RGD Reference Report - A Monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation. - Rat Genome Database

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A Monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation.

Authors: Kruger, B  Schroppel, B  Ashkan, R  Marder, B  Zulke, C  Murphy, B  Kramer, BK  Fischereder, M 
Citation: Kruger B, etal., J Am Soc Nephrol. 2002 Oct;13(10):2585-9.
RGD ID: 8548879
Pubmed: PMID:12239249   (View Abstract at PubMed)

Among the factors modulating transplant rejection and cardiovascular disease, chemokines and their respective receptors deserve special attention. In this respect, increased expression of MCP-1 and the corresponding receptor CCR2 have been demonstrated in renal transplant rejection and coronary artery disease. The impact of the MCP-1-2518G and CCR2-64I genotypes on renal allograft function was investigated in 232 patients who underwent transplantation over an 11-yr period. Genomic DNA was genotyped using PCR with sequence-specific primers followed by restriction fragment length polymorphism analysis. Eighteen (7.8%) patients were homozygous for the MCP-1-2518G mutation. The G/G allele of MCP-1 -2518 behaved as a determinant for long-term allograft survival and resulted in reduction of the mean graft survival, as compared with the heterozygous (A/G) or wild-type (A/A) allele (67 +/- 14 versus 95 +/- 4 mo; Log rank P = 0.0052). The 64I mutation of CCR2 had no effect on kidney graft failure (93 +/- 6 and 91 +/- 5 mo, respectively; P = 0.81). None of the investigated polymorphisms showed a significant shift in gene frequency in acute rejection and rejection-free groups. In conjunction with these findings, peripheral blood mononuclear cells from kidney transplant recipients carrying the G-allele were characterized by a 2.5-fold higher MCP-1 secretion (P < 0.05). In conclusion, recipients of renal transplants homozygous for the -2518 G mutation of the MCP-1 gene are at risk for premature kidney graft failure. This variant of MCP-1 may be a future predictor for long-term kidney graft failure.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL2HumanTransplant Rejection susceptibilityIAGP kidney and DNA:snp:promoter:g.-2518A>G (human)RGD 
Ccl2RatTransplant Rejection susceptibilityISOCCL2 (Homo sapiens)kidney and DNA:snp:promoter:g.-2518A>G (human)RGD 
Ccl2MouseTransplant Rejection susceptibilityISOCCL2 (Homo sapiens)kidney and DNA:snp:promoter:g.-2518A>G (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)

Objects referenced in this article
Gene CCL13 C-C motif chemokine ligand 13 Homo sapiens

Additional Information