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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:heparin
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Accession:CHEBI:28304 term browser browse the term
Definition:A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Synonyms:related_synonym: Bemiparin;   Certoparin;   Cy 222;   Enoxaparin;   Fluxum;   Formula=(C26H40N2O36S5)n;   Heparinic acid;   Parnaparin;   Reviparin;   Sandoparin;   heparina;   heparine;   heparinum
 alt_id: CHEBI:24501;   CHEBI:5664
 xref: CAS:9005-49-6;   DrugBank:DB01109;   KEGG:C00374;   KEGG:D07510
 xref_mesh: MESH:D006493
 xref: PMID:16860191;   PMID:18809206;   PMID:8713797;   Wikipedia:Heparin


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heparin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects activity
multiple interactions
ISO Heparin affects the activity of ABCC1 protein
Heparin affects the reaction [ABCC1 protein affects the transport of Doxorubicin]
CTD PMID:17352253 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ackr3 atypical chemokine receptor 3 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA] CTD PMID:16401727 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Heparin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:16904936 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actr3 actin related protein 3 increases expression EXP Heparin results in increased expression of ACTR3 protein CTD PMID:17488504 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA] CTD PMID:16401727 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Agt angiotensinogen multiple interactions EXP Heparin inhibits the reaction [AGT protein affects the localization of Calcium] CTD PMID:21613610 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein] CTD PMID:14966081 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Anxa6 annexin A6 increases expression EXP Heparin results in increased expression of ANXA6 protein CTD PMID:17488504 NCBI chr10:40,320,581...40,375,605
Ensembl chr10:40,320,581...40,375,605
JBrowse link
G Apcs amyloid P component, serum increases expression ISO Heparin results in increased expression of APCS protein CTD PMID:17162433 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Copper promotes the reaction [Heparin binds to APP protein]; Zinc promotes the reaction [Heparin binds to APP protein] CTD PMID:25835329 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression EXP Heparin results in increased expression of ARHGDIA protein CTD PMID:17488504 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA] CTD PMID:16401727 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Heparin results in increased expression of BAX protein
Heparin inhibits the reaction [arsenite results in increased expression of BAX protein]
CTD PMID:11787776, PMID:26677073 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO Heparin results in increased expression of BCL2 protein
Heparin inhibits the reaction [arsenite results in decreased expression of BCL2 protein]
CTD PMID:11787776, PMID:15205081, PMID:15671997, PMID:26677073 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions
decreases expression
ISO Heparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Heparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]
Heparin results in decreased expression of BMP6 mRNA
CTD PMID:25633564 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A decreases expression ISO Heparin results in decreased expression of BMPR1A mRNA CTD PMID:25633564 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G C3 complement C3 decreases expression ISO Heparin results in decreased expression of C3 protein CTD PMID:7948777, PMID:10568115 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C5 complement C5 decreases expression ISO Heparin results in decreased expression of C5 protein CTD PMID:7948777 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP Heparin affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Capg capping actin protein, gelsolin like increases expression EXP Heparin results in increased expression of CAPG protein CTD PMID:17488504 NCBI chr 4:100,395,693...100,419,447
Ensembl chr 4:100,407,658...100,419,446
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Heparin inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
ISO
EXP
Heparin results in decreased activity of CASP3 protein
Heparin promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [Heparin promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]
CTD PMID:16556679, PMID:30377735 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases activity ISO Heparin results in increased activity of CAT protein CTD PMID:12218949 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 affects binding
multiple interactions
ISO Heparin binds to CCL11 protein
Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein]
CTD PMID:17384413 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Heparin results in decreased expression of CCL2 protein CTD PMID:11053056 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Heparin results in decreased expression of CD40LG protein CTD PMID:16391376 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Heparin results in increased expression of CDKN1A protein CTD PMID:10926548 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
increases expression
ISO Heparin analog results in decreased expression of CDKN1B protein
Heparin analog results in increased expression of CDKN1B protein
