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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionEXP 6480464CTDParaquat results in increased expression of CCL2 mRNAPMID:21921364 PMID:32680482
Ccl2multiple interactionsEXP 6480464CTD[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CCL2 protein; Ambroxol affects the reaction [Paraquat results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CCL2 protein]PMID:21921364 PMID:24376630
Ccl2affects expressionISOCcl2 (Mus musculus)6480464CTDParaquat affects the expression of CCL2 mRNAPMID:26345256
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTDParaquat results in increased expression of CCL2 mRNAPMID:16324872
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDParaquat results in increased expression of CCL2 proteinPMID:36108500
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