CCL8 (chemokine (C-C motif) ligand 8) - Rat Genome Database

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Gene: CCL8 (chemokine (C-C motif) ligand 8) Sus scrofa
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Symbol: CCL8
Name: chemokine (C-C motif) ligand 8
RGD ID: 14175024
Description: ENCODES a protein that exhibits CCR2 chemokine receptor binding (inferred); chemokine activity (inferred); cytokine activity (inferred); INVOLVED IN positive regulation of myoblast differentiation (ortholog); positive regulation of myoblast fusion (ortholog); ASSOCIATED WITH allergic disease (ortholog); chronic obstructive pulmonary disease (ortholog); COVID-19 (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH prostaglandin F2alpha; resveratrol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C motif chemokine 8; chemokine ligand 8; MCP-2; monocyte chemoattractant protein 2; monocyte chemotactic protein 2; small-inducible cytokine A8
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,740,023 - 40,742,022 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,740,468 - 40,741,970 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,456,902 - 42,458,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:7999015   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,740,023 - 40,742,022 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,740,468 - 40,741,970 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,456,902 - 42,458,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,319,435 - 34,321,402 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,319,435 - 34,321,402 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,646,454 - 32,648,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,670,179 - 29,672,534 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,670,178 - 29,672,533NCBI
Celera1729,555,877 - 29,558,232 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,831,806 - 28,834,161 (+)NCBIHuRef
CHM1_11732,709,957 - 32,712,312 (+)NCBICHM1_1
T2T-CHM13v2.01735,266,045 - 35,268,012 (+)NCBIT2T-CHM13v2.0
Ccl8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,006,011 - 82,007,625 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,006,011 - 82,007,625 (+)EnsemblGRCm39 Ensembl
GRCm381182,115,185 - 82,116,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,115,185 - 82,116,799 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,928,687 - 81,930,301 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,931,388 - 81,932,990 (+)NCBIMGSCv36mm8
Celera1186,827,769 - 86,829,383 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1149.91NCBI
CCL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21930,147,882 - 30,150,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11732,029,199 - 32,031,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01722,468,080 - 22,470,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,761,570 - 22,763,933 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,761,064 - 22,763,933 (-)Ensemblpanpan1.1panPan2
CCL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,949,184 - 38,950,702 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,948,184 - 38,950,803 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,172,238 - 38,173,756 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,762,393 - 39,763,911 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,761,932 - 39,764,012 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1938,549,578 - 38,551,096 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,829,060 - 38,830,578 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,917,555 - 38,919,073 (-)NCBIUU_Cfam_GSD_1.0
Ccl8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,927,322 - 37,928,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538805,259 - 806,695 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936538805,273 - 806,715 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,821,149 - 27,823,919 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,821,970 - 27,823,528 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660752,195,968 - 2,198,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCL8
80 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 8 2 3 11 1 3
Below cutoff 2 2 3 2 2 10 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000044167   ⟹   ENSSSCP00000032773
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1240,740,023 - 40,742,022 (-)Ensembl
RefSeq Acc Id: NM_001164515   ⟹   NP_001157987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11240,740,468 - 40,741,970 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001157987   ⟸   NM_001164515
- Peptide Label: precursor
- UniProtKB: P49873 (UniProtKB/Swiss-Prot),   C7F842 (UniProtKB/TrEMBL),   A0A4X1T9X8 (UniProtKB/TrEMBL),   A0A8D0IN88 (UniProtKB/TrEMBL),   A0A8D0MP23 (UniProtKB/TrEMBL),   G8XRI1 (UniProtKB/TrEMBL),   A0A8D0QYD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000032773   ⟸   ENSSSCT00000044167
Protein Domains
Chemokine interleukin-8-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040648 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005012948 UniProtKB/TrEMBL
  ENSSSCG00015010791 UniProtKB/TrEMBL
  ENSSSCG00025015859 UniProtKB/TrEMBL
  ENSSSCG00030054122 UniProtKB/TrEMBL
  ENSSSCG00035063005 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040009841 UniProtKB/TrEMBL
  ENSSSCG00045018219 UniProtKB/TrEMBL
  ENSSSCG00050039158 UniProtKB/TrEMBL
  ENSSSCG00055008574 UniProtKB/TrEMBL
  ENSSSCG00065067533 UniProtKB/Swiss-Prot
  ENSSSCG00070008056 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000044167 ENTREZGENE
  ENSSSCT00000044167.2 UniProtKB/TrEMBL
  ENSSSCT00005020260.1 UniProtKB/TrEMBL
  ENSSSCT00005020325.1 UniProtKB/TrEMBL
  ENSSSCT00015014142.1 UniProtKB/TrEMBL
  ENSSSCT00015014170.1 UniProtKB/TrEMBL
  ENSSSCT00025021300.1 UniProtKB/TrEMBL
  ENSSSCT00030075410.1 UniProtKB/TrEMBL
  ENSSSCT00030075464.1 UniProtKB/TrEMBL
  ENSSSCT00035084695.1 UniProtKB/TrEMBL
  ENSSSCT00035084710.1 UniProtKB/Swiss-Prot
  ENSSSCT00040012751.1 UniProtKB/TrEMBL
  ENSSSCT00045031042.1 UniProtKB/TrEMBL
  ENSSSCT00045031084.1 UniProtKB/TrEMBL
  ENSSSCT00050052806.1 UniProtKB/TrEMBL
  ENSSSCT00050052815.1 UniProtKB/TrEMBL
  ENSSSCT00055016760.1 UniProtKB/TrEMBL
  ENSSSCT00065092718.1 UniProtKB/Swiss-Prot
  ENSSSCT00070015547.1 UniProtKB/TrEMBL
  ENSSSCT00070015556.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100302703 UniProtKB/TrEMBL
NCBI Gene CCL8 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1T9X8 ENTREZGENE
  A0A8D0IN88 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0MP23 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0QYD0 ENTREZGENE, UniProtKB/TrEMBL
  C7F842 ENTREZGENE, UniProtKB/TrEMBL
  CCL8_PIG UniProtKB/Swiss-Prot
  G8XRI1 ENTREZGENE, UniProtKB/TrEMBL
  P49873 ENTREZGENE
UniProt Secondary A0A4X1T9X8 UniProtKB/TrEMBL