CTD PMID:18057711, PMID:20201787 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain affects binding ISO Heparin binds to COL18A1 protein alternative form CTD PMID:15604266 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Crp C-reactive protein increases expression ISO Heparin results in increased expression of CRP protein CTD PMID:16391376 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA] CTD PMID:16401727 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Heparin promotes the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Heparin promotes the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]] CTD PMID:30377735 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions EXP Heparin inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CXCL10 mRNA] CTD PMID:31813902 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Heparin analog results in decreased expression of CXCL12 mRNA; Heparin analog results in decreased expression of CXCL12 protein CTD PMID:20201787 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]] CTD PMID:16401727 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Heparin analog results in decreased expression of CXCR4 mRNA; Heparin analog results in decreased expression of CXCR4 protein CTD PMID:20201787 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 decreases expression EXP Heparin results in decreased expression of DDAH2 protein CTD PMID:17488504 NCBI chr20:5,049,260...5,052,573
Ensembl chr20:5,049,496...5,052,585
JBrowse link
G Des desmin decreases expression EXP Heparin results in decreased expression of DES protein CTD PMID:9111513 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Heparin analog results in decreased expression of E2F1 protein CTD PMID:20201787 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression
decreases secretion
ISO
EXP
Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]; Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]
Heparin results in decreased expression of EDN1 mRNA
Heparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
Heparin results in decreased secretion of EDN1 protein
CTD PMID:1443220, PMID:7509996, PMID:8408661 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egf epidermal growth factor decreases activity ISO Heparin results in decreased activity of EGF protein CTD PMID:12714831 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases phosphorylation
ISO Heparin results in decreased expression of EGFR mRNA; Heparin results in decreased expression of EGFR protein
Heparin results in increased phosphorylation of EGFR protein
CTD PMID:16475731, PMID:16556679 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA] CTD PMID:16401727 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G F10 coagulation factor X decreases activity ISO
EXP
Heparin results in decreased activity of F10 protein CTD PMID:8950779 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II multiple interactions
decreases expression
increases expression
ISO F2 protein promotes the reaction [Heparin results in increased abundance of Nitric Oxide]; Heparin deficiency results in increased cleavage of and results in increased activity of F2 protein; Heparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]; Heparin inhibits the reaction [F2 protein affects the localization of SELP protein]; Heparin inhibits the reaction [F2 protein results in increased cleavage of F2R protein]; Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]; Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]
Heparin results in increased expression of [F2 protein binds to SERPINC1 protein]
Heparin results in decreased expression of F2 protein
Heparin deficiency results in increased expression of F2 protein; Heparin results in increased expression of F2 protein
CTD PMID:7509996, PMID:7895349, PMID:8408661, PMID:9740346, PMID:11869846, PMID:16391376, PMID:16961586, PMID:19468011 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO Heparin inhibits the reaction [F2 protein results in increased cleavage of F2R protein] CTD PMID:19468011 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heparin results in increased expression of FAS protein CTD PMID:15205081 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa affects binding ISO [Heparin binds to PF4 protein] which binds to FCGR2A protein CTD PMID:8282825 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Fga fibrinogen alpha chain increases cleavage ISO Heparin deficiency results in increased cleavage of FGA protein CTD PMID:7895349 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions
affects binding
ISO
EXP
[Heparin analog binds to FGFR2 protein alternative form] which binds to and results in increased activity of FGF1 protein; Heparin analog promotes the reaction [FGF1 protein binds to FGF1 protein]
[Heparin binds to FGFR2 protein alternative form] which binds to FGF1 protein
Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]; Heparin promotes the reaction [FGF1 protein results in increased expression of FGF1 protein]
Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]; Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]
CTD PMID:1379594, PMID:8576258, PMID:10336501, PMID:10860838, PMID:14966081, PMID:16219767 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf10 fibroblast growth factor 10 multiple interactions ISO Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein] CTD PMID:15632068 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Fgf19 fibroblast growth factor 19 affects binding
multiple interactions
ISO Heparin binds to FGF19 protein
Heparin promotes the reaction [FGF19 protein binds to FGFR4 protein]
CTD PMID:10525310, PMID:14730967 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Fgf2 fibroblast growth factor 2 affects binding
decreases expression
multiple interactions
affects activity
ISO
EXP
Heparin binds to FGF2 protein; Heparin binds to FGFR1 protein binds to FGF2 protein
Heparin results in decreased expression of FGF2 protein
[Heparin binds to FGFR2 protein alternative form] which binds to FGF2 protein
Heparin affects the reaction [FGF2 protein binds to FGFR4 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
Heparin affects the activity of FGF2 protein
Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]; Heparin promotes the reaction [FGFR2 protein binds to FGF2 protein]
CTD PMID:1373495, PMID:1379594, PMID:8441232, PMID:10336501, PMID:10860838, PMID:14966081, PMID:15096041, PMID:15232299, PMID:17524524 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf23 fibroblast growth factor 23 increases activity ISO Heparin analog results in increased activity of FGF23 protein CTD PMID:16081635 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Fgf3 fibroblast growth factor 3 affects activity ISO Heparin affects the activity of FGF3 protein CTD PMID:7592624 NCBI chr 1:218,003,018...218,006,942
Ensembl chr 1:218,003,018...218,006,942
JBrowse link
G Fgf4 fibroblast growth factor 4 multiple interactions ISO Heparin binds to and results in increased activity of FGF4 protein CTD PMID:11486033 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Fgf5 fibroblast growth factor 5 affects activity ISO Heparin affects the activity of FGF5 protein CTD PMID:8386828 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fgf7 fibroblast growth factor 7 affects binding EXP [Heparin binds to FGFR2 protein alternative form] which binds to FGF7 protein CTD PMID:10860838 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects binding
multiple interactions
ISO Heparin binds to FGFR1 protein binds to FGF2 protein
Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]; Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]
CTD PMID:1379594, PMID:15096041 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions
affects binding
affects activity
ISO
EXP
[Heparin analog binds to FGFR2 protein alternative form] which binds to and results in increased activity of FGF1 protein; Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein]
[Heparin binds to FGFR2 protein alternative form] which binds to FGF1 protein; [Heparin binds to FGFR2 protein alternative form] which binds to FGF2 protein; [Heparin binds to FGFR2 protein alternative form] which binds to FGF7 protein
Heparin promotes the reaction [FGFR2 protein binds to FGF2 protein]
Heparin affects the activity of FGFR2 protein
CTD PMID:1373495, PMID:10860838, PMID:15632068, PMID:16219767 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 affects activity
multiple interactions
ISO Heparin affects the activity of FGFR3 protein
Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]
CTD PMID:1379594 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 affects binding
multiple interactions
ISO
EXP
Heparin analog binds to FGFR4 protein
Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]; Heparin affects the reaction [FGF2 protein binds to FGFR4 protein]
Heparin promotes the reaction [FGF19 protein binds to FGFR4 protein]; Heparin promotes the reaction [FGFR4 protein binds to FGFR4 protein]
CTD PMID:10336501, PMID:10525310, PMID:10736564, PMID:11278860 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
multiple interactions
ISO
EXP
Heparin results in increased expression of FOS protein
Heparin results in decreased expression of FOS mRNA
Heparin inhibits the reaction [4-O-methyl-12-O-tetradecanoylphorbol 13-acetate results in increased expression of FOS mRNA]
CTD PMID:2099192, PMID:9083085 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions EXP Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein] CTD PMID:16259952 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase affects degradation ISO GNS affects the degradation of Heparin CTD PMID:3391615 NCBI chr 7:63,467,027...63,501,054
Ensembl chr 7:63,467,216...63,499,353
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]] CTD PMID:31813902 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gzmb granzyme B multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA] CTD PMID:16401727 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression
decreases secretion
multiple interactions
ISO Heparin results in decreased expression of HAMP mRNA
Heparin results in decreased secretion of HAMP protein modified form
Heparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Heparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Heparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
CTD PMID:25633564, PMID:25686467 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hgf hepatocyte growth factor multiple interactions
affects binding
increases expression
ISO Heparin promotes the reaction [HGF protein binds to and results in increased activity of MET protein]
HGF protein binds to Heparin
Heparin results in increased expression of HGF protein
CTD PMID:9083085, PMID:18243369 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Heparin inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMOX1 mRNA] CTD PMID:31813902 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpse heparanase multiple interactions ISO [Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate CTD PMID:17121850 NCBI chr14:10,534,358...10,576,686
Ensembl chr14:10,534,423...10,575,224
JBrowse link
G Hrg histidine-rich glycoprotein multiple interactions ISO Heparin inhibits the reaction [Zinc results in increased activity of HRG protein] CTD PMID:8690451 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952
JBrowse link
G Igsf10 immunoglobulin superfamily, member 10 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA] CTD PMID:16401727 NCBI chr 2:149,535,199...149,564,180
Ensembl chr 2:149,533,151...149,564,113
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions
ISO
EXP
Heparin results in increased expression of IL6 protein
Heparin analog results in increased secretion of IL6 protein
Heparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA]
CTD PMID:16391376, PMID:16401727, PMID:25633564, PMID:26476401 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M decreases expression
increases expression
ISO Heparin results in decreased expression of ITGAM protein
Heparin results in increased expression of ITGAM protein
CTD PMID:8595612, PMID:8993250 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Heparin results in decreased expression of ITGAX protein CTD PMID:8993250 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Heparin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:1730747 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA] CTD PMID:16401727 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Krt18 keratin 18 increases expression ISO Heparin results in increased expression of KRT18 protein CTD PMID:15671997 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Ldhb lactate dehydrogenase B decreases expression EXP Heparin results in decreased expression of LDHB protein CTD PMID:17488504 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [etofibrate co-treated with Heparin] results in increased secretion of LPL protein CTD PMID:3179329 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:14966081 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K2 protein] CTD PMID:14966081 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases activity
