Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:2639
Term: amiloride
Definition: A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.
Chemical ID: MESH:D000584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2multiple interactionsEXP 6480464CTDAmiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]PMID:12107048
CCL2decreases expressionISOCcl2 (Rattus norvegicus)6480464CTDAmiloride results in decreased expression of CCL2 mRNA; Amiloride results in decreased expression of CCL2 proteinPMID:11340305
CCL2multiple interactionsISOCcl2 (Rattus norvegicus)6480464CTDAmiloride inhibits the reaction [ALB protein results in increased expression of CCL2 protein]; Amiloride inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Amiloride results in decreased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Amiloride results in decreased expression of CCL2 protein]PMID:11340305
Go Back to source page   Continue to Ontology report