Cxcl10 (C-X-C motif chemokine ligand 10) - Rat Genome Database

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Gene: Cxcl10 (C-X-C motif chemokine ligand 10) Rattus norvegicus
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Symbol: Cxcl10
Name: C-X-C motif chemokine ligand 10
RGD ID: 620209
Description: Enables chemokine activity. Involved in several processes, including response to auditory stimulus; response to gamma radiation; and response to vitamin D. Located in extracellular space. Used to study adult respiratory distress syndrome; myocarditis; proteinuria; renovascular hypertension; and type 1 diabetes mellitus. Biomarker of brain ischemia; encephalitis; and uveitis. Human ortholog(s) of this gene implicated in hepatitis B and middle cerebral artery infarction. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; influenza A pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; chemokine (C-X-C motif) ligand 10; gamma-IP10; interferon-inducible cytokine IP-10; interferon-inducible protein 10; IP-10; protein Mob-1; Scyb10; small inducible cytokine B subfamily (Cys-X-Cys) member 10; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small-inducible cytokine B10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,704,772 - 15,706,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,704,758 - 15,706,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1415,712,934 - 15,715,131 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01417,031,780 - 17,033,977 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01415,727,209 - 15,729,406 (+)NCBIRnor_WKY
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
RH 3.4 Map14182.09RGD
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (IMP)
alopecia areata  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
brain ischemia  (IEP,ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
Carrington Syndrome  (ISO)
celiac disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
common cold  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
cryoglobulinemia  (ISO)
Cytomegalovirus Infections  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
encephalitis  (IEP)
Experimental Autoimmune Myasthenia Gravis  (IEP,IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
fatty liver disease  (ISO)
Foot Ulcer  (ISO)
graft-versus-host disease  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hypothermia  (IEP)
inhalation anthrax  (ISO)
interstitial cystitis  (ISO)
interstitial lung disease  (ISO)
ischemia  (ISO)
Kabuki Syndrome 1  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
myocarditis  (IMP)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
primary biliary cholangitis  (ISO)
progressive myoclonus epilepsy  (ISO)
proteinuria  (IMP)
pulmonary emphysema  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renovascular hypertension  (IDA)
Reperfusion Injury  (IEP,ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (IEP)
Spontaneous Abortions  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
Thyroid Neoplasms  (ISO)
Transplant Rejection  (ISO)
Traumatic Brain Injuries  (ISO)
type 1 diabetes mellitus  (IMP,ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (IEP)
Viral Bronchiolitis  (IEP,ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
acteoside  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alloxanthine  (ISO)
alpha-phellandrene  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
amorolfine  (ISO)
amoxicillin  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
atorvastatin calcium  (EXP)
Aurin  (ISO)
bafilomycin A1  (ISO)
bazedoxifene  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
butanal  (ISO)
butenafine  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium phosphate  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chloroquine  (ISO)
chondroitin sulfate  (ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
dimethoate  (ISO)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
doramapimod  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
eriodictyol  (ISO)
ethanol  (EXP,ISO)
ethionamide  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gadodiamide hydrate  (EXP,ISO)
gemfibrozil  (EXP)
Genipin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
halothane  (EXP)
heparan sulfate  (ISO)
heparin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hydrazine  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indometacin  (ISO)
iodixanol  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isotretinoin  (EXP,ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leptomycin B  (ISO)
levonorgestrel  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lucanthone  (ISO)