ISO
EXP
Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Heparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK1 protein]
Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]
Heparin results in increased activity of MAPK1 protein
CTD PMID:14966081, PMID:16556679, PMID:18057711, PMID:19937756 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
ISO
EXP
Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Heparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK3 protein]
Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
Heparin results in increased activity of MAPK3 protein
CTD PMID:14966081, PMID:16556679, PMID:18057711, PMID:19937756 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Heparin promotes the reaction [MAPT protein binds to MAPT protein]; Mercuric Chloride promotes the reaction [Heparin promotes the reaction [MAPT protein binds to MAPT protein]] CTD PMID:20665688, PMID:31678113 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO Heparin promotes the reaction [HGF protein binds to and results in increased activity of MET protein] CTD PMID:9083085 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mif macrophage migration inhibitory factor affects binding ISO MIF protein binds to Heparin CTD PMID:26852939 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases activity ISO Heparin results in decreased activity of MMP1 protein CTD PMID:10958381 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression ISO Heparin analog results in decreased expression of MMP14 mRNA CTD PMID:26476401 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO Heparin results in decreased activity of MMP2 protein CTD PMID:10958381 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
increases expression
multiple interactions
ISO Heparin results in decreased activity of MMP9 protein
Heparin results in increased expression of MMP9 mRNA; Heparin results in increased expression of MMP9 protein
Heparin results in increased metabolism of and results in increased activity of MMP9 protein
CTD PMID:10958381, PMID:14630814, PMID:16190367 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msn moesin increases expression EXP Heparin results in increased expression of MSN protein CTD PMID:17488504 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
ISO
EXP
Heparin results in increased expression of MYC protein
Heparin results in decreased expression of MYC mRNA
CTD PMID:2099192, PMID:11787776, PMID:16475731 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions EXP Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein] CTD PMID:16259952 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO Heparin analog results in increased expression of NFE2L2 mRNA CTD PMID:26476401 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Park7 Parkinsonism associated deglycase increases expression EXP Heparin results in increased expression of PARK7 protein CTD PMID:17488504 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Heparin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein] CTD PMID:30377735 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfb platelet derived growth factor subunit B affects expression EXP Heparin affects the expression of PDGFB protein CTD PMID:8441232 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression ISO Heparin results in decreased expression of PDGFRA mRNA CTD PMID:16945567 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta decreases expression EXP Heparin results in decreased expression of PDHB protein CTD PMID:17488504 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Pf4 platelet factor 4 affects binding
increases secretion
ISO [Heparin binds to PF4 protein] which binds to FCGR2A protein; Heparin binds to PF4 protein
Heparin results in increased secretion of PF4 protein
CTD PMID:2437338, PMID:2709525, PMID:8282825, PMID:20162249 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Pitpna phosphatidylinositol transfer protein, alpha increases expression EXP Heparin results in increased expression of PITPNA protein CTD PMID:17488504 NCBI chr10:63,731,767...63,772,049
Ensembl chr10:63,731,767...63,772,049
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Heparin results in increased expression of PLAT mRNA; Heparin results in increased expression of PLAT protein CTD PMID:14630814, PMID:16190367 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO Heparin analog results in decreased expression of PLAU mRNA CTD PMID:26476401 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plg plasminogen multiple interactions ISO Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein] CTD PMID:17384413 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Ppbp pro-platelet basic protein increases secretion ISO Heparin results in increased secretion of PPBP protein CTD PMID:2437338 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases activity ISO Heparin deficiency results in increased activity of PROC protein CTD PMID:7895349 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases activity
decreases expression
ISO Heparin analog results in decreased activity of PSMB5 protein
Heparin analog results in decreased expression of PSMB5 mRNA
CTD PMID:26476401 NCBI chr15:33,259,039...33,263,634
Ensembl chr15:33,259,043...33,263,659
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO Heparin analog results in decreased expression of PSMB6 mRNA CTD PMID:26476401 NCBI chr10:57,131,339...57,133,685
Ensembl chr10:57,131,386...57,133,637
JBrowse link
G Psmb7 proteasome 20S subunit beta 7 decreases expression ISO Heparin analog results in decreased expression of PSMB7 mRNA CTD PMID:26476401 NCBI chr 3:22,890,072...22,951,718
Ensembl chr 3:22,871,105...22,952,063
JBrowse link
G Psme1 proteasome activator subunit 1 increases expression EXP Heparin results in increased expression of PSME1 protein CTD PMID:17488504 NCBI chr15:34,256,071...34,258,947
Ensembl chr15:34,256,071...34,258,947
