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Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats.

Authors: Hu, JH  Zheng, XY  Yang, JP  Wang, LN  Ji, FH 
Citation: Hu JH, etal., Neurosci Lett. 2012 May 23;517(1):60-3. doi: 10.1016/j.neulet.2012.04.026. Epub 2012 Apr 15.
Pubmed: (View Article at PubMed) PMID:22531750
DOI: Full-text: DOI:10.1016/j.neulet.2012.04.026

In this study, we examined the involvement of chemokine monocyte chemoattractant protein-1 (MCP-1) in the spinal cord of a rat model of cancer-induced bone pain (CIBP). In this model, CIBP was established by an intramedullary injection of Walker 256 cells into the tibia of rats. We observed a significant increase in expression levels of MCP-1 and its receptor CCR2 in the spinal cord of CIBP rats. Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody attenuated the mechanical allodynia established in CIBP rats. Likewise, an intrathecal injection of exogenous recombinant MCP-1 induced a striking mechanical allodynia in naive rats. These results suggest that increases in spinal MCP-1 and CCR2 expression are involved in the development of mechanical allodynia associated with bone cancer rats.

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RGD ID: 8548845
Created: 2014-03-24
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Last Modified: 2014-03-24
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