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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of CCL2 mRNA; Toluene 2,4-Diisocyanate results in increased expression of CCL2 proteinPMID:19647056 PMID:20219652 PMID:21404309
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDCCL2 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]PMID:26072274
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