CXCL10 (C-X-C motif chemokine ligand 10) - Rat Genome Database

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Gene: CXCL10 (C-X-C motif chemokine ligand 10) Homo sapiens
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Symbol: CXCL10
Name: C-X-C motif chemokine ligand 10
RGD ID: 1352024
HGNC Page HGNC
Description: Enables chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; regulation of leukocyte chemotaxis; and response to virus. Acts upstream of or within cellular response to lipopolysaccharide and positive regulation of T cell migration. Located in extracellular region. Implicated in hepatitis B and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C7; chemokine (C-X-C motif) ligand 10; crg-2; gamma IP10; gamma-IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; small-inducible cytokine B10
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,942,271 - 76,944,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute-On-Chronic Liver Failure  (IEP)
adult respiratory distress syndrome  (ISO)
alopecia areata  (EXP)
asthma  (IEP,ISO)
atopic dermatitis  (EXP)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (EXP)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (EXP,ISO)
bronchiolitis obliterans  (IEP,ISO)
cardiovascular system disease  (EXP)
Carrington Syndrome  (IEP)
celiac disease  (EXP)
cerebrovascular disease  (EXP)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (IEP)
Chronic Hepatitis B  (IEP)
Chronic Hepatitis C  (IEP)
chronic obstructive pulmonary disease  (IEP)
colon carcinoma  (ISO)
Colonic Neoplasms  (EXP)
common cold  (IEP)
coronary restenosis  (IEP)
Coronavirus infectious disease  (ISO)
COVID-19  (EXP,HEP,IEP)
cryoglobulinemia  (IEP)
Cytomegalovirus Infections  (IEP)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IEP)
encephalitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
extrinsic allergic alveolitis  (IEP,ISO)
fatty liver disease  (IEP)
Foot Ulcer  (IEP)
Graft vs Host Disease  (ISO)
hepatitis B  (IAGP)
hepatitis C  (IEP)
hepatocellular carcinoma  (IEP,ISO)
human immunodeficiency virus infectious disease  (IEP)
Human Influenza  (EXP)
Hypothermia  (ISO)
inhalation anthrax  (ISO)
interstitial cystitis  (EXP)
interstitial lung disease  (IEP)
ischemia  (ISO)
liver cirrhosis  (IEP)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
middle cerebral artery infarction  (IDA)
Middle East respiratory syndrome  (ISO)
myasthenia gravis  (IEP)
Myocardial Ischemia  (EXP)
myocarditis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (IEP,ISO)
pleurisy  (ISO)
pneumonia  (ISO)
primary biliary cholangitis  (EXP)
proteinuria  (ISO)
pulmonary emphysema  (IEP)
pulmonary sarcoidosis  (IEP)
pulmonary tuberculosis  (IEP)
renovascular hypertension  (ISO)
Reperfusion Injury  (IEP,ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
severe acute respiratory syndrome  (IEP,ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (EXP)
systemic scleroderma  (IEP)
thoracic aortic aneurysm  (IEP)
Thyroid Neoplasms  (EXP)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (IEP,ISO)
type 2 diabetes mellitus  (IEP)
uveitis  (ISO)
Viral Bronchiolitis  (IEP,ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP)
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrofluoranthene  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acrolein  (ISO)
acteoside  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alloxanthine  (EXP)
aluminium hydroxide  (EXP)
ammonium chloride  (ISO)
amorolfine  (EXP)
amoxicillin  (EXP)
amphetamine  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (EXP)
arsenous acid  (EXP)
asperentin  (ISO)
atorvastatin calcium  (ISO)
Aurin  (EXP)
bafilomycin A1  (EXP)
bazedoxifene  (ISO)
beclomethasone  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (EXP)
butenafine  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium phosphate  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
cefaloridine  (ISO)
celastrol  (EXP,ISO)
ceric oxide  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chloroquine  (EXP)
chondroitin sulfate  (EXP)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethoate  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (EXP)
doramapimod  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
eriodictyol  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fragrance  (EXP)
fulvestrant  (EXP,ISO)
furan  (ISO)
gadodiamide hydrate  (EXP,ISO)
gemfibrozil  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
halothane  (ISO)
heparan sulfate  (EXP)
heparin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP)
hydrazine  (ISO)
hydroxychloroquine  (EXP)
ibuprofen  (EXP)
imiquimod  (EXP)
immunological adjuvant  (EXP,ISO)
indometacin  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP)