Luliconazole  (ISO)
luteolin  (ISO)
LY294002  (ISO)
magnesium dihydroxide  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
Muraglitazar  (EXP)
mycotoxin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
Nonylphenol  (EXP)
NS-398  (ISO)
oleic acid  (ISO)
ospemifene  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 168393  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
procymidone  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
Pyridostigmine bromide  (EXP)
quartz  (EXP)
quercetin  (ISO)
quinapril hydrochloride  (EXP)
raloxifene  (ISO)
remdesivir  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
roflumilast  (ISO)
rolipram  (ISO)
rotenone  (EXP)
rutin  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sotorasib  (ISO)
sterigmatocystin  (ISO)
succimer  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trans-piceid  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
ursodeoxycholic acid  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO,ISS)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA,ISO)
antiviral innate immune response  (ISO)
cellular response to heat  (IEP)
cellular response to interleukin-17  (ISO)
cellular response to lipopolysaccharide  (IBA,ISO)
cellular response to virus  (ISO)
chemokine-mediated signaling pathway  (IBA,ISO)
chemotaxis  (ISO,ISS)
defense response to virus  (ISO)
endothelial cell activation  (ISO)
G protein-coupled receptor signaling pathway  (ISO,ISS)
immune response  (IDA)
inflammatory response  (IBA)
killing of cells of another organism  (ISO)
negative regulation of angiogenesis  (IDA,ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of myoblast fusion  (ISO)
neutrophil chemotaxis  (IBA)
positive chemotaxis  (IEA)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of leukocyte chemotaxis  (IDA)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO,ISS)
positive regulation of T cell migration  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO,ISS)
regulation of endothelial tube morphogenesis  (ISO)
regulation of T cell chemotaxis  (ISO)
response to auditory stimulus  (IEP)
response to bacterium  (ISO)
response to cold  (IEP)
response to gamma radiation  (IEP)
response to lipopolysaccharide  (IEP)
response to virus  (IEP)
response to vitamin D  (IEP)
T cell chemotaxis  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The novel chemokine mob-1: involvement in adult respiratory distress syndrome. Abdullah F, etal., Surgery. 1997 Aug;122(2):303-12.
2. Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. Abu El-Asrar AM, etal., Eur Cytokine Netw. 2006 Sep;17(3):155-65.
3. Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. Agostini C, etal., J Immunol. 1998 Dec 1;161(11):6413-20.
4. CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis. Agostini C, etal., Respir Res. 2005 Feb 22;6:20.
5. High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. Antonelli A, etal., Am J Gastroenterol. 2008 Oct;103(10):2488-94. doi: 10.1111/j.1572-0241.2008.02040.x. Epub 2008 Sep 4.
6. Serum Th1 (CXCL10) and Th2 (CCL2) chemokine levels in children with newly diagnosed Type 1 diabetes: a longitudinal study. Antonelli A, etal., Diabet Med. 2008 Nov;25(11):1349-53.
7. Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture. Bajova H, etal., J Neuroimmunol. 2008 Mar;195(1-2):36-46. Epub 2008 Mar 10.
8. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
9. Diminished inflammatory responses to natural pneumovirus infection among older mice. Bonville CA, etal., Virology. 2007 Nov 10;368(1):182-90. Epub 2007 Jul 25.
10. Early high expression of IP-10 in F344 rats resistant to Sendai virus-induced airway injury. Cai X and Castleman WL, Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1263-9. Epub 2003 Aug 8.
11. Granzyme-b mediated cell death in the spinal cord-injured rat model. Chaitanya GV, etal., Neuropathology. 2008 Dec 24.
12. The role of interferon-γ inducible protein-10 in a mouse model of acute liver injury post induced pluripotent stem cells transplantation. Chan CC, etal., PLoS One. 2012;7(12):e50577. doi: 10.1371/journal.pone.0050577. Epub 2012 Dec 5.
13. SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation. Chang YS, etal., Int J Mol Sci. 2020 Apr 30;21(9). pii: ijms21093179. doi: 10.3390/ijms21093179.
14. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
15. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Chien JY, etal., Respirology. 2006 Nov;11(6):715-22.
16. Chronic CXCL10 alters neuronal properties in rat hippocampal culture. Cho J, etal., J Neuroimmunol. 2009 Feb 15;207(1-2):92-100. Epub 2009 Jan 22.
