GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | decreases expression | EXP | | 6480464 | CTD | Nicotine results in decreased expression of CCL2 mRNA; Nicotine results in decreased expression of CCL2 protein | PMID:15135227 PMID:15976189 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA] | PMID:15135227 | Ccl2 | decreases expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Nicotine results in decreased expression of CCL2 mRNA | PMID:22093924 | Ccl2 | decreases secretion | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Nicotine results in decreased secretion of CCL2 protein | PMID:22093924 | Ccl2 | multiple interactions | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA] | PMID:22093924 | |
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