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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDIbuprofen results in increased expression of CCL2 mRNAPMID:17070997
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDIbuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]PMID:18799549
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDIbuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]PMID:11230753
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