17. Noise overstimulation induces immediate early genes in the rat cochlea. Cho Y, etal., Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):134-48.
18. CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Costa C, etal., Chest. 2008 Jan;133(1):26-33. Epub 2007 Oct 9.
19. Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. Crawford MA, etal., PLoS Pathog. 2010 Nov 18;6(11):e1001199.
20. Angiogenic and angiostatic chemokines in idiopathic pulmonary fibrosis and granulomatous lung disease. Cui A, etal., Respiration. 2010;80(5):372-8. Epub 2009 Oct 6.
21. Regulatory polymorphisms in the promoter of CXCL10 gene and disease progression in male hepatitis B virus carriers. Deng G, etal., Gastroenterology. 2008 Mar;134(3):716-26. doi: 10.1053/j.gastro.2007.12.044. Epub 2008 Jan 1.
22. Cerebral gene expression of superantigen encephalitis in the lewis rat induced by staphylococcal enterotoxin a. Emmer A, etal., Scand J Immunol. 2008 May;67(5):464-72.
23. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
24. Suppression of experimental autoimmune myasthenia gravis by inhibiting the signaling between IFN-gamma inducible protein 10 (IP-10) and its receptor CXCR3. Feferman T, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):87-95. Epub 2009 Feb 20.
25. Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
26. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
27. Hypothermia-enhanced splenic cytokine gene expression is independent of the sympathetic nervous system. Ganta CK, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R558-65.
28. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
29. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
30. Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation. Gremy O, etal., World J Gastroenterol. 2008 Dec 14;14(46):7075-85.
31. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
32. 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Gysemans CA, etal., Endocrinology. 2005 Apr;146(4):1956-64. Epub 2005 Jan 6.
33. IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance. Han GD, etal., J Am Soc Nephrol. 2006 Feb;17(2):442-53. Epub 2005 Dec 28.
34. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
35. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
36. Expression of CXC chemokine IP-10/Mob-1 by primary hepatocytes following heat shock. Hassanshahi G, etal., Saudi Med J. 2007 Apr;28(4):514-8.
37. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
38. Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice. Hu Z, etal., Theranostics. 2017 May 2;7(7):1942-1952. doi: 10.7150/thno.16236. eCollection 2017.
39. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
40. An interferon-gamma-related cytokine storm in SARS patients. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
41. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
42. The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Jha P, etal., Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1030-8.
43. Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome. Jiang Y, etal., Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7. doi: 10.1164/rccm.200407-857OC. Epub 2005 Jan 18.
44. Accumulation of CXCR3-expressing eosinophils and increased concentration of its ligands (IP10 and Mig) in bronchoalveolar lavage fluid of patients with chronic eosinophilic pneumonia. Katoh S, etal., Int Arch Allergy Immunol. 2005 Jul;137(3):229-35. Epub 2005 Jun 13.
45. CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary artery disease. Kawamura A, etal., Circ J. 2003 Oct;67(10):851-4.
46. Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
47. Circulating BAFF and CXCL10 levels predict response to pegylated interferon in patients with HBeAg-positive chronic hepatitis B. Khlaiphuengsin A, etal., Asian Pac J Allergy Immunol. 2019 Jan 13. doi: 10.12932/AP-050718-0365.
48. Forced Expression of CXCL10 Prevents Liver Metastasis of Colon Carcinoma Cells by the Recruitment of Natural Killer Cells. Kikuchi N, etal., Biol Pharm Bull. 2019 Jan 1;42(1):57-65. doi: 10.1248/bpb.b18-00538. Epub 2018 Nov 1.
49. Urine IP-10 as a biomarker of therapeutic response in patients with active pulmonary tuberculosis. Kim SY, etal., BMC Infect Dis. 2018 May 29;18(1):240. doi: 10.1186/s12879-018-3144-3.
50. Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice. Kishi J, etal., Eur Respir J. 2011 Aug;38(2):415-24. Epub 2011 Jan 27.
