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Gene: Ccl2 (C-C motif chemokine ligand 2) Rattus norvegicus
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Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Description: Exhibits chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte migration. Localizes to several cellular components, including the cytoplasm; extracellular space; and neuron projection. Colocalizes with the C-fiber. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and obstructive jaundice. Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); lung disease (multiple); periodontitis (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune hypersensitivity disease (multiple); eye disease (multiple); tuberculosis (multiple); and vasculitis (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2); PARTICIPATES IN angiotensin II signaling pathway; vascular endothelial growth factor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; MCP-1; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic protein 1; Scya2; Sigje; small inducible cytokine A2; Small inducible gene JE; small-inducible cytokine A2
Orthologs:
Homo sapiens (human) : CCL2 (C-C motif chemokine ligand 2)  HGNC  Alliance
Mus musculus (house mouse) : Ccl2 (chemokine (C-C motif) ligand 2)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CCL2 (C-C motif chemokine ligand 2)
Canis lupus familiaris (dog) : CCL2 (C-C motif chemokine ligand 2)
Sus scrofa (pig) : CCL2 (chemokine (C-C motif) ligand 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations