GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | decreases expression | EXP | | 6480464 | CTD | Curcumin results in decreased expression of CCL2 mRNA | PMID:10925121 PMID:11053056 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA] | PMID:22683883 | Ccl2 | decreases expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein | PMID:18403477 | Ccl2 | increases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Curcumin results in increased expression of CCL2 mRNA | PMID:17198877 | Ccl2 | multiple interactions | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] | PMID:20712904 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]] | PMID:17666914 PMID:19152916 PMID:23452621 PMID:33952798 | |
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