51. Decreased T-bet expression and changes in chemokine levels in adults with asthma. Ko FW, etal., Clin Exp Immunol. 2007 Mar;147(3):526-32.
52. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
53. Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. Koniaris LG, etal., J Immunol. 2001 Jul 1;167(1):399-406. doi: 10.4049/jimmunol.167.1.399.
54. Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. Kremlev SG, etal., J Neurosci Res. 2007 Aug 15;85(11):2450-9.
55. Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice. Kumaki Y, etal., Antivir Chem Chemother. 2010 Mar 9;20(4):169-77. doi: 10.3851/IMP1477.
56. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
57. HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection. Lamoury FM, etal., BMC Infect Dis. 2016 Jun 1;16:241. doi: 10.1186/s12879-016-1567-2.
58. Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality. Lehmann JM, etal., Liver Int. 2018 May;38(5):875-884. doi: 10.1111/liv.13610. Epub 2017 Nov 6.
59. CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation. Li CX, etal., J Hepatol. 2016 Nov;65(5):944-952. doi: 10.1016/j.jhep.2016.05.032. Epub 2016 May 28.
60. Identification of chemokine CXCL10 in tumor microenvironment by antibody array as a prognostic marker in hepatocellular carcinoma. Li L, etal., Neoplasma. 2017;64(5):778-786. doi: 10.4149/neo_2017_517.
61. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
62. Ras activation of genes: Mob-1 as a model. Liang P, etal., Proc Natl Acad Sci U S A 1994 Dec 20;91(26):12515-9.
63. Vascular endothelial growth factor induces IP-10 chemokine expression. Lin CS, etal., Biochem Biophys Res Commun 2002 Mar 22;292(1):79-82.
64. CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Lindell DM, etal., Eur J Immunol. 2008 Aug;38(8):2168-79.
65. Expression of the CXC chemokine receptor 3 and its ligands in ischemia-reperfusion injury of liver in rats. Liu Z, etal., Transplant Proc. 2008 Jun;40(5):1300-2.
66. Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma. Lun SW, etal., J Clin Immunol. 2006 Mar;26(2):145-52. Epub 2006 Apr 7.
67. Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway. Ma Q, etal., Pharmacol Res. 2020 Apr 30;158:104850. doi: 10.1016/j.phrs.2020.104850.
68. The chemokine binding protein M3 prevents diabetes induced by multiple low doses of streptozotocin. Martin AP, etal., J Immunol. 2007 Apr 1;178(7):4623-31.
69. C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy. Matsumoto Y, etal., J Immunol. 2004 Sep 1;173(5):3535-41.
70. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. Medoff BD, etal., J Immunol. 2002 May 15;168(10):5278-86.
71. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
72. Alterations of Serum IP-10 and TARC in Patients with Early Acute Rejection after Liver Transplantation. Meng X, etal., Cell Physiol Biochem. 2017;41(3):1063-1071. doi: 10.1159/000464114. Epub 2017 Feb 27.
73. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
74. Chemokine production during hypersensitivity pneumonitis. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
75. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
76. Chemokine response in children with SARS. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
77. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Niewczas MA, etal., Clin J Am Soc Nephrol. 2009 Jan;4(1):62-70. Epub 2008 Dec 10.
78. CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. Nishioka Y, etal., Clin Exp Immunol. 2007 Aug;149(2):317-26. Epub 2007 Jun 5.
79. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
80. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
81. Serum IP-10 levels and increased DPPIV activity are linked to circulating CXCR3+ T cells in cholestatic HCV patients. Rau M, etal., PLoS One. 2018 Dec 3;13(12):e0208225. doi: 10.1371/journal.pone.0208225. eCollection 2018.
82. GOA pipeline RGD automated data pipeline
83. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
84. Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development. Rhode A, etal., J Immunol. 2005 Sep 15;175(6):3516-24.
85. Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Richards TJ, etal., Arthritis Rheum. 2009 Jul;60(7):2183-92.
86. Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection. Riva A, etal., Hepatology. 2014 Aug;60(2):487-96. doi: 10.1002/hep.27139. Epub 2014 May 19.
87. Changes in helper lymphocyte chemokine receptor expression and elevation of IP-10 during acute respiratory syncytial virus infection in infants. Roe MF, etal., Pediatr Allergy Immunol. 2011 Mar;22(2):229-34. doi: 10.1111/j.1399-3038.2010.01032.x.
88. Characterization of cytomegalovirus disease in solid organ transplant recipients by markers of inflammation in plasma. Rollag H, etal., PLoS One. 2013 Apr 8;8(4):e60767. doi: 10.1371/journal.pone.0060767. Print 2013.
89. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Schulthess FT, etal., Cell Metab. 2009 Feb;9(2):125-39.
90. CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice. Shigihara T, etal., J Immunol. 2005 Dec 15;175(12):8401-8.
91. Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL/lpr mice. Shiozawa F, etal., Arthritis Res Ther. 2004;6(1):R78-R86. Epub 2003 Nov 19.
92. Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Spurrell JC, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Jul;289(1):L85-95. Epub 2005 Mar 11.
93. Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats. Steinmetz OM, etal., Am J Physiol Renal Physiol. 2007 Feb;292(2):F876-87. Epub 2006 Oct 24.
94. CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination. Stiles LN, etal., Autoimmunity. 2009 Sep;42(6):484-91. doi: 10.1080/08916930902810708.
95. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
96. Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection. Svensson M, etal., Infect Immun. 2005 Nov;73(11):7541-7. doi: 10.1128/IAI.73.11.7541-7547.2005.
97. Serum inducible protein-10 chemokine as a biomarker for clearance of HCV with and without treatment in Egyptian patients. Tabll A, etal., Hum Antibodies. 2019;27(4):265-273. doi: 10.3233/HAB-190381.
98. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
99. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
100. Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Valbuena G, etal., Am J Pathol. 2003 Oct;163(4):1357-69.
101. Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan. Villapol S, etal., Am J Pathol. 2015 Oct;185(10):2641-52. doi: 10.1016/j.ajpath.2015.06.016.
102. NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. Wallace KL, etal., Blood. 2009 Jul 16;114(3):667-76. Epub 2009 May 11.
103. Expression of CXC chemokine IP-10 in patients with chronic hepatitis B. Wang J, etal., Hepatobiliary Pancreat Dis Int. 2008 Feb;7(1):45-50.
104. Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response. Wang X, etal., J Biol Chem 1996 Sep 27;271(39):24286-93.
105. Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke. Wang X, etal., Mol Pharmacol 2000 Jun;57(6):1190-8.
106. Predictive Value of Serum IFN-γ inducible Protein-10 and IFN-γ/IL-4 Ratio for Liver Fibrosis Progression in CHB Patients. Wang Y, etal., Sci Rep. 2017 Jan 9;7:40404. doi: 10.1038/srep40404.
107. Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids. Ward SE, etal., Antivir Ther. 2005;10(2):263-75.
108. Immune mediators in patients with acute diabetic foot syndrome. Weigelt C, etal., Diabetes Care. 2009 Jun 9.
109. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
110. Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis. Wildbaum G, etal., J Immunol 2002 Jun 1;168(11):5885-92.
111. Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy. Wong CK, etal., Clin Exp Immunol. 2007 Jul;149(1):123-31. Epub 2007 Apr 11.
112. Differential display identifies neuroendocrine-specific protein-A (NSP-A) and interferon-inducible protein 10 (IP-10) as ethanol-responsive genes in the fetal rat brain. Yang J and Zoeller RT, Brain Res Dev Brain Res 2002 Oct 20;138(2):117-33.
