CXCL10 (C-X-C motif chemokine ligand 10) - Rat Genome Database

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Gene: CXCL10 (C-X-C motif chemokine ligand 10) Homo sapiens
Symbol: CXCL10
Name: C-X-C motif chemokine ligand 10
RGD ID: 1352024
Description: Enables chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; regulation of leukocyte chemotaxis; and response to virus. Acts upstream of or within cellular response to lipopolysaccharide and positive regulation of T cell migration. Located in extracellular region. Implicated in hepatitis B and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C7; chemokine (C-X-C motif) ligand 10; crg-2; gamma IP10; gamma-IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; small-inducible cytokine B10
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,942,271 - 76,944,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute-On-Chronic Liver Failure  (IEP)
adult respiratory distress syndrome  (ISO)
alopecia areata  (EXP)
asthma  (IEP,ISO)
atopic dermatitis  (EXP)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (EXP)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (EXP,ISO)
bronchiolitis obliterans  (IEP,ISO)
cardiovascular system disease  (EXP)
Carrington Syndrome  (IEP)
celiac disease  (EXP)
cerebrovascular disease  (EXP)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (IEP)
Chronic Hepatitis B  (IEP)
Chronic Hepatitis C  (IEP)
chronic obstructive pulmonary disease  (IEP)
colon carcinoma  (ISO)
Colonic Neoplasms  (EXP)
common cold  (IEP)
coronary restenosis  (IEP)
Coronavirus infectious disease  (ISO)
cryoglobulinemia  (IEP)
Cytomegalovirus Infections  (IEP)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IEP)
encephalitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP)
extrinsic allergic alveolitis  (IEP,ISO)
fatty liver disease  (IEP)
Foot Ulcer  (IEP)
Graft vs Host Disease  (ISO)
hepatitis B  (IAGP)
hepatitis C  (IEP)
hepatocellular carcinoma  (IEP,ISO)
human immunodeficiency virus infectious disease  (IEP)
Human Influenza  (EXP)
Hypothermia  (ISO)
inhalation anthrax  (ISO)
interstitial cystitis  (EXP)
interstitial lung disease  (IEP)
ischemia  (ISO)
liver cirrhosis  (IEP)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
middle cerebral artery infarction  (IDA)
Middle East respiratory syndrome  (ISO)
myasthenia gravis  (IEP)
Myocardial Ischemia  (EXP)
myocarditis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (IEP,ISO)
pleurisy  (ISO)
pneumonia  (ISO)
primary biliary cholangitis  (EXP)
proteinuria  (ISO)
pulmonary emphysema  (IEP)
pulmonary sarcoidosis  (IEP)
pulmonary tuberculosis  (IEP)
renovascular hypertension  (ISO)
Reperfusion Injury  (IEP,ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
severe acute respiratory syndrome  (IEP,ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (EXP)
systemic scleroderma  (IEP)
thoracic aortic aneurysm  (IEP)
Thyroid Neoplasms  (EXP)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (IEP,ISO)
type 2 diabetes mellitus  (IEP)
uveitis  (ISO)
Viral Bronchiolitis  (IEP,ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP)
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrofluoranthene  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acrolein  (ISO)
acteoside  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alloxanthine  (EXP)
aluminium hydroxide  (EXP)
ammonium chloride  (ISO)
amorolfine  (EXP)
amoxicillin  (EXP)
amphetamine  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apocynin  (EXP)
arsenous acid  (EXP)
asperentin  (ISO)
atorvastatin calcium  (ISO)
Aurin  (EXP)
bafilomycin A1  (EXP)
bazedoxifene  (ISO)
beclomethasone  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (EXP)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (EXP)
butenafine  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium phosphate  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
cefaloridine  (ISO)
celastrol  (EXP,ISO)
ceric oxide  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chloroquine  (EXP)
chondroitin sulfate  (EXP)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethoate  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (EXP)
doramapimod  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
eriodictyol  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fragrance  (EXP)
fulvestrant  (EXP,ISO)
furan  (ISO)
gadodiamide hydrate  (EXP,ISO)
gemfibrozil  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
halothane  (ISO)
heparan sulfate  (EXP)
heparin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP)
hydrazine  (ISO)
hydroxychloroquine  (EXP)
ibuprofen  (EXP)
imiquimod  (EXP)
immunological adjuvant  (EXP,ISO)
indometacin  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP)
isotretinoin  (EXP,ISO)
itraconazole  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
leptomycin B  (EXP)
levonorgestrel  (EXP)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lucanthone  (EXP)
Luliconazole  (EXP)
luteolin  (ISO)
LY294002  (ISO)
magnesium dihydroxide  (EXP)
manganese(II) chloride  (EXP)
melatonin  (ISO)
mercury dichloride  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
Muraglitazar  (ISO)
mycotoxin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naphthalene  (ISO)
naproxen  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
Nonylphenol  (ISO)
NS-398  (EXP)
