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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:30742
Term: ethylene glycol
Definition: A 1,2-glycol compound produced via reaction of ethylene oxide with water.
Chemical ID: MESH:D019855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2affects expressionEXP 6480464CTDEthylene Glycol affects the expression of CCL2 mRNAPMID:31639794
Ccl2increases expressionEXP 6480464CTDEthylene Glycol results in increased expression of CCL2 mRNA; Ethylene Glycol results in increased expression of CCL2 proteinPMID:16284884 PMID:27018375 PMID:34468068 PMID:37244400
Ccl2multiple interactionsEXP 6480464CTD[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 mRNA]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein]; caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 mRNA]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Vitamin K 1 affects the reaction [Ethylene Glycol affects the expression of CCL2 mRNA]PMID:16284884 PMID:27018375 PMID:31639794 PMID:34468068 PMID:37414240
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDEthylene Glycol results in increased expression of CCL2 mRNAPMID:21907259
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