Cxcl9 (C-X-C motif chemokine ligand 9) - Rat Genome Database

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Gene: Cxcl9 (C-X-C motif chemokine ligand 9) Mus musculus
Analyze
Symbol: Cxcl9
Name: C-X-C motif chemokine ligand 9
RGD ID: 1332044
MGI Page MGI
Description: Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Acts upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including central nervous system; limb; retina; testis; and thymus. Orthologous to human CXCL9 (C-X-C motif chemokine ligand 9).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BB139920; C-X-C motif chemokine 9; chemokine (C-X-C motif) ligand 9; CMK; crg-1; crg-10; gamma interferon-induced monokine; gamma-interferon-induced monokine; M119; Mi; Mig; monokine induced by gamma interferon; monokine induced by interferon-gamma; MuMIG; Scyb; Scyb9; small inducible cytokine B subfamily (Cys-X-Cys), member 9; small-inducible cytokine B9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,469,190 - 92,475,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl592,469,206 - 92,475,938 (-)EnsemblGRCm39 Ensembl
GRCm38592,321,331 - 92,328,079 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,321,347 - 92,328,079 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,750,357 - 92,757,105 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36593,398,190 - 93,403,317 (-)NCBIMGSCv36mm8
Celera590,465,046 - 90,472,120 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astemizole  (ISO)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
beta-carotene  (ISO)
bisphenol A  (ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
carbon nanotube  (EXP,ISO)
ceric oxide  (ISO)
chloroquine  (EXP)
cholesterol  (EXP)
choline  (EXP)
chondroitin sulfate  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
crocidolite asbestos  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
digoxin  (EXP)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diquat  (EXP)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
fructose  (EXP)
gadodiamide hydrate  (ISO)
Genipin  (EXP)
glafenine  (ISO)
glucose  (EXP)
glyphosate  (EXP)
Imipenem-cilastatin  (EXP)
indole-3-methanol  (ISO)
isoprenaline  (EXP)
L-ascorbic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
metam  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methylarsonic acid  (EXP)
monosodium L-glutamate  (EXP)
mycotoxin  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
neomycin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nimesulide  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (EXP)
potassium dichromate  (EXP)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
roxarsone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sterigmatocystin  (EXP)
sulindac  (EXP)
tamibarotene  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
TMC-120A  (EXP)
tofacitinib  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
tremolite asbestos  (EXP)
trimellitic anhydride  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vincristine  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc oxide  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis. Agostini C, etal., Respir Res. 2005 Feb 22;6:20.
2. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
3. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
4. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
5. Diminished inflammatory responses to natural pneumovirus infection among older mice. Bonville CA, etal., Virology. 2007 Nov 10;368(1):182-90. Epub 2007 Jul 25.
6. Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. Brozyna S, etal., COPD. 2009 Feb;6(1):4-16.
7. Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model. Chavez-Bueno S, etal., Virol J. 2005 May 25;2:46.
8. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
9. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Chien JY, etal., Respirology. 2006 Nov;11(6):715-22.
10. CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Costa C, etal., Chest. 2008 Jan;133(1):26-33. Epub 2007 Oct 9.
11. Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. Crawford MA, etal., PLoS Pathog. 2010 Nov 18;6(11):e1001199.
12. Angiogenic and angiostatic chemokines in idiopathic pulmonary fibrosis and granulomatous lung disease. Cui A, etal., Respiration. 2010;80(5):372-8. Epub 2009 Oct 6.
13. Local production of inflammatory mediators during childhood parainfluenza virus infection. El Feghaly RE, etal., Pediatr Infect Dis J. 2010 Apr;29(4):e26-31.
14. Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG/CXCL9 via MyD88-dependent signaling in a murine model of airway infection. Eliasson M, etal., Microbes Infect. 2010 Jul;12(7):565-73. Epub 2010 Apr 8.
15. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
16. Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
17. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
18. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
19. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
20. Relationship between circulating levels of IFN-gamma, IL-10, CXCL9 and CCL2 in pulmonary and extrapulmonary tuberculosis is dependent on disease severity. Hasan Z, etal., Scand J Immunol. 2009 Mar;69(3):259-67.
21. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
22. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
23. An interferon-gamma-related cytokine storm in SARS patients. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
24. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
25. Accumulation of CXCR3-expressing eosinophils and increased concentration of its ligands (IP10 and Mig) in bronchoalveolar lavage fluid of patients with chronic eosinophilic pneumonia. Katoh S, etal., Int Arch Allergy Immunol. 2005 Jul;137(3):229-35. Epub 2005 Jun 13.
26. Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
27. Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice. Kishi J, etal., Eur Respir J. 2011 Aug;38(2):415-24. Epub 2011 Jan 27.
28. Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome. Landi A, etal., Cytokine. 2016 Feb;78:27-36. doi: 10.1016/j.cyto.2015.11.018. Epub 2015 Nov 28.
29. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
30. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
31. MGDs mouse GO annotations MGD data from the GO Consortium
32. Chemokine production during hypersensitivity pneumonitis. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
33. Chemokine response in children with SARS. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
34. CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. Nishioka Y, etal., Clin Exp Immunol. 2007 Aug;149(2):317-26. Epub 2007 Jun 5.
35. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
39. Mouse MP Annotation Import Pipeline RGD automated import pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Richards TJ, etal., Arthritis Rheum. 2009 Jul;60(7):2183-92.
42. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
43. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
44. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
45. Regulation of cockroach antigen-induced allergic airway hyperreactivity by the CXCR3 ligand CXCL9. Thomas MS, etal., J Immunol. 2004 Jul 1;173(1):615-23.
46. Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Valbuena G, etal., Am J Pathol. 2003 Oct;163(4):1357-69.
47. NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. Wallace KL, etal., Blood. 2009 Jul 16;114(3):667-76. Epub 2009 May 11.
48. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
49. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
50. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
51. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
Additional References at PubMed
PMID:2115167   PMID:9730606   PMID:9857043   PMID:9935167   PMID:10349636   PMID:10393857   PMID:10714680   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11731434   PMID:12080938  
PMID:12098066   PMID:12126650   PMID:12133969   PMID:12226082   PMID:12368204   PMID:12403783   PMID:12415259   PMID:12477932   PMID:12740040   PMID:14769916   PMID:15187119   PMID:15489334  
PMID:15585657   PMID:15629884   PMID:15708587   PMID:15959530   PMID:16095489   PMID:16141072   PMID:16141073   PMID:16299319   PMID:16365450   PMID:16368965   PMID:16585592   PMID:16602821  
PMID:16768726   PMID:17277133   PMID:17277142   PMID:17296171   PMID:17525185   PMID:17889309   PMID:17902170   PMID:18178850   PMID:18250476   PMID:18287559   PMID:18347328   PMID:18566419  
PMID:18697212   PMID:18716926   PMID:18973912   PMID:19008373   PMID:19017990   PMID:19179419   PMID:19200397   PMID:19344719   PMID:19389928   PMID:19454692   PMID:19487472   PMID:19839009  
PMID:20194716   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22237831   PMID:22277947   PMID:22358057   PMID:22474250   PMID:22679098   PMID:22905138   PMID:22972626   PMID:22980984  
PMID:23012479   PMID:23123063   PMID:23241877   PMID:23352234   PMID:23447686   PMID:23844157   PMID:23875831   PMID:24194600   PMID:24523323   PMID:24700550   PMID:25207638   PMID:25432064  
PMID:25495686   PMID:25595646   PMID:25643352   PMID:25672751   PMID:25713416   PMID:26052942   PMID:26892362   PMID:27022143   PMID:27189410   PMID:27626380   PMID:27686391   PMID:27760760  
PMID:27960090   PMID:27966526   PMID:28282568   PMID:28432083   PMID:28849106   PMID:28891812   PMID:29088306   PMID:29277541   PMID:29712506   PMID:29901197   PMID:29969845   PMID:30619292  
PMID:30779709   PMID:31097342   PMID:31186412   PMID:31712428   PMID:32452398   PMID:33239787   PMID:33510341   PMID:33649580   PMID:33916486   PMID:34188052   PMID:34205098   PMID:34244313  
PMID:34461107   PMID:34533228   PMID:34847356   PMID:34964882   PMID:35314795   PMID:36655287   PMID:36708947   PMID:37516815   PMID:38355793  


Genomics

Comparative Map Data
Cxcl9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,469,190 - 92,475,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl592,469,206 - 92,475,938 (-)EnsemblGRCm39 Ensembl
GRCm38592,321,331 - 92,328,079 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,321,347 - 92,328,079 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,750,357 - 92,757,105 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36593,398,190 - 93,403,317 (-)NCBIMGSCv36mm8
Celera590,465,046 - 90,472,120 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.51NCBI
CXCL9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38476,001,275 - 76,007,509 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl476,001,275 - 76,007,509 (-)EnsemblGRCh38hg38GRCh38
GRCh37476,922,428 - 76,928,662 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,141,647 - 77,147,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 34477,279,801 - 77,285,820NCBI
Celera474,223,036 - 74,229,163 (-)NCBICelera
Cytogenetic Map4q21.1NCBI
HuRef472,674,915 - 72,680,933 (-)NCBIHuRef
CHM1_1476,899,188 - 76,905,206 (-)NCBICHM1_1
T2T-CHM13v2.0479,341,778 - 79,348,012 (-)NCBIT2T-CHM13v2.0
Cxcl9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,007,166 - 16,012,077 (+)NCBIGRCr8