isotretinoin  (EXP,ISO)
itraconazole  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
leptomycin B  (EXP)
levonorgestrel  (EXP)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lucanthone  (EXP)
Luliconazole  (EXP)
luteolin  (ISO)
LY294002  (ISO)
magnesium dihydroxide  (EXP)
manganese(II) chloride  (EXP)
melatonin  (ISO)
mercury dichloride  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
Muraglitazar  (ISO)
mycotoxin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naphthalene  (ISO)
naproxen  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
Nonylphenol  (ISO)
NS-398  (EXP)
oleic acid  (EXP)
ospemifene  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 168393  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP,ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propiconazole  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (EXP)
Pyridostigmine bromide  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
raloxifene  (ISO)
remdesivir  (EXP)
resiquimod  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (EXP)
roflumilast  (EXP)
rolipram  (EXP)
rotenone  (ISO)
rutin  (EXP)
ruxolitinib  (EXP)
S-nitrosoglutathione  (EXP)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP,ISO)
sterigmatocystin  (ISO)
succimer  (EXP,ISO)
sumatriptan  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
temozolomide  (EXP)
terbinafine  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
testosterone undecanoate  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trans-piceid  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
ursodeoxycholic acid  (ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA,IDA)
antiviral innate immune response  (IEP)
blood circulation  (TAS)
cell surface receptor signaling pathway  (TAS)
cell-cell signaling  (TAS)
cellular response to heat  (IEA,ISO)
cellular response to lipopolysaccharide  (IBA,IMP)
cellular response to virus  (IEP)
chemokine-mediated signaling pathway  (IBA,IMP)
chemotaxis  (IDA,IEA,TAS)
defense response  (IEA)
defense response to virus  (IEA,ISO)
endothelial cell activation  (IGI)
G protein-coupled receptor signaling pathway  (IMP)
immune response  (IEA,ISO)
inflammatory response  (IBA,IEA,TAS)
killing of cells of another organism  (IDA)
muscle organ development  (TAS)
negative regulation of angiogenesis  (IDA,IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of myoblast fusion  (IEA,ISO)
neutrophil chemotaxis  (IBA)
positive chemotaxis  (IEA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO,TAS)
positive regulation of leukocyte chemotaxis  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IDA)
positive regulation of release of sequestered calcium ion into cytosol  (IDA)
positive regulation of T cell migration  (IDA)
positive regulation of transcription by RNA polymerase II  (TAS)
regulation of apoptotic process  (IDA)
regulation of catalytic activity  (IEA)
regulation of cell population proliferation  (IDA)
regulation of endothelial tube morphogenesis  (IDA)
regulation of T cell chemotaxis  (IDA)
response to auditory stimulus  (IEA,ISO)
response to bacterium  (IEA,ISO)
response to cold  (IEA,ISO)
response to gamma radiation  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to virus  (IEA,ISO)
response to vitamin D  (IEA,ISO)
signal transduction  (TAS)
T cell chemotaxis  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:2437586   PMID:3925348   PMID:7540647   PMID:7566098   PMID:8145049   PMID:8423327   PMID:8608232   PMID:8798675   PMID:9022006   PMID:9060447   PMID:9462486   PMID:9705166  
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Genomics

Comparative Map Data
CXCL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,942,271 - 76,944,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
Cxcl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,494,497 - 92,496,748 (-)NCBIGRCm39mm39
GRCm39 Ensembl592,494,497 - 92,496,748 (-)Ensembl
GRCm38592,346,638 - 92,348,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,346,638 - 92,348,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,775,667 - 92,777,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36593,421,841 - 93,424,054 (-)NCBImm8
Celera590,490,436 - 90,492,644 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.57NCBI
Cxcl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21415,704,772 - 15,706,969 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1415,704,758 - 15,706,975 (+)Ensembl
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
RH 3.4 Map14182.09RGD
Cytogenetic Map14p22NCBI
Cxcl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433748,284 - 750,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433748,392 - 750,890 (-)NCBIChiLan1.0ChiLan1.0
