CCL2 (C-C motif chemokine ligand 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CCL2 (C-C motif chemokine ligand 2) Homo sapiens
Analyze
Symbol: CCL2
Name: C-C motif chemokine ligand 2
RGD ID: 731046
HGNC Page HGNC:10618
Description: Predicted to enable CCR2 chemokine receptor binding activity and chemokine activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and regulation of apoptotic process. Located in extracellular region. Implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); liver disease (multiple); lung disease (multiple); nephritis (multiple); and retinal disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; MGC9434; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; monocyte secretory protein JE; SCYA2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small-inducible cytokine A2; SMC-CF
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,255,285 - 34,257,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,255,274 - 34,257,208 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,582,304 - 32,584,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,606,409 - 29,608,335 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,606,408 - 29,608,331NCBI
Celera1729,492,130 - 29,494,042 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,767,599 - 28,769,525 (+)NCBIHuRef
CHM1_11732,646,183 - 32,648,095 (+)NCBICHM1_1
T2T-CHM13v2.01735,201,562 - 35,203,480 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Anterior Uveitis  (IEP)
Acute Liver Failure  (IEP)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (IEP,ISO)
acute necrotizing pancreatitis  (ISO)
Acute-On-Chronic Liver Failure  (IEP)
adult respiratory distress syndrome  (EXP)
age related macular degeneration  (ISS)
aggressive periodontitis  (IAGP)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (IEP,ISO)
allergic conjunctivitis  (ISO)
allergic disease  (EXP)
anemia  (ISO)
Animal Hepatitis  (ISO)
anterior uveitis  (IAGP,ISO)
anti-basement membrane glomerulonephritis  (ISO)
arteriosclerosis  (ISO)
asthma  (EXP,IAGP,IEP,ISO)
atherosclerosis  (EXP,ISO)
autistic disorder  (IEP)
autoimmune hepatitis  (EXP)
Bacteremia  (IEP)
bacterial pneumonia  (ISO)
Behcet's disease  (IAGP,IEP)
bipolar disorder  (IAGP)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (EXP,ISO)
brain ischemia  (EXP,ISO)
Bronchial Hyperreactivity  (EXP,ISO)
bronchiolitis obliterans  (ISO)
calcinosis  (EXP)
cardiomyopathy  (ISO)
Cardiotoxicity  (EXP)
cardiovascular system disease  (EXP,IEP)
carotid artery disease  (EXP)
Carotid Artery Injuries  (IMP,ISO)
Carrington Syndrome  (IEP)
cerebral infarction  (ISO)
Chagas disease  (ISO)
Chemical and Drug Induced Liver Injury  (EXP,ISO)
cholangitis  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (IEP)
Chronic Hepatitis C  (IEP)
Chronic Intermittent Hypoxia  (ISO)
chronic obstructive pulmonary disease  (EXP,IEP)
Chronic Periodontitis  (IEP)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
colitis  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (IDA)
congenital diaphragmatic hernia  (EXP)
congestive heart failure  (EXP,ISO)
contact dermatitis  (ISO)
Contusions  (ISO)
coronary artery disease  (EXP,IAGP,IEP,ISO)
Coronary Artery Disease, Development of, in HIV  (IAGP)
Coronavirus infectious disease  (EXP)
COVID-19  (EXP,HEP,IEP)
crescentic glomerulonephritis  (ISO)
Crohn's disease  (EXP)
cryptococcosis  (ISO)
cutaneous leishmaniasis  (EXP)
cystic fibrosis  (IEP)
Delayed Hypersensitivity  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (EXP,IEP,ISO)
diabetic retinopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (EXP)
Duchenne muscular dystrophy  (EXP)
end stage renal disease  (EXP,IAGP,ISO)
Endometrial Neoplasms  (EXP)
endometriosis  (IEP)
endomyocardial fibrosis  (ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Orchitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (EXP,IMP,ISO)
Eye Neoplasms  (ISO)
familial hyperlipidemia  (IDA)
Febrile Neutropenia  (IEP)
fibromyalgia  (IEP)
fungal infectious disease  (IEP)
gastritis  (ISO)
genetic disease  (IAGP)
Geographic Atrophy  (IEP)
gestational diabetes  (IEP)
gliosarcoma  (ISO)
glomerulonephritis  (EXP)
Granulomatous Interstitial Nephritis  (ISO)
Granulomatous Vasculitis  (ISO)
Graves ophthalmopathy  (IEP)
Guillain-Barre syndrome  (IEP)
Hearing Loss, Noise-Induced  (ISO)
heart valve disease  (EXP)
hemarthrosis  (ISO)
hemolytic-uremic syndrome  (ISO)
Henoch-Schoenlein purpura  (IAGP,IEP)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (IDA,IEP,ISO)
herpes simplex  (ISO)
herpes simplex virus keratitis  (ISO)
human immunodeficiency virus infectious disease  (EXP,IAGP,IEP)
Human Influenza  (EXP,ISO)
Hyperalgesia  (EXP,ISO)
hyperglycemia  (EXP)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (EXP,ISO)
Hyperoxaluria  (EXP)
hypertension  (EXP,ISO)
Hypoxia  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (EXP,ISO)
Inflammatory Breast Neoplasms  (EXP)
influenza  (ISO)
Insulin Resistance  (EXP,IAGP,ISO)
interstitial lung disease  (IEP,ISO)
interstitial nephritis  (EXP)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
intracranial vasospasm  (ISO)
invasive aspergillosis  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
ischemia  (IAGP)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (IEP)
limited scleroderma  (ISO)
lipodystrophy  (IEP)
liver cirrhosis  (EXP,ISO)
liver disease  (EXP)
Liver Metastasis  (IEP)
Liver Reperfusion Injury  (ISO)
Lower Extremity Deep Vein Thrombosis  (IEP)
lung disease  (ISO)
Lung Injury  (EXP)
lupus nephritis  (IAGP,IEP)
Lyme Neuroborreliosis  (IEP)
macular degeneration  (IEP,ISO)
macular retinal edema  (IEP)
membranoproliferative glomerulonephritis  (ISO)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (EXP)
middle cerebral artery infarction  (EXP)
Middle East respiratory syndrome  (ISO)
Mouth Neoplasms  (EXP,IAGP)
multiple myeloma  (EXP)
Multiple Organ Failure  (ISO)
multiple sclerosis  (IAGP)
myocardial infarction  (IAGP,ISO)
Myocardial Ischemia  (EXP,ISO)
Myocardial Reperfusion Injury  (EXP,ISO)
myocarditis  (IEP)
Nasal Polyps  (IEP)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (ISO)
nephritis  (IEP)
neural tube defect  (EXP)
Neurodevelopmental Disorders  (IAGP)
obesity  (EXP,IEP,ISO)
obstructive jaundice  (ISO)
obstructive sleep apnea  (IEP)
oral squamous cell carcinoma  (IAGP,ISO)
orchitis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Pain  (ISO)
Painful Neuropathy  (ISO)
pancreatitis  (IMP,ISO)
Perennial Allergic Rhinitis  (IEP)
Peri-Implantitis  (IEP)
periapical periodontitis  (ISO)
Periodontal Cyst  (IEP)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Peritoneal Fibrosis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural disease  (EXP)
pneumocystosis  (IEP)
pneumonia  (EXP,ISO)
portal hypertension  (IEP)
Premature Obstetric Labor  (EXP)
proliferative diabetic retinopathy  (IAGP,IEP)
Pulmonary Contusion  (ISO)
pulmonary edema  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (IEP)
pulmonary fibrosis  (EXP,ISO)
pulmonary hypertension  (EXP,ISO)
pulmonary tuberculosis  (EXP,IAGP)
Reperfusion Injury  (EXP,ISO)
Respiratory Tract Granuloma  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (EXP)
retinal detachment  (IEP,ISO)
retinitis  (ISO)
rheumatoid arthritis  (IEP)
sarcoma  (ISO)
schizophrenia  (EXP)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (EXP,IEP,ISO)
silicosis  (EXP)
skin melanoma  (IAGP)
spina bifida  (EXP,IAGP)
Spinal Cord Compression  (EXP,ISO)
squamous cell carcinoma  (EXP)
status epilepticus  (EXP,ISO)
steatotic liver disease  (EXP,ISO)
Stroke  (IAGP,ISO)
systemic lupus erythematosus  (IAGP)
systemic scleroderma  (IEP)
temporal arteritis  (IAGP)
thrombocytopenia  (IAGP)
thyroid gland disease  (EXP)
Thyroid Neoplasms  (EXP)
toxic shock syndrome  (IEP)
transient cerebral ischemia  (ISO)
Transplant Rejection  (IAGP,ISO)
Triple Negative Breast Neoplasms  (EXP)
tuberculosis  (EXP,IAGP)
type 1 diabetes mellitus  (IEP,ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (EXP)
uveitis  (IEP,ISO)
Vasculitis of the Skin  (IAGP)
Venous Thrombosis  (ISO)
viral pneumonia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-abscisic acid  (EXP)
(+)-catechin  (EXP,ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(-)-anisomycin  (EXP)
(-)-Arctigenin  (ISO)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(24S)-24-hydroxycholesterol  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trimethylbenzene  (EXP)
1,3-benzothiazole-2-thiol  (EXP)
1,4-benzoquinone  (EXP)
1,4-naphthoquinone  (EXP)
1,4-phenylenediamine  (EXP,ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
13-HPODE  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-tert-butylhydroquinone  (EXP)
22-Hydroxycholesterol  (EXP)
24,25-Dihydroxyvitamin D  (EXP)
26-hydroxycholesterol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-(1H-indol-3-yl)propanoic acid  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4',5,7-Trimethoxyflavone  (EXP)
4'-hydroxydiclofenac  (EXP)
4'-Methoxychalcone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (EXP)
4-nitroquinoline N-oxide  (ISO)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (EXP)
7alpha-hydroxycholesterol  (EXP)
8-Br-cAMP  (EXP,ISO)
9-cis-retinoic acid  (EXP)
9-hydroxycanthin-6-one  (EXP)
acarbose  (ISO)
acetaldehyde  (EXP)
acetamide  (ISO)
acetoacetic acid  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylic acid  (ISO)
acrylonitrile  (EXP,ISO)
acteoside  (EXP)
actinomycin D  (EXP)
acyclovir  (EXP)
adenine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
AICA ribonucleotide  (ISO)
albendazole  (EXP)
alclometasone dipropionate  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alexidine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
allopurinol  (EXP,ISO)
alloxan  (EXP)
alloxanthine  (EXP)
allyl alcohol  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
alpha-naphthoflavone  (EXP)
aluminium hydroxide  (EXP)
aluminium oxide  (EXP)
ambroxol  (ISO)
amiloride  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlexanox  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amprenavir  (EXP)
anagliptin  (EXP)
andrographolide  (EXP,ISO)
Anemoside B4  (EXP)
angiotensin II  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
apocynin  (EXP)
Archazolid B  (EXP)
argatroban  (ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
asbestos  (EXP,ISO)
aspalathin  (EXP)
aspartame  (ISO)
astressin 2B  (ISO)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
aurantio-obtusin  (ISO)
azathioprine  (EXP)
azithromycin  (ISO)
Bardoxolone methyl  (EXP,ISO)
baricitinib  (EXP)
barium sulfate  (ISO)
bathocuproine disulfonic acid  (EXP)
beclomethasone  (EXP)
benazepril  (ISO)
benzalkonium chloride  (EXP,ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (EXP)
benzethonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzofurans  (EXP)
benzoic acid  (EXP)
benzylpenicillin  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beta-D-glucan  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
betamethasone  (EXP)
bezafibrate  (EXP,ISO)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boron nitride  (EXP)
bortezomib  (EXP)
BQ 123  (ISO)
Brevianamide A  (ISO)
bromodichloromethane  (ISO)
Bucillamine  (EXP)
budesonide  (EXP,ISO)
butanal  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (EXP)
Calcimycin  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium dichloride  (ISO)
calcium oxalate  (ISO)
calcium silicate  (ISO)
calcium(0)  (EXP)
Calphostin C  (EXP)
camostat  (ISO)
camptothecin  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
carmustine  (EXP)
carnosine  (ISO)
carrageenan  (ISO)
catechol  (EXP)
celecoxib  (ISO)
cephaeline  (EXP)
ceric oxide  (EXP,ISO)
cerivastatin  (EXP)
ceruletide  (ISO)
CGP 52608  (EXP)
chenodeoxycholic acid  (ISO)
chlorambucil  (EXP)
chlornitrofen  (ISO)
chlorobenzene  (EXP)
chloroethene  (ISO)
chloroform  (EXP)
chlorogenic acid  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP,ISO)
chondroitin sulfate  (EXP)
chromium(3+) trichloride  (EXP,ISO)
chromium(6+)  (EXP)
chrysin 5,7-dimethyl ether  (EXP)
ciguatoxin CTX1B  (ISO)
cilostazol  (EXP)
cimetidine  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citric acid  (EXP)
clobenpropit  (EXP)
clofibrate  (EXP)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
codeine  (EXP)
compound 48/80  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
coumermycin A1  (ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (EXP)
CU-O LINKAGE  (EXP)
cucurbitacin B  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (ISO)
dapagliflozin  (ISO)
daunorubicin  (EXP)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
dequalinium  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP,ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP,ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (EXP)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dienogest  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
digitoxigenin  (EXP)
digitoxin  (EXP)
digoxigenin  (EXP)
digoxin  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dimemorfan  (ISO)
dimethoate  (EXP)
dimethyl fumarate  (EXP,ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (EXP)
dimethylarsinous acid  (EXP)
diminazene diaceturate  (EXP)
dinitrogen  (EXP)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
dipyridamole  (ISO)
disulfiram  (EXP)
dobutamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
efavirenz  (EXP)
elemental selenium  (EXP)
ellagic acid  (EXP)
emetine  (EXP)
enalapril  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
enzacamene  (EXP)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
ergosterol  (ISO)
eriodictyol  (EXP)
erlotinib hydrochloride  (EXP)
erythromycin A  (ISO)
esculetin  (ISO)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethionamide  (ISO)
Ethyl icosapentate  (ISO)
ethylene glycol  (EXP,ISO)
ethylisopropylamiloride  (EXP)
eugenol  (EXP,ISO)
eupatilin  (ISO)
euxanthone  (EXP)
fasudil  (ISO)
febuxostat  (EXP)
felodipine  (ISO)
fenbendazole  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
ferric oxide  (EXP)
ferroheme b  (ISO)
ferulic acid  (ISO)
Fidarestat  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
flavone  (EXP)
flavonoids  (ISO)
flucloxacillin  (ISO)
