RGD Reference Report - Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats. - Rat Genome Database

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Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats.

Authors: Kang, ES  Lee, GT  Kim, BS  Kim, CH  Seo, GH  Han, SJ  Hur, KY  Ahn, CW  Ha, H  Jung, M  Ahn, YS  Cha, BS  Lee, HC 
Citation: Kang ES, etal., Eur J Pharmacol. 2008 Jan 28;579(1-3):418-25. Epub 2007 Nov 1.
RGD ID: 2306989
Pubmed: PMID:18031723   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejphar.2007.10.070   (Journal Full-text)

Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 diabetic animal models. In the present study we investigated the effects of LAB on the prevention of diabetic nephropathy in type 2 diabetic Otsuka Long-Evans-Tokushima Fatty (OLETF) rats. LAB (20 mg/kg) was given orally once daily to 10-week-old male OLETF rats for 28 weeks. Treatment of OLETF rats with LAB had little effects on body weight and blood glucose levels. Treatment with LAB resulted in significant reduction in blood pressure. LAB markedly attenuated albuminuria and significantly lowered levels of lipid peroxidation, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-beta (TGF-beta1) expression in renal tissues of OLETF rats. In addition, LAB inhibited the progression of glomerular hypertrophy, mesangial expansion, and expansion of the extracellular matrix in the renal cortex. Collectively, these results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing blood pressure, oxidative stress, and MCP-1 expression. Our results suggest that LAB might be a new therapeutic agent for the prevention of nephropathy in type 2 diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies  ISOCcl2 (Rattus norvegicus)2306989; 2306989associated with Diabetes Mellitus more ...RGD 
Diabetic Nephropathies  IEP 2306989associated with Diabetes Mellitus more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)

Objects referenced in this article
Gene CCL13 C-C motif chemokine ligand 13 Homo sapiens

Additional Information