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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2increases expressionEXP 6480464CTDtitanium dioxide results in increased expression of CCL2 mRNAPMID:19695317 PMID:22342292
CCL2increases secretionEXP 6480464CTDtitanium dioxide results in increased secretion of CCL2 proteinPMID:25526690
CCL2multiple interactionsEXP 6480464CTD[Silver Compounds binds to [Nitrogen binds to titanium dioxide]] which results in increased secretion of CCL2 proteinPMID:30711708
CCL2affects expressionISOCcl2 (Rattus norvegicus)6480464CTDtitanium dioxide affects the expression of CCL2 mRNAPMID:30012374
CCL2increases expressionISOCcl2 (Mus musculus)6480464CTDtitanium dioxide results in increased expression of CCL2 mRNA; titanium dioxide results in increased expression of CCL2 proteinPMID:19464567 PMID:21259345 PMID:23557971 PMID:27760801
CCL2increases expressionISOCcl2 (Rattus norvegicus)6480464CTDtitanium dioxide results in increased expression of CCL2PMID:22939914
CCL2multiple interactionsISOCcl2 (Mus musculus)6480464CTD[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CCL2 mRNA; titanium dioxide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]PMID:27216632 PMID:29950665
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