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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:79078
Term: aspalathin
Definition: A member of the class of dihydrochalcones that is the 2-C-beta-D-glucopyranide of phloroglucinol and which is substituted at position 4 by a 3-(3,4-dihydroxyphenyl)propanoyl group. A metabolite of red bush, Aspalathus linearis (and present in the herbal tea made from the leaves), aspalathin exhibits significant hypoglycemic activity.
Chemical ID: MESH:C517016
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2multiple interactionsEXP 6480464CTDaspalathin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 protein]PMID:25338943
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