fludrocortisone  (EXP)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
Fluridone  (EXP,ISO)
flutamide  (ISO)
fluticasone  (EXP)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP)
furan  (ISO)
Fusarenone X  (ISO)
gadodiamide hydrate  (EXP,ISO)
gadolinium trichloride  (ISO)
gallic acid  (ISO)
Garcinol  (EXP)
gefitinib  (EXP,ISO)
gemcitabine  (EXP)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gingerenone A  (EXP,ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glycerol  (EXP)
glycidol  (ISO)
glycine betaine  (ISO)
glycyrrhizinic acid  (ISO)
glyoxylic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
GW 4064  (ISO)
GW 501516  (EXP,ISO)
GW 7647  (EXP)
gypenoside LXXV  (ISO)
halothane  (ISO)
harmaline  (EXP)
heme b  (ISO)
hemin  (ISO)
heparin  (ISO)
hesperetin  (EXP)
Hexachloro-1,3-butadiene  (ISO)
hexadecanoic acid  (EXP,ISO)
Hexadimethrine bromide  (ISO)
histamine  (EXP)
homocysteine  (EXP)
Honokiol  (ISO)
HU-308  (EXP)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP,ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (EXP)
ibuprofen  (EXP,ISO)
icosanoid  (ISO)
Ile(5)-angiotensin II  (EXP)
imiquimod  (EXP)
indinavir  (EXP)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP,ISO)
iodixanol  (ISO)
iodoacetic acid  (EXP)
iohexol  (ISO)
ionomycin  (EXP)
irbesartan  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (EXP)
Isoangustone A  (EXP)
isoeugenol  (EXP)
isoflurane  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (ISO)
ketoconazole  (EXP,ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lanatoside C  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
Leonurine  (ISO)
leptomycin B  (EXP)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lidocaine  (EXP)
lignin  (ISO)
limonin  (ISO)
linoleic acid  (EXP)
linuron  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lithium chloride  (ISO)
loganin  (ISO)
lopinavir  (EXP)
lorcaserin  (ISO)
losartan  (EXP,ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
m-xylene  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manidipine  (ISO)
mebendazole  (EXP)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
meclocycline  (EXP)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
melamine  (EXP)
melatonin  (ISO)
mephedrone  (ISO)
mercury dichloride  (EXP,ISO)
metam  (ISO)
metformin  (EXP,ISO)
methadone  (ISO)
methapyrilene  (ISO)
methimazole  (EXP,ISO)
methionine sulfoximine  (EXP)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl methacrylate  (EXP)
methyl salicylate  (EXP)
Methylbenzethonium chloride  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
metyrapone  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (EXP,ISO)
mitomycin C  (EXP)
MJN110  (ISO)
MK 571  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
montelukast  (EXP,ISO)
morin  (ISO)
morphine  (ISO)
Morroniside  (ISO)
Muraglitazar  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,O-dimethyltyramine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-5'-carboxamidoadenosine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naloxone  (EXP)
naphthalene  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
naringin  (ISO)
nebivolol  (EXP)
nelfinavir  (EXP)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP,ISO)
nitrofen  (ISO)
nitrogen dioxide  (EXP,ISO)
nitroprusside  (ISO)
Nivalenol  (ISO)
nocodazole  (EXP)
nonane  (ISO)
Nonidet P-40  (EXP)
Nonylphenol  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP)
NSC 23766  (EXP)
obeticholic acid  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oroxylin A  (ISO)
ouabain  (ISO)
oxalic acid  (EXP)
oxaliplatin  (ISO)
oxytetracycline  (EXP)
ozone  (EXP,ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (EXP)
palmatine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (EXP,ISO)
PCB138  (ISO)
PD 168393  (EXP)
PD123319  (ISO)
pemetrexed  (EXP)
pentachlorophenol  (EXP)
pentanal  (EXP)
Pentoxifylline  (EXP,ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (EXP,ISO)
permethrin  (ISO)
PF-956980  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenol  (EXP)
phentermine  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phloretin  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (ISO)
phthalic anhydride  (ISO)
phylloquinone  (ISO)
physostigmine  (ISO)
phytoestrogen  (ISO)
picolinic acid  (EXP)
pioglitazone  (EXP,ISO)
piperidines  (EXP)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
plumbagin  (ISO)
poly(I:C)  (EXP,ISO)
polymyxin B2  (EXP,ISO)
pomalidomide  (EXP)
potassium chromate  (EXP)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
probucol  (EXP)
procyanidin B2  (ISO)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propan-2-ol  (EXP,ISO)
propanal  (EXP)
propidium  (EXP)
Proscillaridin  (EXP)
prostaglandin E2  (EXP,ISO)
prostaglandin I2  (EXP)
psicose  (EXP)
puromycin  (EXP)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrvinium  (EXP)
quartz  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP,ISO)
ramipril  (EXP)
razoxane  (ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (EXP)
remdesivir  (EXP)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (EXP)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (EXP)
rofecoxib  (EXP)
roflumilast  (EXP)
rolipram  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
rucaparib  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (EXP,ISO)
Salinomycin  (EXP)
Salmeterol xinafoate  (EXP)
salubrinal  (ISO)
saroglitazar  (EXP)
sarpogrelate  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH772984  (ISO)
scoparone  (EXP,ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
Sinomenine  (ISO)
sirtinol  (EXP)
SL-327  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium chlorate  (EXP)
sodium chloride  (EXP)
sodium cholate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
Sodium oleate  (EXP)
sodium stibogluconate  (EXP)
SR 144528  (EXP)
stavudine  (EXP)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
styrene  (EXP,ISO)
succimer  (EXP,ISO)
sucrose  (ISO)
sulfaphenazole  (EXP)
sulfapyridine  (EXP)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tagatose  (EXP)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (EXP)
terameprocol  (ISO)
terbinafine  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
Tetramethylthiourea  (ISO)
tetraphene  (EXP)
tetrathiomolybdate(2-)  (EXP,ISO)
thalidomide  (EXP)
thapsigargin  (EXP,ISO)
theophylline  (EXP)
thiamethoxam  (ISO)
thioacetamide  (EXP,ISO)
Tiopronin  (EXP)
Tiron  (EXP)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
tofacitinib  (EXP)
Tolmetin glucuronide  (EXP)
toluene  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
trans-isoeugenol  (EXP)
trans-piceid  (EXP)
tremolite asbestos  (ISO)
triamcinolone  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
Tungsten carbide  (EXP)
tunicamycin  (EXP,ISO)
undecane  (ISO)
uranium atom  (ISO)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (ISO)
valproic acid  (EXP)
valsartan  (EXP,ISO)
vanadyl sulfate  (EXP,ISO)
vanillin  (EXP)
vemurafenib  (EXP)
venetoclax  (EXP)
verteporfin  (ISO)
vincaleukoblastine  (ISO)
vincristine  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (EXP)
water  (ISO)
withaferin A  (EXP)
wortmannin  (ISO)
xanthohumol  (ISO)
XL147  (ISO)
Y-27632  (ISO)
zalcitabine  (ISO)
zidovudine  (EXP)
zileuton  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
ziram  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (TAS)
animal organ morphogenesis  (TAS)
animal organ regeneration  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA)
astrocyte cell migration  (IDA)
cell adhesion  (TAS)
cell chemotaxis  (IEA)
cell surface receptor signaling pathway  (TAS)
cell surface receptor signaling pathway via JAK-STAT  (TAS)
cellular homeostasis  (TAS)
cellular response to ATP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fatty acid  (ISO)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to glucose stimulus  (ISO)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-1  (IEP,ISO,ISS)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO,ISS)
cellular response to lipoprotein particle stimulus  (ISO)
cellular response to macrophage colony-stimulating factor stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to tumor necrosis factor  (IEP,ISO,ISS)
cellular response to type II interferon  (IEP,ISO,ISS)
cellular response to xenobiotic stimulus  (ISO)
chemokine-mediated signaling pathway  (IBA,ISO)
chemotaxis  (IEA,TAS)
chronic inflammatory response  (ISO)
cytokine-mediated signaling pathway  (IDA,ISO)
cytoskeleton organization  (IDA)
eosinophil chemotaxis  (IBA)
G protein-coupled receptor signaling pathway  (TAS)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (TAS)
glial cell migration  (ISO)
helper T cell extravasation  (ISS)
humoral immune response  (TAS)
immune response  (IEA)
inflammatory response  (IBA,IEA)
intracellular calcium ion homeostasis  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
lymphocyte chemotaxis  (ISO)
macrophage chemotaxis  (IDA,ISO)
mammary gland involution  (ISO)
maternal process involved in female pregnancy  (ISO)
maternal process involved in parturition  (ISO)
monocyte chemotaxis  (IDA)
negative regulation of angiogenesis  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IMP)
negative regulation of glial cell apoptotic process  (IDA)
negative regulation of natural killer cell chemotaxis  (IDA)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of vascular endothelial cell proliferation  (IMP)
neutrophil chemotaxis  (ISO)
osteoclast differentiation  (ISO)
positive regulation of apoptotic cell clearance  (ISS)
positive regulation of calcium ion import  (IDA)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (IBA)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cellular extravasation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of endothelial cell apoptotic process  (IMP)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immune complex clearance by monocytes and macrophages  (ISO)
positive regulation of leukocyte mediated cytotoxicity  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISS)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of synaptic transmission  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISS)
positive regulation of T cell activation  (ISS)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of wound healing  (ISO)
regulation of cell shape  (IDA)
regulation of vascular endothelial growth factor production  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to bacterium  (ISO,NAS)
response to cyclosporin A  (ISO)
response to ethanol  (ISO)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to hypoxia  (ISO)
response to isolation stress  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to progesterone  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin B3  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISS)
signal transduction  (IEA,NAS)
transforming growth factor beta receptor signaling pathway  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)
viral genome replication  (TAS)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury. Abcouwer SF, etal., J Neuroinflammation. 2013 Dec 10;10:149. doi: 10.1186/1742-2094-10-149.
2. Similar pattern of MCP-1 expression in spinal cords and eyes of Lewis rats with experimental autoimmune encephalomyelitis associated anterior uveitis. Adamus G, etal., J Neurosci Res. 1997 Nov 15;50(4):531-8.
3. MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythematosus. Aguilar F, etal., Tissue Antigens. 2001 Nov;58(5):335-8.
4. ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Aki K, etal., Am J Physiol Renal Physiol. 2010 Apr;298(4):F870-82. Epub 2010 Jan 13.
5. Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats. Al Masri AA and El Eter E, World J Gastroenterol. 2012 May 14;18(18):2188-96. doi: 10.3748/wjg.v18.i18.2188.
6. Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease. Alisi A, etal., Expert Rev Mol Diagn. 2014 Jul;14(6):763-71. doi: 10.1586/14737159.2014.928205. Epub 2014 Jun 13.
7. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Ambati J, etal., Nat Med. 2003 Nov;9(11):1390-7. Epub 2003 Oct 19.
8. MCP-1 gene haplotype association in biopsy proven giant cell arteritis. Amoli MM, etal., J Rheumatol. 2005 Mar;32(3):507-10.
9. Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation. Aoki T, etal., Stroke. 2009 Mar;40(3):942-51. Epub 2009 Jan 22.
10. Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia. Aquino VM, etal., J Pediatr Hematol Oncol. 2012 Aug;34(6):e241-5. doi: 10.1097/MPH.0b013e31824e498d.
11. Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. Arimura N, etal., Lab Invest. 2009 Mar;89(3):278-89. Epub 2009 Jan 12.
12. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. Ashwood P, etal., J Neuroimmunol. 2011 Mar;232(1-2):196-9. doi: 10.1016/j.jneuroim.2010.10.025. Epub 2010 Nov 20.
13. Elevated circulating levels of C-C chemokines in patients with congestive heart failure. Aukrust P, etal., Circulation. 1998 Mar 31;97(12):1136-43.
14. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. Auten RL, etal., Am J Respir Crit Care Med. 2009 Dec 15;180(12):1218-26. Epub 2009 Sep 17.
15. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Ayers CM, etal., Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):296-302. doi: 10.1002/alr.20046. Epub 2011 Apr 11.
16. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Baeck C, etal., Gut. 2012 Mar;61(3):416-26. doi: 10.1136/gutjnl-2011-300304. Epub 2011 Aug 3.
17. Effect of exercise on cardiac tissue oxidative and inflammatory mediators in chronic kidney disease. Bai Y, etal., Am J Nephrol. 2009;29(3):213-21. Epub 2008 Sep 17.
18. Revisiting the prognostic value of monocyte chemotactic protein 1 and interleukin-6 in the sepsis-3 era. Barre M, etal., J Crit Care. 2018 Feb;43:21-28. doi: 10.1016/j.jcrc.2017.08.024. Epub 2017 Aug 15.
19. Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection. Bauer CM, etal., PLoS One. 2010 Oct 12;5(10):e13251.
20. Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosis. Becker MJ, etal., J Antimicrob Chemother. 2003 Sep;52(3):428-34. Epub 2003 Aug 13.
21. MCP-1 and CCR2 gene variants in oral squamous cell carcinoma. Bektas-Kayhan K, etal., Oral Dis. 2012 Jan;18(1):55-9. doi: 10.1111/j.1601-0825.2011.01843.x. Epub 2011 Aug 24.