CXCL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1454,020,204 - 54,022,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,020,204 - 54,022,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0448,182,355 - 48,184,733 (+)NCBIMhudiblu_PPA_v0panPan3
CXCL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132598,406 - 599,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32597,987 - 599,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,282,571 - 41,284,090 (+)NCBI
ROS_Cfam_1.032623,230 - 624,745 (-)NCBI
ROS_Cfam_1.0 Ensembl32622,462 - 624,803 (-)Ensembl
UMICH_Zoey_3.132622,982 - 624,501 (-)NCBI
UNSW_CanFamBas_1.032577,290 - 578,808 (-)NCBI
UU_Cfam_GSD_1.03239,590,894 - 39,592,413 (+)NCBI
Cxcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,442,665 - 11,446,615 (+)NCBI
SpeTri2.0NW_00493667660,869 - 63,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,829,909 - 75,831,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2875,881,457 - 75,882,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,526,657 - 24,529,193 (-)NCBIChlSab1.1chlSab2
ChlSab1.1724,526,657 - 24,529,193 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl724,526,680 - 24,529,130 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660372,868,983 - 2,871,422 (-)NCBIVero_WHO_p1.0
Cxcl10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475714,989,241 - 14,991,650 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
SHGC4-1008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,944,093 - 76,944,333UniSTSGRCh37
Build 36477,163,117 - 77,163,357RGDNCBI36
Celera474,244,850 - 74,245,090RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,696,543 - 72,696,783UniSTS
TNG Radiation Hybrid Map444004.0UniSTS
Stanford-G3 RH Map44279.0UniSTS
GeneMap99-G3 RH Map44263.0UniSTS
D4S3268  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,942,904 - 76,943,048UniSTSGRCh37
Build 36477,161,928 - 77,162,072RGDNCBI36
Celera474,243,660 - 74,243,804RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,695,355 - 72,695,499UniSTS
G33799  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,943,997 - 76,944,275UniSTSGRCh37
Build 36477,163,021 - 77,163,299RGDNCBI36
Celera474,244,754 - 74,245,032RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,696,447 - 72,696,725UniSTS
CXCL10__1179  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,942,204 - 76,942,989UniSTSGRCh37
Build 36477,161,228 - 77,162,013RGDNCBI36
Celera474,242,961 - 74,243,745RGD
HuRef472,694,655 - 72,695,440UniSTS
STS-X02530  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,942,613 - 76,942,749UniSTSGRCh37
Build 36477,161,637 - 77,161,773RGDNCBI36
Celera474,243,370 - 74,243,506RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,695,064 - 72,695,200UniSTS
GeneMap99-GB4 RH Map4433.89UniSTS
G33388  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,942,769 - 76,942,927UniSTSGRCh37
Build 36477,161,793 - 77,161,951RGDNCBI36
Celera474,243,525 - 74,243,683RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,695,220 - 72,695,378UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:236
Interacting mature miRNAs:251
Transcripts:ENST00000306602
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 4 3 4 5 3 1 3 1 19 3 1 1
Medium 208 175 298 149 473 142 304 48 227 140 247 505 10 160 135 1
Low 1203 1457 1094 359 754 249 2052 886 1705 227 705 787 117 684 1408 3 2
Below cutoff 810 1076 291 96 476 57 1336 959 1538 33 412 205 43 1 302 917 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000306602   ⟹   ENSP00000305651
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)Ensembl
RefSeq Acc Id: NM_001565   ⟹   NP_001556
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38476,021,118 - 76,023,497 (-)NCBI
GRCh37476,942,269 - 76,944,689 (-)ENTREZGENE
Build 36477,161,295 - 77,163,674 (-)NCBI Archive
HuRef472,694,720 - 72,697,139 (-)ENTREZGENE
CHM1_1476,918,847 - 76,921,265 (-)NCBI
Sequence:
RefSeq Acc Id: NR_168520
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38476,021,118 - 76,023,497 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001556 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH10954 (Get FASTA)   NCBI Sequence Viewer  
  CAA26370 (Get FASTA)   NCBI Sequence Viewer  
  EAX05772 (Get FASTA)   NCBI Sequence Viewer  
  EAX05773 (Get FASTA)   NCBI Sequence Viewer  
  P02778 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001556   ⟸   NM_001565
- Peptide Label: precursor
- UniProtKB: P02778 (UniProtKB/Swiss-Prot),   A0A024RDA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000305651   ⟸   ENST00000306602

Promoters
RGD ID:6867766
Promoter ID:EPDNEW_H7048
Type:initiation region
Name:CXCL10_1
Description:C-X-C motif chemokine ligand 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38476,023,497 - 76,023,557EPDNEW
RGD ID:6802236
Promoter ID:HG_KWN:48516
