Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:146245
Term: SR 144528
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid with the amino group of (1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-amine. A potent and selective cannabinoid receptor type 2 (CB2 receptor) inverse agonist (Ki = 0.6 nM).
Chemical ID: MESH:C110630
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2multiple interactionsISORGD:7310466480464CTDSR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-2-hydroxy-4-1 1-dimethylheptylphenyl-4-3-hydroxypropylcyclohexanol results in increased expression of CCL2 mRNA]] SR 144528 inhibits the reaction [CNR2 protein promotes the reaction [3-2-hydroxy-4-1 1-dimethylheptylphenyl-4-3-hydroxypropylcyclohexanol results in increased expression of CCL2 protein]]

PMID:10218491
Go Back to source page   Continue to Ontology report