22. Nonsteroidal anti-inflammatory drug induces proinflammatory damage in gastric mucosa through NF-kappaB activation and neutrophil infiltration: anti-inflammatory role of heme oxygenase-1 against nonsteroidal anti-inflammatory drug. Bindu S, etal., Free Radic Biol Med. 2013 Dec;65:456-67. doi: 10.1016/j.freeradbiomed.2013.07.027. Epub 2013 Jul 23.
23. Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNFalpha), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia. Blanco I, etal., Clin Rheumatol. 2010 Feb;29(2):189-97. doi: 10.1007/s10067-009-1318-5. Epub 2009 Nov 19.
24. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
25. Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia. Blease K, etal., J Immunol. 2001 Feb 1;166(3):1832-42.
26. Chemokine MCP1/CCL2 gene polymorphism influences Henoch-Schonlein purpura susceptibility in Iranian Azeri-Turkish patients. Bonyadi M, etal., Int J Dermatol. 2015 Nov;54(11):1269-74. doi: 10.1111/ijd.12940. Epub 2015 Jul 30.
27. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Borges VM, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L586-95. Epub 2009 Jul 31.
28. Vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behcet's patients with venous thrombosis. Bozoglu E, etal., Clin Exp Rheumatol. 2005 Jul-Aug;23(4 Suppl 38):S42-8.
29. Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. Campanholle G, etal., Inflamm Res. 2010 Oct;59(10):861-9. Epub 2010 Apr 16.
30. Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver. Campbell SJ, etal., Am J Pathol. 2005 May;166(5):1487-97.
31. Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Catalan V, etal., Clin Endocrinol (Oxf). 2008 Feb;68(2):213-9. Epub 2007 Sep 4.
32. The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population. Cermakova Z, etal., Int J Immunogenet. 2005 Oct;32(5):315-8.
33. Sequential evaluation of serum monocyte chemotactic protein 1 among asymptomatic state and acute exacerbation and remission of asthma in children. Chan CK, etal., J Asthma. 2009 Apr;46(3):225-8.
34. Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia. Chao J, etal., Am J Respir Cell Mol Biol. 2011 Jul;45(1):53-61. doi: 10.1165/rcmb.2010-0264OC. Epub 2010 Sep 2.
35. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Chen MC, etal., Diabetologia. 2001 Mar;44(3):325-32.
36. Role of macrophage infiltration in the orbital fat of patients with Graves' ophthalmopathy. Chen MH, etal., Clin Endocrinol (Oxf). 2008 Aug;69(2):332-7. doi: 10.1111/j.1365-2265.2008.03219.x. Epub 2008 Feb 12.
37. CCR2-64I gene polymorphism increase susceptibility to oral cancer. Chen MK, etal., Oral Oncol. 2011 Jul;47(7):577-82. doi: 10.1016/j.oraloncology.2011.04.008. Epub 2011 May 12.
38. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. Chiu BC, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):106-16. Epub 2003 Jan 10.
39. Effect of Sipjeondaebo-tang on cancer-induced anorexia and cachexia in CT-26 tumor-bearing mice. Choi YK, etal., Mediators Inflamm. 2014;2014:736563. doi: 10.1155/2014/736563. Epub 2014 May 14.
40. An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Codullo V, etal., Ann Rheum Dis. 2011 Jun;70(6):1115-21. Epub 2011 Feb 1.
41. HIV-infected patients with lipodystrophy have higher rates of carotid atherosclerosis: the role of monocyte chemoattractant protein-1. Coll B, etal., Cytokine. 2006 Apr;34(1-2):51-5. Epub 2006 May 12.
42. Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury. Colombo G, etal., Shock. 2007 Mar;27(3):326-33.
43. Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease. Czaja MJ, etal., J Leukoc Biol. 1994 Jan;55(1):120-6.
44. Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats. Dai Q, etal., Br J Pharmacol. 2007 Dec;152(7):1042-8. Epub 2007 Oct 8.
45. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Dansereau MA, etal., J Neurochem. 2008 Jul;106(2):757-69. Epub 2008 Apr 17.
46. Microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina. Davies MH, etal., Mol Vis. 2006 May 10;12:467-77.
47. ETS-1 and ETS-2 are upregulated in a transgenic mouse model of pigmented ocular neoplasm. De la Houssaye G, etal., Mol Vis. 2008;14:1912-28. Epub 2008 Oct 29.
48. Systemic inflammation without gliosis mediates cognitive deficits through impaired BDNF expression in bile duct ligation model of hepatic encephalopathy. Dhanda S, etal., Brain Behav Immun. 2018 May;70:214-232. doi: 10.1016/j.bbi.2018.03.002. Epub 2018 Mar 5.
49. MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma. Dhaouadi T, etal., Iran J Allergy Asthma Immunol. 2013 Mar;12(1):29-36. doi: 012.01/ijaai.2936.
50. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
51. Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice. Dol F, etal., J Cardiovasc Pharmacol. 2001 Sep;38(3):395-405.
52. Upregulation of retinal neuronal MCP-1 in the rodent model of diabetic retinopathy and its function in vitro. Dong N, etal., Invest Ophthalmol Vis Sci. 2012 Nov 9;53(12):7567-75. doi: 10.1167/iovs.12-9446.
53. Monocyte chemoattractant protein 1 (MCP-1/CCL2) contributes to thymus atrophy in acute myeloid leukemia. Driss V, etal., Eur J Immunol. 2015 Feb;45(2):396-406. doi: 10.1002/eji.201444736. Epub 2014 Dec 4.
54. High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy. El-Asrar AM, etal., Mol Vis. 2011;17:1829-38. Epub 2011 Jul 6.
55. TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats. Elmarakby AA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R76-83. Epub 2007 Nov 7.
56. Expression of chemokine and receptors in Lewis rats with experimental autoimmune anterior uveitis. Fang IM, etal., Exp Eye Res. 2004 Jun;78(6):1043-55.
57. The role of the beta chemokines in experimental obliterative bronchiolitis. Farivar AS, etal., Exp Mol Pathol. 2003 Dec;75(3):210-6.
58. Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease. Fisher NC, etal., Gut. 1999 Sep;45(3):416-20. doi: 10.1136/gut.45.3.416.
59. Proinflammatory genetic profiles in subjects with history of ischemic stroke. Flex A, etal., Stroke. 2004 Oct;35(10):2270-5. Epub 2004 Aug 12.
60. Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein 1. Flory CM, etal., Lab Invest. 1993 Oct;69(4):396-404.
61. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
62. Urinary MCP-1/creatinine in Henoch-Schonlein purpura and its relationship with nephritis. Fuentes Y, etal., Pediatr Nephrol. 2014 Jun;29(6):1047-52. doi: 10.1007/s00467-013-2740-0. Epub 2014 Jan 12.
63. Monocyte chemotactic and activating factor/monocyte chemoattractant protein-1-mediated histamine release from human nasal mucosa. Fujikura T and Otsuka H, Arch Otolaryngol Head Neck Surg. 1998 Dec;124(12):1331-5.
64. Association of vitreous inflammatory factors with diabetic macular edema. Funatsu H, etal., Ophthalmology. 2009 Jan;116(1):73-9.
65. Enhanced expression and production of monocyte chemoattractant protein-1 in myocarditis. Fuse K, etal., Clin Exp Immunol. 2001 Jun;124(3):346-52.
66. Monocyte chemoattractant protein-1 is a mediator of acute excitotoxic injury in neonatal rat brain. Galasso JM, etal., Neuroscience. 2000;101(3):737-44.
67. Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals. Ganachari M, etal., PLoS One. 2010 Jan 25;5(1):e8881.
68. Spinal injection of TNF-alpha-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. Gao YJ, etal., Glia. 2010 Nov 15;58(15):1871-80. doi: 10.1002/glia.21056.
69. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. Garcia GE, etal., FASEB J. 2008 Feb;22(2):445-54. Epub 2007 Sep 26.
70. DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency. Ghonim MA, etal., J Allergy Clin Immunol. 2015 Feb;135(2):425-40. doi: 10.1016/j.jaci.2014.09.005. Epub 2014 Oct 19.
71. Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells. Giunti S, etal., Diabetologia. 2008 Jan;51(1):198-207. Epub 2007 Oct 30.
72. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
73. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
74. Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection. Goodyear A, etal., J Immunol. 2010 Feb 1;184(3):1445-54. Epub 2009 Dec 30.
75. Concentration of interferon-inducible T cell chemoattractant and monocyte chemotactic protein-1 in serum and cerebrospinal fluid of patients with Lyme borreliosis. Grygorczuk S, etal., Rocz Akad Med Bialymst. 2005;50:173-8.
76. Monocyte chemoattractant protein-1 (MCP-1/CCL2) in experimental autoimmune orchitis. Guazzone VA, etal., J Reprod Immunol 2003 Dec;60(2):143-57.
77. Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation. Guo W, etal., Neurosci Bull. 2012 Apr;28(2):193-207. doi: 10.1007/s12264-012-1218-6.
78. Relationship among MIF, MCP-1, viral loads, and HBs Ag levels in chronic hepatitis B patients. Güneş H, etal., Turk J Med Sci. 2015;45(3):634-7.
79. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
80. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
81. 22-Oxacalcitriol prevents progression of peritoneal fibrosis in a mouse model. Hirose M, etal., Perit Dial Int. 2013 Mar-Apr;33(2):132-42. doi: 10.3747/pdi.2011.00234. Epub 2012 Oct 2.
82. Sialic Acid Reduces Acute Endotoxemia-induced Liver Dysfunction in the Rat. Ho CH, etal., Shock. 2008 Dec 4.
83. The pathogenesis of pulmonary contusion: an open chest model in the rat. Hoth JJ, etal., J Trauma. 2006 Jul;61(1):32-44; discussion 44-5.
84. Monocyte chemoattractant protein-1 -2518 A/G single nucleotide polymorphism in Chinese Han patients with ocular Behcet's disease. Hou S, etal., Hum Immunol. 2010 Jan;71(1):79-82. doi: 10.1016/j.humimm.2009.09.354. Epub .
85. Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats. Hu JH, etal., Neurosci Lett. 2012 May 23;517(1):60-3. doi: 10.1016/j.neulet.2012.04.026. Epub 2012 Apr 15.
86. Expressions of HIF-1α and MiR-210 in aqueous humor of patients with central retinal vein occlusion combined with macular edema. Hu P, etal., Pak J Med Sci. 2022 May-Jun;38(5):1327-1332. doi: 10.12669/pjms.38.5.5092.
87. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
88. An interferon-gamma-related cytokine storm in SARS patients. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
89. Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice. Huang L, etal., Exp Neurol. 2018 Feb;300:41-50. doi: 10.1016/j.expneurol.2017.10.024. Epub 2017 Oct 27.
90. Chronic ethanol ingestion induces aortic inflammation/oxidative endothelial injury and hypertension in rats. Husain K, etal., Hum Exp Toxicol. 2010 Oct 4.
91. The therapeutic effect of nano-encapsulated and nano-emulsion forms of carvacrol on experimental liver fibrosis. Hussein J, etal., Biomed Pharmacother. 2017 Jun;90:880-887. doi: 10.1016/j.biopha.2017.04.020. Epub 2017 Apr 21.
92. Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-kappaB activation. Hwang SY, etal., Am J Physiol Renal Physiol. 2008 Jan;294(1):F236-44. Epub 2007 Oct 31.
93. Captopril suppresses inflammation in endotoxin-induced uveitis in rats. Ilieva I, etal., Exp Eye Res. 2006 Sep;83(3):651-7. Epub 2006 May 12.
94. Blocking of monocyte chemoattractant protein-1 (MCP-1) activity attenuates the severity of acute pancreatitis in rats. Ishibashi T, etal., J Gastroenterol. 2008;43(1):79-85. Epub 2008 Feb 24.
95. Hypoxic-ischemic injury induces monocyte chemoattractant protein-1 expression in neonatal rat brain. Ivacko J, etal., J Cereb Blood Flow Metab. 1997 Jul;17(7):759-70.
96. Assessment of genetic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in Japanese. Iwai N, etal., Circ J. 2006 Jul;70(7):805-9.
97. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
98. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Jain SK, etal., Antioxid Redox Signal. 2009 Feb;11(2):241-9.
99. Distinct chemokine and cytokine gene expression pattern of murine dendritic cells and macrophages in response to Mycobacterium tuberculosis infection. Jang S, etal., J Leukoc Biol. 2008 Nov;84(5):1264-70. Epub 2008 Aug 14.
100. Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats. Jee Y, etal., J Neuroimmunol. 2002 Jul;128(1-2):49-57.
101. Association of monocyte chemoattractant protein-1 (MCP-1) 2518A/G polymorphism with proliferative diabetic retinopathy in Korean type 2 diabetes. Jeon HJ, etal., Yonsei Med J. 2013 May 1;54(3):621-5. doi: 10.3349/ymj.2013.54.3.621.
102. Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain. Jeon SM, etal., Brain Res. 2009 Jan 28;1251:103-11. Epub 2008 Nov 27.
103. Expression of monocyte chemoattractant protein-1 and its induction by tumor necrosis factor receptor 1 in sensory neurons in the ventral rhizotomy model of neuropathic pain. Jeon SM, etal., Neuroscience. 2011 Sep 8;190:354-66. doi: 10.1016/j.neuroscience.2011.06.036. Epub 2011 Jun 25.
104. MIP-1alpha and MCP-1 Induce Migration of Human Umbilical Cord Blood Cells in Models of Stroke. Jiang L, etal., Curr Neurovasc Res. 2008 May;5(2):118-24.
105. Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome. Jiang Y, etal., Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7. doi: 10.1164/rccm.200407-857OC. Epub 2005 Jan 18.
106. [Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats] Jin HF, etal., Zhonghua Yi Xue Za Zhi. 2008 Aug 19;88(32):2235-9.
107. Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration. Jonas JB, etal., Arch Ophthalmol. 2010 Oct;128(10):1281-6. doi: 10.1001/archophthalmol.2010.227.
108. Potential role of monocyte chemoattractant protein 1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat. Jones ML, etal., J Immunol. 1992 Sep 15;149(6):2147-54.