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000399485,   NM_001565
Position:
Human AssemblyChrPosition (strand)Source
Build 36477,163,374 - 77,163,874 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q21.1-21.23(chr4:75453111-84094295)x1 copy number loss See cases [RCV000050786] Chr4:75453111..84094295 [GRCh38]
Chr4:76378321..85015448 [GRCh37]
Chr4:76597345..85234472 [NCBI36]
Chr4:4q21.1-21.23
pathogenic
GRCh38/hg38 4q21.1(chr4:75729757-76160423)x1 copy number loss See cases [RCV000051054] Chr4:75729757..76160423 [GRCh38]
Chr4:76654941..77081576 [GRCh37]
Chr4:76873965..77300600 [NCBI36]
Chr4:4q21.1
uncertain significance
GRCh38/hg38 4q13.3-21.21(chr4:71128874-78099088)x3 copy number gain See cases [RCV000051774] Chr4:71128874..78099088 [GRCh38]
Chr4:71994591..79020242 [GRCh37]
Chr4:72213455..79239266 [NCBI36]
Chr4:4q13.3-21.21
pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3
pathogenic
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
Chr4:4q13.2-21.23
pathogenic
GRCh38/hg38 4q13.3-21.22(chr4:71079179-81802208)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|See cases [RCV000053295] Chr4:71079179..81802208 [GRCh38]
Chr4:71944896..82723361 [GRCh37]
Chr4:72163760..82942385 [NCBI36]
Chr4:4q13.3-21.22
pathogenic
GRCh38/hg38 4q13.3-22.1(chr4:74031395-90421127)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|See cases [RCV000053296] Chr4:74031395..90421127 [GRCh38]
Chr4:74897112..91342278 [GRCh37]
Chr4:75115976..91561301 [NCBI36]
Chr4:4q13.3-22.1
pathogenic
GRCh38/hg38 4q13.3-21.3(chr4:72262258-86002147)x3 copy number gain See cases [RCV000138312] Chr4:72262258..86002147 [GRCh38]
Chr4:73127975..86923300 [GRCh37]
Chr4:73346839..87142324 [NCBI36]
Chr4:4q13.3-21.3
pathogenic
GRCh38/hg38 4q21.1-21.21(chr4:75801143-79005805)x3 copy number gain See cases [RCV000141486] Chr4:75801143..79005805 [GRCh38]
Chr4:76722296..79926959 [GRCh37]
Chr4:76941320..80145983 [NCBI36]
Chr4:4q21.1-21.21
pathogenic
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
Chr4:4q13.2-22.3
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q13.3-21.1(chr4:74890695-77318961)x1 copy number loss not provided [RCV000682421] Chr4:74890695..77318961 [GRCh37]
Chr4:4q13.3-21.1
uncertain significance
GRCh37/hg19 4q13.3-21.1(chr4:75353931-77183033)x1 copy number loss not provided [RCV000682422] Chr4:75353931..77183033 [GRCh37]
Chr4:4q13.3-21.1
uncertain significance
GRCh37/hg19 4q21.1(chr4:76770579-76998151)x3 copy number gain not provided [RCV000682423] Chr4:76770579..76998151 [GRCh37]
Chr4:4q21.1
likely benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q13.3-21.23(chr4:72680879-86426232)x1 copy number loss not provided [RCV001005556] Chr4:72680879..86426232 [GRCh37]
Chr4:4q13.3-21.23
pathogenic
GRCh37/hg19 4q13.2-21.21(chr4:68950363-79738598)x1 copy number loss not provided [RCV001005553] Chr4:68950363..79738598 [GRCh37]
Chr4:4q13.2-21.21
pathogenic
GRCh37/hg19 4q13.3-21.1(chr4:71561780-78304341)x1 copy number loss not provided [RCV000846231] Chr4:71561780..78304341 [GRCh37]
Chr4:4q13.3-21.1
pathogenic
GRCh37/hg19 4q13.2-21.22(chr4:68242784-82991431)x3 copy number gain not provided [RCV000845944] Chr4:68242784..82991431 [GRCh37]
Chr4:4q13.2-21.22
pathogenic
NM_001565.4(CXCL10):c.85C>T (p.Arg29Cys) single nucleotide variant not provided [RCV000953209] Chr4:76022794 [GRCh38]
Chr4:76943947 [GRCh37]
Chr4:4q21.1
benign
NM_001565.4(CXCL10):c.243C>A (p.Ala81=) single nucleotide variant not provided [RCV000906715] Chr4:76022401 [GRCh38]
Chr4:76943554 [GRCh37]
Chr4:4q21.1
benign
GRCh37/hg19 4q21.1(chr4:76714825-76978984)x3 copy number gain not provided [RCV001259273] Chr4:76714825..76978984 [GRCh37]
Chr4:4q21.1
uncertain significance
GRCh37/hg19 4q13.3-21.3(chr4:71412409-87920784)x1 copy number loss See cases [RCV001263040] Chr4:71412409..87920784 [GRCh37]
Chr4:4q13.3-21.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10637 AgrOrtholog
COSMIC CXCL10 COSMIC
Ensembl Genes ENSG00000169245 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000305651 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000306602 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000169245 GTEx
HGNC ID HGNC:10637 ENTREZGENE
Human Proteome Map CXCL10 Human Proteome Map
InterPro Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:3627 UniProtKB/Swiss-Prot
NCBI Gene 3627 ENTREZGENE
OMIM 147310 OMIM
PANTHER PTHR10179 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35568 PharmGKB
PRINTS SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A0A024RDA4 ENTREZGENE
  CXL10_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q96QJ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CXCL10  C-X-C motif chemokine ligand 10  CXCL10  chemokine (C-X-C motif) ligand 10  Symbol and/or name change 5135510 APPROVED