oleic acid  (EXP)
ospemifene  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 168393  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP,ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propiconazole  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (EXP)
Pyridostigmine bromide  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
raloxifene  (ISO)
remdesivir  (EXP)
resiquimod  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (EXP)
roflumilast  (EXP)
rolipram  (EXP)
rotenone  (ISO)
rutin  (EXP)
ruxolitinib  (EXP)
S-nitrosoglutathione  (EXP)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP,ISO)
sterigmatocystin  (ISO)
succimer  (EXP,ISO)
sumatriptan  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
temozolomide  (EXP)
terbinafine  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
testosterone undecanoate  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trans-piceid  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
ursodeoxycholic acid  (ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA,IDA)
antiviral innate immune response  (IEP)
blood circulation  (TAS)
cell surface receptor signaling pathway  (TAS)
cell-cell signaling  (TAS)
cellular response to heat  (IEA,ISO)
cellular response to lipopolysaccharide  (IBA,IMP)
cellular response to virus  (IEP)
chemokine-mediated signaling pathway  (IBA,IMP)
chemotaxis  (IDA,IEA,TAS)
defense response  (IEA)
defense response to virus  (IEA,ISO)
endothelial cell activation  (IGI)
G protein-coupled receptor signaling pathway  (IMP)
immune response  (IEA,ISO)
inflammatory response  (IBA,IEA,TAS)
killing of cells of another organism  (IDA)
muscle organ development  (TAS)
negative regulation of angiogenesis  (IDA,IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of myoblast fusion  (IEA,ISO)
neutrophil chemotaxis  (IBA)
positive chemotaxis  (IEA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO,TAS)
positive regulation of leukocyte chemotaxis  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IDA)
positive regulation of release of sequestered calcium ion into cytosol  (IDA)
positive regulation of T cell migration  (IDA)
positive regulation of transcription by RNA polymerase II  (TAS)
regulation of apoptotic process  (IDA)
regulation of catalytic activity  (IEA)
regulation of cell population proliferation  (IDA)
regulation of endothelial tube morphogenesis  (IDA)
regulation of T cell chemotaxis  (IDA)
response to auditory stimulus  (IEA,ISO)
response to bacterium  (IEA,ISO)
response to cold  (IEA,ISO)
response to gamma radiation  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to virus  (IEA,ISO)
response to vitamin D  (IEA,ISO)
signal transduction  (TAS)
T cell chemotaxis  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
1. Abdullah F, etal., Surgery. 1997 Aug;122(2):303-12.
2. Abu El-Asrar AM, etal., Eur Cytokine Netw. 2006 Sep;17(3):155-65.
3. Agostini C, etal., J Immunol. 1998 Dec 1;161(11):6413-20.
4. Agostini C, etal., Respir Res. 2005 Feb 22;6:20.
5. Antonelli A, etal., Am J Gastroenterol. 2008 Oct;103(10):2488-94. doi: 10.1111/j.1572-0241.2008.02040.x. Epub 2008 Sep 4.
6. Antonelli A, etal., Diabet Med. 2008 Nov;25(11):1349-53.
7. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
8. Bonville CA, etal., Virology. 2007 Nov 10;368(1):182-90. Epub 2007 Jul 25.
9. Cai X and Castleman WL, Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1263-9. Epub 2003 Aug 8.
10. Chaitanya GV, etal., Neuropathology. 2008 Dec 24.
11. Chan CC, etal., PLoS One. 2012;7(12):e50577. doi: 10.1371/journal.pone.0050577. Epub 2012 Dec 5.
12. Chang YS, etal., Int J Mol Sci. 2020 Apr 30;21(9). pii: ijms21093179. doi: 10.3390/ijms21093179.
13. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
14. Chien JY, etal., Respirology. 2006 Nov;11(6):715-22.
15. Costa C, etal., Chest. 2008 Jan;133(1):26-33. Epub 2007 Oct 9.
16. Crawford MA, etal., PLoS Pathog. 2010 Nov 18;6(11):e1001199.
17. Cui A, etal., Respiration. 2010;80(5):372-8. Epub 2009 Oct 6.
18. Deng G, etal., Gastroenterology. 2008 Mar;134(3):716-26. doi: 10.1053/j.gastro.2007.12.044. Epub 2008 Jan 1.
19. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
20. Feferman T, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):87-95. Epub 2009 Feb 20.
21. Fine JS, etal., Inflammation. 2003 Aug;27(4):161-74.
22. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
23. Ganta CK, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R558-65.
24. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
25. GOA_HUMAN data from the GO Consortium
26. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
27. Han GD, etal., J Am Soc Nephrol. 2006 Feb;17(2):442-53. Epub 2005 Dec 28.
28. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
29. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
30. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
31. Hu Z, etal., Theranostics. 2017 May 2;7(7):1942-1952. doi: 10.7150/thno.16236. eCollection 2017.
32. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
33. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
34. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
35. Jha P, etal., Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1030-8.
36. Jiang Y, etal., Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7. doi: 10.1164/rccm.200407-857OC. Epub 2005 Jan 18.
