CCL2 (C-C motif chemokine ligand 2) - Rat Genome Database

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Gene: CCL2 (C-C motif chemokine ligand 2) Canis lupus familiaris
Symbol: CCL2
Name: C-C motif chemokine ligand 2
RGD ID: 12355366
Description: ENCODES a protein that exhibits CCR2 chemokine receptor binding (ortholog); chemokine activity (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN aging (ortholog); animal organ regeneration (ortholog); astrocyte cell migration (ortholog); PARTICIPATES IN angiotensin II signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-23 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Anterior Uveitis (ortholog); Acute Liver Failure (ortholog); FOUND IN axon terminus (ortholog); C-fiber (ortholog); cytoplasm (ortholog); INTERACTS WITH cannabidiol; gentamycin; luteolin
Type: protein-coding
Also known as: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; MCP-1; monocyte chemoattractant protein-1; monocyte chemotactic protein 1; small-inducible cytokine A2
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1939,008,187 - 39,009,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,231,467 - 38,233,216 (-)NCBI
ROS_Cfam_1.0939,822,383 - 39,824,132 (-)NCBI
UMICH_Zoey_3.1938,608,720 - 38,610,469 (-)NCBI
UNSW_CanFamBas_1.0938,897,447 - 38,899,196 (-)NCBI
UU_Cfam_GSD_1.0938,976,777 - 38,978,526 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Anterior Uveitis  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (ISO)
aggressive periodontitis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
anemia  (ISO)
Animal Hepatitis  (ISO)
anterior uveitis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
calcinosis  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Carrington Syndrome  (ISO)
Chagas disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangitis  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
colitis  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
Contusions  (ISO)
coronary artery disease  (ISO)
Coronary Artery Disease, Development of, in HIV  (ISO)
Coronavirus infectious disease  (ISO)
crescentic glomerulonephritis  (ISO)
Crohn's disease  (ISO)
cryptococcosis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Duchenne muscular dystrophy  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
endomyocardial fibrosis  (ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Orchitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Eye Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
Febrile Neutropenia  (ISO)
fibromyalgia  (ISO)
fungal infectious disease  (ISO)
gastritis  (ISO)
Geographic Atrophy  (ISO)
gestational diabetes  (ISO)
gliosarcoma  (ISO)
glomerulonephritis  (ISO)
Granulomatous Interstitial Nephritis  (ISO)
Granulomatous Vasculitis  (ISO)
Graves Ophthalmopathy  (ISO)
Guillain-Barre syndrome  (ISO)
Hearing Loss, Noise-Induced  (ISO)
heart valve disease  (ISO)
hemarthrosis  (ISO)
hemolytic-uremic syndrome  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
herpes simplex virus keratitis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxaluria  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
Inflammatory Breast Neoplasms  (ISO)
influenza  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial aneurysm  (ISO)
intracranial vasospasm  (ISO)
invasive aspergillosis  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
limited scleroderma  (ISO)
lipodystrophy  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
Lower Extremity Deep Vein Thrombosis  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
lupus nephritis  (ISO)
Lyme Neuroborreliosis  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
neural tube defect  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
obstructive jaundice  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
orchitis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Pain  (ISO)
Painful Neuropathy  (ISO)
pancreatitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
periapical periodontitis  (ISO)
Periodontal Cyst  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Peritoneal Fibrosis  (ISO)
pleural disease  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
portal hypertension  (ISO)
Premature Obstetric Labor  (ISO)
proliferative diabetic retinopathy  (ISO)
Pulmonary Contusion  (ISO)
pulmonary edema  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
Respiratory Tract Granuloma  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis  (ISO)
rheumatoid arthritis  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
silicosis  (ISO)
skin melanoma  (ISO)
spina bifida  (ISO)
Spinal Cord Compression  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
thyroid gland disease  (ISO)
Thyroid Neoplasms  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
Triple Negative Breast Neoplasms  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
uveitis  (ISO)
Vasculitis of the Skin  (ISO)
Venous Thrombosis  (ISO)
viral pneumonia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
cannabidiol  (EXP)
gentamycin  (EXP)
luteolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ regeneration  (ISO)
astrocyte cell migration  (ISO)
cell chemotaxis  (IEA)
cellular calcium ion homeostasis  (ISO)
cellular response to ATP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fatty acid  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to lipoprotein particle stimulus  (ISO)
cellular response to macrophage colony-stimulating factor stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
chemokine-mediated signaling pathway  (ISO)
chemotaxis  (IEA)
chronic inflammatory response  (ISO)
cytokine-mediated signaling pathway  (ISO)
cytoskeleton organization  (ISO)
glial cell migration  (ISO)
helper T cell extravasation  (ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
leukocyte migration involved in inflammatory response  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
lymphocyte chemotaxis  (ISO)
macrophage chemotaxis  (ISO)
MAPK cascade  (ISO)
maternal process involved in female pregnancy  (ISO)
maternal process involved in parturition  (ISO)
monocyte chemotaxis  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of glial cell apoptotic process  (ISO)
negative regulation of natural killer cell chemotaxis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
neutrophil chemotaxis  (ISO)
positive regulation of apoptotic cell clearance  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cellular extravasation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immune complex clearance by monocytes and macrophages  (ISO)
positive regulation of leukocyte mediated cytotoxicity  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of synaptic transmission  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISS)
positive regulation of T cell activation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of wound healing  (ISO)
protein kinase B signaling  (ISO)
regulation of cell shape  (ISO)
regulation of vascular endothelial growth factor production  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to antibiotic  (ISO)
response to bacterium  (ISO)
response to cyclosporin A  (ISO)
response to ethanol  (ISO)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to progesterone  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin B3  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISS)
signal transduction  (IEA)
transforming growth factor beta receptor signaling pathway  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