109. Plasma and whole-blood chemokine levels in patients with Behcet's disease. Kaburaki T, etal., Graefes Arch Clin Exp Ophthalmol. 2003 May;241(5):353-8. Epub 2003 Apr 23.
110. Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer. Kagaya T, etal., Cancer Gene Ther. 2006 Apr;13(4):357-66.
111. Roles and relationship of macrophages and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the ischemic and reperfused rat heart. Kakio T, etal., Lab Invest. 2000 Jul;80(7):1127-36.
112. Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats. Kang ES, etal., Eur J Pharmacol. 2008 Jan 28;579(1-3):418-25. Epub 2007 Nov 1.
113. Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury. Kanngiesser M, etal., J Pain. 2012 May;13(5):485-97. doi: 10.1016/j.jpain.2012.02.010.
114. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1alpha and VEGF. Kaur J and Sanyal SN, Mol Carcinog. 2011 Jan 25. doi: 10.1002/mc.20736.
115. Monocyte chemoattractant protein-1-dependent increase of V alpha 14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection. Kawakami K, etal., J Immunol. 2001 Dec 1;167(11):6525-32.
116. Chemokine and chemokine receptor expression during experimental autoimmune uveoretinitis in mice. Keino H, etal., Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):111-5. Epub 2003 Jan 28.
117. Higher activity by opaque endometriotic lesions than nonopaque lesions. Khan KN, etal., Acta Obstet Gynecol Scand. 2004 Apr;83(4):375-82.
118. Neutrophils and reactive oxygen intermediates mediate glucan-induced pulmonary granuloma formation through the local induction of monocyte chemoattractant protein-1. Kilgore KS, etal., Lab Invest. 1997 Feb;76(2):191-201.
119. Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation. Kim B, etal., J Leukoc Biol. 2006 Dec;80(6):1405-15. Epub 2006 Sep 22.
120. Plasma levels of MCP-1 and adiponectin in obstructive sleep apnea syndrome. Kim J, etal., Arch Otolaryngol Head Neck Surg. 2010 Sep;136(9):896-9.
121. Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat. Kim JS, etal., J Neuroimmunol. 1995 Feb;56(2):127-34.
122. Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein. Kim Y, etal., J Biol Chem. 2012 Jul 27;287(31):25844-59. doi: 10.1074/jbc.M112.348284. Epub 2012 Jun 7.
123. Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Kimura H, etal., Lab Invest. 1998 May;78(5):571-81.
124. Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis. Kimura K, etal., J Diabetes Investig. 2019 May;10(3):659-666. doi: 10.1111/jdi.12964. Epub 2018 Dec 16.
125. Circulating levels of MCP-1 are increased in women with gestational diabetes. Klein K, etal., Prenat Diagn. 2008 Sep;28(9):845-51.
126. Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Ko GJ, etal., Nephrol Dial Transplant. 2008 Sep;23(9):2750-60. Epub 2008 Apr 3.
127. The role of monocyte chemoattractant protein-1 in biliary atresia. Kobayashi H, etal., J Pediatr Surg. 2006 Dec;41(12):1967-72. doi: 10.1016/j.jpedsurg.2006.08.018.
128. Angiotensin-receptor blockade reduces border zone myocardial monocyte chemoattractant protein-1 expression and macrophage infiltration in post-infarction ventricular remodeling. Kohno T, etal., Circ J. 2008 Oct;72(10):1685-92. Epub 2008 Aug 28.
129. Comparison of cytokine levels from undiluted vitreous of untreated patients with retinal vein occlusion. Koss MJ, etal., Acta Ophthalmol. 2012 Mar;90(2):e98-e103. doi: 10.1111/j.1755-3768.2011.02292.x. Epub 2011 Nov 8.
130. Association of serum MCP-1 concentration and MCP-1 polymorphism with insulin resistance in Japanese individuals with obese type 2 diabetes. Kouyama K, etal., Kobe J Med Sci. 2008 Feb 8;53(6):345-54.
131. Monocyte chemoattractant protein-1 in the aqueous humour of patients with age-related macular degeneration. Kramer M, etal., Clin Experiment Ophthalmol. 2012 Aug;40(6):617-25. doi: 10.1111/j.1442-9071.2011.02747.x. Epub 2012 Feb 20.
132. A Monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation. Kruger B, etal., J Am Soc Nephrol. 2002 Oct;13(10):2585-9.
133. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. Kuboyama K, etal., J Cereb Blood Flow Metab. 2011 Sep;31(9):1930-41. doi: 10.1038/jcbfm.2011.49. Epub 2011 Apr 13.
134. Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation? Kuwahara F, etal., Hypertension. 2004 Apr;43(4):739-45. Epub 2004 Feb 16.
135. HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection. Lamoury FM, etal., BMC Infect Dis. 2016 Jun 1;16:241. doi: 10.1186/s12879-016-1567-2.
136. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
137. Effect of glucocorticoid pretreatment on oxidative liver injury and survival in jaundiced rats with endotoxin cholangitis. Lee CW, etal., World J Surg. 2006 Dec;30(12):2217-26. doi: 10.1007/s00268-006-0143-0.
138. Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. Lee I, etal., J Immunol. 2003 Dec 15;171(12):6929-35.
139. Early up-regulation of chemokine expression in fulminant hepatic failure. Leifeld L, etal., J Pathol. 2003 Mar;199(3):335-44. doi: 10.1002/path.1298.
140. Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis. Li JH, etal., Saudi Med J. 2008 Aug;29(8):1088-94.
141. Colchicine Attenuates Inflammatory Cells Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy. Li JJ, etal., Am J Physiol Renal Physiol. 2009 Apr 15.
142. Intravenous transfusion of endothelial colony-forming cells attenuates vascular degeneration after cerebral aneurysm induction. Li S, etal., Brain Res. 2014 Dec 17;1593:65-75. doi: 10.1016/j.brainres.2014.09.077. Epub 2014 Oct 12.
143. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
144. Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation. Li X, etal., Invest Ophthalmol Vis Sci. 2014 Aug 26;55(10):6224-34. doi: 10.1167/iovs.14-14613.
145. Effects of bone marrow-derived endothelial progenitor cell transplantation on vein microenvironment in a rat model of chronic thrombosis. Li XQ, etal., Chin Med J (Engl). 2007 Dec 20;120(24):2245-9.
146. TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats. Lin ZP, etal., Mol Med Rep. 2020 Aug;22(2):651-660. doi: 10.3892/mmr.2020.11134. Epub 2020 May 7.
147. [Relationship between the level of MCP-1 expression in sera of RA patients and ILD]. Ling T, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Jan;26(1):59-60.
148. The expression of MCP-1 and CCR2 in induced rats periapical lesions. Liu L, etal., Arch Oral Biol. 2014 May;59(5):492-9. doi: 10.1016/j.archoralbio.2014.02.008. Epub 2014 Feb 22.
149. MCP1 -2518 polymorphism and chronic obstructive pulmonary disease in Taiwanese men. Liu SF, etal., Exp Lung Res. 2010 Jun;36(5):277-83.
150. Expression of monocyte chemoattractant protein-1 in the cerebral artery after experimental subarachnoid hemorrhage. Lu H, etal., Brain Res. 2009 Mar 25;1262:73-80. Epub 2009 Jan 21.
151. Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway. Ma Q, etal., Pharmacol Res. 2020 Apr 30;158:104850. doi: 10.1016/j.phrs.2020.104850.
152. Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury. Mak A and Uetrecht J, J Immunotoxicol. 2019 Jan 21:1-6. doi: 10.1080/1547691X.2018.1516014.
153. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Mandrekar P, etal., Hepatology. 2011 Dec;54(6):2185-97. doi: 10.1002/hep.24599.
154. Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus. Manley NC, etal., Brain Res. 2007 Nov 28;1182:138-43. Epub 2007 Sep 22.
155. Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors. Manome Y, etal., Cancer Immunol Immunother. 1995 Oct;41(4):227-35.
156. Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease. Marsillach J, etal., BMC Gastroenterol. 2009 Jan 14;9:3.
157. Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma. Marukawa Y, etal., Cancer Gene Ther. 2012 May;19(5):312-9. doi: 10.1038/cgt.2012.3. Epub 2012 Mar 9.
158. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Mathai SK, etal., Lab Invest. 2010 Jun;90(6):812-23. Epub 2010 Apr 19.
159. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
160. Increased monocyte chemoattractant protein 1 (MCP-1/CCL-2) serum level in acute myeloid leukemia. Mazur G, etal., Neoplasma. 2007;54(4):285-9.
161. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. McDermott DH, etal., Circulation. 2005 Aug 23;112(8):1113-20.
162. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. McGreal EP, etal., Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):649-58. Epub 2010 May 7.
163. Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries. Miller AP, etal., Circulation. 2004 Sep 21;110(12):1664-9. Epub 2004 Sep 7.
164. Persistent airway inflammation and emphysema progression on CT in ex-smokers observed for 4 years. Miller M, etal., Chest. 2010 Oct 21.
165. Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock. Minutoli L, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):272-80. Epub 2008 Apr 12.
166. Tumor progression is associated with increasing CD11b+ cells and CCL2 in Lewis rat sarcoma. Mishra R, etal., Anticancer Res. 2015 Feb;35(2):703-11.
167. In vivo effect of surfactant on inflammatory cytokines during endotoxin-induced lung injury in rodents. Mittal N and Sanyal SN, J Immunotoxicol. 2011 Oct-Dec;8(4):274-83. Epub 2011 Jul 18.
168. Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats. Miyazaki A, etal., Graefes Arch Clin Exp Ophthalmol. 2008 May;246(5):747-57. Epub 2007 Dec 18.
169. Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus. Moon JY, etal., J Korean Med Sci. 2007 Oct;22(5):810-4.
170. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. Na TY, etal., J Pathol. 2015 Apr;235(5):710-20. doi: 10.1002/path.4494. Epub 2015 Jan 5.
171. Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. Nakazawa T, etal., Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2425-30. Epub 2007 Feb 6.
172. MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis. Narasaraju T, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):732-43. Epub 2009 Jul 17.
173. Renal response to repetitive exposure to heme proteins: chronic injury induced by an acute insult. Nath KA, etal., Kidney Int. 2000 Jun;57(6):2423-33.
174. Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1. Nath KA, etal., Kidney Int. 2001 Jan;59(1):106-17.
175. Chemokine response in children with SARS. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
176. Lipid metabolism and inflammation modulated by Vitamin D in liver of diabetic rats. Ning C, etal., Lipids Health Dis. 2015 Apr 18;14:31. doi: 10.1186/s12944-015-0030-5.
177. Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice. Nio Y, etal., Diabetologia. 2012 Dec;55(12):3350-8. doi: 10.1007/s00125-012-2710-2. Epub 2012 Sep 16.
178. Effects of pitavastatin on monocyte chemoattractant protein-1 in hyperlipidemic patients. Nomura S, etal., Blood Coagul Fibrinolysis. 2009 Sep;20(6):440-7. doi: 10.1097/MBC.0b013e32832e0618.
179. Monocyte chemoattractant protein-1 is excreted in excessive amounts in the urine of patients with lupus nephritis. Noris M, etal., Lab Invest. 1995 Dec;73(6):804-9.
180. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. Ockinger J, etal., Genes Immun. 2010 Mar;11(2):142-54. Epub 2009 Oct 29.
181. Disruption of tumor necrosis factor-alpha gene diminishes the development of atherosclerosis in ApoE-deficient mice. Ohta H, etal., Atherosclerosis. 2005 May;180(1):11-7. Epub 2005 Jan 20.
182. Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. Olearczyk JJ, etal., Clin Sci (Lond). 2009 Jan;116(1):61-70.
183. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
184. Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Ono K, etal., Lab Invest. 1999 Feb;79(2):195-203.
185. Monocyte chemoattractant protein 1 and chemokine receptor CCR2 productions in Guillain-Barre syndrome and experimental autoimmune neuritis. Orlikowski D, etal., J Neuroimmunol. 2003 Jan;134(1-2):118-27.
186. Expression of monocyte chemoattractant protein-1 in proximal tubular epithelial cells in a rat model of progressive kidney failure. Ota T, etal., J Lab Clin Med. 2002 Jul;140(1):43-51.
187. IL-1 beta, IL-6, KC and MCP-1 are elevated in synovial fluid from haemophilic mice with experimentally induced haemarthrosis. Ovlisen K, etal., Haemophilia. 2009 May;15(3):802-10.
188. High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. Oyama Y, etal., Lab Invest. 2010 Jun;90(6):853-66. doi: 10.1038/labinvest.2010.64. Epub 2010 Mar 15.
189. Monocyte chemoattractant protein-1 promoter -2518 polymorphism may have an influence on clinical heterogeneity of bipolar I disorder in the Korean population. Pae CU, etal., Neuropsychobiology 2004;49(3):111-4.
190. Endogenous VEGF-A is responsible for mitogenic effects of MCP-1 on vascular smooth muscle cells. Parenti A, etal., Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1978-84. Epub 2003 Dec 23.
191. Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): impact of vehicle for topical induction. Pauluhn J Regul Toxicol Pharmacol. 2008 Feb;50(1):144-54. Epub 2007 Sep 21.
192. Possible new role of monocyte chemoattractant protein-1 in hemodialysis patients with cardiovascular disease. Pawlak K, etal., Am J Nephrol. 2004 Nov-Dec;24(6):635-40. Epub 2004 Dec 22.
193. Monocyte chemoattractant protein-1 -2518 A/G single nucleotide polymorphism might be associated with renal disease and thrombocytopenia of SLE. Piotrowski P, etal., J Biomed Biotechnol. 2010;2010:130265. doi: 10.1155/2010/130265. Epub 2010 Apr 21.
194. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
195. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
196. Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury. Prakash J, etal., J Am Soc Nephrol. 2008 Nov;19(11):2086-97. doi: 10.1681/ASN.2007070794. Epub 2008 Jul 23.
197. Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. Rachid MA, etal., Microbes Infect. 2006 Jul;8(8):2113-9. Epub 2006 Jun 6.
198. Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion. Raghavendran K, etal., J Surg Res. 2009 Aug;155(2):273-82. Epub 2008 Sep 16.
199. The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses. Raghavendran K, etal., Shock. 2005 Aug;24(2):132-8.
200. Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1. Rand ML, etal., Am J Pathol. 1996 Mar;148(3):855-64.
201. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
202. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
203. The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat. Rhodes JK, etal., J Neurotrauma. 2009 Apr;26(4):507-25.
204. Use of inflammatory molecules to predict the occurrence of fever in onco-hematological patients with neutropenia. Ribeiro AF, etal., Braz J Med Biol Res. 2013 Feb;46(2):200-6. Epub 2013 Feb 1.
205. Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats. Richard C, etal., J Cardiovasc Pharmacol. 2008 Sep;52(3):278-85.
206. Increased cytokines, chemokines and soluble adhesion molecules in exhaled breath condensate of asthmatic children. Robroeks CM, etal., Clin Exp Allergy. 2010 Jan;40(1):77-84.
207. Melanoma susceptibility and progression: Association study between polymorphisms of the chemokine (CCL2) and chemokine receptors (CX3CR1, CCR5). Rodero M, etal., J Dermatol Sci. 2007 Apr;46(1):72-6. Epub 2006 Dec 13.
208. MCP-1 and MIP3-alpha serum levels in acute liver failure and molecular adsorbent recirculating system (MARS) treatment: a pilot study. Roth GA, etal., Scand J Gastroenterol. 2009;44(6):745-51. doi: 10.1080/00365520902770086.
209. Therapeutic Effects of Evasin-1, a Chemokine Binding Protein, in Bleomycin-Induced Pulmonary Fibrosis. Russo RC, etal., Am J Respir Cell Mol Biol. 2010 Sep 10.
210. Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Ryan J, etal., Lab Invest. 2011 Dec;91(12):1727-38. doi: 10.1038/labinvest.2011.137. Epub 2011 Sep 5.
211. Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes mellitus and periodontitis: an experimental study in rats. Sakallioglu EE, etal., Clin Oral Investig. 2008 Mar;12(1):83-9. Epub 2007 Sep 18.
212. Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. Sarma NJ, etal., J Virol. 2014 Apr;88(7):3733-43. doi: 10.1128/JVI.03060-13. Epub 2014 Jan 15.
213. Increased expression of CCAAT/enhancer binding protein-beta and -delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats. Sato Y, etal., Diabetologia. 2007 Feb;50(2):481-9. Epub 2006 Dec 16.
214. Perioperative glycine treatment attenuates ischemia/reperfusion injury and ameliorates smooth muscle dysfunction in intestinal transplantation. Schaefer N, etal., Transplantation. 2008 May 15;85(9):1300-10.
215. The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats. Schafer A, etal., Br J Pharmacol. 2008 Jul;154(5):1047-54. Epub 2008 May 12.
216. Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients. Schmidt K, etal., Arthritis Res Ther. 2009;11(4):R111. Epub 2009 Jul 17.
217. Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-beta. Schneider A, etal., Kidney Int. 1999 Jul;56(1):135-44.
218. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Sennlaub F, etal., EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.
219. Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis. Shahrara S, etal., J Immunol. 2008 Mar 1;180(5):3447-56.
220. Altered serum transforming growth factor-beta1 and monocyte chemoattractant protein-1 levels in obstructive jaundice. Sheen-Chen SM, etal., World J Surg. 2004 Oct;28(10):967-70. Epub 2004 Sep 29.
221. Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6. Sheryanna A, etal., J Am Soc Nephrol. 2007 Apr;18(4):1167-79. Epub 2007 Feb 21.
222. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
223. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Shiraya S, etal., Atherosclerosis. 2009 Jan;202(1):34-40. Epub 2008 Apr 6.
224. Differential expression of chemokines and chemokine receptors in inflammatory periapical diseases. Silva TA, etal., Oral Microbiol Immunol. 2005 Oct;20(5):310-6.
225. Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal-copper, high-fructose diet in male rats. Song M, etal., Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1;308(11):G934-45. doi: 10.1152/ajpgi.00285.2014. Epub 2015 Mar 26.
226. The evolving systemic and local biomarker milieu at different stages of disease progression in rat adjuvant-induced arthritis. Stolina M, etal., J Clin Immunol. 2009 Mar;29(2):158-74. Epub 2008 Aug 26.
227. Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction. Stumpf C, etal., Clin Sci (Lond). 2009 Jan;116(1):45-52.
228. Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model. Takahashi M, etal., Clin Exp Metastasis. 2009;26(7):817-28. Epub 2009 Jul 24.
229. Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Tam FW, etal., Cytokine. 2009 Apr 29.
230. Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. Tanaka M, etal., J Heart Lung Transplant. 2005 Nov;24(11):1906-14. Epub 2005 Jul 27.
231. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain. Tanaka T, etal., Neurosci Res. 2004 Apr;48(4):463-9.
232. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
233. Cytokine profiles of bronchoalveolar lavage fluid in patients with pneumocystis pneumonia. Tasaka S, etal., Microbiol Immunol. 2010 Jul;54(7):425-33.
234. Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia. Tateno H, etal., Eur Respir J. 2001 May;17(5):962-8.
235. A laboratory model of toxin-induced hemolytic uremic syndrome. Taylor CM, etal., Kidney Int. 1999 Apr;55(4):1367-74.
236. Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. Teng KY, etal., Mol Cancer Ther. 2017 Feb;16(2):312-322. doi: 10.1158/1535-7163.MCT-16-0124. Epub 2016 Dec 15.
237. Altered chemokine response in an animal model of multiple organ dysfunction syndrome induced by zymosan. Thomas NJ, etal., J Pediatr Surg. 2005 Mar;40(3):464-9.
238. Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules. Tikellis C, etal., Atherosclerosis. 2008 Jul;199(1):55-64. Epub 2008 Feb 21.
239. Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. Tominaga T, etal., Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5181-8. doi: 10.1167/iovs.09-3637. Epub 2009 Jun 24.
240. Cardiopulmonary alterations in mRNA expression for interleukin-1beta, the interleukin-6 superfamily and CXC-chemokines during development of postischaemic heart failure in the rat. Tonnessen T, etal., Clin Physiol Funct Imaging. 2003 Sep;23(5):263-8.
241. Immune cell recruitment following acoustic trauma. Tornabene SV, etal., Hear Res. 2006 Dec;222(1-2):115-24. Epub 2006 Nov 1.
242. Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma. Tsuchiyama T, etal., Cancer Gene Ther. 2003 Apr;10(4):260-9. doi: 10.1038/sj.cgt.7700571.
243. Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats. Tsuruta S, etal., Int J Mol Med. 2004 Nov;14(5):837-42.
244. Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. Tucci M, etal., Arthritis Rheum. 2004 Jun;50(6):1842-9.
245. Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10. Tumpey TM, etal., J Leukoc Biol. 1998 Apr;63(4):486-92.
246. Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Tuo J, etal., Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3827-36.
247. Anti-monocyte chemoattractant protein-1 gene therapy inhibits restenotic changes (neointimal hyperplasia) after balloon injury in rats and monkeys. Usui M, etal., FASEB J. 2002 Nov;16(13):1838-40. Epub 2002 Sep 5.
248. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes. Venza I, etal., J Periodontol. 2010 Jan;81(1):99-108. doi: 10.1902/jop.2009.090358.
249. Chemokines in acute anterior uveitis. Verma MJ, etal., Curr Eye Res. 1997 Dec;16(12):1202-8.
250. Social isolation stress facilitates chemically induced oral carcinogenesis. Verza FA, etal., PLoS One. 2021 Jan 7;16(1):e0245190. doi: 10.1371/journal.pone.0245190. eCollection 2021.
251. Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. Vicentini L, etal., J Immunol. 2002 Jun 15;168(12):6446-54.
252. Distribution in ocular structures and optic pathways of immunocompetent and glial cells in an experimental allergic encephalomyelitis (EAE) relapsing model. Villarroya H, etal., J Neurosci Res. 2001 Mar 15;63(6):525-35.
253. Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis. Volpato M, etal., Oncotarget. 2016 May 10;7(19):28139-50. doi: 10.18632/oncotarget.8579.
254. Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1). Wada T, etal., FASEB J. 1996 Oct;10(12):1418-25.
255. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
256. Endothelial dysfunction, macrophage infiltration and NADPH oxidase-dependent superoxide production were attenuated by erythropoietin in streptozotocin-induced diabetic rat aorta. Wang J, etal., Pharmacology. 2013;91(1-2):48-58. doi: 10.1159/000343963. Epub 2012 Nov 15.
257. Clinical significance and different levels of urinary monocyte chemoattractant protein-1 in type 2 diabetes mellitus. Wang QY and Chen FQ, Diabetes Res Clin Pract. 2009 Feb;83(2):215-9. Epub 2008 Dec 20.
258. Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis. Wang Y, etal., Int Immunopharmacol. 2006 Dec 5;6(12):1825-32. Epub 2006 Aug 31.
259. Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats. Watts JA, etal., J Mol Cell Cardiol. 2006 Aug;41(2):296-307. Epub 2006 Jun 30.
260. Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis. Wegscheider BJ, etal., Mol Vis. 2005 Nov 1;11:896-900.
261. Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology. Wilkinson-Berka JL, etal., Circ Res. 2009 Jan 2;104(1):124-33. doi: 10.1161/CIRCRESAHA.108.176008. Epub 2008 Nov 26.
262. Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia. Wohlleben G, etal., J Immunol. 2003 May 1;170(9):4601-11.
263. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Wu H, etal., Kidney Int. 2005 Jun;67(6):2178-86.
264. Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells. Wu L, etal., Mol Endocrinol. 2004 Mar;18(3):666-78. Epub 2003 Dec 18.
265. Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. Wu Y, etal., J Pharmacol Sci. 2006 Aug;101(4):335-43. Epub 2006 Aug 5.
266. [Effects of N-acetylcysteine on mRNA expression of monocyte chemotactic protein and macrophage inflammatory protein 2 in acute necrotizing pancreatitis: experiment with rats] Xu CF, etal., Zhonghua Yi Xue Za Zhi. 2008 Mar 11;88(10):711-5.
267. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
268. Inhibition of laser-induced choroidal neovascularization by atorvastatin by downregulation of monocyte chemotactic protein-1 synthesis in mice. Yamada K, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1839-43.
269. A synthetic selective inhibitor of factor Xa, DX-9065a, reduces monocyte chemoattractant protein-1 expression after ischemia-reperfusion injury in rat liver. Yamaguchi Y, etal., Dig Dis Sci. 1999 Dec;44(12):2568-76. doi: 10.1023/a:1026667912632.
270. Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats. Yamaguchi Y, etal., Hepatology. 1998 Mar;27(3):727-34.
271. Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma. Yamamoto T and Nishioka K, J Invest Dermatol. 2003 Sep;121(3):510-6.
272. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Yang H, etal., Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(23):2817-20.
273. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
274. Chemokine gene polymorphisms in idiopathic anterior uveitis. Yeo TK, etal., Cytokine. 2006 Jul;35(1-2):29-35. Epub 2006 Sep 6.
275. Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells. Yisireyili M, etal., Nagoya J Med Sci. 2017 Nov;79(4):477-486. doi: 10.18999/nagjms.79.4.477.
276. Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. Yoshida Y, etal., Br J Ophthalmol. 2008 Jan;92(1):93-4. Epub 2007 Jun 25.
277. Chemokine MCP1/CCL2 and RANTES/CCL5 gene polymorphisms influence Henoch-Schonlein purpura susceptibility and severity. Yu HH, etal., J Formos Med Assoc. 2015 Apr;114(4):347-52. doi: 10.1016/j.jfma.2012.12.007. Epub 2013 Feb 1.
278. The role of redox status on chemokine expression in acute pancreatitis. Yubero S, etal., Biochim Biophys Acta. 2009 Feb;1792(2):148-54. Epub 2008 Dec 9.
279. Targeting peripheral immune response reduces the severity of necrotizing acute pancreatitis. Yubero S, etal., Crit Care Med. 2009 Jan;37(1):240-5. doi: 10.1097/CCM.0b013e31819320fc.
280. Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. Zeng Y, etal., Biol Pharm Bull. 2007 Aug;30(8):1438-44.
281. [Effects of astragalus on renal tubulointerestitial lesions and expression of NF-kappaB and MCP-1 in renal tissues in rat experimental IgA nephropathy] Zhang GZ, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10(2):173-8.
282. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. Zhang H, etal., J Nanobiotechnology. 2019 Feb 19;17(1):29. doi: 10.1186/s12951-019-0461-7.
283. CCL2-CCR2 signaling promotes hepatic ischemia/reperfusion injury. Zhang J, etal., J Surg Res. 2016 May 15;202(2):352-62. doi: 10.1016/j.jss.2016.02.029. Epub 2016 Mar 3.
284. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. Zhang K, etal., J Immunol. 1994 Nov 15;153(10):4733-41.
285. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. Zhang ZJ, etal., J Neuroinflammation. 2012 Jul 9;9:136. doi: 10.1186/1742-2094-9-136.
286. Anti-monocyte chemoattractant protein 1 gene therapy attenuates experimental chronic pancreatitis induced by dibutyltin dichloride in rats. Zhao HF, etal., Gut. 2005 Dec;54(12):1759-67.
287. The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats. Zhao LM, etal., Pflugers Arch. 2015 Nov;467(11):2275-85. doi: 10.1007/s00424-015-1694-4. Epub 2015 Feb 27.
288. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
289. Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese. Zhu XL, etal., Chin J Dent Res. 2010;13(2):109-14.
290. Serum monocyte chemoattractant protein-1 concentrations associate with diabetes status but not arterial stiffness in children with type 1 diabetes. Zineh I, etal., Diabetes Care. 2009 Mar;32(3):465-7. Epub 2008 Dec 17.
291. Therapeutic effects of dichloromethane fraction of Securidaca inappendiculata on adjuvant-induced arthritis in rat. Zuo J, etal., J Ethnopharmacol. 2014 Apr 28;153(2):352-8. doi: 10.1016/j.jep.2014.02.015. Epub 2014 Feb 26.
