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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:132853
Term: acteoside
Definition: A glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid.
Chemical ID: MESH:C058956
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDacteoside results in decreased expression of CCL2 mRNAPMID:21756928 PMID:21967610
Ccl2decreases secretionISOCCL2 (Homo sapiens)6480464CTDacteoside results in decreased secretion of CCL2 proteinPMID:21967610
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDacteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]PMID:21756928
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