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA] CTD PMID:16401727 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO Heparin results in decreased phosphorylation of PTK2 protein CTD PMID:18674534 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Pxn paxillin decreases phosphorylation ISO Heparin results in decreased phosphorylation of PXN protein CTD PMID:18674534 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA] CTD PMID:16401727 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Heparin analog results in decreased expression of and results in decreased phosphorylation of RB1 protein CTD PMID:20201787 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Heparin inhibits the reaction [arsenite affects the localization of RELA protein]; Heparin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:10843908, PMID:26677073 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a1 S100 calcium binding protein A1 affects expression EXP Heparin affects the expression of S100A1 protein CTD PMID:12186470 NCBI chr 2:189,900,505...189,905,348
Ensembl chr 2:189,900,667...189,903,219
JBrowse link
G S100a6 S100 calcium binding protein A6 affects expression
increases expression
EXP Heparin affects the expression of S100A6 protein
Heparin results in increased expression of S100A6 protein
CTD PMID:12186470, PMID:17488504 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G S100b S100 calcium binding protein B affects expression EXP Heparin affects the expression of S100B protein CTD PMID:12186470 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Sdc1 syndecan 1 decreases expression ISO Heparin analog results in decreased expression of SDC1 mRNA CTD PMID:26476401 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sdc2 syndecan 2 decreases expression ISO Heparin analog results in decreased expression of SDC2 mRNA CTD PMID:26476401 NCBI chr 7:71,572,731...71,686,139
Ensembl chr 7:71,572,941...71,686,044
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Heparin analog results in increased expression of SDC4 mRNA CTD PMID:26476401 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sell selectin L decreases expression
increases expression
ISO Heparin results in decreased expression of SELL protein
Heparin results in increased expression of SELL protein
CTD PMID:8595612, PMID:8993250 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Selp selectin P multiple interactions
increases expression
ISO Heparin inhibits the reaction [F2 protein affects the localization of SELP protein]; Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]
Heparin results in increased expression of SELP protein
CTD PMID:9740346, PMID:10544909 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Septin2 septin 2 increases expression EXP Heparin results in increased expression of SEPTIN2 protein CTD PMID:17488504 NCBI chr 9:100,624,876...100,658,053
Ensembl chr 9:100,624,876...100,658,050
JBrowse link
G Serpinc1 serpin family C member 1 decreases expression
multiple interactions
ISO Heparin deficiency results in decreased expression of SERPINC1 protein; Heparin results in decreased expression of SERPINC1 protein
Heparin results in increased expression of [F2 protein binds to SERPINC1 protein]
Heparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]
CTD PMID:73932, PMID:7895349, PMID:8122184, PMID:11869846, PMID:16961586 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein] CTD PMID:16401727 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions EXP Heparin promotes the reaction [Doxorubicin results in increased secretion of SFRP1 protein] CTD PMID:30377735 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA] CTD PMID:16401727 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Slk STE20-like kinase multiple interactions EXP Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA] CTD PMID:16401727 NCBI chr 1:267,359,761...267,415,735
Ensembl chr 1:267,359,830...267,412,810
JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression EXP Heparin results in increased expression of STIP1 protein CTD PMID:17488504 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Tagln2 transgelin 2 decreases expression EXP Heparin results in decreased expression of TAGLN2 protein CTD PMID:17488504 NCBI chr13:90,807,196...90,814,119
Ensembl chr13:90,807,199...90,814,119
JBrowse link
G Tfrc transferrin receptor multiple interactions
decreases expression
EXP
ISO
Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA]
Heparin results in decreased expression of TFRC protein
CTD PMID:16401727, PMID:25633564 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Heparin results in decreased expression of TGFB1 mRNA CTD PMID:15149336 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Heparin inhibits the reaction [TNF protein affects the localization of RELA protein]
Heparin results in increased expression of TNF protein
CTD PMID:10843908, PMID:17162433 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Heparin analog results in decreased expression of TP53 protein CTD PMID:20201787 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A affects binding ISO Heparin binds to VEGFA protein alternative form CTD PMID:20376344 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pharmaceutical 19255
          drug 19255
            hematologic agent 4364
              anticoagulant 4157
                heparin 139
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            heteroorganic entity 19165
                              organochalcogen compound 18873
                                organooxygen compound 18795
                                  carbohydrates and carbohydrate derivatives 12193
                                    carbohydrate 12193
                                      polysaccharide 3039
                                        polysaccharide derivative 3021
                                          aminoglycan 390
                                            glycosaminoglycan 365
                                              sulfated glycosaminoglycan 183
                                                heparins 139
                                                  heparin 139
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.