37. Katoh S, etal., Int Arch Allergy Immunol. 2005 Jul;137(3):229-35. Epub 2005 Jun 13.
38. Kawamura A, etal., Circ J. 2003 Oct;67(10):851-4.
39. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
40. Khlaiphuengsin A, etal., Asian Pac J Allergy Immunol. 2019 Jan 13. doi: 10.12932/AP-050718-0365.
41. Kikuchi N, etal., Biol Pharm Bull. 2019 Jan 1;42(1):57-65. doi: 10.1248/bpb.b18-00538. Epub 2018 Nov 1.
42. Kim SY, etal., BMC Infect Dis. 2018 May 29;18(1):240. doi: 10.1186/s12879-018-3144-3.
43. Kishi J, etal., Eur Respir J. 2011 Aug;38(2):415-24. Epub 2011 Jan 27.
44. Ko FW, etal., Clin Exp Immunol. 2007 Mar;147(3):526-32.
45. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
46. Koniaris LG, etal., J Immunol. 2001 Jul 1;167(1):399-406. doi: 10.4049/jimmunol.167.1.399.
47. Kremlev SG, etal., J Neurosci Res. 2007 Aug 15;85(11):2450-9.
48. Kumaki Y, etal., Antivir Chem Chemother. 2010 Mar 9;20(4):169-77. doi: 10.3851/IMP1477.
49. Lamoury FM, etal., BMC Infect Dis. 2016 Jun 1;16:241. doi: 10.1186/s12879-016-1567-2.
50. Lehmann JM, etal., Liver Int. 2018 May;38(5):875-884. doi: 10.1111/liv.13610. Epub 2017 Nov 6.
51. Li CX, etal., J Hepatol. 2016 Nov;65(5):944-952. doi: 10.1016/j.jhep.2016.05.032. Epub 2016 May 28.
52. Li L, etal., Neoplasma. 2017;64(5):778-786. doi: 10.4149/neo_2017_517.
53. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
54. Lindell DM, etal., Eur J Immunol. 2008 Aug;38(8):2168-79.
55. Liu Z, etal., Transplant Proc. 2008 Jun;40(5):1300-2.
56. Lun SW, etal., J Clin Immunol. 2006 Mar;26(2):145-52. Epub 2006 Apr 7.
57. Ma Q, etal., Pharmacol Res. 2020 Apr 30;158:104850. doi: 10.1016/j.phrs.2020.104850.
58. Martin AP, etal., J Immunol. 2007 Apr 1;178(7):4623-31.
59. Matsumoto Y, etal., J Immunol. 2004 Sep 1;173(5):3535-41.
60. Medoff BD, etal., J Immunol. 2002 May 15;168(10):5278-86.
61. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
62. Meng X, etal., Cell Physiol Biochem. 2017;41(3):1063-1071. doi: 10.1159/000464114. Epub 2017 Feb 27.
63. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
64. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
65. Niewczas MA, etal., Clin J Am Soc Nephrol. 2009 Jan;4(1):62-70. Epub 2008 Dec 10.
66. Nishioka Y, etal., Clin Exp Immunol. 2007 Aug;149(2):317-26. Epub 2007 Jun 5.
67. Pipeline to import KEGG annotations from KEGG into RGD
68. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
69. Rau M, etal., PLoS One. 2018 Dec 3;13(12):e0208225. doi: 10.1371/journal.pone.0208225. eCollection 2018.
70. RGD automated import pipeline for gene-chemical interactions
71. Rhode A, etal., J Immunol. 2005 Sep 15;175(6):3516-24.
72. Richards TJ, etal., Arthritis Rheum. 2009 Jul;60(7):2183-92.
73. Riva A, etal., Hepatology. 2014 Aug;60(2):487-96. doi: 10.1002/hep.27139. Epub 2014 May 19.
74. Roe MF, etal., Pediatr Allergy Immunol. 2011 Mar;22(2):229-34. doi: 10.1111/j.1399-3038.2010.01032.x.
75. Rollag H, etal., PLoS One. 2013 Apr 8;8(4):e60767. doi: 10.1371/journal.pone.0060767. Print 2013.
76. Schulthess FT, etal., Cell Metab. 2009 Feb;9(2):125-39.
77. Shigihara T, etal., J Immunol. 2005 Dec 15;175(12):8401-8.
78. Shiozawa F, etal., Arthritis Res Ther. 2004;6(1):R78-R86. Epub 2003 Nov 19.
79. Spurrell JC, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Jul;289(1):L85-95. Epub 2005 Mar 11.
80. Steinmetz OM, etal., Am J Physiol Renal Physiol. 2007 Feb;292(2):F876-87. Epub 2006 Oct 24.
81. Stiles LN, etal., Autoimmunity. 2009 Sep;42(6):484-91. doi: 10.1080/08916930902810708.
82. Svensson M, etal., Infect Immun. 2005 Nov;73(11):7541-7. doi: 10.1128/IAI.73.11.7541-7547.2005.
83. Tabll A, etal., Hum Antibodies. 2019;27(4):265-273. doi: 10.3233/HAB-190381.
84. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
85. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
86. Valbuena G, etal., Am J Pathol. 2003 Oct;163(4):1357-69.
87. Villapol S, etal., Am J Pathol. 2015 Oct;185(10):2641-52. doi: 10.1016/j.ajpath.2015.06.016.
88. Wallace KL, etal., Blood. 2009 Jul 16;114(3):667-76. Epub 2009 May 11.
89. Wang J, etal., Hepatobiliary Pancreat Dis Int. 2008 Feb;7(1):45-50.
90. Wang X, etal., Mol Pharmacol 2000 Jun;57(6):1190-8.
91. Wang Y, etal., Sci Rep. 2017 Jan 9;7:40404. doi: 10.1038/srep40404.
92. Ward SE, etal., Antivir Ther. 2005;10(2):263-75.
93. Weigelt C, etal., Diabetes Care. 2009 Jun 9.
94. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
95. Wong CK, etal., Clin Exp Immunol. 2007 Jul;149(1):123-31. Epub 2007 Apr 11.
96. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
97. Yang XY, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Sep;29(9):587-90.
98. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
99. Zeng X, etal., Infect Immun. 2005 Dec;73(12):8226-36.
100. Zeremski M, etal., J Infect Dis. 2015 Jun 1;211(11):1795-9. doi: 10.1093/infdis/jiu807. Epub 2014 Dec 15.
101. Zhai Y, etal., Hepatology. 2008 Jan;47(1):207-14. doi: 10.1002/hep.21986.
102. Zhang X, etal., J Hepatol. 2014 Dec;61(6):1365-75. doi: 10.1016/j.jhep.2014.07.006. Epub 2014 Jul 15.
103. Zhang X, etal., Theranostics. 2017 Jul 8;7(11):2822-2836. doi: 10.7150/thno.19068. eCollection 2017.
104. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
PMID:2437586   PMID:3925348   PMID:7540647   PMID:7566098   PMID:8145049   PMID:8423327   PMID:8608232   PMID:8798675   PMID:9022006   PMID:9060447   PMID:9462486   PMID:9705166  
PMID:10201891   PMID:10201901   PMID:10233762   PMID:10903763   PMID:10982368   PMID:11083865   PMID:11110785   PMID:11157474   PMID:11390394   PMID:11401991   PMID:11467655   PMID:11559369  
PMID:11818520   PMID:11867072   PMID:11878903   PMID:11897701   PMID:12016104   PMID:12089333   PMID:12117914   PMID:12117926   PMID:12126650   PMID:12162873   PMID:12173928   PMID:12189440  
PMID:12270371   PMID:12356205   PMID:12384933   PMID:12393716   PMID:12441140   PMID:12445801   PMID:12477932   PMID:12539042   PMID:12571234   PMID:12584353   PMID:12603854   PMID:12663757  
PMID:12667820   PMID:12668159   PMID:12698106   PMID:12718750   PMID:12737818   PMID:12782716   PMID:12794718   PMID:12819030   PMID:12819903   PMID:12847218   PMID:12847282   PMID:12856973  
PMID:12884299   PMID:12930373   PMID:12946268   PMID:12949249   PMID:14550288   PMID:14600836   PMID:14630801   PMID:14739277   PMID:15063730   PMID:15081247   PMID:15081261   PMID:15150261  
PMID:15307834   PMID:15315758   PMID:15489334   PMID:15518810   PMID:15644410   PMID:15745922   PMID:15814716   PMID:15879427   PMID:15880073   PMID:15885315   PMID:15919935   PMID:15944327  
PMID:15988033   PMID:16181055   PMID:16200621   PMID:16210647   PMID:16243485   PMID:16484616   PMID:16490936   PMID:16507178   PMID:16581825   PMID:16645011   PMID:16697675   PMID:16733654  
PMID:16825597   PMID:16864907   PMID:16867276   PMID:16920957   PMID:16931519   PMID:16934957   PMID:16969644   PMID:17018607   PMID:17052298   PMID:17085967   PMID:17211148   PMID:17244787  
PMID:17250724   PMID:17255201   PMID:17360657   PMID:17364892   PMID:17467667   PMID:17505511   PMID:17541284   PMID:17628646   PMID:17652371   PMID:17668902   PMID:17763275   PMID:17763328  
PMID:17766680   PMID:17875534   PMID:17912012   PMID:17943641   PMID:17957030   PMID:17963704   PMID:17996064   PMID:18037659   PMID:18046562   PMID:18085351   PMID:18240029   PMID:18259970  
PMID:18275857   PMID:18281042   PMID:18282714   PMID:18379127   PMID:18415893   PMID:18424889   PMID:18538864   PMID:18569454   PMID:18645041   PMID:18647352   PMID:18682747   PMID:18684849  
PMID:18702954   PMID:18729739   PMID:18798334   PMID:18855195   PMID:18973545   PMID:18985732   PMID:18986693   PMID:19031697   PMID:19065267   PMID:19070948   PMID:19088500   PMID:19105984  
PMID:19134328   PMID:19155980   PMID:19175890   PMID:19181310   PMID:19195322   PMID:19203362   PMID:19223260   PMID:19258635   PMID:19274094   PMID:19281798   PMID:19327225   PMID:19342252  
PMID:19342664   PMID:19410617   PMID:19441886   PMID:19447045   PMID:19459809   PMID:19470579   PMID:19472212   PMID:19479051   PMID:19506876   PMID:19508602   PMID:19523460   PMID:19558503  
PMID:19590927   PMID:19639049   PMID:19641142   PMID:19694638   PMID:19756997   PMID:19800124   PMID:19817957   PMID:19821051   PMID:19827943   PMID:19880820   PMID:19887486   PMID:19901067  
PMID:19918044   PMID:19939453   PMID:19941336   PMID:19969087   PMID:20041150   PMID:20041963   PMID:20056178   PMID:20059481   PMID:20137269   PMID:20137825   PMID:20144041   PMID:20153790  
PMID:20164184   PMID:20186422   PMID:20186843   PMID:20187787   PMID:20299237   PMID:20302596   PMID:20404089   PMID:20473322   PMID:20485145   PMID:20485444   PMID:20523065   PMID:20525556  