Additional References at PubMed
PMID:1661560   PMID:1857712   PMID:2004761   PMID:2071154   PMID:2322286   PMID:2357211   PMID:2465924   PMID:2501656   PMID:2513477   PMID:2518726   PMID:2648385   PMID:2923622  
PMID:7545673   PMID:7651403   PMID:8051410   PMID:8107690   PMID:8195247   PMID:8627182   PMID:8631787   PMID:8639605   PMID:8642344   PMID:8898111   PMID:8989326   PMID:9287323  
PMID:9364936   PMID:9405404   PMID:9407497   PMID:9501225   PMID:9548499   PMID:9558113   PMID:9670957   PMID:9789057   PMID:9792375   PMID:9792674   PMID:9837883   PMID:9973507  
PMID:10068657   PMID:10072545   PMID:10198043   PMID:10453044   PMID:10477718   PMID:10529171   PMID:10542238   PMID:10587439   PMID:10623817   PMID:10644332   PMID:10706668   PMID:10734104  
PMID:10751368   PMID:10770925   PMID:10918580   PMID:10925302   PMID:10982368   PMID:10985244   PMID:11083865   PMID:11145723   PMID:11154208   PMID:11313374   PMID:11350939   PMID:11500196  
PMID:11544456   PMID:11750041   PMID:11751881   PMID:11776402   PMID:11878903   PMID:11912219   PMID:11929421   PMID:11989790   PMID:11999660   PMID:12009356   PMID:12022754   PMID:12067898  
PMID:12078856   PMID:12082252   PMID:12089333   PMID:12093796   PMID:12117737   PMID:12127997   PMID:12149192   PMID:12183528   PMID:12186702   PMID:12195705   PMID:12204371   PMID:12207323  
PMID:12234797   PMID:12271471   PMID:12351486   PMID:12358851   PMID:12372466   PMID:12374865   PMID:12391099   PMID:12391196   PMID:12393171   PMID:12397639   PMID:12399623   PMID:12408680  
PMID:12410798   PMID:12413001   PMID:12419245   PMID:12443832   PMID:12460032   PMID:12462338   PMID:12470469   PMID:12473373   PMID:12477932   PMID:12485413   PMID:12488502   PMID:12505750  
PMID:12520153   PMID:12520365   PMID:12540965   PMID:12632067   PMID:12651071   PMID:12665582   PMID:12724308   PMID:12753088   PMID:12758167   PMID:12787135   PMID:12805068   PMID:12826189  
PMID:12826377   PMID:12846738   PMID:12904997   PMID:12944979   PMID:12946945   PMID:12957789   PMID:12960255   PMID:13679391   PMID:14517168   PMID:14517792   PMID:14550782   PMID:14571188  
PMID:14576080   PMID:14597108   PMID:14602575   PMID:14620921   PMID:14647058   PMID:14651522   PMID:14660607   PMID:14687706   PMID:14733721   PMID:14767014   PMID:15005768   PMID:15016614  
PMID:15022320   PMID:15033992   PMID:15041705   PMID:15067078   PMID:15077296   PMID:15081318   PMID:15082170   PMID:15110609   PMID:15115316   PMID:15123743   PMID:15135805   PMID:15167690  
PMID:15191525   PMID:15191888   PMID:15191916   PMID:15194470   PMID:15203564   PMID:15226634   PMID:15257681   PMID:15280531   PMID:15288699   PMID:15296827   PMID:15302103   PMID:15312962  
PMID:15349727   PMID:15389752   PMID:15466648   PMID:15468376   PMID:15481145   PMID:15488313   PMID:15489334   PMID:15529362   PMID:15545821   PMID:15579297   PMID:15599324   PMID:15602730  
PMID:15607028   PMID:15611878   PMID:15630704   PMID:15654958   PMID:15677312   PMID:15722361   PMID:15740484   PMID:15745922   PMID:15780578   PMID:15832427   PMID:15848524   PMID:15866653  
PMID:15880317   PMID:15883814   PMID:15900302   PMID:15919935   PMID:15976326   PMID:15979992   PMID:16003740   PMID:16004967   PMID:16009177   PMID:16009638   PMID:16020745   PMID:16034137  
PMID:16050950   PMID:16078996   PMID:16095529   PMID:16105652   PMID:16129702   PMID:16160188   PMID:16195477   PMID:16204411   PMID:16206161   PMID:16206198   PMID:16213182   PMID:16214031  
PMID:16230097   PMID:16249002   PMID:16278381   PMID:16280328   PMID:16307829   PMID:16309586   PMID:16318581   PMID:16351713   PMID:16352737   PMID:16356504   PMID:16359995   PMID:16362156  
PMID:16397773   PMID:16415174   PMID:16427785   PMID:16436595   PMID:16439461   PMID:16439481   PMID:16439891   PMID:16445900   PMID:16474202   PMID:16479072   PMID:16504689   PMID:16516290  
PMID:16518346   PMID:16524739   PMID:16597919   PMID:16609683   PMID:16631114   PMID:16636247   PMID:16636603   PMID:16672419   PMID:16697212   PMID:16697675   PMID:16705739   PMID:16712788  
PMID:16719905   PMID:16730843   PMID:16733654   PMID:16741188   PMID:16750572   PMID:16751386   PMID:16781696   PMID:16795034   PMID:16802342   PMID:16804844   PMID:16814297   PMID:16825597  
PMID:16828028   PMID:16835702   PMID:16867220   PMID:16872505   PMID:16873204   PMID:16903979   PMID:16934270   PMID:16939660   PMID:16980310   PMID:16988194   PMID:16997300   PMID:17008880  
PMID:17032917   PMID:17046994   PMID:17052731   PMID:17062130   PMID:17065190   PMID:17082648   PMID:17091019   PMID:17098977   PMID:17138827   PMID:17187019   PMID:17202846   PMID:17207568  
PMID:17218539   PMID:17262819   PMID:17280738   PMID:17283105   PMID:17307163   PMID:17322498   PMID:17364892   PMID:17376903   PMID:17379849   PMID:17384985   PMID:17390372   PMID:17395051  
PMID:17404035   PMID:17407231   PMID:17416748   PMID:17417600   PMID:17424890   PMID:17426779   PMID:17431224   PMID:17458901   PMID:17465499   PMID:17485071   PMID:17486299   PMID:17490777  
PMID:17495598   PMID:17522215   PMID:17525255   PMID:17530707   PMID:17582674   PMID:17596666   PMID:17625600   PMID:17694504   PMID:17700210   PMID:17703277   PMID:17703412   PMID:17704101  
PMID:17706208   PMID:17707134   PMID:17728497   PMID:17763208   PMID:17767550   PMID:17804911   PMID:17884268   PMID:17886678   PMID:17917677   PMID:17920586   PMID:17922439   PMID:17928143  
PMID:17934860   PMID:17940904   PMID:17943082   PMID:17949278   PMID:17968796   PMID:17975143   PMID:18021937   PMID:18022660   PMID:18032547   PMID:18040846   PMID:18042260   PMID:18055544  
PMID:18060801   PMID:18061474   PMID:18069114   PMID:18069417   PMID:18070228   PMID:18074388   PMID:18089573   PMID:18093183   PMID:18093816   PMID:18158188   PMID:18164957   PMID:18172114  
PMID:18186797   PMID:18190912   PMID:18191726   PMID:18203956   PMID:18205260   PMID:18208975   PMID:18230355   PMID:18242157   PMID:18266131   PMID:18266972   PMID:18270300   PMID:18271757  
PMID:18272603   PMID:18274642   PMID:18276775   PMID:18310503   PMID:18314120   PMID:18334747   PMID:18347511   PMID:18371304   PMID:18373164   PMID:18381789   PMID:18395486   PMID:18395775  
PMID:18402383   PMID:18436581   PMID:18439751   PMID:18443042   PMID:18458846   PMID:18469140   PMID:18495743   PMID:18506929   PMID:18508485   PMID:18515987   PMID:18521742   PMID:18522702  
PMID:18525219   PMID:18528529   PMID:18570214   PMID:18611860   PMID:18615095   PMID:18619701   PMID:18623207   PMID:18636124   PMID:18637012   PMID:18646053   PMID:18651322   PMID:18656701  
PMID:18660381   PMID:18660489   PMID:18665050   PMID:18678243   PMID:18684531   PMID:18690522   PMID:18702954   PMID:18710415   PMID:18718072   PMID:18758234   PMID:18784079   PMID:18790652  
PMID:18804983   PMID:18808740   PMID:18818748   PMID:18824549   PMID:18829011   PMID:18837094   PMID:18855195   PMID:18937353   PMID:18940815   PMID:18953909   PMID:18954908   PMID:18962899  
PMID:18976655   PMID:18976766   PMID:18977211   PMID:18996102   PMID:18996288   PMID:19001328   PMID:19002595   PMID:19009499   PMID:19014891   PMID:19017462   PMID:19019335   PMID:19020833  
PMID:19032843   PMID:19032844   PMID:19032966   PMID:19034671   PMID:19048368   PMID:19055601   PMID:19072670   PMID:19074885   PMID:19099590   PMID:19099689   PMID:19100389   PMID:19115220  
PMID:19132243   PMID:19136823   PMID:19147409   PMID:19148342   PMID:19152916   PMID:19154405   PMID:19155472   PMID:19156168   PMID:19166999   PMID:19167353   PMID:19168721   PMID:19170716  
PMID:19176388   PMID:19185603   PMID:19187096   PMID:19211266   PMID:19215923   PMID:19218821   PMID:19228389   PMID:19233564   PMID:19234509   PMID:19242604   PMID:19247692   PMID:19247801  
PMID:19258635   PMID:19258923   PMID:19267279   PMID:19277984   PMID:19281798   PMID:19287949   PMID:19288202   PMID:19298002   PMID:19317061   PMID:19327225   PMID:19328242   PMID:19332042  
PMID:19347053   PMID:19357773   PMID:19360344   PMID:19361458   PMID:19364494   PMID:19371341   PMID:19376162   PMID:19379593   PMID:19392835   PMID:19411748   PMID:19420105   PMID:19423540  
PMID:19426980   PMID:19439012   PMID:19441883   PMID:19441886   PMID:19443842   PMID:19446037   PMID:19450143   PMID:19458908   PMID:19465691   PMID:19479998   PMID:19494437   PMID:19496969  
PMID:19506371   PMID:19524871   PMID:19525388   PMID:19526283   PMID:19527514   PMID:19555664   PMID:19558503   PMID:19565503   PMID:19573434   PMID:19576791   PMID:19587356   PMID:19587833  
PMID:19625220   PMID:19628738   PMID:19632522   PMID:19639050   PMID:19641159   PMID:19642141   PMID:19642908   PMID:19644155   PMID:19646633   PMID:19658300   PMID:19664934   PMID:19668598  
PMID:19706805   PMID:19711822   PMID:19720836   PMID:19726280   PMID:19729601   PMID:19736361   PMID:19755790   PMID:19755933   PMID:19760754   PMID:19773451   PMID:19777601   PMID:19781192  
PMID:19781803   PMID:19819989   PMID:19822078   PMID:19828696   PMID:19833726   PMID:19844201   PMID:19851831   PMID:19864434   PMID:19866475   PMID:19881959   PMID:19885629   PMID:19893256  
PMID:19902472   PMID:19904283   PMID:19906815   PMID:19913121   PMID:19923858   PMID:19926874   PMID:19929093   PMID:19938194   PMID:19941075   PMID:19942750   PMID:19948975   PMID:19957783  
PMID:19995900   PMID:20000039   PMID:20004457   PMID:20016208   PMID:20029197   PMID:20029451   PMID:20031554   PMID:20038977   PMID:20040767   PMID:20041150   PMID:20041183   PMID:20056178  
PMID:20087947   PMID:20097750   PMID:20100200   PMID:20102417   PMID:20121167   PMID:20125127   PMID:20137666   PMID:20138641   PMID:20140679   PMID:20177146   PMID:20179890   PMID:20187772  
PMID:20193755   PMID:20196868   PMID:20221866   PMID:20228199   PMID:20231199   PMID:20237358   PMID:20237496   PMID:20299238   PMID:20299783   PMID:20339010   PMID:20339966   PMID:20349326  
PMID:20351714   PMID:20364004   PMID:20368224   PMID:20370601   PMID:20374368   PMID:20389059   PMID:20406462   PMID:20406964   PMID:20416077   PMID:20423879   PMID:20430117   PMID:20431065  
PMID:20432237   PMID:20437404   PMID:20438785   PMID:20442634   PMID:20446021   PMID:20449800   PMID:20449809   PMID:20451256   PMID:20452482   PMID:20484496   PMID:20485444   PMID:20488574  
PMID:20503287   PMID:20504881   PMID:20523065   PMID:20526368   PMID:20531015   PMID:20540976   PMID:20546673   PMID:20563852   PMID:20570966   PMID:20573518   PMID:20576301   PMID:20602615  
PMID:20605053   PMID:20607592   PMID:20610178   PMID:20617559   PMID:20625355   PMID:20628086   PMID:20634732   PMID:20637631   PMID:20650649   PMID:20673868   PMID:20677014   PMID:20681057  
PMID:20692455   PMID:20725607   PMID:20726788   PMID:20737475   PMID:20811626   PMID:20818133   PMID:20825374   PMID:20859200   PMID:20861640   PMID:20880493   PMID:20934684   PMID:20947712  
PMID:20950459   PMID:20960176   PMID:20962626   PMID:20965747   PMID:21033620   PMID:21037509   PMID:21072187   PMID:21073393   PMID:21087336   PMID:21097527   PMID:21102463   PMID:21107756  
PMID:21114970   PMID:21133811   PMID:21134984   PMID:21135144   PMID:21147091   PMID:21148795   PMID:21181544   PMID:21183736   PMID:21187454   PMID:21190865   PMID:21199725   PMID:21220697  
PMID:21224075   PMID:21247529   PMID:21251883   PMID:21264298   PMID:21327296   PMID:21328336   PMID:21354997   PMID:21361908   PMID:21368227   PMID:21376205   PMID:21383955   PMID:21384169  
PMID:21385934   PMID:21397653   PMID:21401388   PMID:21413027   PMID:21423810   PMID:21447688   PMID:21450101   PMID:21486440   PMID:21486949   PMID:21504590   PMID:21527853   PMID:21529268  
PMID:21529952   PMID:21532752   PMID:21551367   PMID:21556333   PMID:21569455   PMID:21574823   PMID:21610567   PMID:21615418   PMID:21620438   PMID:21627744   PMID:21654748   PMID:21691937  
PMID:21701898   PMID:21726903   PMID:21734368   PMID:21744268   PMID:21760952   PMID:21774078   PMID:21787749   PMID:21799302   PMID:21851000   PMID:21855541   PMID:21858104   PMID:21859809  
PMID:21868018   PMID:21868706   PMID:21873635   PMID:21890375   PMID:21898402   PMID:21900689   PMID:21906274   PMID:21910857   PMID:21920519   PMID:21924076   PMID:21930770   PMID:21951843  
PMID:21951854   PMID:21961038   PMID:21975431   PMID:21991356   PMID:21992868   PMID:22026334   PMID:22037282   PMID:22037980   PMID:22059352   PMID:22081934   PMID:22117412   PMID:22117820  
