RGD Reference Report - The role of monocyte chemoattractant protein-1 in biliary atresia. - Rat Genome Database

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The role of monocyte chemoattractant protein-1 in biliary atresia.

Authors: Kobayashi, Hiroyuki  Tamatani, Takuya  Tamura, Tsuyoshi  Kusafuka, Junichi  Koga, Hiroyuki  Yamataka, Atsuyuki  Lane, Geoffrey J  Miyahara, Katsumi  Sueyoshi, Noriyoshi  Miyano, Takeshi 
Citation: Kobayashi H, etal., J Pediatr Surg. 2006 Dec;41(12):1967-72. doi: 10.1016/j.jpedsurg.2006.08.018.
RGD ID: 14995924
Pubmed: PMID:17161183   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jpedsurg.2006.08.018   (Journal Full-text)


BACKGROUND: The aim of this study was to explain the role of monocyte chemoattractant protein-1 (MCP-1) in biliary atresia (BA).
METHODS: Concentrations of serum MCP-1 and collagen type IV were measured in 38 patients with BA by using commercially available kits. MCP-1 was also assessed in liver biopsy specimens by using immunohistochemistry. Subjects were classified into groups. Group 1 comprised BA patients with normal liver function (n = 13), group II comprised BA patients with moderate liver dysfunction (n = 18), group III comprised BA patients older than 20 years awaiting liver transplantation (n = 7), and the control group comprised age-matched patients without evidence of liver disease (n = 23).
RESULTS: Serum MCP-1 levels were significantly increased in group II compared with group I (P < .0001) and the control group (P < .0001). Serum MCP-1 levels in group III were lower than in the control group (P < .0001). There was a significant linear correlation between serum MCP-1 levels and type IV collagen levels in group II. Group II subjects with portal hypertension (PH) had higher MCP-1 levels than those without PH (P = .0009). Biopsy specimens showed MCP-1 was expressed mainly on biliary epithelial cells, vascular endothelial cells, and hepatocytes in group II.
CONCLUSIONS: These findings suggest that MCP-1 probably plays a significant role in the development of progressive liver fibrosis in BA.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL2Humanportal hypertension  IEP associated with biliary atresiaRGD 
Ccl2Ratportal hypertension  ISOCCL2 (Homo sapiens)associated with biliary atresiaRGD 
Ccl2Mouseportal hypertension  ISOCCL2 (Homo sapiens)associated with biliary atresiaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)


Additional Information