PMID:20592450   PMID:20626297   PMID:20648615   PMID:20680966   PMID:20833730   PMID:20856926   PMID:20929277   PMID:20942936   PMID:20943047   PMID:20948191   PMID:20980518   PMID:21045270  
PMID:21054674   PMID:21062959   PMID:21099280   PMID:21106778   PMID:21167783   PMID:21183794   PMID:21191639   PMID:21219680   PMID:21254158   PMID:21270681   PMID:21274647   PMID:21303425  
PMID:21314817   PMID:21390311   PMID:21454254   PMID:21457060   PMID:21475065   PMID:21489350   PMID:21497908   PMID:21508508   PMID:21531038   PMID:21601475   PMID:21613464   PMID:21645215  
PMID:21649525   PMID:21708014   PMID:21725974   PMID:21802343   PMID:21811993   PMID:21812928   PMID:21849907   PMID:21873635   PMID:21897004   PMID:21906079   PMID:21912394   PMID:21958213  
PMID:21962843   PMID:21966356   PMID:22004287   PMID:22008312   PMID:22022583   PMID:22037980   PMID:22038159   PMID:22053613   PMID:22058116   PMID:22117591   PMID:22136974   PMID:22160826  
PMID:22168752   PMID:22178859   PMID:22192885   PMID:22367045   PMID:22390571   PMID:22393386   PMID:22401175   PMID:22471703   PMID:22472061   PMID:22491449   PMID:22496888   PMID:22562465  
PMID:22564606   PMID:22621182   PMID:22634718   PMID:22652417   PMID:22675025   PMID:22685032   PMID:22697070   PMID:22738089   PMID:22746298   PMID:22800603   PMID:22809599   PMID:22814248  
PMID:22892369   PMID:22896023   PMID:22905138   PMID:22975476   PMID:22989785   PMID:22996399   PMID:23011799   PMID:23012327   PMID:23024806   PMID:23034049   PMID:23056251   PMID:23065240  
PMID:23092582   PMID:23118425   PMID:23118858   PMID:23144331   PMID:23150742   PMID:23213058   PMID:23265968   PMID:23272100   PMID:23288171   PMID:23291247   PMID:23291435   PMID:23306067  
PMID:23312578   PMID:23322900   PMID:23333920   PMID:23352833   PMID:23376103   PMID:23383108   PMID:23437705   PMID:23458521   PMID:23502337   PMID:23505918   PMID:23535064   PMID:23542734  
PMID:23559389   PMID:23589576   PMID:23600831   PMID:23614810   PMID:23620790   PMID:23629827   PMID:23630573   PMID:23684765   PMID:23740952   PMID:23743311   PMID:23762283   PMID:23770038  
PMID:23776175   PMID:23838123   PMID:23873303   PMID:23899720   PMID:23902475   PMID:23905710   PMID:23975214   PMID:23977293   PMID:23994383   PMID:23998932   PMID:24023775   PMID:24025324  
PMID:24063316   PMID:24096630   PMID:24127910   PMID:24147028   PMID:24153332   PMID:24182907   PMID:24196705   PMID:24247066   PMID:24257594   PMID:24273934   PMID:24278230   PMID:24349056  
PMID:24407030   PMID:24430489   PMID:24438378   PMID:24451065   PMID:24464131   PMID:24499523   PMID:24582930   PMID:24586509   PMID:24600982   PMID:24609754   PMID:24659862   PMID:24670704  
PMID:24699306   PMID:24701034   PMID:24705033   PMID:24715380   PMID:24742347   PMID:24750380   PMID:24753255   PMID:24767350   PMID:24868552   PMID:24935307   PMID:24977661   PMID:24999581  
PMID:24999582   PMID:25013801   PMID:25033426   PMID:25064159   PMID:25135111   PMID:25157027   PMID:25175315   PMID:25203349   PMID:25221954   PMID:25222013   PMID:25251331   PMID:25342131  
PMID:25344904   PMID:25353097   PMID:25366387   PMID:25378811   PMID:25415223   PMID:25503583   PMID:25559603   PMID:25605650   PMID:25613532   PMID:25618120   PMID:25648521   PMID:25671296  
PMID:25693758   PMID:25702175   PMID:25713416   PMID:25741937   PMID:25760840   PMID:25765738   PMID:25769924   PMID:25811465   PMID:25839711   PMID:25856395   PMID:25858769   PMID:25930096  
PMID:25943894   PMID:25948873   PMID:25961500   PMID:25973761   PMID:25982097   PMID:26020377   PMID:26031809   PMID:26042934   PMID:26079660   PMID:26102027   PMID:26116899   PMID:26136521  
PMID:26153763   PMID:26253531   PMID:26275808   PMID:26285074   PMID:26317795   PMID:26336986   PMID:26339406   PMID:26339796   PMID:26346028   PMID:26361424   PMID:26385705   PMID:26406121  
PMID:26462839   PMID:26464192   PMID:26553462   PMID:26555697   PMID:26602091   PMID:26658573   PMID:26687629   PMID:26694099   PMID:26708691   PMID:26771653   PMID:26786652   PMID:26801009  
PMID:26827189   PMID:26831417   PMID:26861446   PMID:26881918   PMID:26895737   PMID:26907493   PMID:26910919   PMID:26950614   PMID:27002757   PMID:27012046   PMID:27034164   PMID:27152707  