113. [The possible mechanism of lung injury induced by severe acute respiratory syndrome coronavirus spike glycoprotein]. Yang XY, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Sep;29(9):587-90.
114. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
115. Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Zeng X, etal., Infect Immun. 2005 Dec;73(12):8226-36.
116. Intrahepatic and Peripheral CXCL10 Expression in Hepatitis C Virus-Infected Patients Treated With Telaprevir, Pegylated Interferon, and Ribavirin. Zeremski M, etal., J Infect Dis. 2015 Jun 1;211(11):1795-9. doi: 10.1093/infdis/jiu807. Epub 2014 Dec 15.
117. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Zhai Y, etal., Hepatology. 2008 Jan;47(1):207-14. doi: 10.1002/hep.21986.
118. CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. Zhang X, etal., J Hepatol. 2014 Dec;61(6):1365-75. doi: 10.1016/j.jhep.2014.07.006. Epub 2014 Jul 15.
119. C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis. Zhang X, etal., Theranostics. 2017 Jul 8;7(11):2822-2836. doi: 10.7150/thno.19068. eCollection 2017.
Additional References at PubMed
PMID:7540647   PMID:8608232   PMID:11157474   PMID:11894098   PMID:12581489   PMID:12782716   PMID:12949249   PMID:15465598   PMID:16382019   PMID:16484616   PMID:16830364   PMID:17277142  
PMID:18645041   PMID:19008373   PMID:19470579   PMID:20041150   PMID:20452033   PMID:20720435   PMID:21917786   PMID:22292067   PMID:22634718   PMID:22652417   PMID:23012479   PMID:23270423  
PMID:23620790   PMID:23776175   PMID:23844157   PMID:24337539   PMID:24732949   PMID:24770897   PMID:25561167   PMID:26572542   PMID:26891076   PMID:27271043   PMID:28046003   PMID:29637744  
PMID:29880386   PMID:30448292   PMID:31881846   PMID:32265928   PMID:34830041   PMID:35542987   PMID:35548957  


Genomics

Comparative Map Data
Cxcl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,704,772 - 15,706,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,704,758 - 15,706,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1415,712,934 - 15,715,131 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01417,031,780 - 17,033,977 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01415,727,209 - 15,729,406 (+)NCBIRnor_WKY
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
RH 3.4 Map14182.09RGD
Cytogenetic Map14p22NCBI
CXCL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh37476,942,271 - 76,944,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36Build 36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBICelera
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
T2T-CHM13v2.0479,361,779 - 79,364,158 (-)NCBIT2T-CHM13v2.0
Cxcl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,494,497 - 92,496,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl592,494,497 - 92,496,748 (-)EnsemblGRCm39 Ensembl
GRCm38592,346,638 - 92,348,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,346,638 - 92,348,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,775,667 - 92,777,880 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36593,421,841 - 93,424,054 (-)NCBIMGSCv36mm8
Celera590,490,436 - 90,492,644 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.57NCBI
Cxcl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433748,284 - 750,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433748,392 - 750,890 (-)NCBIChiLan1.0ChiLan1.0
CXCL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1454,020,204 - 54,022,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,020,204 - 54,022,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0448,182,355 - 48,184,733 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CXCL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132598,406 - 599,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32597,987 - 599,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,282,571 - 41,284,090 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.032623,230 - 624,745 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl32622,462 - 624,803 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.132622,982 - 624,501 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.032577,290 - 578,808 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03239,590,894 - 39,592,413 (+)NCBIUU_Cfam_GSD_1.0
Cxcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,442,665 - 11,446,615 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493667660,621 - 63,106 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493667660,869 - 63,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,829,909 - 75,831,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2875,881,457 - 75,882,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,526,657 - 24,529,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl724,526,680 - 24,529,130 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660372,868,983 - 2,871,422 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcl10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475714,989,084 - 14,991,910 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475714,989,241 - 14,991,650 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cxcl10
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:86
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000003075
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat

Markers in Region
RH130528  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,706,654 - 15,706,872 (+)MAPPERmRatBN7.2
Rnor_6.01417,212,616 - 17,212,833NCBIRnor6.0
Rnor_5.01417,128,748 - 17,128,965UniSTSRnor5.0
RGSC_v3.41417,267,869 - 17,268,086UniSTSRGSC3.4
Celera1415,101,100 - 15,101,317UniSTS
RH 3.4 Map14178.3UniSTS
Cytogenetic Map14p22UniSTS
RH142310  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,706,425 - 15,706,606 (+)MAPPERmRatBN7.2
Rnor_6.01417,212,387 - 17,212,567NCBIRnor6.0
Rnor_5.01417,128,519 - 17,128,699UniSTSRnor5.0
RGSC_v3.41417,267,640 - 17,267,820UniSTSRGSC3.4
Celera1415,100,871 - 15,101,051UniSTS
RH 3.4 Map14182.09UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 14 2 18 2 12 6 1
Low 2 39 43 39 1 39 8 9 37 23 32 10 8
Below cutoff 4 2 37 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_139089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U22520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000003075   ⟹   ENSRNOP00000003649
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1415,704,758 - 15,706,975 (+)Ensembl
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)Ensembl
RefSeq Acc Id: NM_139089   ⟹   NP_620789
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21415,704,772 - 15,706,969 (+)NCBI
Rnor_6.01417,210,733 - 17,212,930 (+)NCBI
Rnor_5.01417,126,865 - 17,129,062 (+)NCBI
RGSC_v3.41417,265,986 - 17,268,183 (+)RGD
Celera1415,099,217 - 15,101,414 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620789 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB60485 (Get FASTA)   NCBI Sequence Viewer  
  AAC52811 (Get FASTA)   NCBI Sequence Viewer  
  AAH58444 (Get FASTA)   NCBI Sequence Viewer  
  EDL88637 (Get FASTA)   NCBI Sequence Viewer  
  P48973 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_620789   ⟸   NM_139089
- Peptide Label: precursor
- UniProtKB: Q6GTC7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003649   ⟸   ENSRNOT00000003075

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48973-F1-model_v2 AlphaFold P48973 1-98 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699211
Promoter ID:EPDNEW_R9736
Type:single initiation site
Name:Cxcl10_1
Description:C-X-C motif chemokine ligand 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01417,210,721 - 17,210,781EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620209 AgrOrtholog
BioCyc Gene G2FUF-16260 BioCyc
Ensembl Genes ENSRNOG00000022256 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003649 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003075 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918440 IMAGE-MGC_LOAD
InterPro Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:245920 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72680 IMAGE-MGC_LOAD
NCBI Gene 245920 ENTREZGENE
PANTHER PTHR10179 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Cxcl10 PhenoGen
PRINTS SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CXL10_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6GTC7 ENTREZGENE
UniProt Secondary P70538 UniProtKB/Swiss-Prot
  Q6GTC7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Cxcl10  C-X-C motif chemokine ligand 10  Cxcl10  chemokine (C-X-C motif) ligand 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cxcl10  chemokine (C-X-C motif) ligand 10      Symbol and Name status set to approved 1299863 APPROVED
2003-03-04 Cxcl10  chemokine (C-X-C motif) ligand 10  Scyb10  small inducible cytokine B subfamily (Cys-X-Cys), member 10  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-08-07 Scyb10  small inducible cytokine B subfamily (Cys-X-Cys), member 10      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in the induction of experimental autoimmune encephalomyelitis 625606
gene_expression mRNA expression in brain increases after ethanol consumption 727439
gene_process responsible for turning naive CD4positive T cells into polarized Th1 cells 625606
gene_process stimulates the directional migration of activated T cells 625606
gene_product member of the CXC chemokine family 625606