RGD Reference Report - Urinary MCP-1/creatinine in Henoch-Schonlein purpura and its relationship with nephritis. - Rat Genome Database

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Urinary MCP-1/creatinine in Henoch-Schonlein purpura and its relationship with nephritis.

Authors: Fuentes, Y  Hernandez, AM  Garcia-Roca, P  Valverde, S  Velasquez-Jones, LF  Sosa, G  Duarte-Duran, UO  Ortiz, L  Maldonado, R  Faugier, E  Ramon-Garcia, G  Medeiros, M 
Citation: Fuentes Y, etal., Pediatr Nephrol. 2014 Jun;29(6):1047-52. doi: 10.1007/s00467-013-2740-0. Epub 2014 Jan 12.
RGD ID: 11528565
Pubmed: PMID:24414608   (View Abstract at PubMed)
DOI: DOI:10.1007/s00467-013-2740-0   (Journal Full-text)

BACKGROUND: Monocyte chemotactic protein-1 (MCP-1) plays a direct role in the infiltration of macrophages and monocytes during the early stages of Henoch-Schonlein purpura (HSP) nephritis. The aim of this study was to compare the urinary MCP-1/creatinine levels in children with and without HSP nephritis and determine if they are associated with the severity of renal lesions. METHODS: We included 77 patients with HSP and 25 healthy control children. Levels of serum creatinine, urinalysis, and 12-h proteinuria assessments were performed. Urinary MCP-1 levels were determined by ELISA. RESULTS: Fifty-seven patients had nephritis (74 %). Urinary MCP-1/creatinine levels were significantly higher in patients with HSP nephritis (median, 653 pg/mg) compared to those with HSP without nephritis (median, 269 pg/mg) or healthy children (191 pg/mg). In addition, higher MCP-1/creatinine levels were observed in HSP patients who had renal biopsy (median, 1,412 pg/mg) in comparison to HSP patients without renal biopsy (median, 302 pg/mg). The urinary MCP-1 cut-off value of 530 pg/mg could be used to distinguish patients who undergo renal biopsy with a sensitivity of 81 % and specificity of 77 %. CONCLUSIONS: Urinary MCP-1/creatinine levels are elevated in the early stages of severe HSP nephritis and can be used as a biomarker for HSP nephritis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL2Humannephritis  IEP associated with Purpura more ...RGD 
Ccl2Ratnephritis  ISOCCL2 (Homo sapiens)associated with Purpura more ...RGD 
Ccl2Mousenephritis  ISOCCL2 (Homo sapiens)associated with Purpura more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)


Additional Information