PMID:27156612   PMID:27165799   PMID:27173614   PMID:27180202   PMID:27271043   PMID:27271323   PMID:27355513   PMID:27375180   PMID:27389865   PMID:27390897   PMID:27400932   PMID:27422384  
PMID:27428020   PMID:27450011   PMID:27470388   PMID:27490802   PMID:27498551   PMID:27503209   PMID:27522581   PMID:27541605   PMID:27548845   PMID:27551049   PMID:27574027   PMID:27585367  
PMID:27614982   PMID:27617644   PMID:27637385   PMID:27650493   PMID:27718226   PMID:27764787   PMID:27826704   PMID:27863059   PMID:27863395   PMID:27922126   PMID:27935598   PMID:27941826  
PMID:27955890   PMID:28051885   PMID:28074184   PMID:28077582   PMID:28111710   PMID:28122962   PMID:28142122   PMID:28146100   PMID:28148302   PMID:28205564   PMID:28233092   PMID:28234905  
PMID:28246678   PMID:28262979   PMID:28278706   PMID:28336310   PMID:28375674   PMID:28381538   PMID:28411045   PMID:28413983   PMID:28419006   PMID:28465448   PMID:28501799   PMID:28544362  
PMID:28592626   PMID:28610785   PMID:28614914   PMID:28698095   PMID:28717003   PMID:28744018   PMID:28753407   PMID:28802168   PMID:28808319   PMID:28855240   PMID:28862188   PMID:28880456  
PMID:28899907   PMID:28902772   PMID:28906016   PMID:29053336   PMID:29058291   PMID:29115683   PMID:29116188   PMID:29122683   PMID:29127442   PMID:29223680   PMID:29247155   PMID:29285564  
PMID:29528582   PMID:29532873   PMID:29549479   PMID:29559124   PMID:29663331   PMID:29764370   PMID:29795466   PMID:29853737   PMID:29860220   PMID:29902349   PMID:29980471   PMID:29987050  
PMID:30018088   PMID:30029901   PMID:30029914   PMID:30081186   PMID:30188739   PMID:30242057   PMID:30268671   PMID:30467622   PMID:30472104   PMID:30523038   PMID:30718282   PMID:30813187  
PMID:30851700   PMID:30974283   PMID:31059842   PMID:31072618   PMID:31209409   PMID:31216116   PMID:31388072   PMID:31412247   PMID:31421626   PMID:31440475   PMID:31440939   PMID:31440940  
PMID:31485460   PMID:31530029   PMID:31636098   PMID:31651197   PMID:31666025   PMID:31836011   PMID:31866063   PMID:31924747   PMID:31926497   PMID:32037509   PMID:32037514   PMID:32126552  
PMID:32165324   PMID:32228128   PMID:32238853   PMID:32240245   PMID:32363951   PMID:32417506   PMID:32446265   PMID:32446778   PMID:32515478   PMID:32587340   PMID:32641985   PMID:32701583  
PMID:32706090   PMID:32730345   PMID:32794336   PMID:32816891   PMID:32841529   PMID:32860784   PMID:32870689   PMID:32873571   PMID:32926524   PMID:32943658   PMID:32989803   PMID:33106516  
PMID:33118080   PMID:33121429   PMID:33236620   PMID:33236621   PMID:33253709   PMID:33260038   PMID:33326977   PMID:33337555   PMID:33345267   PMID:33362789   PMID:33378361   PMID:33387195  
PMID:33406104   PMID:33421057   PMID:33453262   PMID:33494515   PMID:33548977   PMID:33574564   PMID:33612760   PMID:33651323   PMID:33689775   PMID:33758270   PMID:33766427   PMID:33778831  
PMID:33809279   PMID:33810947   PMID:33841438   PMID:33845543   PMID:33865267   PMID:33930221   PMID:34101271   PMID:34158843   PMID:34205098   PMID:34217849   PMID:34220848   PMID:34271200  
PMID:34381047   PMID:34419254   PMID:34481469   PMID:34504204   PMID:34531848   PMID:34559160   PMID:34626520   PMID:34659199   PMID:34663207   PMID:34663639   PMID:34691031   PMID:34710089  
PMID:34710525   PMID:34794429   PMID:34830041   PMID:34902344   PMID:34916676  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,942,271 - 76,944,650 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39592,494,497 - 92,496,748 (-)NCBIGRCm39mm39
GRCm39 Ensembl592,494,497 - 92,496,748 (-)Ensembl
GRCm38592,346,638 - 92,348,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,346,638 - 92,348,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,775,667 - 92,777,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36593,421,841 - 93,424,054 (-)NCBImm8
Celera590,490,436 - 90,492,644 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.57NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21415,704,772 - 15,706,969 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1415,704,758 - 15,706,975 (+)Ensembl
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
RH 3.4 Map14182.09RGD
