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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:64243
Term: monosodium L-glutamate
Definition: An optically active form of monosodium glutamate having L-configuration.
Chemical ID: MESH:D012970
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionISOCcl2 (Mus musculus)6480464CTDSodium Glutamate results in decreased expression of CCL2 mRNAPMID:20111022
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTDSodium Glutamate results in increased expression of CCL2 mRNA; Sodium Glutamate results in increased expression of CCL2 proteinPMID:19724016
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTD[Fats, Unsaturated co-treated with Sodium Glutamate] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein]; SRT1720 inhibits the reaction [Sodium Glutamate results in increased expression of CCL2 mRNA]; SRT1720 inhibits the reaction [Sodium Glutamate results in increased expression of CCL2 protein]PMID:19724016 PMID:23783067
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