Additional References at PubMed
PMID:9024159   PMID:18717642   PMID:22986270   PMID:26231926   PMID:26267090   PMID:27863550   PMID:29304171   PMID:30588734  


Comparative Map Data
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1939,008,187 - 39,009,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,231,467 - 38,233,216 (-)NCBI
ROS_Cfam_1.0939,822,383 - 39,824,132 (-)NCBI
UMICH_Zoey_3.1938,608,720 - 38,610,469 (-)NCBI
UNSW_CanFamBas_1.0938,897,447 - 38,899,196 (-)NCBI
UU_Cfam_GSD_1.0938,976,777 - 38,978,526 (-)NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1734,255,218 - 34,257,203 (+)EnsemblGRCh38hg38GRCh38
GRCh381734,255,285 - 34,257,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371732,582,304 - 32,584,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,606,409 - 29,608,335 (+)NCBINCBI36hg18NCBI36
Build 341729,606,408 - 29,608,331NCBI
Celera1729,492,130 - 29,494,042 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1728,767,599 - 28,769,525 (+)NCBIHuRef
CHM1_11732,646,183 - 32,648,095 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391181,926,403 - 81,928,278 (+)NCBIGRCm39mm39
GRCm39 Ensembl1181,926,397 - 81,928,279 (+)Ensembl
GRCm381182,035,577 - 82,037,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,035,571 - 82,037,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,849,079 - 81,850,954 (+)NCBIGRCm37mm9NCBIm37
MGSCv361181,851,769 - 81,853,422 (+)NCBImm8
Celera1191,649,026 - 91,650,901 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1149.82NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21067,005,424 - 67,007,222 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)Ensembl
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11722,821,336 - 22,823,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,820,890 - 22,823,384 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01722,528,154 - 22,530,091 (-)NCBIMhudiblu_PPA_v0panPan3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1240,798,109 - 40,800,028 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,798,109 - 40,800,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,514,202 - 42,516,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11627,763,354 - 27,765,437 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660752,254,637 - 2,256,540 (-)NCBIVero_WHO_p1.0



Reference Sequences
RefSeq Acc Id: NM_001003297   ⟹   NP_001003297
Dog AssemblyChrPosition (strand)Source
CanFam3.1939,008,187 - 39,009,932 (-)NCBI
Dog10K_Boxer_Tasha938,231,467 - 38,233,216 (-)NCBI
ROS_Cfam_1.0939,822,383 - 39,824,132 (-)NCBI
UMICH_Zoey_3.1938,608,720 - 38,610,469 (-)NCBI
UNSW_CanFamBas_1.0938,897,447 - 38,899,196 (-)NCBI
UU_Cfam_GSD_1.0938,976,777 - 38,978,526 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001003297 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA84911 (Get FASTA)   NCBI Sequence Viewer  
  P52203 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003297   ⟸   NM_001003297
- Peptide Label: precursor
- UniProtKB: P52203 (UniProtKB/Swiss-Prot)
- Sequence:

RGD ID:13684653
Promoter ID:EPDNEW_C2723
Type:single initiation site
Description:C-C motif chemokine 2 precursor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Dog AssemblyChrPosition (strand)Source
CanFam3.1939,010,002 - 39,010,062EPDNEW

Additional Information

Database Acc Id Source(s)
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report cfa:403981 UniProtKB/Swiss-Prot
PANTHER PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-27 CCL2  C-C motif chemokine ligand 2    chemokine (C-C motif) ligand 2  Symbol and/or name change 5135510 APPROVED