Cytogenetic Map14p22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955433748,284 - 750,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433748,392 - 750,890 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1454,020,204 - 54,022,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,020,204 - 54,022,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0448,182,355 - 48,184,733 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.132598,406 - 599,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32597,987 - 599,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,282,571 - 41,284,090 (+)NCBI
ROS_Cfam_1.032623,230 - 624,745 (-)NCBI
ROS_Cfam_1.0 Ensembl32622,462 - 624,803 (-)Ensembl
UMICH_Zoey_3.132622,982 - 624,501 (-)NCBI
UNSW_CanFamBas_1.032577,290 - 578,808 (-)NCBI
UU_Cfam_GSD_1.03239,590,894 - 39,592,413 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440528511,442,665 - 11,446,615 (+)NCBI
SpeTri2.0NW_00493667660,869 - 63,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,829,909 - 75,831,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2875,881,457 - 75,882,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1724,526,657 - 24,529,193 (-)NCBIChlSab1.1chlSab2
ChlSab1.1724,526,657 - 24,529,193 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl724,526,680 - 24,529,130 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660372,868,983 - 2,871,422 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462475714,989,241 - 14,991,650 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,944,093 - 76,944,333UniSTSGRCh37
Build 36477,163,117 - 77,163,357RGDNCBI36
Celera474,244,850 - 74,245,090RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,696,543 - 72,696,783UniSTS
TNG Radiation Hybrid Map444004.0UniSTS
Stanford-G3 RH Map44279.0UniSTS
GeneMap99-G3 RH Map44263.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,942,904 - 76,943,048UniSTSGRCh37
Build 36477,161,928 - 77,162,072RGDNCBI36
Celera474,243,660 - 74,243,804RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,695,355 - 72,695,499UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,943,997 - 76,944,275UniSTSGRCh37
Build 36477,163,021 - 77,163,299RGDNCBI36
Celera474,244,754 - 74,245,032RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,696,447 - 72,696,725UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,942,204 - 76,942,989UniSTSGRCh37
Build 36477,161,228 - 77,162,013RGDNCBI36
Celera474,242,961 - 74,243,745RGD
HuRef472,694,655 - 72,695,440UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,942,613 - 76,942,749UniSTSGRCh37
Build 36477,161,637 - 77,161,773RGDNCBI36
Celera474,243,370 - 74,243,506RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,695,064 - 72,695,200UniSTS
GeneMap99-GB4 RH Map4433.89UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37476,942,769 - 76,942,927UniSTSGRCh37
Build 36477,161,793 - 77,161,951RGDNCBI36
Celera474,243,525 - 74,243,683RGD
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map4p15.1-p14UniSTS
HuRef472,695,220 - 72,695,378UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:236
Interacting mature miRNAs:251
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 4 3 4 5 3 1 3 1 19 3 1 1
Medium 208 175 298 149 473 142 304 48 227 140 247 505 10 160 135 1
Low 1203 1457 1094 359 754 249 2052 886 1705 227 705 787 117 684 1408 3 2
Below cutoff 810 1076 291 96 476 57 1336 959 1538 33 412 205 43 1 302 917 1


Reference Sequences
RefSeq Acc Id: ENST00000306602   ⟹   ENSP00000305651
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)Ensembl
RefSeq Acc Id: NM_001565   ⟹   NP_001556
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38476,021,118 - 76,023,497 (-)NCBI
GRCh37476,942,269 - 76,944,689 (-)ENTREZGENE
Build 36477,161,295 - 77,163,674 (-)NCBI Archive
HuRef472,694,720 - 72,697,139 (-)ENTREZGENE
CHM1_1476,918,847 - 76,921,265 (-)NCBI
RefSeq Acc Id: NR_168520
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh38476,021,118 - 76,023,497 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001556 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH10954 (Get FASTA)   NCBI Sequence Viewer  
  CAA26370 (Get FASTA)   NCBI Sequence Viewer  
  EAX05772 (Get FASTA)   NCBI Sequence Viewer  
  EAX05773 (Get FASTA)   NCBI Sequence Viewer  
  P02778 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001556   ⟸   NM_001565
- Peptide Label: precursor
- UniProtKB: P02778 (UniProtKB/Swiss-Prot),   A0A024RDA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000305651   ⟸   ENST00000306602

RGD ID:6867766