PMID:22125641   PMID:22131127   PMID:22132892   PMID:22138288   PMID:22142522   PMID:22147846   PMID:22152380   PMID:22159219   PMID:22183310   PMID:22197827   PMID:22203484   PMID:22210436  
PMID:22226505   PMID:22240432   PMID:22265030   PMID:22276574   PMID:22288595   PMID:22300682   PMID:22301094   PMID:22303443   PMID:22319587   PMID:22321225   PMID:22362506   PMID:22377751  
PMID:22378888   PMID:22381103   PMID:22384203   PMID:22396538   PMID:22412388   PMID:22420243   PMID:22422499   PMID:22425139   PMID:22427564   PMID:22448134   PMID:22466290   PMID:22472119  
PMID:22476561   PMID:22484917   PMID:22487967   PMID:22490648   PMID:22493691   PMID:22541401   PMID:22543850   PMID:22554651   PMID:22558273   PMID:22612293   PMID:22617682   PMID:22619484  
PMID:22640593   PMID:22641100   PMID:22664781   PMID:22669976   PMID:22691208   PMID:22694757   PMID:22697070   PMID:22707193   PMID:22711527   PMID:22729037   PMID:22733495   PMID:22739041  
PMID:22750227   PMID:22752804   PMID:22759858   PMID:22762377   PMID:22763298   PMID:22766373   PMID:22815949   PMID:22823210   PMID:22848642   PMID:22857869   PMID:22859936   PMID:22861370  
PMID:22868806   PMID:22927430   PMID:22942263   PMID:22942727   PMID:22961048   PMID:22980664   PMID:22981148   PMID:22985557   PMID:22989614   PMID:22992722   PMID:23007133   PMID:23017229  
PMID:23037589   PMID:23039889   PMID:23069648   PMID:23071112   PMID:23090289   PMID:23128233   PMID:23135705   PMID:23143679   PMID:23151275   PMID:23154550   PMID:23160182   PMID:23161207  
PMID:23166687   PMID:23180368   PMID:23185481   PMID:23185512   PMID:23190742   PMID:23192155   PMID:23206327   PMID:23211090   PMID:23224211   PMID:23228281   PMID:23255244   PMID:23274856  
PMID:23300810   PMID:23303452   PMID:23349788   PMID:23350010   PMID:23352833   PMID:23375122   PMID:23383108   PMID:23383162   PMID:23402987   PMID:23408426   PMID:23416968   PMID:23418647  
PMID:23427179   PMID:23429817   PMID:23434371   PMID:23474119   PMID:23490412   PMID:23515495   PMID:23529020   PMID:23542734   PMID:23548612   PMID:23555755   PMID:23557387   PMID:23559389  
PMID:23583295   PMID:23618428   PMID:23629827   PMID:23657965   PMID:23667177   PMID:23686489   PMID:23698775   PMID:23704830   PMID:23712703   PMID:23728617   PMID:23762283   PMID:23770363  
PMID:23771498   PMID:23782302   PMID:23816715   PMID:23831464   PMID:23836536   PMID:23845159   PMID:23845726   PMID:23886148   PMID:23887394   PMID:23890452   PMID:23916117   PMID:23924795  
PMID:23930970   PMID:23933403   PMID:23939977   PMID:23954399   PMID:23982944   PMID:23996571   PMID:23998687   PMID:23999007   PMID:24043886   PMID:24044867   PMID:24053559   PMID:24058270  
PMID:24059294   PMID:24077340   PMID:24078580   PMID:24083412   PMID:24086554   PMID:24147028   PMID:24162774   PMID:24164868   PMID:24183600   PMID:24184699   PMID:24185682   PMID:24246157  
PMID:24265821   PMID:24271554   PMID:24273921   PMID:24289089   PMID:24291552   PMID:24312451   PMID:24330528   PMID:24340030   PMID:24344240   PMID:24359561   PMID:24367564   PMID:24379347  
PMID:24382482   PMID:24418364   PMID:24451065   PMID:24463275   PMID:24480730   PMID:24489972   PMID:24495780   PMID:24503185   PMID:24531425   PMID:24531940   PMID:24550391   PMID:24578220  
PMID:24583146   PMID:24586454   PMID:24608713   PMID:24609754   PMID:24615033   PMID:24639350   PMID:24646773   PMID:24647150   PMID:24667918   PMID:24668612   PMID:24676787   PMID:24720638  
PMID:24727473   PMID:24764682   PMID:24782172   PMID:24786287   PMID:24788844   PMID:24809310   PMID:24813355   PMID:24840331   PMID:24862889   PMID:24875922   PMID:24878609   PMID:24905457  
PMID:24939570   PMID:24963148   PMID:24966899   PMID:24968246   PMID:24970800   PMID:24975639   PMID:24981451   PMID:24993819   PMID:24994463   PMID:25005456   PMID:25023776   PMID:25033895  
PMID:25036364   PMID:25039002   PMID:25044948   PMID:25051493   PMID:25060177   PMID:25063291   PMID:25064159   PMID:25095655   PMID:25119828   PMID:25120764   PMID:25121610   PMID:25149422  
PMID:25154422   PMID:25199511   PMID:25206284   PMID:25221954   PMID:25234163   PMID:25234717   PMID:25240755   PMID:25261725   PMID:25266801   PMID:25272052   PMID:25280384   PMID:25289731  
PMID:25312961   PMID:25318604   PMID:25323428   PMID:25329075   PMID:25336430   PMID:25340820   PMID:25345762   PMID:25370917   PMID:25406462   PMID:25411415   PMID:25413568   PMID:25433580  
PMID:25445541   PMID:25466836   PMID:25474480   PMID:25492482   PMID:25497142   PMID:25499426   PMID:25500149   PMID:25503251   PMID:25528160   PMID:25555372   PMID:25560580   PMID:25581570  
PMID:25593081   PMID:25608886   PMID:25613133   PMID:25620350   PMID:25639755   PMID:25648911   PMID:25655256   PMID:25666182   PMID:25683933   PMID:25704572   PMID:25711967   PMID:25721605  
PMID:25738355   PMID:25744294   PMID:25744730   PMID:25753871   PMID:25760046   PMID:25769927   PMID:25772168   PMID:25786118   PMID:25808810   PMID:25818534   PMID:25834072   PMID:25875728  
PMID:25890876   PMID:25893607   PMID:25901081   PMID:25902044   PMID:25913234   PMID:25917126   PMID:25940417   PMID:25943894   PMID:25943983   PMID:25962150   PMID:25966143   PMID:25966175  
PMID:25968940   PMID:25981750   PMID:25993304   PMID:26006043   PMID:26008233   PMID:26020416   PMID:26026089   PMID:26027727   PMID:26031809   PMID:26058873   PMID:26065367   PMID:26083329  
PMID:26093057   PMID:26095031   PMID:26100848   PMID:26104579   PMID:26124338   PMID:26125747   PMID:26155942   PMID:26158606   PMID:26163174   PMID:26183340   PMID:26223686   PMID:26241961  
PMID:26244388   PMID:26277553   PMID:26277777   PMID:26318885   PMID:26335292   PMID:26345838   PMID:26354107   PMID:26365696   PMID:26413869   PMID:26429304   PMID:26429331   PMID:26438062  
PMID:26455502   PMID:26490115   PMID:26494772   PMID:26504171   PMID:26514518   PMID:26518714   PMID:26556868   PMID:26573462   PMID:26587801   PMID:26603571   PMID:26604074   PMID:26625205  
PMID:26626202   PMID:26648448   PMID:26673018   PMID:26679085   PMID:26684239   PMID:26701136   PMID:26701731   PMID:26705742   PMID:26714421   PMID:26719799   PMID:26733169   PMID:26749463  
PMID:26757431   PMID:26767865   PMID:26787627   PMID:26802601   PMID:26825581   PMID:26839895   PMID:26867220   PMID:26879207   PMID:26881918   PMID:26885690   PMID:26908203   PMID:26909897  
PMID:26925413   PMID:26940485   PMID:26943967   PMID:26950614   PMID:26979087   PMID:26992429   PMID:26994898   PMID:27020638   PMID:27044356   PMID:27048855   PMID:27064875   PMID:27090943  
PMID:27125354   PMID:27129293   PMID:27145753   PMID:27160403   PMID:27167681   PMID:27171378   PMID:27177223   PMID:27259755   PMID:27270225   PMID:27278779   PMID:27283985   PMID:27288357  
PMID:27316788   PMID:27359339   PMID:27363047   PMID:27375180   PMID:27392463   PMID:27400932   PMID:27458015   PMID:27472286   PMID:27505625   PMID:27510015   PMID:27510253   PMID:27530322  
PMID:27530408   PMID:27541266   PMID:27548845   PMID:27558873   PMID:27605665   PMID:27614743   PMID:27624649   PMID:27666332   PMID:27668844   PMID:27749243   PMID:27788494   PMID:27819723  
PMID:27820834   PMID:27856463   PMID:27859608   PMID:27888616   PMID:27918953   PMID:27921117   PMID:27925202   PMID:27940361   PMID:27960564   PMID:27988512   PMID:27995732   PMID:28025034  
PMID:28038968   PMID:28043030   PMID:28045930   PMID:28054838   PMID:28074184   PMID:28077158   PMID:28095095   PMID:28104240   PMID:28131166   PMID:28161330   PMID:28164676   PMID:28170001  
PMID:28202856   PMID:28215642   PMID:28330776   PMID:28336215   PMID:28341837   PMID:28347237   PMID:28381538   PMID:28383062   PMID:28391993   PMID:28407300   PMID:28427824   PMID:28433894  
PMID:28458180   PMID:28472164   PMID:28472795   PMID:28501927   PMID:28610785   PMID:28618950   PMID:28623996   PMID:28655771   PMID:28690186   PMID:28691415   PMID:28707148   PMID:28730964  
PMID:28765037   PMID:28765968   PMID:28790030   PMID:28843961   PMID:28852897   PMID:28860098   PMID:28886122   PMID:28886321   PMID:28914666   PMID:28928376   PMID:28951461   PMID:29023999  
PMID:29057937   PMID:29073812   PMID:29084208   PMID:29086194   PMID:29098933   PMID:29107385   PMID:29115520   PMID:29132256   PMID:29133591   PMID:29145242   PMID:29154245   PMID:29164336  
PMID:29167233   PMID:29171996   PMID:29194906   PMID:29205349   PMID:29288710   PMID:29295871   PMID:29352259   PMID:29358188   PMID:29369549   PMID:29390552   PMID:29409972   PMID:29414320  
PMID:29451067   PMID:29458367   PMID:29461240   PMID:29568096   PMID:29579545   PMID:29594759   PMID:29609686   PMID:29664944   PMID:29694633   PMID:29702196   PMID:29720895   PMID:29722145  
PMID:29739040   PMID:29760459   PMID:29768320   PMID:29794013   PMID:29808619   PMID:29864522   PMID:29871779   PMID:29901584   PMID:29995756   PMID:30001635   PMID:30048972   PMID:30109559  
PMID:30142333   PMID:30175654   PMID:30229833   PMID:30230985   PMID:30237493   PMID:30284076   PMID:30296742   PMID:30339714   PMID:30343691   PMID:30357416   PMID:30368555   PMID:30368911  
PMID:30374624   PMID:30380100   PMID:30401716   PMID:30419802   PMID:30528869   PMID:30530386   PMID:30537206   PMID:30539387   PMID:30551392   PMID:30557342   PMID:30586705   PMID:30683902  
PMID:30730243   PMID:30764873   PMID:30804043   PMID:30816272   PMID:30816510   PMID:30851700   PMID:30852582   PMID:30939601   PMID:30961613   PMID:31013606   PMID:31077149   PMID:31077446  
PMID:31101774   PMID:31152776   PMID:31172941   PMID:31189648   PMID:31270884   PMID:31295376   PMID:31297636   PMID:31318583   PMID:31350345   PMID:31376422   PMID:31377844   PMID:31388753  
PMID:31441843   PMID:31461349   PMID:31471711   PMID:31489646   PMID:31495394   PMID:31530029   PMID:31541326   PMID:31545552   PMID:31557402   PMID:31557637   PMID:31562254   PMID:31611552  
PMID:31664304   PMID:31665136   PMID:31680444   PMID:31705064   PMID:31710162   PMID:31729527   PMID:31739217   PMID:31809964   PMID:31814187   PMID:31816951   PMID:31847640   PMID:31883300  
PMID:31883400   PMID:31886209   PMID:31901598   PMID:31914700   PMID:31921102   PMID:31930665   PMID:31943636   PMID:31964990   PMID:31987595   PMID:31991021   PMID:32084055   PMID:32091964  
PMID:32103760   PMID:32214219   PMID:32296183   PMID:32371379   PMID:32376549   PMID:32383535   PMID:32422289   PMID:32427982   PMID:32471499   PMID:32483412   PMID:32485729   PMID:32513696  
PMID:32518084   PMID:32531145   PMID:32548715   PMID:32552226   PMID:32559816   PMID:32572902   PMID:32606566   PMID:32640896   PMID:32663289   PMID:32672363   PMID:32749897   PMID:32788344  
PMID:32943658   PMID:33079302   PMID:33121429   PMID:33125115   PMID:33146689   PMID:33148888   PMID:33166788   PMID:33180392   PMID:33197425   PMID:33217242   PMID:33228783   PMID:33278887  
PMID:33330982   PMID:33332775   PMID:33369072   PMID:33370546   PMID:33381602   PMID:33398678   PMID:33400985   PMID:33405050   PMID:33413449   PMID:33508012   PMID:33540898   PMID:33577998  
PMID:33599317   PMID:33609191   PMID:33638245   PMID:33645008   PMID:33667285   PMID:33711968   PMID:33715310   PMID:33737658   PMID:33797637   PMID:33827260   PMID:33852994   PMID:33880998  
PMID:33888841   PMID:33902378   PMID:33920100   PMID:33927191   PMID:33974569   PMID:33988313   PMID:34032817   PMID:34079541   PMID:34086734   PMID:34112803   PMID:34143525   PMID:34199409  
PMID:34233864   PMID:34239022   PMID:34256095   PMID:34273357   PMID:34294770   PMID:34356595   PMID:34367126   PMID:34391381   PMID:34445235   PMID:34454292   PMID:34459091   PMID:34459335  
PMID:34499269   PMID:34511129   PMID:34511342   PMID:34515610   PMID:34525267   PMID:34531848   PMID:34624603   PMID:34638857   PMID:34752683   PMID:34804061   PMID:34824220   PMID:34830041  
PMID:34903680   PMID:34907983   PMID:34930225   PMID:34969653   PMID:35055107   PMID:35177591   PMID:35183036   PMID:35196657   PMID:35242296   PMID:35328046   PMID:35363774   PMID:35562953  
PMID:35567558   PMID:35644972   PMID:35692875   PMID:35726234   PMID:35753602   PMID:35775484   PMID:35785026   PMID:35960063   PMID:36011581   PMID:36038549   PMID:36057907   PMID:36076499  
PMID:36107264   PMID:36110847   PMID:36155203   PMID:36274485   PMID:36314210   PMID:36342644   PMID:36398464   PMID:36419353   PMID:36434424   PMID:36438499   PMID:36564084   PMID:36575043  
