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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2multiple interactionsEXP 6480464CTDValsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]PMID:15284299 PMID:17624267
Ccl2decreases expressionISOCcl2 (Mus musculus)6480464CTDValsartan results in decreased expression of CCL2 mRNAPMID:35235860
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDFluorouracil promotes the reaction [Valsartan results in decreased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; Valsartan promotes the reaction [Fluorouracil results in decreased expression of CCL2 mRNA]PMID:18436887 PMID:29266779 PMID:35235860
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTD[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]PMID:16705055 PMID:19225232 PMID:28973481
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