mRatBN7.21415,722,868 - 15,727,779 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,722,908 - 15,728,435 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1415,731,069 - 15,735,970 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,049,915 - 17,054,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,745,354 - 15,750,255 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,228,832 - 17,233,743 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,228,856 - 17,234,712 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,144,966 - 17,150,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,284,085 - 17,288,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11417,284,135 - 17,289,652 (+)NCBI
Celera1415,117,313 - 15,122,212 (+)NCBICelera
Cytogenetic Map14p22NCBI
Cxcl9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433724,515 - 732,192 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433724,566 - 731,945 (-)NCBIChiLan1.0ChiLan1.0
CXCL9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2354,065,785 - 54,071,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1454,255,545 - 54,261,580 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0448,198,478 - 48,204,658 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1454,036,343 - 54,042,502 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,036,342 - 54,042,502 (+)Ensemblpanpan1.1panPan2
Cxcl9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,466,180 - 11,472,856 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493667632,128 - 40,329 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493667633,580 - 40,323 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,663,501 - 71,670,271 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,665,541 - 71,670,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,801,515 - 75,806,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,507,121 - 24,513,830 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl724,507,130 - 24,513,121 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660372,849,313 - 2,855,487 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcl9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475714,995,716 - 15,011,893 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475714,995,649 - 15,009,771 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cxcl9
376 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:774
Count of miRNA genes:482
Interacting mature miRNAs:563
Transcripts:ENSMUST00000113093
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
BB139920  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38592,321,498 - 92,321,644UniSTSGRCm38
MGSCv37592,750,524 - 92,750,670UniSTSGRCm37
Celera590,465,213 - 90,465,359UniSTS
Cytogenetic Map5E2UniSTS
cM Map553.0UniSTS
Whitehead/MRC_RH51121.84UniSTS
Cxcl9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E2UniSTS
cM Map553.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000113093   ⟹   ENSMUSP00000108716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl592,469,206 - 92,475,938 (-)Ensembl
GRCm38.p6 Ensembl592,321,347 - 92,328,079 (-)Ensembl
Ensembl Acc Id: ENSMUST00000202404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl592,474,482 - 92,475,937 (-)Ensembl
GRCm38.p6 Ensembl592,326,623 - 92,328,078 (-)Ensembl
RefSeq Acc Id: NM_008599   ⟹   NP_032625
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39592,469,190 - 92,475,938 (-)NCBI
GRCm38592,321,331 - 92,328,079 (-)ENTREZGENE
MGSCv37592,750,357 - 92,757,105 (-)RGD
Celera590,465,046 - 90,472,120 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032625   ⟸   NM_008599
- Peptide Label: precursor
- UniProtKB: Q8C9J0 (UniProtKB/Swiss-Prot),   Q99J60 (UniProtKB/Swiss-Prot),   P18340 (UniProtKB/Swiss-Prot),   Q8C9B8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000108716   ⟸   ENSMUST00000113093
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18340-F1-model_v2 AlphaFold P18340 1-126 view protein structure

Promoters
RGD ID:6887172
Promoter ID:EPDNEW_M7037
Type:multiple initiation site
Name:Cxcl9_1
Description:Mus musculus chemokine (C-X-C motif) ligand 9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38592,328,079 - 92,328,139EPDNEW
RGD ID:6837318
Promoter ID:MM_KWN:42889
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000031365,   NM_008599
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36592,756,704 - 92,757,204 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1352449 AgrOrtholog
Ensembl Genes ENSMUSG00000029417 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000113093 ENTREZGENE
  ENSMUST00000113093.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17329 UniProtKB/Swiss-Prot
MGD MGI:1352449 ENTREZGENE
NCBI Gene 17329 ENTREZGENE
PANTHER C-X-C MOTIF CHEMOKINE 9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cxcl9 PhenoGen
PRINTS SMALLCYTKCXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CXCL9_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U089_MOUSE UniProtKB/TrEMBL
  Q8C9B8 ENTREZGENE, UniProtKB/TrEMBL
  Q8C9J0 ENTREZGENE
  Q99J60 ENTREZGENE
UniProt Secondary Q8C9J0 UniProtKB/Swiss-Prot
  Q99J60 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Cxcl9  C-X-C motif chemokine ligand 9  Cxcl9  chemokine (C-X-C motif) ligand 9  Symbol and/or name change 5135510 APPROVED