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_620789   ⟸   NM_139089
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000003649   ⟸   ENSRNOT00000003075

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699211
Promoter ID:EPDNEW_R9736
Type:single initiation site
Name:Cxcl10_1
Description:C-X-C motif chemokine ligand 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01417,210,721 - 17,210,781EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620209 AgrOrtholog
Ensembl Genes ENSRNOG00000022256 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003649 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003075 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918440 IMAGE-MGC_LOAD
InterPro Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:245920 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72680 IMAGE-MGC_LOAD
NCBI Gene 245920 ENTREZGENE
PANTHER PTHR10179 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Cxcl10 PhenoGen
PRINTS SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CXL10_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70538 UniProtKB/Swiss-Prot
  Q6GTC7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Cxcl10  C-X-C motif chemokine ligand 10  Cxcl10  chemokine (C-X-C motif) ligand 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cxcl10  chemokine (C-X-C motif) ligand 10      Symbol and Name status set to approved 1299863 APPROVED
2003-03-04 Cxcl10  chemokine (C-X-C motif) ligand 10  Scyb10  small inducible cytokine B subfamily (Cys-X-Cys), member 10  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-08-07 Scyb10  small inducible cytokine B subfamily (Cys-X-Cys), member 10      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in the induction of experimental autoimmune encephalomyelitis 625606
gene_expression mRNA expression in brain increases after ethanol consumption 727439
gene_process responsible for turning naive CD4positive T cells into polarized Th1 cells 625606
gene_process stimulates the directional migration of activated T cells 625606
gene_product member of the CXC chemokine family 625606