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Gene: CXCL10 (C-X-C motif chemokine ligand 10) Homo sapiens
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Symbol: CXCL10
Name: C-X-C motif chemokine ligand 10
Description: Exhibits CXCR3 chemokine receptor binding activity; heparin binding activity; and receptor ligand activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of release of sequestered calcium ion into cytosol; and regulation of leukocyte migration. Localizes to extracellular region. Implicated in hepatitis B and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C7; chemokine (C-X-C motif) ligand 10; crg-2; gamma IP10; gamma-IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; small-inducible cytokine B10
Orthologs:
Mus musculus (house mouse) : Cxcl10 (chemokine (C-X-C motif) ligand 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cxcl10 (C-X-C motif chemokine ligand 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cxcl10 (C-X-C motif chemokine ligand 10)
Pan paniscus (bonobo/pygmy chimpanzee) : CXCL10 (C-X-C motif chemokine ligand 10)
Canis lupus familiaris (dog) : CXCL10 (C-X-C motif chemokine ligand 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cxcl10 (C-X-C motif chemokine ligand 10)
Sus scrofa (pig) : CXCL10 (C-X-C motif chemokine ligand 10)
Chlorocebus sabaeus (African green monkey) : CXCL10 (C-X-C motif chemokine ligand 10)
Heterocephalus glaber (naked mole-rat) : Cxcl10 (C-X-C motif chemokine ligand 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,942,269 - 76,944,689 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on CXCL10
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352024
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.