PMID:36592055   PMID:36628560   PMID:36672263   PMID:36685497   PMID:36753015   PMID:36768186   PMID:36794673   PMID:36809184   PMID:36835050   PMID:36854521   PMID:36872292   PMID:36923280  
PMID:37058963   PMID:37086937   PMID:37096803   PMID:37114304   PMID:37132640   PMID:37148770   PMID:37149962   PMID:37208442   PMID:37247914   PMID:37341066   PMID:37352031   PMID:37437927  
PMID:37455894   PMID:37500699   PMID:37518010   PMID:37646031   PMID:37697486   PMID:37740208   PMID:37766239   PMID:37769276   PMID:37770883   PMID:37834172   PMID:37850256   PMID:37861543  
PMID:37862725   PMID:37915048   PMID:37922289   PMID:38005838   PMID:38049786   PMID:38169464   PMID:38181585   PMID:38316963   PMID:38332001   PMID:38387908   PMID:38428413   PMID:38441377  


Genomics

Comparative Map Data
CCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,255,285 - 34,257,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,255,274 - 34,257,208 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,582,304 - 32,584,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,606,409 - 29,608,335 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,606,408 - 29,608,331NCBI
Celera1729,492,130 - 29,494,042 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,767,599 - 28,769,525 (+)NCBIHuRef
CHM1_11732,646,183 - 32,648,095 (+)NCBICHM1_1
T2T-CHM13v2.01735,201,562 - 35,203,480 (+)NCBIT2T-CHM13v2.0
Ccl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,926,403 - 81,928,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,926,397 - 81,928,279 (+)EnsemblGRCm39 Ensembl
GRCm381182,035,577 - 82,037,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,035,571 - 82,037,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,849,079 - 81,850,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,851,769 - 81,853,422 (+)NCBIMGSCv36mm8
Celera1191,649,026 - 91,650,901 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1149.82NCBI
Ccl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,503,077 - 67,504,875 (+)NCBIGRCr8
mRatBN7.21067,005,424 - 67,007,222 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,626,649 - 71,628,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,131,996 - 71,133,794 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,593,121 - 66,594,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21930,208,206 - 30,210,212 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11732,089,476 - 32,091,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01722,528,154 - 22,530,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,821,336 - 22,823,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,820,890 - 22,823,384 (-)Ensemblpanpan1.1panPan2
CCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1939,008,187 - 39,009,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,231,467 - 38,233,216 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,822,383 - 39,824,132 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1938,608,720 - 38,610,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,897,447 - 38,899,196 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,976,777 - 38,978,526 (-)NCBIUU_Cfam_GSD_1.0
CCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,798,109 - 40,800,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,798,109 - 40,800,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,514,202 - 42,516,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,763,354 - 27,765,437 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,763,555 - 27,765,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660752,254,637 - 2,256,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCL2
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000017.11:g.34253212= single nucleotide variant Susceptibility to HIV infection [RCV000015269] Chr17:34253212 [GRCh38]
Chr17:32580231 [GRCh37]
Chr17:17q12		 pathogenic|protective
NM_002982.4(CCL2):c.77-109= single nucleotide variant Susceptibility to HIV infection [RCV000015270] Chr17:34256113 [GRCh38]
Chr17:32583132 [GRCh37]
Chr17:17q12		 pathogenic|protective
NC_000017.11:g.34252769A>G single nucleotide variant CCL2-related condition [RCV003974826]|Coronary artery disease, development of, in HIV [RCV000015273]|Coronary artery disease, modifier of [RCV000015272]|Mycobacterium tuberculosis, susceptibility to [RCV000015274]|Spina bifida, susceptibility to [RCV000015271] Chr17:34252769 [GRCh38]
Chr17:32579788 [GRCh37]
Chr17:17q12		 pathogenic|risk factor|benign
GRCh38/hg38 17q12(chr17:33642695-34549211)x3 copy number gain See cases [RCV000054013] Chr17:33642695..34549211 [GRCh38]
Chr17:31969714..32876230 [GRCh37]
Chr17:28993827..29900343 [NCBI36]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:33670906-34596087)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|See cases [RCV000054042] Chr17:33670906..34596087 [GRCh38]
Chr17:31997925..32923106 [GRCh37]
Chr17:29022038..29947219 [NCBI36]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:33715517-34301601)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|See cases [RCV000054043] Chr17:33715517..34301601 [GRCh38]
Chr17:32042536..32628620 [GRCh37]
Chr17:29066649..29652733 [NCBI36]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:33777728-34301601)x3 copy number gain See cases [RCV000135956] Chr17:33777728..34301601 [GRCh38]
Chr17:32104747..32628620 [GRCh37]
Chr17:29128860..29652733 [NCBI36]
Chr17:17q12		 uncertain significance
GRCh38/hg38 17q12(chr17:33671097-34595982)x3 copy number gain See cases [RCV000139003] Chr17:33671097..34595982 [GRCh38]
Chr17:31998116..32923001 [GRCh37]
Chr17:29022229..29947114 [NCBI36]
Chr17:17q12		 likely benign
GRCh38/hg38 17q12(chr17:33671106-34595887)x3 copy number gain See cases [RCV000140285] Chr17:33671106..34595887 [GRCh38]
Chr17:31998125..32922906 [GRCh37]
Chr17:29022238..29947019 [NCBI36]
Chr17:17q12		 likely benign
GRCh37/hg19 17q12(chr17:31982779-32917705)x3 copy number gain See cases [RCV000449299] Chr17:31982779..32917705 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000445952] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000511904] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:32064314-32643063)x3 copy number gain See cases [RCV000511568] Chr17:32064314..32643063 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q12(chr17:32351496-34455576)x1 copy number loss not provided [RCV000683918] Chr17:32351496..34455576 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2		 pathogenic
GRCh37/hg19 17q12(chr17:31957257-32944153)x3 copy number gain not provided [RCV000846469] Chr17:31957257..32944153 [GRCh37]
Chr17:17q12		 uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787392] Chr17:31889285..33557612 [GRCh37]
Chr17:17q12		 uncertain significance
NC_000017.11:g.34251039C>A single nucleotide variant not provided [RCV001357292] Chr17:34251039 [GRCh38]
Chr17:32578058 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:31959226-32937658) copy number gain not specified [RCV002052595] Chr17:31959226..32937658 [GRCh37]
Chr17:17q12		 uncertain significance
NM_002982.4(CCL2):c.146C>T (p.Ala49Val) single nucleotide variant Inborn genetic diseases [RCV003189168] Chr17:34256291 [GRCh38]
Chr17:32583310 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q11.2-12(chr17:30572862-35843988) copy number loss Chromosome 17q12 deletion syndrome [RCV003319594] Chr17:30572862..35843988 [GRCh37]
Chr17:17q11.2-12		 pathogenic
NM_002982.4(CCL2):c.144C>T (p.Leu48=) single nucleotide variant CCL2-related condition [RCV003911900] Chr17:34256289 [GRCh38]
Chr17:32583308 [GRCh37]
Chr17:17q12		 likely benign
NM_002982.4(CCL2):c.105T>C (p.Cys35=) single nucleotide variant CCL2-related condition [RCV003979697] Chr17:34256250 [GRCh38]
Chr17:32583269 [GRCh37]
Chr17:17q12		 benign
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR124-2hsa-miR-124-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19404929

Predicted Target Of
Summary Value
Count of predictions:623
Count of miRNA genes:484
Interacting mature miRNAs:529
Transcripts:ENST00000225831, ENST00000580907, ENST00000582017
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D17S1269  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,582,301 - 32,582,403UniSTSGRCh37
Build 361729,606,414 - 29,606,516RGDNCBI36
Celera1729,492,135 - 29,492,237RGD
Cytogenetic Map17q11.2-q12UniSTS
HuRef1728,767,604 - 28,767,706UniSTS
GDB:607769  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,582,389 - 32,582,514UniSTSGRCh37
Build 361729,606,502 - 29,606,627RGDNCBI36
Celera1729,492,223 - 29,492,348RGD
Cytogenetic Map17q11.2-q12UniSTS
HuRef1728,767,692 - 28,767,817UniSTS
CCL2_498  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,583,437 - 32,584,272UniSTSGRCh37
Build 361729,607,550 - 29,608,385RGDNCBI36
Celera1729,493,257 - 29,494,092RGD
HuRef1728,768,740 - 28,769,575UniSTS
D17S1988  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q11.2-q12UniSTS
Whitehead-YAC Contig Map17 UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 10 18 5 2 2 6 2 4 6 7 40 11 5
Medium 1816 1680 1345 356 353 265 2257 1059 1309 324 729 1258 96 1 943 1407 3 1
Low 519 734 354 256 451 184 2003 1055 2051 79 656 196 73 250 1317 1 1
Below cutoff 28 513 9 5 594 6 77 70 357 3 39 47 4 59

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF519531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV733621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY357296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG530064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D26087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC727557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M37719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S69738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X60001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y18933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000225831   ⟹   ENSP00000225831
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,255,285 - 34,257,203 (+)Ensembl
RefSeq Acc Id: ENST00000580907   ⟹   ENSP00000462156
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,255,274 - 34,257,208 (+)Ensembl
RefSeq Acc Id: ENST00000582017
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,256,208 - 34,257,203 (+)Ensembl
RefSeq Acc Id: ENST00000624362
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,255,285 - 34,257,203 (+)Ensembl
RefSeq Acc Id: NM_002982   ⟹   NP_002973
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,255,285 - 34,257,203 (+)NCBI
GRCh371732,582,296 - 32,584,222 (+)ENTREZGENE
Build 361729,606,409 - 29,608,335 (+)NCBI Archive
HuRef1728,767,599 - 28,769,525 (+)ENTREZGENE
CHM1_11732,646,183 - 32,648,095 (+)NCBI
T2T-CHM13v2.01735,201,562 - 35,203,480 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_002973   ⟸   NM_002982
- Peptide Label: precursor
- UniProtKB: B2R4V3 (UniProtKB/Swiss-Prot),   Q9UDF3 (UniProtKB/Swiss-Prot),   P13500 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000462156   ⟸   ENST00000580907
RefSeq Acc Id: ENSP00000225831   ⟸   ENST00000225831
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13500-F1-model_v2 AlphaFold P13500 1-99 view protein structure

Promoters
RGD ID:7234583
Promoter ID:EPDNEW_H23037
Type:initiation region
Name:CCL2_1
Description:C-C motif chemokine ligand 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,255,285 - 34,255,345EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10618 AgrOrtholog
COSMIC CCL2 COSMIC
Ensembl Genes ENSG00000108691 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000225831 ENTREZGENE
  ENST00000225831.4 UniProtKB/Swiss-Prot
  ENST00000580907.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000108691 GTEx
HGNC ID HGNC:10618 ENTREZGENE
Human Proteome Map CCL2 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6347 UniProtKB/Swiss-Prot
NCBI Gene 6347 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 2 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA130413151 PharmGKB
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R4V3 ENTREZGENE
  CCL2_HUMAN UniProtKB/Swiss-Prot
  J3KRT7_HUMAN UniProtKB/TrEMBL
  P13500 ENTREZGENE
  Q9UDF3 ENTREZGENE
UniProt Secondary B2R4V3 UniProtKB/Swiss-Prot
  Q9UDF3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL2  C-C motif chemokine ligand 2  CCL2  chemokine (C-C motif) ligand 2  Symbol and/or name change 5135510 APPROVED