Promoter ID:EPDNEW_H7048
Type:initiation region
Description:C-X-C motif chemokine ligand 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh38476,023,497 - 76,023,557EPDNEW
RGD ID:6802236
Promoter ID:HG_KWN:48516
SO ACC ID:SO:0000170
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000399485,   NM_001565
Human AssemblyChrPosition (strand)Source
Build 36477,163,374 - 77,163,874 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q21.1-21.23(chr4:75453111-84094295)x1 copy number loss See cases [RCV000050786] Chr4:75453111..84094295 [GRCh38]
Chr4:76378321..85015448 [GRCh37]
Chr4:76597345..85234472 [NCBI36]
GRCh38/hg38 4q21.1(chr4:75729757-76160423)x1 copy number loss See cases [RCV000051054] Chr4:75729757..76160423 [GRCh38]
Chr4:76654941..77081576 [GRCh37]
Chr4:76873965..77300600 [NCBI36]
uncertain significance
GRCh38/hg38 4q13.3-21.21(chr4:71128874-78099088)x3 copy number gain See cases [RCV000051774] Chr4:71128874..78099088 [GRCh38]
Chr4:71994591..79020242 [GRCh37]
Chr4:72213455..79239266 [NCBI36]
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
GRCh38/hg38 4q13.3-21.22(chr4:71079179-81802208)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|See cases [RCV000053295] Chr4:71079179..81802208 [GRCh38]
Chr4:71944896..82723361 [GRCh37]
Chr4:72163760..82942385 [NCBI36]
GRCh38/hg38 4q13.3-22.1(chr4:74031395-90421127)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|See cases [RCV000053296] Chr4:74031395..90421127 [GRCh38]
Chr4:74897112..91342278 [GRCh37]
Chr4:75115976..91561301 [NCBI36]
GRCh38/hg38 4q13.3-21.3(chr4:72262258-86002147)x3 copy number gain See cases [RCV000138312] Chr4:72262258..86002147 [GRCh38]
Chr4:73127975..86923300 [GRCh37]
Chr4:73346839..87142324 [NCBI36]
GRCh38/hg38 4q21.1-21.21(chr4:75801143-79005805)x3 copy number gain See cases [RCV000141486] Chr4:75801143..79005805 [GRCh38]
Chr4:76722296..79926959 [GRCh37]
Chr4:76941320..80145983 [NCBI36]
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
GRCh37/hg19 4q13.3-21.1(chr4:74890695-77318961)x1 copy number loss not provided [RCV000682421] Chr4:74890695..77318961 [GRCh37]
uncertain significance
GRCh37/hg19 4q13.3-21.1(chr4:75353931-77183033)x1 copy number loss not provided [RCV000682422] Chr4:75353931..77183033 [GRCh37]
uncertain significance
GRCh37/hg19 4q21.1(chr4:76770579-76998151)x3 copy number gain not provided [RCV000682423] Chr4:76770579..76998151 [GRCh37]
likely benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
GRCh37/hg19 4q13.3-21.23(chr4:72680879-86426232)x1 copy number loss not provided [RCV001005556] Chr4:72680879..86426232 [GRCh37]
GRCh37/hg19 4q13.2-21.21(chr4:68950363-79738598)x1 copy number loss not provided [RCV001005553] Chr4:68950363..79738598 [GRCh37]
GRCh37/hg19 4q13.3-21.1(chr4:71561780-78304341)x1 copy number loss not provided [RCV000846231] Chr4:71561780..78304341 [GRCh37]
GRCh37/hg19 4q13.2-21.22(chr4:68242784-82991431)x3 copy number gain not provided [RCV000845944] Chr4:68242784..82991431 [GRCh37]
NM_001565.4(CXCL10):c.85C>T (p.Arg29Cys) single nucleotide variant not provided [RCV000953209] Chr4:76022794 [GRCh38]
Chr4:76943947 [GRCh37]
NM_001565.4(CXCL10):c.243C>A (p.Ala81=) single nucleotide variant not provided [RCV000906715] Chr4:76022401 [GRCh38]
Chr4:76943554 [GRCh37]
GRCh37/hg19 4q21.1(chr4:76714825-76978984)x3 copy number gain not provided [RCV001259273] Chr4:76714825..76978984 [GRCh37]
uncertain significance
GRCh37/hg19 4q13.3-21.3(chr4:71412409-87920784)x1 copy number loss See cases [RCV001263040] Chr4:71412409..87920784 [GRCh37]

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10637 AgrOrtholog
Ensembl Genes ENSG00000169245 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000305651 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000306602 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000169245 GTEx
Human Proteome Map CXCL10 Human Proteome Map
InterPro Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:3627 UniProtKB/Swiss-Prot
OMIM 147310 OMIM
PANTHER PTHR10179 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35568 PharmGKB
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt Secondary Q96QJ5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CXCL10  C-X-C motif chemokine ligand 10  CXCL10  chemokine (C-X-C motif) ligand 10  Symbol and/or name change 5135510 APPROVED