RGD Reference Report - Proinflammatory genetic profiles in subjects with history of ischemic stroke. - Rat Genome Database

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Proinflammatory genetic profiles in subjects with history of ischemic stroke.

Authors: Flex, A  Gaetani, E  Papaleo, P  Straface, G  Proia, AS  Pecorini, G  Tondi, P  Pola, P  Pola, R 
Citation: Flex A, etal., Stroke. 2004 Oct;35(10):2270-5. Epub 2004 Aug 12.
RGD ID: 1581163
Pubmed: PMID:15308783   (View Abstract at PubMed)
DOI: DOI:10.1161/01.STR.0000140740.19421.fe   (Journal Full-text)

BACKGROUND AND PURPOSE: Proinflammatory genetic profiles, resulting from the combination of single nucleotide polymorphisms in genes encoding inflammatory molecules, may contribute to the development and progression of cardiovascular diseases. We evaluated the association between history of ischemic stroke and genetic profiles determined by the synergistic effects of polymorphisms in genes encoding prototypical inflammatory proteins. METHODS: The study included 237 individuals with history of ischemic stroke and 223 age-matched and gender-matched controls. The polymorphisms of the C-reactive protein (CRP), interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin (E-sel), and matrix metalloproteinase-3 (MMP-3) genes were studied. RESULTS: IL-6 GG, IL-6 GC, MCP-1 GG, ICAM-1 EE, E-sel AA, and MMP-3 5A5A genotypes were significantly and independently associated with stroke history. The odds of stroke increased with the number of high-risk genotypes: carrying 1 proinflammatory gene variant conferred a risk of 3.3 (1.6 to 6.9), whereas individuals concomitantly carrying 2 and 3 proinflammatory gene variants had adjusted odds ratios of 21.0 (7.6 to 57.5) and 50.3 (10.2 to 248.1), respectively. CONCLUSIONS: Proinflammatory genetic profiles are significantly more common in subjects with stroke history. Synergistic effects between proinflammatory genotypes might be potential markers for cerebrovascular diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ischemia  IAGP 1581163 RGD 
ischemia  ISOCCL2 (Homo sapiens)1581163; 1581163 RGD 
Stroke  IAGP 1581163DNA:snp:promoter:g.-2518A>G (human)RGD 
Stroke  ISOCCL2 (Homo sapiens)1581163; 1581163DNA:snp:promoter:g.-2518A>G (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)

Objects referenced in this article
Gene CCL13 C-C motif chemokine ligand 13 Homo sapiens

Additional Information