GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | increases expression | EXP | | 6480464 | CTD | Dexamethasone results in increased expression of CCL2 mRNA | PMID:18234956 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | Dexamethasone inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Dexamethasone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] | PMID:25851902 | Ccl2 | increases expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Dexamethasone results in increased expression of CCL2 mRNA | PMID:21041162 | Ccl2 | increases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Dexamethasone results in increased expression of CCL2 mRNA | PMID:19853017 | Ccl2 | multiple interactions | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein]; [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the susceptibility to Ethanol] which results in increased secretion of CCL2 protein; [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the susceptibility to GHRL protein] which results in increased secretion of CCL2 protein; [Amiodarone co-treated with Dexamethasone] results in increased expression of CCL2 mRNA; [Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein; [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CCL2 mRNA; [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CCL2 mRNA]; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA; Dexamethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CCL2 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA] | PMID:15187150 PMID:16054899 PMID:23503329 PMID:25900201 PMID:27568862 PMID:31751647 PMID:32171850 PMID:33140555 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein]; [Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein; [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of CCL2 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CCL2 mRNA; Dexamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Dexamethasone inhibits the reaction [Mitomycin results in increased expression of CCL2 mRNA]; Dexamethasone inhibits the reaction [Mitomycin results in increased secretion of CCL2 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] | PMID:15187150 PMID:16997883 PMID:19255438 PMID:20002897 PMID:27568862 PMID:28628672 PMID:36416909 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |